Dietary soyasaponin supplementation to pea protein concentrate reveals nutrigenomic interactions underlying enteropathy in Atlantic salmon (Salmo salar)

Kortner, Trond M; Skugor, Stanko; Penn, Michael H; Mydland, Liv Torunn; Djordjevic, Brankica; Hillestad, Marie; Krasnov, Aleksei; Krogdahl, Åshild

doi:10.1186/1746-6148-8-101

Table 4 Differentially expressed genes in PPC + S group related to metabolism (mean fold change of PPC control group levels)

From: Dietary soyasaponin supplementation to pea protein concentrate reveals nutrigenomic interactions underlying enteropathy in Atlantic salmon (Salmo salar)

Gene	Fold change ±SE
*Amino acid metabolism*
Cysteine dioxygenase type 1	−46.28±10.52
L-pipecolic acid oxidase	−10.32±1.68
D-amino-acid oxidase	−2.95±0.66
Kynurenine 3-monooxygenase	−3.39±0.27
Gamma-glutamyltransferase 5	−2.84±0.63
Aspartate aminotransferase, cytoplasmic	−4.03±0.99
Aspartate aminotransferase, mitochondrial	−1.85±0.18
4-aminobutyrate aminotransferase	−3.85±1.04
Alpha-aminoadipate aminotransferase	−2.13±0.32
Guanidinoacetate N-methyltransferase	−7.45±1.38
Arginine N-methyltransferase 3	2.48±0.42
Diamine acetyltransferase 2	−2.65±0.70
Amidohydrolase domain containing 1	−3.01±0.84
Gamma-glutamyl hydrolase	−1.91±0.22
Methylmalonate-semialdehyde dehydrogenase	−3.85±0.85
3-hydroxyisobutyrate dehydrogenase	−1.80±0.12
Methionine-R-sulfoxide reductase B2	−2.60±0.67
Lysine ketoglutarate reductase	−2.29±0.51
Glycine cleavage system H protein	−2.29±0.53
Glutaminase	−3.56±0.31
Adenylosuccinate synthase like 2	−1.74±0.05
Folylpolyglutamate synthase	−2.14±0.22
Ammonium transporter Rh type B	−3.99±1.73
*Transporters*
B0,+−type amino acid transporter 1	−3.60±1.00
Sodium-dependent neutral amino acid transporter B0	−14.12±7.68
Taurine transporter	−1.85±0.27
Sodium-dependent phosphate transport protein 2A	−6.13±2.69
Facilitated glucose transporter, member 8	−4.08±1.68
Facilitated glucose transporter member, 11	−1.9±0.40
Solute carrier family 15 member 1	−4.11±0.98
Sodium/glucose cotransporter 2	−2.15±0.47
Monocarboxylate transporter 9	−3.31±0.81
Solute carrier family 22 member 7	−4.35±1.16
ATPase, Cu++ transporting, beta	−2.25±0.44
Sulfate transporter	−3.86±0.94
Solute carrier family 13 member 3	−6.15±3.13
Two pore calcium channel protein 1	−3.77±1.03
Transcobalamin-2	−4.36±1.37
Aquaporin-8	−14.24±4.90
Aquaporin FA-CHIP	−1.89±0.28
Calcium activated chloride channel 2	1.83±0.33
Solute carrier family 12, member 8	2.53±0.49
Chloride channel protein 3	2.92±0.82
Sodium-coupled neutral amino acid transporter 2	2.32±0.45
Multidrug resistance associated protein 2	2.59±0.86
*Lipid and steroid metabolism*
Peroxisome proliferator-activated receptor gamma	−1.98±0.30
StAR-related lipid transfer protein 5	1.93±0.33
25-hydroxycholesterol 7-alpha-hydroxylase	−1.94±0.13
Alpha-methylacyl-CoA racemase	−2.58±0.83
Sterolin 1	−3.14±0.92
Very long-chain acyl-CoA synthetase	−2.45±0.80
Fatty acyl-CoA hydrolase , medium chain	−4.25±0.78
Acyl-CoA dehydrogenase	−2.50±0.65
Isovaleryl-CoA dehydrogenase, mitochondrial	−2.12±0.42
Peroxisomal bifunctional enzyme	−2.21±0.51
Peroxisomal 3,2-trans-enoyl-CoA isomerase	−2.20±0.42
Hydroxyacid oxidase 2	−6.13±2.15
Fatty aldehyde dehydrogenase	−1.98±0.34
Acyl-CoA desaturase	−2.74±0.26
Delta-6 fatty acyl desaturase	−2.03±0.15
Peroxisomal trans-2-enoyl-CoA reductase	−1.93±0.26
Fatty acid desaturase domain family, member 6	−3.04±0.62
Acyl-coenzyme A thioesterase 5	−2.30±0.39
Ganglioside GM2 activator	−2.68±0.37
Dihydroxyacetone kinase 2	−2.06±0.25
1-acyl-sn-glycerol-3-phosphate acyltransferase delta	−2.06±0.32
Phospholipase B1	−3.81±1.22
Retinol dehydrogenase 8	−3.27±0.88
Lecithin retinol acyltransferase	−1.88±0.11
Beta-carotene 15, 15-monooxygenase 1	−4.8±1.20
Epidermal retinal dehydrogenase 2	−5.42±1.83
Dehydrogenase/reductase SDR family member 12	−2.19±0.31
Sphingomyelin phosphodiesterase 1, acid lysosomal 1	−2.62±0.61
3-oxo-5-beta-steroid 4-dehydrogenase	−2.25±0.57
Lipocalin	−1.67±0.09
Apolipoprotein A-I-1	−4.96±1.73
Apolipoprotein A-I-2	−4.74±1.75
Fatty acid-binding protein, intestinal	−6.95±2.39
Fatty acid-binding protein, liver-type	−2.23±0.29
apolipoprotein B	−2.91±0.06
Apolipoprotein A-IV	−1.90±0.35
Apolipoprotein A-II	−5.56±0.95
Carnitine palmitoyl transferase I	−1.86±0.17
Arylacetamide deacetylase	−3.56±0.31
2-acylglycerol O-acyltransferase 2-A	−3.89±1.40
N-acylsphingosine amidohydrolase 2	−6.64±2.12
*Proteases*
Angiotensin I converting enzyme 2	−3.42±0.87
Aspartyl aminopeptidase	−1.97±0.32
Carboxypeptidase N catalytic chain	−4.06±0.90
Cathepsin K	1.86±0.22
Cathepsin L.1	−7.30±2.89
Cathepsin M	−1.82±0.14
Glutamyl aminopeptidase	−1.86±0.26
Legumain	−4.17±1.25
Meprin A, alpha	−4.10±1.38
Metalloproteinase inhibitor 3	−12.75±5.59
Pancreatic secretory trypsin inhibitor	−2.35±0.21
Peptidase D	−2.99±0.79
Probable serine carboxypeptidase CPVL	−4.08±1.21
Serine carboxypeptidase 1	−3.99±1.30
Xaa-Pro aminopeptidase 1	−2.09±0.45
N-acetylated alpha-linked acidic dipeptidase-like 1	−2.55±0.6
Digestive cysteine proteinase 2	−3.37±0.94
Lactase-phlorizin hydrolase preproprotein	−8.55±2.13
*Xenobiotic metabolism*
Alanine--glyoxylate aminotransferase 2	−1.91±0.17
Aldehyde dehydrogenase family 9 member A1-A	−1.82±0.14
Succinate-semialdehyde dehydrogenase, mitochondrial	−2.40±0.36
Aryl hydrocarbon receptor nuclear translocator-like	−2.28±0.6
Arylamine N-acetyltransferase	−4.88±2.36
Cytochrome P450	−3.00±0.93
Cytochrome P450 24A1, mitochondrial	−4.67±1.00
Cytochrome P450 2M1	−5.15±0.55
Cytochrome P450 3A27	−2.44±0.57
Cytochrome P450 4F3	−2.47±0.47
Cytochrome P450 monooxygenase CYP2K1v2	−5.94±2.24
cytochrome P450, family 26, subfamily A1-2	−2.76±0.68
Epoxide hydrolase 2	−2.17±0.53
Fatty acid amide hydrolase 2	−2.05±0.13
Nitrilase homolog 2	−2.24±0.22
Probable thiopurine S-methyltransferase	−2.56±0.54
Aldehyde dehydrogenase, mitochondrial	−2.08±0.34
Sulfotransferase 6B1	−2.83±0.92
UDP-glucuronosyltransferase 2A2	−3.63±0.83

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