|
Mycobacterium aviumsubsp.
hominissuis
|
---|
Time after inoculation
|
6 weeks
|
8 weeks
|
12 weeks
|
---|
Animal no
|
#1
|
#2
|
#3
|
#4
|
#5
|
#6
|
#7
|
#8
|
#9
|
#10
|
---|
|
m
|
h
|
c
|
p
|
m
|
h
|
c
|
p
|
m
|
h
|
c
|
p
|
m
|
h
|
c
|
p
|
m
|
h
|
c
|
p
|
m
|
h
|
c
|
p
|
m
|
h
|
c
|
p
|
m
|
h
|
c
|
p
|
m
|
h
|
c
|
p
|
m
|
h
|
c
|
p
|
---|
Lnn. mandibulares
|
-
|
-
|
+
|
+
|
-
|
-
|
+
|
-
|
-
|
-
|
+
|
-
|
-
|
-
|
+
|
+
|
-
|
-
|
+
|
-
|
-
|
-
|
+
|
+
|
+
|
+*
|
+
|
-
|
-
|
+
|
+
|
+
|
+
|
+*
|
+
|
+
|
-
|
+*
|
+
|
+
|
Tonsils
|
-
|
+*
|
+
|
+
|
-
|
-
|
+
|
+
|
-
|
-
|
+
|
+
|
-
|
-
|
+
|
+
|
-
|
-
|
+
|
+
|
-
|
-
|
+
|
-
|
-
|
-
|
+
|
-
|
-
|
-
|
C
|
+
|
-
|
+*
|
+
|
+
|
-
|
+*
|
+
|
-
|
Lnn. bifurcationis sinn.
|
-
|
-
|
+
|
+
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
+
|
+
|
-
|
-
|
-
|
+
|
Lung
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
+
|
-
|
nd
|
-
|
-
|
-
|
-
|
Spleen
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
+
|
-
|
-
|
-
|
nd
|
-
|
-
|
-
|
+
|
Liver
|
-
|
-
|
-
|
-
|
-
|
+
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
+
|
-
|
-
|
-
|
+
|
-
|
+
|
+
|
+*
|
-
|
nd
|
-
|
-
|
-
|
+
|
Lnn. jejunales
|
-
|
-
|
+
|
+
|
-
|
-
|
+
|
+
|
-
|
+*
|
+
|
+
|
-
|
-
|
+
|
+
|
-
|
+*
|
-
|
-
|
-
|
+*
|
+
|
+
|
+
|
+*
|
+
|
+
|
+
|
+*
|
+
|
+
|
+
|
+*
|
+
|
nd
|
-
|
+*
|
+
|
-
|
Lnn. ileocolici
|
-
|
-
|
+
|
-
|
-
|
-
|
+
|
+
|
-
|
-
|
-
|
-
|
-
|
-
|
+
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
+
|
-
|
+
|
+*
|
+
|
+
|
-
|
+*
|
+
|
+
|
+
|
+*
|
+
|
nd
|
-
|
+
|
-
|
-
|
Lnn. colici
|
-
|
-
|
+
|
-
|
-
|
-
|
+
|
+
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
+
|
-
|
-
|
-
|
-
|
-
|
+
|
+*
|
+
|
+
|
+
|
+*
|
+
|
nd
|
-
|
-
|
-
|
-
|
Jejunal Peyer's patches
|
-
|
-
|
+
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
+
|
+
|
-
|
-
|
+
|
-
|
-
|
-
|
-
|
nd
|
-
|
+
|
-
|
-
|
-
|
+
|
-
|
-
|
-
|
+
|
-
|
nd
|
-
|
-
|
-
|
-
|
Ileal Peyer's patches
|
-
|
-
|
+
|
+
|
-
|
-
|
+
|
-
|
-
|
-
|
+
|
-
|
-
|
+
|
+
|
+
|
-
|
-
|
-
|
-
|
-
|
-
|
+
|
nd
|
-
|
+
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
+*
|
-
|
nd
|
-
|
+
|
-
|
-
|
Faeces
|
nd
|
nd
|
+
|
nd
|
nd
|
nd
|
+
|
nd
|
nd
|
nd
|
+
|
nd
|
nd
|
nd
|
+
|
nd
|
nd
|
nd
|
-
|
nd
|
nd
|
nd
|
+
|
nd
|
nd
|
nd
|
-
|
nd
|
nd
|
nd
|
-
|
nd
|
nd
|
nd
|
-
|
nd
|
nd
|
nd
|
-
|
nd
|
|
Mycobacterium avium
subsp.
avium
|
Time after inoculation
|
6 weeks
|
12 weeks
|
Animal no
|
#11
|
#12
|
#13
|
#14
|
#15
|
#16
|
#17
|
#18
|
#19
|
#20
|
|
m
|
h
|
c
|
p
|
m
|
h
|
c
|
p
|
m
|
h
|
c
|
p
|
m
|
h
|
c
|
p
|
m
|
h
|
c
|
p
|
m
|
h
|
c
|
p
|
m
|
h
|
c
|
p
|
m
|
h
|
c
|
p
|
m
|
h
|
c
|
p
|
m
|
h
|
c
|
P
|
Lnn. mandibulares
|
-
|
+*
|
+
|
+
|
-
|
+
|
+
|
-
|
-
|
-
|
+
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
+
|
-
|
-
|
-
|
+
|
-
|
-
|
-
|
+
|
+
|
-
|
+
|
+
|
-
|
-
|
+*
|
+
|
-
|
-
|
+*
|
+
|
+
|
Tonsils
|
-
|
+
|
-
|
+
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
+
|
-
|
+
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
+*
|
+
|
+
|
-
|
+*
|
+
|
+
|
Lnn. bifurcationis sinn.
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
+
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
+
|
-
|
-
|
-
|
+
|
-
|
-
|
-
|
-
|
-
|
+
|
Lung
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
+
|
-
|
+
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
+
|
-
|
-
|
-
|
+
|
-
|
-
|
-
|
+
|
-
|
+
|
-
|
+
|
Spleen
|
-
|
+
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
+
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
+
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
+
|
-
|
-
|
-
|
+
|
Liver
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
+
|
-
|
-
|
-
|
+
|
-
|
-
|
-
|
-
|
-
|
+
|
-
|
-
|
-
|
-
|
-
|
+
|
Lnn. jejunales
|
-
|
-
|
+
|
+
|
-
|
-
|
+
|
-
|
-
|
-
|
+
|
-
|
-
|
-
|
+
|
-
|
-
|
-
|
+
|
+
|
-
|
-
|
-
|
-
|
-
|
-
|
+
|
-
|
+
|
+*
|
+
|
-
|
+
|
+*
|
+
|
+
|
-
|
+
|
+
|
+
|
Lnn. ileocolici
|
+
|
+
|
+
|
+
|
-
|
-
|
+
|
+
|
-
|
-
|
-
|
-
|
-
|
-
|
+
|
-
|
-
|
-
|
+
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
+
|
+
|
-
|
+
|
+
|
+
|
+
|
-
|
-
|
+
|
-
|
Lnn. colici
|
-
|
-
|
-
|
+
|
-
|
-
|
+
|
-
|
-
|
+
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
+
|
+
|
-
|
-
|
+
|
-
|
-
|
-
|
+
|
-
|
-
|
-
|
-
|
+
|
-
|
-
|
-
|
-
|
-
|
-
|
+
|
-
|
Jejunal Peyer's patches
|
-
|
-
|
+
|
+
|
-
|
-
|
+
|
-
|
-
|
+
|
+
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
+
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
+
|
-
|
+
|
*
|
+
|
-
|
+
|
-
|
-
|
-
|
+
|
Ileal Peyer's patches
|
-
|
-
|
+
|
+
|
-
|
+*
|
+
|
-
|
-
|
-
|
+
|
+
|
-
|
-
|
-
|
-
|
-
|
-
|
+
|
-
|
-
|
+
|
+
|
+
|
-
|
-
|
-
|
-
|
-
|
+
|
+
|
-
|
-
|
+
|
-
|
+
|
-
|
+*
|
+
|
-
|
Faeces
|
nd
|
nd
|
-
|
nd
|
nd
|
nd
|
-
|
nd
|
nd
|
nd
|
-
|
nd
|
nd
|
nd
|
-
|
nd
|
nd
|
nd
|
-
|
nd
|
nd
|
nd
|
-
|
nd
|
nd
|
nd
|
-
|
nd
|
nd
|
nd
|
-
|
nd
|
nd
|
nd
|
-
|
nd
|
nd
|
nd
|
-
|
nd
|
- hominissuis or Mycobacterium avium subsp. avium
- m = macroscopic examination. Positive when visible tuberculous lesions are present
- h = histopathological examination. Positive when granulomatous lesions present. * indicates the presence of acid-fast bacilli
- c = cultural examination: Positive when acid-fast staining, characteristic colonies are present
- p = real time PCR: Positive at Ct values ≤ 38
- nd = not done or not applicable
- C = contaminated