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Table 2 Linkage data between the merle phenotype and CFA10 markers. List of the CFA10 genotyped markers in the sub-pedigree (left), the complete pedigree (middle) and all the studied pedigrees (right), with their two point Lod scores and recombination fractions (θ). All markers were selected from CanFam 1.0 sequence draft except FH2293 and C10769 taken from Guyon et al.[13]. The markers are ordered in the table from the centromere to the telomere. a markers flanking the SOX10 gene. Values in bold correspond to the highest Lod scores obtained in the three conditions.

From: Coat colour in dogs: identification of the Merlelocus in the Australian shepherd breed

    Two point Lod scores values
    θ at Lod max Lod scores at θ
  Gene/Marker names Marker Position (in bp) θ Lod max 0.001 0.01 0.05 0.1 0.15 0.2 0.3
Lod scores in the sub-pedigree CFA10.1 3,109459–3,109703 0.00 6.32 6.31 6.22 5.79 5.23 4.64 4.02 2.68
  CFA10.2 3,150322–3,150695 0.00 6.92 6.91 6.82 6.37 5.78 5.16 4.50 3.05
  CFA10.3 3,169429–3,169640 0.00 3.01 3.01 2.95 2.72 2.42 2.10 1.76 1.06
  CFA10.4 3,452451–3,452757 0.04 5.94 4.82 5.71 5.90 5.55 5.04 4.44 3.04
  CFA10.5 c 3,533969–3,534312 0.00 6.92 6.91 6.81 6.35 5.73 5.09 4.40 2.90
  CFA10.6 4,050670–4,050915 0.00 3.01 3.01 2.96 2.74 2.46 2.17 1.86 1.20
  CFA10.7 4,901919–4,902276 0.00 7.23 7.21 7.11 6.65 6.04 5.39 4.71 3.20
  CFA10.8 6,938580–6,938928 0.00 7.23 7.21 7.11 6.65 6.04 5.39 4.71 3.20
  CFA10.9 8,539383–8,539710 0.50 0.00 -20.08 -11.15 -5.16 -2.85 -1.68 -0.98 -0.31
  CFA10.10 9,459108–9,459324 0.07 2.62 1.21 2.15 2.60 2.57 2.40 2.16 1.52
  CFA10.11 10,599594–10,599989 0.04 5.08 3.91 4.82 5.07 4.79 4.35 3.84 2.64
  CFA10.12 12,963916–12,964094 0.15 2.55 -4.49 -0.58 1.79 2.43 2.55 2.44 1.83
  CFA10.13 13,290922–13,291305 0.18 0.75 -2.99 -1.03 0.21 0.60 0.73 0.74 0.57
  CFA10.14 13,687824–13,688059 0.11 3.44 -1.49 1.42 3.09 3.43 3.36 3.10 2.25
  CFA10.15 15,287513–15,287805 0.14 2.22 -2.99 -0.06 1.69 2.15 2.21 2.08 1.51
  CFA10.16 16,325750–16,325992 0.09 3.67 0.61 2.53 3.55 3.66 3.49 3.19 2.33
  CFA10.17 16,883188–16,883575 0.12 2.95 -2.09 0.83 2.53 2.92 2.91 2.72 2.02
  CFA10.18 17,574178–17,574420 0.08 3.87 0.91 2.82 3.79 3.84 3.61 3.25 2.31
  CFA10.19 18,220318–18,220600 0.10 4.20 -0.58 2.31 3.93 4.20 4.07 3.74 2.75
  CFA10.20 19,075239–19,075433 0.12 3.19 -1.79 1.12 2.81 3.17 3.13 2.90 2.10
  CFA10.21 19,999011–19,999231 0.26 0.51 -11.69 -5.76 -1.88 -0.50 0.12 0.41 0.47
  CFA10.22 21,607022–21,607316 0.10 4.45 -0.28 2.61 4.20 4.45 4.30 3.95 2.90
  CFA10.23 21,956041–21,956337 0.10 4.45 -0.28 2.61 4.20 4.45 4.30 3.95 2.90
  CFA10.24 23,113457–23,113656 0.25 0.92 -13.18 -6.27 -1.77 -0.17 0.52 0.83 0.85
  CFA10.25 24,031569–24,031859 0.10 3.51 -1.19 1.70 3.28 3.51 3.34 2.97 1.93
  CFA10.26 25,504535–25,504764 0.14 2.73 -4.19 -0.29 2.05 2.65 2.73 2.57 1.89
  CFA10.27 25,930447–25,930692 0.12 1.84 -1.49 0.45 1.58 1.83 1.81 1.67 1.16
  CFA10.28 26,491052–26,491288 0.13 1.66 -1.79 0.16 1.32 1.62 1.65 1.56 1.16
  CFA10.29 27,391154–27,391817 0.18 2.36 -6.88 -1.98 1.09 2.04 2.33 2.33 1.87
  CFA10.30 28,230039–28,230419 0.30 0.69 -18.28 -9.37 -3.47 -1.27 -0.23 0.33 0.69
  CFA10.31a 29,232270–29,232511 0.13 3.51 -3.28 0.61 2.90 3.46 3.49 3.27 2.45
  CFA10.32a 29,355913–29,355989 0.14 3.09 -3.88 0.02 2.37 2.99 3.08 2.94 2.24
  CFA10.33a 29,483066–29,483109 0.13 2.40 -2.69 0.23 1.95 2.37 2.38 2.22 1.58
  CFA10.34a 29,826073–29,826290 0.14 2.52 -2.69 0.24 2.00 2.45 2.51 2.38 1.81
  CFA10.35a 29,834441–29,834690 0.16 2.74 -6.28 -1.39 1.63 2.51 2.73 2.67 2.08
  SOX10 29,856920–29,867728          
  CFA10.36a 29,861299–29,861547 0.08 3.60 0.61 2.52 3.51 3.58 3.37 3.02 2.10
  CFA10.37a 29,868038–29,868267 0.14 3.38 -3.58 0.32 2.67 3.29 3.37 3.21 2.47
  CFA10.38a 30,176995–30,177378 0.11 3.65 -1.19 1.71 3.35 3.65 3.55 3.26 2.38
  FH2293a 31,696028–31,696274 0.13 3.56 -3.28 0.61 2.93 3.50 3.54 3.34 2.53
  C10.769a 36,663349–36,663563 0.18 1.50 -5.99 -2.06 0.42 1.20 1.46 1.49 1.18
Lod scores in the complete pedigree CFA10.1 3,109459–3,109703 0.00 11.74 11.72 11.54 10.70 9.61 8.46 7.27 4.71
  CFA10.2 3,150322–3,150695 0.02 11.97 11.13 11.91 11.63 10.64 9.48 8.20 5.38
  CFA10.3 3,169429–3,169640 0.00 6.62 6.61 6.50 5.98 5.30 4.60 3.86 2.33
  CFA10.4 3,452451–3,452757 0.03 13.82 11.73 13.46 13.65 12.67 11.36 9.88 6.55
  CFA10.5 c 3,533969–3,534312 0.02 8.77 7.82 8.65 8.58 7.88 7.01 6.03 3.86
  CFA10.6 4,050670–4,050915 0.00 6.92 6.91 6.79 6.24 5.51 4.76 3.99 2.41
  CFA10.7 4,901919–4,902276 0.00 15.65 15.63 15.39 14.30 12.88 11.40 9.84 6.54
  CFA10.8 6,938580–6,938928 0.02 14.90 14.13 14.87 14.39 13.16 11.72 10.17 6.76
  CFA10.9 8,539383–8,539710 0.19 2.48 -14.38 -5.54 0.02 1.78 2.38 2.47 1.89
Lod scores in the complete pedigree plus families
of dachshund, Beauce shepherd and Border collie
CFA10.1 3,109459–3,109703 0.04 10.67 8.43 10.21 10.61 9.91 8.91 7.74 5.09
  CFA10.2 3,150322–3,150695 0.04 10.97 8.73 10.51 10.91 10.21 9.21 8.04 5.39
  CFA10.3 3,169429–3,169640 0.00 6.02 6.01 5.91 5.44 4.84 4.22 3.56 2.20
  CFA10.4 3,452451–3,452757 0.03 14.38 12.33 14.05 14.19 13.15 11.79 10.25 6.83
  CFA10.5 c 3,533969–3,534312 0.02 8.77 7.82 8.65 8.58 7.89 7.02 6.05 3.90
  CFA10.6 4,050670–4,050915 0.03 6.99 6.01 6.86 6.85 6.23 5.46 4.61 2.82
  CFA10.7 4,901919–4,902276 0.00 19.87 19.83 19.52 18.11 16.28 14.37 12.37 8.15
  CFA10.8 6,938580–6,938928 0.00 19.57 19.53 19.22 17.82 15.99 14.08 12.09 7.91
  CFA10.9 8,539383–8,539710 0.16 4.23 -11.97 -3.16 2.25 3.83 4.22 4.10 3.02