Presence of an acute phase response in sheep with clinical classical scrapie

BMC Veterinary Research

Table 1 Presentation of the natural cases of classical scrapie

ID	Admitted	Sampled	Age	Genotype	Clinical presentation	Brain	Brain PrP^Sc
S1	10.02.94	14.02.94	6	VRQ/VRQ	Pruritic, nervous, tremors	Vacuolisation with astrocytosis	Positive
S2	20.03.96	07.05.96	5	VRQ/VRQ	Pruritic, ataxia, nervous, altered mental state	Vacuolisation with astrocytosis	Positive
S3	27.08.98	16.09.98	7	ARQ/VRQ	Pruritus with hyperkeratosis	Vacuolisation with astrocytosis	Positive
S4	14.07.99	15.09.99	2	ARQ/VRQ	Normal	Vacuolisation with astrocytosis	Positive
S5	14.02.01	23.02.01	7	VRQ/VRQ	Pruritic	Vacuolisation with astrocytosis	Positive

Overview over admission dates and time of euthanasia, age in years, PrP genotype, clinical presentation at time of euthanasia and pathognomonic histopathology of the brain of the five natural classical scrapie cases. PrP^Sc was identified by immunohistochemistry on sections of the brain as described by Ersdal et al. (2005) [3]

ISSN: 1746-6148