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Table 2 Characteristics of PH permeability of histologically intact skin

From: The percutaneous permeation of a combination of 0.1% octenidine dihydrochloride and 2% 2-phenoxyethanol (octenisept®) through skin of different species in vitro

Parameter Cattle Dog Cat Horse
  Mean STD Mean STD Mean STD Mean STD
Jmax (μg/cm2/h) 1231.04 162.65 392.06 159.09 580.87 379.56 1298.78 178.97
Papp (cm/s) 1.71E-05 2.26E-06 5.45E-06 2.21E-06 8.07E-06 5.27E-06 1.80E-05 2.49E-06
Recovery 6 h (%) 13.25 1.86 5.88 2.28 6.00 2.35 28.36 3.48
Recovery 28 h (%) 37.01 2.18 38.80 15.68 35.09 15.79 61.10 1.64
  1. Flux Jmax, apparent permeability coefficient Papp, and recoveries after 6 and 28 hours of PH obtained in diffusion experiments with histologically intact split skin of different animals after 28 hours (n = 6) calculated from the maximum absorption according to Niedorf et al. (2008) [14]