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Table 2 Protection of pigs with Ap97 vaccine against A. pleuropneumoniae and M. hyopneumoniae infection

From: A recombinant chimera comprising the R1 and R2 repeat regions of M. hyopneumoniae P97 and the N-terminal region of A. pleuropneumoniaeApxIII elicits immune responses

Immunogen Challenge Body temperaturea # of pigs with clinical signs / # of pigs challenged Lung lesion scoreb(Mean ± SD)
    Coughing Dyspnea (tachypnea) Depression Nasal discharge  
Ap97 A. pleuropneumoniae and M. hyopneumoniae -,-,-,-,-,- 1/6 0/6 0/6 0/6 2.00 ± 0.71*
PBS A. pleuropneumoniae and M. hyopneumoniae +,+,++,++,++,++ 6/6 5/6 5/6 6/6 62.30 ± 4.38
  1. aMaximum measured rectal temperature. –, ≤ 39.5°C; +, 39.5 to 42°C; ++, ≥ 42°C.
  2. bTotal area (0–100%) of the lung affected by any type of pneumonia lesion [51]. Data are presented as the mean ± SD (n = 6). *P < 0.01, significantly different from the corresponding PBS-treated group (unpaired t-test).
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