Table 3 Clinicopathologic characteristics of canine mammary carcinoma
From: Elevated Krüppel-like factor 4 transcription factor in canine mammary carcinoma
KLF4 expression (Quick score) | ||||||
|---|---|---|---|---|---|---|
low/moderate (< 9) | High (≧ 9) | N | P | |||
n | % | n | % | |||
Age | ||||||
< 12 years | 14 | 45.2% | 17 | 38.6% | 31 | 0.572 |
≧ 12 years | 17 | 54.8% | 27 | 61.4% | 44 | |
Ovariohysterectomy | ||||||
No | 26 | 83.9% | 33 | 75.0% | 59 | 0.356 |
Yes | 5 | 16.1% | 11 | 25.0% | 16 | |
Tumor Size | ||||||
T1 (< 3 cm) | 15 | 48.4% | 11 | 25.0% | 26 | |
T2 (≧ 3 cm, < 5 cm) | 7 | 22.6% | 18 | 40.9% | 25 | 0.089 |
T3 (> 5 cm) | 9 | 29.0% | 15 | 34.1% | 24 | |
Grade | ||||||
I | 12 | 38.7% | 5 | 11.4% | 17 | |
II | 14 | 45.2% | 22 | 50.0% | 36 | 0.009 |
III | 5 | 16.1% | 17 | 38.6% | 22 | |
Histological classification | ||||||
Carcinoma in benign tumor | 5 | 16.1% | 0 | 0.0% | 5 | |
Complex carcinoma | 14 | 45.2% | 21 | 47.7% | 35 | 0.020 |
Simple carcinoma | 12 | 38.7% | 23 | 52.3% | 35 | |
Location of affected gland | ||||||
cranial | 10 | 32.3% | 17 | 38.6% | 27 | 0.571 |
caudal | 21 | 67.7% | 27 | 61.4% | 48 | |
Stage | ||||||
I | 15 | 48.4% | 5 | 11.4% | 20 | |
II | 5 | 16.1% | 13 | 29.5% | 18 | |
III | 4 | 12.9% | 7 | 15.9% | 11 | 0.006 |
IV | 4 | 12.9% | 15 | 34.1% | 19 | |
V | 3 | 9.7% | 4 | 9.1% | 7 | |
ER | ||||||
Negative | 16 | 51.6% | 23 | 52.3% | 39 | 0.955 |
Positive | 15 | 48.4% | 21 | 47.7% | 36 | |
PR | ||||||
Negative | 6 | 19.4% | 5 | 11.4% | 11 | 0.509 |
Positive | 25 | 80.6% | 39 | 88.6% | 64 | |
Her-2/neu | ||||||
Negative | 26 | 83.9% | 32 | 72.7% | 58 | 0.281 |
Positive | 5 | 16.1% | 12 | 27.3% | 17 | |
Molecular phenotyping | ||||||
Basal | 10 | 32.3% | 15 | 34.1% | 25 | |
HER-2 overexpressing | 2 | 6.5% | 5 | 11.4% | 7 | |
Luminal A | 12 | 38.7% | 14 | 31.8% | 26 | 0.761 |
Luminal B | 3 | 9.7% | 7 | 15.9% | 10 | |
Null | 4 | 12.9% | 3 | 6.8% | 7 | |
Survival a | ||||||
< 24 months | 9 | 56.3% | 34 | 89.5% | 43 | 0.010 |
≧ 24 months | 7 | 43.8% | 4 | 10.5% | 11 | |