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Oncology

The oncology section considers research that addresses the etiology and treatment of cancer in veterinary patients. Research describing cancer prevention, therapeutic strategies, molecular diagnostics, genetics and genomics, epidemiology and comparative oncology are encouraged. Comparative and translational studies are also considered. 

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  1. Enzymatic activity of Telomerase Reverse Transcriptase (TERT) is important in maintaining the telomere length and has been implicated in cancer and aging related pathology. Since cancer susceptibility as well as ...

    Authors: Camille A McAloney, Kevin A T Silverstein, Jaime F Modiano and Anindya Bagchi

    Citation: BMC Veterinary Research 2014 10:20

    Content type: Research article

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  2. This study evaluated tyrosine kinase receptor (TKR) expression and activation in canine pulmonary adenocarcinoma (cpAC) biospecimens. As histological similarities exist between human and cpAC, we hypothesized ...

    Authors: Evan T Mariotti, Christopher Premanandan and Gwendolen Lorch

    Citation: BMC Veterinary Research 2014 10:19

    Content type: Research article

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  3. Molecular techniques that detect canine lymphoma cells by their clonal antigen receptor gene rearrangement play an increasing role for diagnosis as well as for monitoring minimal residual disease during and af...

    Authors: Kathrin FA Langner, Alexa E Joetzke, Verena Nerschbach, Nina Eberle, Hans-Joachim Schuberth, Mirja Koy, Ingo Nolte and Daniela Betz

    Citation: BMC Veterinary Research 2014 10:1

    Content type: Methodology article

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  4. The significance of the serotonergic system in bone physiology and, more specifically, the importance of the five hydroxytryptamine receptor 2A (5HTR2A) in normal osteoblast proliferation have been previously ...

    Authors: Shay Bracha, Austin Viall, Cheri Goodall, Bernadette Stang, Craig Ruaux, Bernard Seguin and Patrick E Chappell

    Citation: BMC Veterinary Research 2013 9:251

    Content type: Research article

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  5. The receptor kinase inhibitor toceranib phosphate (Palladia) was approved for use in dogs in 2009 using a dose of 3.25 mg/kg administered every other day. Preliminary data suggests that lower doses of toeceran...

    Authors: Luis Feo Bernabe, Roberta Portela, Sandra Nguyen, William C Kisseberth, Michael Pennell, Mark F Yancey and Cheryl A London

    Citation: BMC Veterinary Research 2013 9:190

    Content type: Research article

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  6. The objective of this study was to evaluate the effect on outcomes of intraoperative recombinant human interleukin-2 injection after surgical resection of peripheral nerve sheath tumours. In this double-blind ...

    Authors: Annika N Haagsman, Astrid CS Witkamp, Bart E Sjollema, Marja JL Kik and Jolle Kirpensteijn

    Citation: BMC Veterinary Research 2013 9:155

    Content type: Research article

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  7. Spontaneous canine mammary tumors constitute a serious clinical problem. There are significant differences in survival between cases with different tumor grades. Unfortunately, the distinction between various ...

    Authors: Karol M Pawłowski, Henryk Maciejewski, Kinga Majchrzak, Izabella Dolka, Jan A Mol, Tomasz Motyl and Magdalena Król

    Citation: BMC Veterinary Research 2013 9:138

    Content type: Research article

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  8. Hairy and enhancer of split 1 (HES1), a basic helix-loop-helix transcriptional repressor, is a downstream target of Notch signaling. Notch signaling and HES1 expression have been linked to growth and survival ...

    Authors: Deanna D Dailey, Kristin P Anfinsen, Liza E Pfaff, EJ Ehrhart, J Brad Charles, Tina B Bønsdorff, Douglas H Thamm, Barbara E Powers, Thora J Jonasdottir and Dawn L Duval

    Citation: BMC Veterinary Research 2013 9:130

    Content type: Research article

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  9. In both women and female dogs, the most prevalent type of malignant neoplasm is the spontaneous mammary tumor. In dogs, half of these are malignant. The treatment of choice for the canine patients is surgical ...

    Authors: Karol M Pawłowski, Joanna Mucha, Kinga Majchrzak, Tomasz Motyl and Magdalena Król

    Citation: BMC Veterinary Research 2013 9:119

    Content type: Research article

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  10. Osteosarcoma (OSA) is the most common primary bone tumor of dogs and carries a poor prognosis despite aggressive treatment. An improved understanding of the biology of OSA is critically needed to allow for dev...

    Authors: Milan Milovancev, Ian Hilgart-Martiszus, Michael J McNamara, Cheri P Goodall, Bernard Seguin, Shay Bracha and Samanthi I Wickramasekara

    Citation: BMC Veterinary Research 2013 9:116

    Content type: Research article

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  11. Oxidative stress, an excess of reactive oxygen species (ROS), causes lipid peroxidation resulting in cell and tissue damages. It may be associated with the development and progression of cancers in dogs. Malon...

    Authors: Arayaporn Macotpet, Fanan Suksawat, Peerapol Sukon, Komgrit Pimpakdee, Ekkachai Pattarapanwichien, Roongpet Tangrassameeprasert and Patcharee Boonsiri

    Citation: BMC Veterinary Research 2013 9:101

    Content type: Research article

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  12. Canine lymphoma represents the most frequent haematopoietic cancer and it shares some similarities with human non-Hodgkin lymphoma. Matrix metalloproteinases (MMPs) and vascular endothelial growth factor (VEGF...

    Authors: Arianna Aricò, Mery Giantin, Maria Elena Gelain, Fulvio Riondato, Stefano Comazzi, Barbara C Rütgen, Sabine E Essler, Mauro Dacasto, Massimo Castagnaro and Luca Aresu

    Citation: BMC Veterinary Research 2013 9:94

    Content type: Research article

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  13. The antibody Ki-67 is a reliable and easy tool to accurately assess the growth fraction of neoplasms in humans and animals, and it has been used to predict the clinical outcome. Therefore, the aim of the prese...

    Authors: Rodrigo Storti Pereira, Augusto Schweigert, Guilherme Dias de Melo, Fernando Vissani Fernandes, Felipe Augusto Ruiz Sueiro and Gisele Fabrino Machado

    Citation: BMC Veterinary Research 2013 9:83

    Content type: Research article

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  14. Triple negative breast cancer (TNBC) in humans is defined by the absence of oestrogen receptor (ER), progesterone receptor (PR) and HER2 overexpression. Mammalian target of rapamycin (mTOR) is overexpressed in...

    Authors: Lorella Maniscalco, Yolanda Millán, Selina Iussich, Mauro Denina, Raquel Sánchez-Céspedes, Francesca Gattino, Bartolomeo Biolatti, Nobuo Sasaki, Takayuki Nakagawa, Maria Flavia Di Renzo, Juana Martín de las Mulas and Raffaella De Maria

    Citation: BMC Veterinary Research 2013 9:80

    Content type: Research article

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  15. The frequency of mammary malignancies in canine patients is even three times over than in human. In various types of cancer different intracellular signalling pathways are perturbed, thus the patients with pat...

    Authors: Karol M Pawłowski, Henryk Maciejewski, Izabella Dolka, Jan A Mol, Tomasz Motyl and Magdalena Król

    Citation: BMC Veterinary Research 2013 9:78

    Content type: Research article

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  16. Autophagy is a self-catabolic mechanism that degrades unnecessary cellular components through lysosomal enzymes. Beclin-1, an autophagy-related protein, establishes the first connection between autophagy and t...

    Authors: Jing-Lan Liu, Kai-Chian Chang, Chun-Chih Lo, Pei-Yi Chu and Chen-Hsuan Liu

    Citation: BMC Veterinary Research 2013 9:75

    Content type: Research article

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  17. The limited within-breed genetic heterogeneity and an enrichment of disease-predisposing alleles have made the dog a very suitable model for the identification of genes associated with risk for specific diseas...

    Authors: Kaja Sverdrup Borge, Malin Melin, Patricio Rivera, Stein Istre Thoresen, Matthew Thomas Webster, Henrik von Euler, Kerstin Lindblad-Toh and Frode Lingaas

    Citation: BMC Veterinary Research 2013 9:69

    Content type: Research article

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  18. Tumor-associated macrophages (TAMs) have high impact on the cancer development because they can facilitate matrix invasion, angiogenesis, and tumor cell motility. It gives cancer cells the capacity to invade n...

    Authors: Magdalena Król, Kinga Majchrzak, Joanna Mucha, Agata Homa, Małgorzata Bulkowska, Arleta Jakubowska, Malwina Karwicka, Karol M Pawłowski and Tomasz Motyl

    Citation: BMC Veterinary Research 2013 9:65

    Content type: Research article

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  19. Osteosarcoma (OS) affects over 8000 dogs/year in the United States. The disease usually arises in the appendicular skeleton and metastasizes to the lung. Dogs with localized appendicular disease benefit from l...

    Authors: Kevin Marley, Stuart C Helfand, Wade A Edris, John E Mata, Alix I Gitelman, Jan Medlock and Bernard Séguin

    Citation: BMC Veterinary Research 2013 9:15

    Content type: Research article

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  20. STAT3 [1] has been shown to be dysregulated in nearly every major cancer, including osteosarcoma (OS). Constitutive activation of STAT3, via aberrant phosphorylation, leads to proliferation, cell survival and ...

    Authors: Jason I Couto, Misty D Bear, Jiayuh Lin, Michael Pennel, Samuel K Kulp, William C Kisseberth and Cheryl A London

    Citation: BMC Veterinary Research 2012 8:244

    Content type: Research article

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  21. Stratified keratinizing squamous epithelium in the ovary has been associated with the diagnosis of ovarian teratoma in cows. Recently, the diagnosis of “epidermoid cyst” has been proposed. A case of squamous m...

    Authors: Renato Lima Santos, Dimitre Giancarlo de Medeiros Peixoto, Andréia Pereira Turchetti, Álan Maia Borges, Ernane Fagundes do Nascimento and Tatiane Alves Paixão

    Citation: BMC Veterinary Research 2012 8:235

    Content type: Case report

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  22. This study aimed to evaluate the relationship between the molecular phenotype of the primary mammary tumor and its related lymph node metastasis in the dog to develop prognostic-predictive models and targeted ...

    Authors: Germana Beha, Barbara Brunetti, Pietro Asproni, Luisa Vera Muscatello, Francesca Millanta, Alessandro Poli, Giuseppe Sarli and Cinzia Benazzi

    Citation: BMC Veterinary Research 2012 8:219

    Content type: Research article

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  23. Bovine papillomaviruses (BPVs) types 1 and 2 are the only known papillomaviruses able to jump the species. In fact, BPVs 1/2 induce neoplasia in their natural bovine host but infection is also associated to ne...

    Authors: Gennaro Altamura, Maria Strazzullo, Annunziata Corteggio, Romina Francioso, Franco Roperto, Maurizio D'Esposito and Giuseppe Borzacchiello

    Citation: BMC Veterinary Research 2012 8:218

    Content type: Research article

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  24. Chemokines play multiple roles in the development and progression in a variety of tumors. Chemokine (C-X-C motif) ligand 7 (CXCL7) has been found associated with pro-inflammatory responses, but its role in can...

    Authors: Hsin-Chien Chiang, Yu-Shan Wang, Chung-Hsi Chou, Albert Taiching Liao, Rea-Min Chu and Chen-Si Lin

    Citation: BMC Veterinary Research 2012 8:216

    Content type: Research article

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  25. Myeloid derived suppressor cells (MDSCs) are a recently described population of immune cells that significantly contribute to the immunosuppression seen in cancer patients. MDSCs are one of the most important ...

    Authors: Matthew Sherger, William Kisseberth, Cheryl London, Susan Olivo-Marston and Tracey L Papenfuss

    Citation: BMC Veterinary Research 2012 8:209

    Content type: Research article

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  26. Components of the extracellular matrix have been studied in an attempt to elucidate the mechanisms involved in the biological behaviour of tumours. The presence of the proteoglycan versican has been strongly a...

    Authors: Karine A Damasceno, Angélica C Bertagnolli, Alessandra Estrela-Lima, Lorena GR Ribeiro, Bruna S Rabelo, Cecília B Campos, André LB Barros and Geovanni D Cassali

    Citation: BMC Veterinary Research 2012 8:195

    Content type: Research article

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  27. Ghrelin is a natural ligand of the growth hormone secretagogue receptor (GHS-R). They are often co-expressed in multiple human tumors and related cancer cell lines what can indicate that the ghrelin/GHS-R axis...

    Authors: Kinga Majchrzak, Karol M Pawłowski, Emilia J Orzechowska, Izabella Dolka, Joanna Mucha, Tomasz Motyl and Magdalena Król

    Citation: BMC Veterinary Research 2012 8:170

    Content type: Research article

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  28. Canine hemangiosarcoma (HSA) is a malignant tumor with poor long-term prognosis due to development of metastasis despite aggressive treatment. The phosphatidyl-inositol-3 kinase/Akt/mammalian target of rapamyc...

    Authors: Atsuko Murai, Samah Abou Asa, Atsushi Kodama, Akihiro Hirata, Tokuma Yanai and Hiroki Sakai

    Citation: BMC Veterinary Research 2012 8:128

    Content type: Research article

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  29. Canine mast cell tumour proliferation depends to a large extent on the activity of KIT, a tyrosine kinase receptor. Inhibitors of the KIT tyrosine kinase have recently been introduced and successfully applied ...

    Authors: Robert Klopfleisch, Anja Meyer, Patricia Schlieben, Angelika Bondzio, Chris Weise, Dido Lenze, Michael Hummel, Ralf Einspanier and Achim D Gruber

    Citation: BMC Veterinary Research 2012 8:96

    Content type: Research article

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  30. Melanocytic proliferations are common in horses but the diagnosis of malignancy is not always straightforward. To improve diagnosis and prognosis, markers of malignancy are needed. Receptor for activated C kin...

    Authors: Cécile Campagne, Sophia Julé, Florence Bernex, Mercedes Estrada, Geneviève Aubin-Houzelstein, Jean-Jacques Panthier and Giorgia Egidy

    Citation: BMC Veterinary Research 2012 8:95

    Content type: Research article

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  31. The bone morphogenetic proteins (BMPs) belong to a unique group of proteins that includes the growth factor TGF-β. BMPs play important roles in cell differentiation, cell proliferation, and inhibition of cell ...

    Authors: Rose Eli Grassi Rici, Dayane Alcântara, Paula Fratini, Cristiane Valverde Wenceslau, Carlos Eduardo Ambrósio, Maria Angelica Miglino and Durvanei Augusto Maria

    Citation: BMC Veterinary Research 2012 8:17

    Content type: Research article

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COVID-19 Announcement

As a result of the significant disruption that is being caused by the COVID-19 pandemic we are very aware that many researchers will have difficulty in meeting the timelines associated with our peer review process during normal times.  Please do let us know if you need additional time. Our systems will continue to remind you of the original timelines but we intend to be highly flexible at this time. Thank you.

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