Table 3 List of metabolites with significant changes between the groups upon MANOVA (normalized mean values ± S.D.)
From: Metabolomic biomarkers correlating with hepatic lipidosis in dairy cows
Metabolite | Category | Group 1 | Group 2 | Group 3 | Group 4 | Pvalue |
|---|---|---|---|---|---|---|
Glutamine | Amino acids | 100 ± 28.7 | 50.1 ± 24.3 | 49.6 ± 13.4 | 30.8 ± 5.9 | ≤ 0.0004 |
Glycine | 100 ± 21.9 | 66.6 ± 23.4 | 52.0 ± 11.8 | 49.0 ± 9.3 | ≤ 0.0004 | |
PC aa C30:2 | Phosphatidyl-cholines | 100 ± 15.7 | 87.7 ± 24.1 | 118.4 ± 32.9 | 139.0 ± 16.2 | 0.004 |
PC aa C32:2 | 100 ± 17.3 | 81.7 ± 38.4 | 121.0 ± 62.0 | 159.0 ± 39.7 | 0.002 | |
PC aa C36:2 | 100 ± 15.0 | 66.2 ± 33.8 | 52.8 ± 13.9 | 40.8 ± 10.8 | 0.002 | |
PC aa C36:3 | 100 ± 15.2 | 58.4 ± 20.7 | 50.5 ± 14.4 | 50.0 ± 13.0 | ≤ 0.0004 | |
PC aa C36:4 | 100 ± 11.5 | 60.8 ± 21.7 | 50.2 ± 13.4 | 51.6 ± 14.4 | ≤ 0.0004 | |
PC aa C38:3 | 100 ± 14.5 | 58.3 ± 20.7 | 49.1 ± 14.7 | 45.9 ± 10.3 | ≤ 0.0004 | |
PC aa C38:4 | 100 ± 11.7 | 70.7 ± 22.2 | 55.3 ± 21.0 | 59.5 ± 14.9 | 0.002 | |
PC aa C38:6 | 100 ± 15.5 | 70.1 ± 16.0 | 79.1 ± 12.4 | 78.5 ± 12.7 | 0.006 | |
PC aa C40:2 | 100 ± 17.7 | 70.6 ± 39.5 | 51.0 ± 21.4 | 34.1 ± 12.0 | 0.004 | |
PC aa C40:3 | 100 ± 18.3 | 45.0 ± 18.4 | 40.1 ± 12.6 | 32.3 ± 6.9 | ≤ 0.0004 | |
PC aa C40:4 | 100 ± 10.6 | 68.0 ± 26.6 | 55.1 ± 17.5 | 49.2 ± 10.2 | 0.001 | |
PC aa C42:2 | 100 ± 11.2 | 76.4 ± 35.9 | 64.7 ± 25.9 | 36.6 ± 9.4 | 0.005 | |
PC ae C34:1 | 100 ± 12.7 | 71.4 ± 23.9 | 62.0 ± 10.3 | 58.1 ± 10.6 | 0.001 | |
PC ae C36:2 | 100 ± 15.8 | 63.7 ± 24.5 | 58.6 ± 10.6 | 55.7 ± 12.1 | 0.001 | |
PC ae C36:3 | 100 ± 17.8 | 61.3 ± 14.3 | 58.3 ± 12.8 | 60.8 ± 8.8 | ≤ 0.0004 | |
PC ae C38:2 | 100 ± 14.8 | 73.9 ± 31.8 | 54.3 ± 16.6 | 42.6 ± 7.5 | 0.001 | |
PC ae C38:3 | 100 ± 11.7 | 56.9 ± 18.2 | 50.0 ± 15.8 | 41.3 ± 8.0 | ≤ 0.0004 | |
PC ae C38:4 | 100 ± 17.8 | 67.4 ± 14.1 | 68.8 ± 17.1 | 63.7 ± 14.2 | 0.002 | |
PC ae C40:2 | 100 ± 7.6 | 62.5 ± 17.4 | 62.9 ± 9.9 | 57.1 ± 12.6 | ≤ 0.0004 | |
PC ae C40:3 | 100 ± 11.5 | 61.7 ± 13.2 | 65.1 ± 10.3 | 75.2 ± 10.2 | ≤ 0.0004 | |
SM C18:0 | Sphingomyelins | 100 ± 22.4 | 67.2 ± 34 | 49.2 ± 48.6 | 14.2 ± 20.5 | 0.003 |
SM C18:1 | 100 ± 21.9 | 66.9 ± 33.3 | 53.5 ± 20.2 | 34.0 ± 10.2 | 0.002 | |
SM C24:1 | 100 ± 13.7 | 52.2 ± 16.5 | 62.3 ± 15.5 | 47.8 ± 9.7 | ≤ 0.0004 | |
SM C26:1 | 100 ± 14.8 | 45.9 ± 16.3 | 57.8 ± 12.9 | 42.2 ± 7.9 | ≤ 0.0004 | |
SM (OH) C22:1 | Hydroxy-sphingomyelins | 100 ± 13.0 | 52.1 ± 18.1 | 68.8 ± 16.6 | 67.7 ± 12.8 | ≤ 0.0004 |
SM (OH) C22:2 | 100 ± 10.6 | 48.0 ± 15.4 | 56.5 ± 15.9 | 55.6 ± 11.9 | ≤ 0.0004 | |
SM (OH) C24:1 | 100 ± 6.0 | 56.3 ± 21.8 | 74.2 ± 15.2 | 58.0 ± 13.9 | ≤ 0.0004 |