Pharmacology and toxicology

Section edited by Wolfgang Bäumer and Manfred Kietzmann

The pharmacology and toxicology section covers all aspects of research involved with basic and clinical pharmacology and toxicology, including pharmacodynamics, pharmacokinetics, therapeutic drug monitoring, drug interactions, pharmacogenetics, pharmacoepidemiology, pharmacovigilance, pharmacoeconomics, randomized controlled clinical trials and rational pharmacology in livestock, companion animals, equines, wild animals, fish and laboratory animals.

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  1. Research article

    Effects of feeding drunken horse grass infected with Epichloë gansuensis endophyte on animal performance, clinical symptoms and physiological parameters in sheep

    Many reports showed that grass-endophyte symbiosis induced livestock poisoned. Yet, there is no study evaluating clinical symptoms and physiological parameters in sheep fed Epichloë gansuensis endophyte-infected ...

    Ying Liang, Hucheng Wang, Chunjie Li, Zhibiao Nan and Fadi Li

    BMC Veterinary Research 2017 13:223

    Published on: 19 July 2017

  2. Research article

    Prediction of marbofloxacin dosage for the pig pneumonia pathogens Actinobacillus pleuropneumoniae and Pasteurella multocida by pharmacokinetic/pharmacodynamic modelling

    Bacterial pneumonia in pigs occurs widely and requires antimicrobial therapy. It is commonly caused by the pathogens Actinobacillus pleuropneumoniae and Pasteurella multocida. Marbofloxacin is an antimicrobial dr...

    Lucy Dorey, Ludovic Pelligand and Peter Lees

    BMC Veterinary Research 2017 13:209

    Published on: 1 July 2017

  3. Research article

    Efficacy and safety of oral robenacoxib (tablet) for the treatment of pain associated with soft tissue surgery in client-owned dogs

    Non-steroidal anti-inflammatory drugs (NSAIDs) have been proven to be effective in controlling peri-operative pain in dogs. Robenacoxib is an NSAID with high selectivity for the cyclooxygenase (COX)-2 isoform....

    Gabriele Friton, Caryn Marie Thompson, Daniela Karadzovska, Stephen King and Jonathan N. King

    BMC Veterinary Research 2017 13:197

    Published on: 26 June 2017

  4. Research article

    Safety pharmacology and subchronic toxicity of jinqing granules in rats

    Jinqing granules which are made of a mixture extract that contains Radix Tinosporae and Canarii fructus in proportions according to a longstanding formula have a good effect on the prevention and treatment of gas...

    Xuerong Zhou, Qian Rong, Min Xu, Yuanli Zhang, Qi Dong, Yuanling Xiao, Qiji Liu, Helin Chen, Xiaoyu Yang, Kaisheng Yu, Yinglun Li, Ling Zhao, Gang Ye, Fei Shi and Cheng Lv

    BMC Veterinary Research 2017 13:179

    Published on: 17 June 2017

  5. Research article

    Integrated pharmacokinetic–Pharmacodynamic (PK/PD) model to evaluate the in vivo antimicrobial activity of Marbofloxacin against Pasteurella multocida in piglets

    Marbofloxacin is a veterinary fluoroquinolone with high activity against Pasteurella multocida. We evaluated it’s in vivo activity against P. multocida based on in vivo time-kill data in swine using a tissue-cage...

    Qing Lin Zeng, Xian Mei, Jia Su, Xiao Hong Li, Wen Guang Xiong, Yan Lu and Zhen Ling Zeng

    BMC Veterinary Research 2017 13:178

    Published on: 15 June 2017

  6. Research article

    Arsenic affects inflammatory cytokine expression in Gallus gallus brain tissues

    The heavy metal arsenic is widely distributed in nature and posses a serious threat to organism’s health. However, little is known about the arsenic-induced inflammatory response in the brain tissues of birds ...

    Xiao Sun, Ying He, Ying Guo, Siwen Li, Hongjing Zhao, Yu Wang, Jingyu Zhang and Mingwei Xing

    BMC Veterinary Research 2017 13:157

    Published on: 5 June 2017

  7. Research article

    National post-market surveillance assessment of veterinary medicines in Korea during the past decade

    Veterinary medicines have been widely used for the prevention and treatment of diseases, growth promotion, and to promote feeding efficacy in livestock. As the veterinary medicine industry has steadily grown, ...

    JeongWoo Kang, Hae-chul Park, Yang ho Jang, Md Akil Hossain, Kyunghun Jeong, Mi young Jeong, Seon-Jong Yun, Sung-won Park, Dae gyun Kim and Kwang-jick Lee

    BMC Veterinary Research 2017 13:136

    Published on: 22 May 2017

  8. Research article

    Association of Polybrominated Diphenyl Ethers (PBDEs) and Polychlorinated Biphenyls (PCBs) with Hyperthyroidism in Domestic Felines, Sentinels for Thyroid Hormone Disruption

    Hyperthyroidism is the most common endocrine disorder observed in domestic felines; however, its etiology is largely unknown. Two classes of persistent organic pollutants, polybrominated diphenyl ethers (PBDEs...

    Kyla M. Walter, Yan-ping Lin, Philip H. Kass and Birgit Puschner

    BMC Veterinary Research 2017 13:120

    Published on: 3 May 2017

  9. Research article

    Sedation levels in dogs: a validation study

    The aim of this study was to assess validation evidence for a sedation scale for dogs. We hypothesized that the chosen sedation scale would be unreliable when used by different raters and show poor discriminat...

    Marika C. Wagner, Kent G. Hecker and Daniel S. J. Pang

    BMC Veterinary Research 2017 13:110

    Published on: 18 April 2017

  10. Research article

    Refinement of intraperitoneal injection of sodium pentobarbital for euthanasia in laboratory rats (Rattus norvegicus)

    The Canadian Council on Animal Care and American Veterinary Medical Association classify intraperitoneal (IP) pentobarbital as an acceptable euthanasia method in rats. However, national guidelines do not exist...

    Katie K Zatroch, Cameron G. Knight, Julie N. Reimer and Daniel S. J. Pang

    BMC Veterinary Research 2017 13:60

    Published on: 21 February 2017

  11. Research article

    Pharmacokinetic and pharmacodynamic modeling of sarafloxacin against avian pathogenic Escherichia coli in Muscovy ducks

    This study focused on utilizing pharmacokinetics/pharmacodynamics (PK/PD) modeling to optimize therapeutic dosage regimens of sarafloxacin against avian pathogenic Escherichia. coli O78 strain in Muscovy ducks. T...

    Yang Yu, Yu Feng Zhou, Jian Sun, Wei Shi, Xiao Ping Liao and Ya Hong Liu

    BMC Veterinary Research 2017 13:47

    Published on: 10 February 2017

  12. Research article

    Clinical evaluation of a combination therapy of imepitoin with phenobarbital in dogs with refractory idiopathic epilepsy

    Imepitoin was tested as a combination treatment with phenobarbital in an open-label mono-centre cohort study in dogs with drug-resistant epilepsy. Diagnosis of idiopathic epilepsy was based on clinical finding...

    Jasmin Neßler, Chris Rundfeldt, Wolfgang Löscher, Draginja Kostic, Thomas Keefe and Andrea Tipold

    BMC Veterinary Research 2017 13:33

    Published on: 25 January 2017

  13. Research article

    Pharmacokinetics and in vitro efficacy of salicylic acid after oral administration of acetylsalicylic acid in horses

    Although acetylsalicylic acid (ASA) is not frequently used as a therapeutic agent in horses, its metabolite SA is of special interest in equestrianism since it is a natural component of many plants used as hor...

    Kathrin Buntenkötter, Maren Osmers, Ina Schenk, Wilhelm Schänzer, Marc Machnik, Michael Düe and Manfred Kietzmann

    BMC Veterinary Research 2017 13:28

    Published on: 19 January 2017

  14. Research article

    The gastro protective effects of Cibotium barometz hair on ethanol-induced gastric ulcer in Sprague-Dawley rats

    Cibotium barometz is a medical herb used traditionally in the Malaysian peninsula for several ailments, including gastric ulcer. The aim of this study was assessment the anti-ulcer eff...

    Nahla Saeed AL-Wajeeh, Maryam Hajerezaie, Suzita Mohd Noor, Mohammed Farouq Halabi, Nawal Al-Henhena, Ainnul Hamidah Syahadah Azizan, Sareh Kamran, Pouya Hassandarvish, Abdrabuh N. Shwter, Hamed karimian, Hapipah Mohd Ali and Mahmood Ameen Abdulla

    BMC Veterinary Research 2017 13:27

    Published on: 19 January 2017

  15. Research article

    The using of a piglets as a model for evaluating the dipyrone hematological effects

    Dipyrone (MET, metamizole) is a non-steroidal anti-inflammatory drug commonly used both in human and in veterinary medicine. After oral administration, is broken down rapidly to metabolites which largely retai...

    Artur Burmańczuk, Andrzej Milczak, Tomasz Grabowski, Monika Osypiuk and Cezary Kowalski

    BMC Veterinary Research 2016 12:263

    Published on: 25 November 2016

  16. Research article

    Estimation of tulathromycin depletion in plasma and milk after subcutaneous injection in lactating goats using a nonlinear mixed-effects pharmacokinetic modeling approach

    Extra-label use of tulathromycin in lactating goats is common and may cause violative residues in milk. The objective of this study was to develop a nonlinear mixed-effects pharmacokinetic (NLME-PK) model to e...

    Zhoumeng Lin, Matthew Cuneo, Joan D. Rowe, Mengjie Li, Lisa A. Tell, Shayna Allison, Jan Carlson, Jim E. Riviere and Ronette Gehring

    BMC Veterinary Research 2016 12:258

    Published on: 18 November 2016

  17. Research article

    In vitro susceptibility of four antimicrobials against Riemerella anatipestifer isolates: a comparison of minimum inhibitory concentrations and mutant prevention concentrations for ceftiofur, cefquinome, florfenicol, and tilmicosin

    Mutant prevention concentration (MPC) is an alternative pharmacodynamic parameter that has been used to measure antimicrobial activity and represents the propensities of antimicrobial agents to select resistan...

    Yafei Li, Yanan Zhang, Huanzhong Ding, Xian Mei, Wei Liu, Jiaxiong Zeng and Zhenling Zeng

    BMC Veterinary Research 2016 12:250

    Published on: 9 November 2016

  18. Research article

    Pharmacokinetics (PK), pharmacodynamics (PD), and PK-PD integration of ceftiofur after a single intravenous, subcutaneous and subcutaneous-LA administration in lactating goats

    Bacterial pneumonia in goats is usually caused by Mannheimia haemolytica and Pasteurella multocida. Another important infection disease in lactating goats is intramammary infection producing mastitis, usually ass...

    Emilio Fernández-Varón, Carlos Cárceles-García, Juan Manuel Serrano-Rodríguez and Carlos M. Cárceles-Rodríguez

    BMC Veterinary Research 2016 12:232

    Published on: 13 October 2016

  19. Research article

    Evaluation of injectable robenacoxib for the treatment of post-operative pain in cats: results of a randomized, masked, placebo-controlled clinical trial

    Few pharmaceuticals are registered in cats for the management of post-operative pain and inflammation. The objective of this study was to assess the field efficacy and safety of an injectable formulation of th...

    Stephen King, Elizabeth S. Roberts and Jonathan N. King

    BMC Veterinary Research 2016 12:215

    Published on: 29 September 2016

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