Lack of evidence of a beneficial effect of azathioprine in dogs treated with prednisolone for idiopathic immune-mediated hemolytic anemia: a retrospective cohort study

Table 1 Clinical signs and laboratory results for dogs in the AP protocol group and the P protocol group at time of diagnosis

	Azathioprine- Prednisolone Protocol				Prednisolone Protocol
Clinical signs	Present	Absent	na		Present	Absent	n	Pb
Anorexia	119	30	149		55	17	72	0.554
Vomiting	44	105	149		27	46	73	0.263
Diarrhea	23	126	149		17	56	73	0.153
Dyspnea	16	133	149		4	69	73	0.199
Fever	69	80	149		33	38	72	0.981
Pale mucous membranes	146	3	149		72	1	73	0.735
Icterus	57	92	149		27	46	73	0.855
Petechiae	8	141	149		1	72	73	0.156
Red urine	47	102	149		17	55	72	0.223
Laboratory results	Median	Range	n	Reference	Median	Range	n
Hematocrit (%)	13	0.04-0.27	149	42-57	12	0.05-0.26	73	0.36
Reticulocytes (%)	8	0.1-90	147	< 2	5.8	0.1-51.5	64	0.29
Corrected reticulocytes (%)	2.7	0.01-19.2	147	< 2	2	0.02-14.3	64	0.11
Osmotic red cell fragility (mOsm/L)	238	120-317	139	< 162	250	131-317	28	0.28
Leukocytes (x10⁹/L)	27.9	2.1-130	148	5.9-13.8	21.7	5.7-78.6	68	0.3
Band neutrophils (x10⁹/L)	1.4	0-22.1	148	0-0.3	1	0-21.9	67	0.08
Urea (mmol/L)	7.6	2.9-69.5	123	3.0-12.5	7.4	2.3-49.5	45	0.8
Creatinine (μmol/L)	41.8	0.4-652	112	< 50	41.2	6.5-228.4	48	0.16
PT^c (seconds)	8	6-12	98	7 ± 1	7	7-10	13	0.74
APTT^d (seconds)	19.8	11-98	98	14 ± 1	17.4	9.1-64.8	37	0.98
Fibrinogen (g/L)	3.9	0.6-13.8	96	2-5	5	2.3-8.2	13	0.11
Thrombocytes (x10⁹/L)	122	0-958	140	150-400	230	9-1079	65	0.00001*
Duration of clinical signs (days)	6	0-141	149		3	0-131	73	0.015*

ISSN: 1746-6148