The percutaneous permeation of a combination of 0.1% octenidine dihydrochloride and 2% 2-phenoxyethanol (octenisept®) through skin of different species in vitro

Table 1 Amount of OCT and PH in animal skin layers

	Skin residue (μg/cm²)	Cattle		Cattle "barrier disrupted"		Dog		Cat		Horse
		Mean	STD	Mean	STD	Mean	STD	Mean	STD	Mean	STD
	Stratum corneum	1.00	0.28	---	---	0.65	0.34	1.79	0.32	0.99	0.57
OCT	Dermis	3.36	1.81	5.10	1.15	2.79	0.94	4.67	1.61	2.58	1.01
	Total amount	4.37	1.84			3.44	0.99	6.46	1.76	3.57	1.37
	Stratum corneum	317.04	66.67	---	---	40.94	14.11	82.25	16.41	345.70	126.99
PH	Dermis	108.93	20.33	197.08	85.43	79.01	40.28	124.97	55.55	111.67	32.98
	Total amount	407.81	67.65			113.13	44.90	207.21	59.70	457.37	144.67

Amount of OCT and PH in the stratum corneum and the dermis of the split skin samples after 28 hours experiments (n = 4-6)

ISSN: 1746-6148