Figure 1
From: Investigation of SNPs in the porcine desmoglein 1 gene
Structure of the porcine desmoglein 1 gene and gene product. A, The four extracellular domains (EC1-4) of the porcine desmoglein 1. (PIG)DSG1 is modelled on top of the crystal structure of C-cadherin. The 3D structure indicates that the cleavage site is situated between EC3 and EC4 [7] (green). The amino acids of the important loop in human sequence is also in the porcine structure placed on a loop on the opposite side of EC3 (yellow) [8]. B, The arrangement of the porcine desmoglein 1 protein. The cleavage site and the putative alignment motif are marked with arrows in the extracellular domains. EA: Extracellular anchor domain, IA: Intracellular anchor domain, IC: Intracellular domain. [7]