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Prioritising which parameters to measure in treatment trials for cats with chronic kidney disease

Who is conducting this study?

This study is being undertaken as part of PhD research at the Centre for Evidence-based Veterinary Medicine (CEVM) at the University of Nottingham School of Veterinary Medicine and Science and has received ethical approval from the ethics committee at the School of Veterinary Medicine and Science, University of Nottingham.
The study will be conducted online, using questionnaires distributed to an anonymous panel of people. The aim of the study is to reach consensus (agreement) on which things are the most important to measure in treatment trials that involve cats with chronic kidney disease (CKD). 


Who is being invited to join the panel?

Owners who currently own cats with CKD or have done in the past and people working with, or on behalf of, cats with CKD such as: veterinary surgeons, veterinary nurses, researchers, clinical pathologists, veterinary journal editors and those working in the pharmaceutical and food industries and for regulatory agencies.


Why is this work important?

In trials that involve cats with CKD that have already been published there are nearly 100 different parameters that have been measured and there is no agreement as to which are the most important. 
With your help, we are aiming to develop a “core set” of parameters to measure in all future treatment trials involving cats with CKD. This will make it easier for the results of future trials of new and existing treatments to be compared and combined, which will improve our understanding of which treatments are most effective in cats with CKD. Consequently, this will then help vets and owners make better decisions when choosing the most appropriate treatment for cats with CKD. 
The concept of developing core sets of parameters for treatment trials is well established in human medicine, where they are called “core outcome sets”. You can read more about core outcome sets here: http://www.comet-initiative.org/


What will your participation involve?

If you decide to be involved in this study and are selected to be part of our panel, you will receive up to 4 emails, over 3-4 months, asking you to complete online questionnaires. 
In the first questionnaire you will be asked for your consent for the information and answers that you provide being used in our research. The information you provide will be kept in the strictest confidence, only Hannah Doit, Marnie Brennan and Rachel Dean will have access to your contact information and it will only be used to contact you about this study. The answers you give in the questionnaire will be anonymised so that no individual can be identified in the results of the study. 
The first questionnaire will be comprised of two parts, which will be sent separately. We are likely to send the first email in June. They will take around 20 minutes to complete and will ask you to rate the importance of measuring different parameters when testing treatments for cats with CKD. You will have two to three weeks to complete each round. 
In the second part of the study you will be given the results of the first two questionnaires from the panel as a whole, and you will have the chance to change your answers if you wish. In the third part of the study, we will ask you more directly about which parameters you think are the most important to include in the core set. You will have 3 weeks to complete each questionnaire. 


What do you need to do next? 

If you wish to join this study, please fill in your contact information here:
https://nottingham.onlinesurveys.ac.uk/cat-ckd-research and we will contact you soon to let you know if you have been selected for the panel. 

If you have any questions about this work, please email us: Hannah.Doit@nottingham.ac.uk with the subject line: CKD

Many thanks,

Hannah, Rachel and Marnie

Hannah Doit (PhD Student), Dr Rachel Dean & Dr Marnie Brennan
 
Centre for Evidence-based Veterinary Medicine,
School of Veterinary Medicine and Science,
University of Nottingham,
Sutton Bonington Campus
LE12 5RD

www.nottingham.ac.uk/cevm