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Table 3 List of metabolites with significant changes between the groups upon MANOVA (normalized mean values ± S.D.)

From: Metabolomic biomarkers correlating with hepatic lipidosis in dairy cows

Metabolite Category Group 1 Group 2 Group 3 Group 4 Pvalue
Glutamine Amino acids 100 ± 28.7 50.1 ± 24.3 49.6 ± 13.4 30.8 ± 5.9 ≤ 0.0004
Glycine 100 ± 21.9 66.6 ± 23.4 52.0 ± 11.8 49.0 ± 9.3 ≤ 0.0004
PC aa C30:2 Phosphatidyl-cholines 100 ± 15.7 87.7 ± 24.1 118.4 ± 32.9 139.0 ± 16.2 0.004
PC aa C32:2 100 ± 17.3 81.7 ± 38.4 121.0 ± 62.0 159.0 ± 39.7 0.002
PC aa C36:2 100 ± 15.0 66.2 ± 33.8 52.8 ± 13.9 40.8 ± 10.8 0.002
PC aa C36:3 100 ± 15.2 58.4 ± 20.7 50.5 ± 14.4 50.0 ± 13.0 ≤ 0.0004
PC aa C36:4 100 ± 11.5 60.8 ± 21.7 50.2 ± 13.4 51.6 ± 14.4 ≤ 0.0004
PC aa C38:3 100 ± 14.5 58.3 ± 20.7 49.1 ± 14.7 45.9 ± 10.3 ≤ 0.0004
PC aa C38:4 100 ± 11.7 70.7 ± 22.2 55.3 ± 21.0 59.5 ± 14.9 0.002
PC aa C38:6 100 ± 15.5 70.1 ± 16.0 79.1 ± 12.4 78.5 ± 12.7 0.006
PC aa C40:2 100 ± 17.7 70.6 ± 39.5 51.0 ± 21.4 34.1 ± 12.0 0.004
PC aa C40:3 100 ± 18.3 45.0 ± 18.4 40.1 ± 12.6 32.3 ± 6.9 ≤ 0.0004
PC aa C40:4 100 ± 10.6 68.0 ± 26.6 55.1 ± 17.5 49.2 ± 10.2 0.001
PC aa C42:2 100 ± 11.2 76.4 ± 35.9 64.7 ± 25.9 36.6 ± 9.4 0.005
PC ae C34:1 100 ± 12.7 71.4 ± 23.9 62.0 ± 10.3 58.1 ± 10.6 0.001
PC ae C36:2 100 ± 15.8 63.7 ± 24.5 58.6 ± 10.6 55.7 ± 12.1 0.001
PC ae C36:3 100 ± 17.8 61.3 ± 14.3 58.3 ± 12.8 60.8 ± 8.8 ≤ 0.0004
PC ae C38:2 100 ± 14.8 73.9 ± 31.8 54.3 ± 16.6 42.6 ± 7.5 0.001
PC ae C38:3 100 ± 11.7 56.9 ± 18.2 50.0 ± 15.8 41.3 ± 8.0 ≤ 0.0004
PC ae C38:4 100 ± 17.8 67.4 ± 14.1 68.8 ± 17.1 63.7 ± 14.2 0.002
PC ae C40:2 100 ± 7.6 62.5 ± 17.4 62.9 ± 9.9 57.1 ± 12.6 ≤ 0.0004
PC ae C40:3 100 ± 11.5 61.7 ± 13.2 65.1 ± 10.3 75.2 ± 10.2 ≤ 0.0004
SM C18:0 Sphingomyelins 100 ± 22.4 67.2 ± 34 49.2 ± 48.6 14.2 ± 20.5 0.003
SM C18:1 100 ± 21.9 66.9 ± 33.3 53.5 ± 20.2 34.0 ± 10.2 0.002
SM C24:1 100 ± 13.7 52.2 ± 16.5 62.3 ± 15.5 47.8 ± 9.7 ≤ 0.0004
SM C26:1 100 ± 14.8 45.9 ± 16.3 57.8 ± 12.9 42.2 ± 7.9 ≤ 0.0004
SM (OH) C22:1 Hydroxy-sphingomyelins 100 ± 13.0 52.1 ± 18.1 68.8 ± 16.6 67.7 ± 12.8 ≤ 0.0004
SM (OH) C22:2 100 ± 10.6 48.0 ± 15.4 56.5 ± 15.9 55.6 ± 11.9 ≤ 0.0004
SM (OH) C24:1 100 ± 6.0 56.3 ± 21.8 74.2 ± 15.2 58.0 ± 13.9 ≤ 0.0004
  1. Group 1, without hepatic lipidosis; groups 2–4, progressive stages of hepatic lipidosis.