Table 4 Details of atypical scrapie cases in sheep in (or from) the Sheep Unit.
From: Atypical scrapie in sheep from a UK research flock which is free from classical scrapie
| Â | Sheep G320 | Sheep Y071 | Sheep D337 |
|---|---|---|---|
Birth date (and place) | 5 May 2000 (Sheep Unit) Born to a surrogate ewe following embryo transfer. | 1 September 1999 (New Zealand). Imported to UK July 2001 | 1 September 1997 (New Zealand). Imported to UK February 1998 |
Breed | Cheviot | Cheviot | Cheviot |
Sex | Female | Female | Female |
Genotype | AFRQ/AFRQ | AFRQ/ALRQ | AFRQ/AFRQ |
Breeding history | Lambed February 2002; May 2003; April 2004; June 2006 | Lambed May 2003, May 2005, April 2006; February 2007 | Never bred |
Length of stay in Sheep Unit | 6 y 4 mo | 5 y 2 mo – sent to Sardinia in January 2007 | 6 mo – sent Institute for Animal Health in September 1998 |
Research project (if any) which this animal was on | Not on a research project | Not on a research project, but sent to Sardinia to lamb | Blood transfusion in September 1999 from a sheep challenged with BSE |
Date of death | 5 Sept. 2006 | 19 June 2007 | 2 May 2007 |
Age at death | 6 y 4 mo | 7 y 9 mo | 9 y 7 mo |
Clinical signs | Malaise, circling & blindness, ataxia (see additional file 1) | None seen before death. Routine cull. | None seen before death. End of experiment cull. |
Immunocyto-chemistry | Positive throughout the brain | Positive cerebellum, but medulla negative | Positive throughout the brain |
Western blot | Cortex positive | Cerebellum positive | Brain weakly positive |