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Table 2 Presence of selected TSE-like clinical signs or combination of signs observed at the pre-cull assessment

From: Transmissibility studies of vacuolar changes in the rostral colliculus of pigs

Clinical signs Group A Group B Group C Group D A-B B-C B-D
Repeatable over-reactivity to menace testing 2 6 2 0 ns ns 0.0031
Apprehension towards observer 0 5 0 1 0.01 0.01 ns
Repeatable over-reactivity to probing of the neck 1 7 1 1 0.006 0.006 0.006
Stiff gait 0 4 3 0 0.033 ns 0.033
Ataxia 0 5 0 1 0.01 0.01 0.0498
Apprehension, over-reactivity & ataxia/stiff gait 0 5 0 0 0.0108 0.0108 0.0108
Apprehension & over-reactivity 0 5 0 0 0.0108 0.0108 0.0108
Apprehension & ataxia/stiff gait* 0 5 0 1 0.0108 0.0108 ns
Over-reactivity & ataxia/stiff gait* 0 8 0 0 0.0001 0.0001 0.0001
  1. The numbers in the first four columns (groups A-D) refer to the number of animals displaying this particular sign or combination of signs. Columns 5-7 list the P value by group comparison; ns = not significant (P > 0.05).
  2. Group A = NZ brain, includes pig that was not inoculated (N = 10)
  3. Group B = BSE (N = 9)
  4. Group C = Pre-1996 group (N = 10)
  5. Group D = Post-1996 group (N = 10)
  6. * Signs associated with a prion disease; the one animal in group D with multiple abscesses is listed for completeness although a prion disease was not suspected (see text).