CXCR4 expression in feline mammary carcinoma cells: evidence of a proliferative role for the SDF-1/CXCR4 axis

BMC Veterinary Research

Table 1 Clinico-pathological features of feline mammary tissues

Cat n.	Sample n.*	Sex	Age (yrs)	Breed	Histology	Grade	CXCR4 score
1	1a	F	13	DSH	STPC	II	3+
	1b				STPC	II	1+
2	2	FS	14	DSH	STPC	III	2+
	2M				metastasis (adipose tissue)		2+
3	3a	FS	7	DSH	STPC	III	1+
	3b				STPC	III	3+
4	4a	FS	15	DSH	STPC	III	2+
	4aM				metastasis (lymph node)		3+
	4b				STPC	III	2+
5	5a	F	10	DSH	STPC	III	1+
	5b				STPC	III	2+
	5bM				metastasis (lymph node)		3+
6	6a	FS	12	DSH	STPC	III	2+
	6b				STPC	III	2+
7	7a	F	15	DSH	STPC	III	2+
	7b				STPC	III	2+
8	8	FS	12	DSH	STPC	II	3+
	8M				metastasis (lymph node)		1+
9	9a	F	8	DSH	SC	III	1+
	9b				SC	III	0
10	10	F	14	DSH	SC	III	2+
11	11	FS	9	DSH	SC	III	3+
12	12	FS	14	DSH	SC	III	2+
	12M				metastasis (lymph node)		3+
13	13	F	10	DSH	SC	III	3+
14	14	F	5	DSH	SC	III	1+
15	15	F	19	PC	CC	III	2+
16	16	FS	13	DSH	CC	III	3+
17	17	FS	9	DSH	CC	III	1+
18	18	FS	14	DSH	CC	III	1+
19	19	FS	9	DSH	STC	II	2+
20	20	FS	n.a	DSH	STC	III	2+
21	21	F	12	DSH	STC	III	0
22	22	FS	11	DSH	CC	III	3+
23	23	FS	19	DSH	ASC	III	2+
	23M				metastasis (lung)		3+
24	24	FS	12	DSH	CC	III	2+
25	25	FS	4	DSH	BA	-	1+
26	26	FS	8	DSH	CA	-	0
27	27	FS	12	DSH	NORMAL (M4 D)	-	0
28	28	FS	19	DSH	NORMAL (M1 S)	-	0
29	29	FS	11	DSH	NORMAL (M4 D)	-	0
30	30	F	8	DSH	NORMAL (M2 S)	-	0

F, female, FS, female spayed; DSH, domestic short-hair; PC, persian; STPC, simple tubulopapillary carcinoma; SC, solid carcinoma; STC, simple tubular carcinoma; CC, cribriform carcinoma; BA, basaloid adenoma; CA, complex adenoma; ASC, adenosquamous carcinoma; n.a., not available. For normal tissues the mammary gland topography is indicated. *a and b indicate samples from two glands of the same cat, M labels metastatic tissue. Primary tumours and corresponding metastases of the same cat are reported in bold.

ISSN: 1746-6148