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Table 1 Presentation of the natural cases of classical scrapie

From: Presence of an acute phase response in sheep with clinical classical scrapie

ID Admitted Sampled Age Genotype Clinical presentation Brain Brain PrPSc
S1 10.02.94 14.02.94 6 VRQ/VRQ Pruritic, nervous, tremors Vacuolisation with astrocytosis Positive
S2 20.03.96 07.05.96 5 VRQ/VRQ Pruritic, ataxia, nervous, altered mental state Vacuolisation with astrocytosis Positive
S3 27.08.98 16.09.98 7 ARQ/VRQ Pruritus with hyperkeratosis Vacuolisation with astrocytosis Positive
S4 14.07.99 15.09.99 2 ARQ/VRQ Normal Vacuolisation with astrocytosis Positive
S5 14.02.01 23.02.01 7 VRQ/VRQ Pruritic Vacuolisation with astrocytosis Positive
  1. Overview over admission dates and time of euthanasia, age in years, PrP genotype, clinical presentation at time of euthanasia and pathognomonic histopathology of the brain of the five natural classical scrapie cases. PrPSc was identified by immunohistochemistry on sections of the brain as described by Ersdal et al. (2005) [3]