A recombinant chimera comprising the R1 and R2 repeat regions of M. hyopneumoniae P97 and the N-terminal region of A. pleuropneumoniaeApxIII elicits immune responses

Table 2 Protection of pigs with Ap97 vaccine against A. pleuropneumoniae and M. hyopneumoniae infection

Immunogen	Challenge	Body temperature^a	# of pigs with clinical signs / # of pigs challenged				Lung lesion score^b(Mean ± SD)
			Coughing	Dyspnea (tachypnea)	Depression	Nasal discharge
Ap97	A. pleuropneumoniae and M. hyopneumoniae	-,-,-,-,-,-	1/6	0/6	0/6	0/6	2.00 ± 0.71^*
PBS	A. pleuropneumoniae and M. hyopneumoniae	+,+,++,++,++,++	6/6	5/6	5/6	6/6	62.30 ± 4.38

^aMaximum measured rectal temperature. –, ≤ 39.5°C; +, 39.5 to 42°C; ++, ≥ 42°C.
^bTotal area (0–100%) of the lung affected by any type of pneumonia lesion [51]. Data are presented as the mean ± SD (n = 6). *P < 0.01, significantly different from the corresponding PBS-treated group (unpaired t-test).

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