Structure of the porcine desmoglein 1 gene and gene product. A, The four extracellular domains (EC1-4) of the porcine desmoglein 1. (PIG)DSG1 is modelled on top of the crystal structure of C-cadherin. The 3D structure indicates that the cleavage site is situated between EC3 and EC4  (green). The amino acids of the important loop in human sequence is also in the porcine structure placed on a loop on the opposite side of EC3 (yellow) . B, The arrangement of the porcine desmoglein 1 protein. The cleavage site and the putative alignment motif are marked with arrows in the extracellular domains. EA: Extracellular anchor domain, IA: Intracellular anchor domain, IC: Intracellular domain.