Figure 1

Alignment of pig AKR1C mRNAs. Conserved residues T24, L54, Y55, H117, F118, W227, N306 and Y310 involved in substrate binding are highlighted in yellow [52] and residues highlighted in blue are invariant residues found in all AKRs [53]. Residues Asp274Asn in AKR1C1, Ile16Phe, Tyr216Asn, Val234Phe in AKR1C2 and Val97Phe in AKR1C3 in red are non-synonymous amino acid polymorphisms identified in cDNA and genomic sequence of Meishan and White composite pigs. Dashes indicate residues that are absent, shading indicates identity and asterisks represent 10 bp increments.