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Table 2 Summary of PrPSc detection in multiple tissues from sheep transfused with different blood components from scrapie infected sheep.

From: Classical scrapie prions in ovine blood are associated with B lymphocytes and platelet-rich plasma

Blood components Recipient PrPSc detection by IHC *Scrapie
  PRNP Antemortem Postmortem positive (%)
   Rectal tissues Rectal
tissues
Other lymphoid tissues  
Whole blood MARQ/MARQ 4/4 4/4 4/4 100
  MARQ/MVRQ 3/4 4/4 4/4 100
  MARQ/TARQ 0/2 0/2 0/2 0
  TARQ/MVRQ 0/3 2/3 3/3 100
Buffy coat MARQ/MARQ 3/3 3/3 3/3 100
  MARQ/TARQ 1/2 1/2 2/2 100
PBMCs MVRQ/MVRQ 4/5 5/5 5/5 100
  MARQ/MVRQ 6/9 7/9 9/9 100
  TARQ/MVRQ 1/1 1/1 1/1 100
CD72+ B lymphocytes MVRQ/MVRQ 3/3 3/3 3/3 100
CD21+ B lymphocytes MVRQ/MVRQ 2/3 3/3 3/3 100
Platelet-rich plasma MARQ/MARQ 2/3 2/3 2/3 67
Platelet-poor plasma MARQ/MARQ 0/3 0/3 0/3 0
  1. Other lymphoid tissues = retropharyngeal lymph nodes, palatine tonsil, spleen, ileo-cecal junction, ileo-cecal lymph node or mesenteric lymph nodes; IHC = immunohistochemistry; *Scrapie positive PrPSc was detected in one or more lymphoid tissues at necropsy