Table 1 Linkage data between the merle phenotype and markers flanking the TYRP1 gene and MITF and PAX3 candidate genes. Two point Lod scores and recombination fractions (θ) between the merle phenotype and the markers flanking TYRP1, MITF and PAX3 genes calculated on the sub-pedigree. a CFA: Canis familiaris chromosome. b Starred markers were selected from the CanFam 1.0 canine sequence draft. Significant exclusions (<-2) are indicated in bold.
From: Coat colour in dogs: identification of the Merlelocus in the Australian shepherd breed
θ at Lod score max | Lod scores at θ | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
CFAa | Gene/Markersb | Gene/Marker Position in bp | θ | Lod score max | 0.001 | 0.01 | 0.05 | 0.1 | 0.15 | 0.2 | 0.3 |
CFA11 | TYRP1 | 34,664779–34,683148 | |||||||||
FH2319 | 35,863893–35,864169 | 0.5 | 0.0 | -23.083 | -13.146 | -6.442 | -3.802 | -2.429 | -1.582 | -0.661 | |
Ren105l03 | 39,857761–39,857999 | 0.5 | 0.0 | -15.888 | -8.939 | -4.278 | -2.471 | -1.549 | -0.995 | -0.417 | |
Ren96j16 | 22,981531–22,981669 | 0.5 | 0.0 | -13.194 | -8.198 | -4.721 | -3.24 | -2.384 | -1.786 | -0.963 | |
Ren130E03 | 22,981511–22,981683 | 0.5 | 0.0 | -13.194 | -8.198 | -4.721 | -3.24 | -2.384 | -1.786 | -0.963 | |
Ren159M20 | 23,456266–23,456464 | 0.5 | 0.0 | -19.789 | -11.82 | -6.37 | -4.141 | -2.915 | -2.1 | -1.061 | |
CFA20 | MITF | 24,701418–24,735483 | |||||||||
Ren100j13 | 25,668407–25,668570 | 0.5 | 0.0 | -24.585 | -14.621 | -7.791 | -4.988 | -3.442 | -2.417 | -1.131 | |
Ren178E07 | 26,911251–26,911383 | 0.5 | 0.0 | -12.593 | -7.605 | -4.164 | -2.729 | -1.923 | -1.377 | -0.671 | |
Ren105M20 | 19,606338–19,606486 | 0.4 | 0.087 | -8.992 | -5.016 | -2.327 | -1.264 | -0.709 | -0.367 | -0.011 | |
Ren67C18 | 22,361131–22,361265 | 0.5 | 0.0 | -11.992 | -7.012 | -3.606 | -2.218 | -1.462 | -0.969 | -0.379 | |
Pax3.2* | 30,185679–30,186031 | 0.27 | 0.147 | -9.89 | -4.957 | -1.763 | -0.644 | -0.159 | 0.063 | 0.137 | |
CFA37 | PAX3 | 31,332182–31,429995 | |||||||||
Pax3.1* | 31,368786–31,369020 | 0.5 | 0.0 | -20.085 | -11.159 | -5.204 | -2.924 | -1.779 | -1.101 | -0.418 | |
Ren75L05 | 31,649572–31,649607 | 0.5 | 0.0 | -9.294 | -5.321 | -2.65 | -1.605 | -1.065 | -0.732 | -0.36 | |