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Table 3 Clinicopathologic characteristics of canine mammary carcinoma

From: Elevated Krüppel-like factor 4 transcription factor in canine mammary carcinoma

  KLF4 expression (Quick score)  
  low/moderate (< 9) High ( 9) N P
  n % n %   
Age
< 12 years 14 45.2% 17 38.6% 31 0.572
12 years 17 54.8% 27 61.4% 44  
Ovariohysterectomy
No 26 83.9% 33 75.0% 59 0.356
Yes 5 16.1% 11 25.0% 16  
Tumor Size
T1 (< 3 cm) 15 48.4% 11 25.0% 26  
T2 ( 3 cm, < 5 cm) 7 22.6% 18 40.9% 25 0.089
T3 (> 5 cm) 9 29.0% 15 34.1% 24  
Grade
I 12 38.7% 5 11.4% 17  
II 14 45.2% 22 50.0% 36 0.009
III 5 16.1% 17 38.6% 22  
Histological classification
Carcinoma in benign tumor 5 16.1% 0 0.0% 5  
Complex carcinoma 14 45.2% 21 47.7% 35 0.020
Simple carcinoma 12 38.7% 23 52.3% 35  
Location of affected gland
cranial 10 32.3% 17 38.6% 27 0.571
caudal 21 67.7% 27 61.4% 48  
Stage
I 15 48.4% 5 11.4% 20  
II 5 16.1% 13 29.5% 18  
III 4 12.9% 7 15.9% 11 0.006
IV 4 12.9% 15 34.1% 19  
V 3 9.7% 4 9.1% 7  
ER
Negative 16 51.6% 23 52.3% 39 0.955
Positive 15 48.4% 21 47.7% 36  
PR
Negative 6 19.4% 5 11.4% 11 0.509
Positive 25 80.6% 39 88.6% 64  
Her-2/neu
Negative 26 83.9% 32 72.7% 58 0.281
Positive 5 16.1% 12 27.3% 17  
Molecular phenotyping
Basal 10 32.3% 15 34.1% 25  
HER-2 overexpressing 2 6.5% 5 11.4% 7  
Luminal A 12 38.7% 14 31.8% 26 0.761
Luminal B 3 9.7% 7 15.9% 10  
Null 4 12.9% 3 6.8% 7  
Survival a
< 24 months 9 56.3% 34 89.5% 43 0.010
24 months 7 43.8% 4 10.5% 11  
  1. a Twenty-one cases lacked survival data and were excluded from the analysis.