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Section edited by Cheryl London

The oncology section publishes research findings which focus on studies that address the etiology and treatment of cancer in veterinary patients. Research describing cancer prevention, therapeutic strategies, molecular diagnostics, genetics and genomics, epidemiology and comparative oncology are encouraged. Comparative and translational studies are also considered. 

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  1. Content type: Research article

    Radiation therapy is a palliative treatment modality for canine osteosarcoma, with transient improvement in analgesia observed in many cases. However there is room for improvement in outcome for these patients...

    Authors: Fernanda B. Mantovani, Jodi A. Morrison and Anthony J. Mutsaers

    Citation: BMC Veterinary Research 2016 12:82

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  2. Content type: Research article

    Equine sarcoids are locally invasive, fibroblastic benign skin tumors. Bovine papillomavirus type-1 (BPV-1) and/or Bovine papillomavirus type-2 (BPV-2) are believed to be the causative agent of sarcoids, altho...

    Authors: Manuela Martano, Annunziata Corteggio, Brunella Restucci, Maria Ester De Biase, Giuseppe Borzacchiello and Paola Maiolino

    Citation: BMC Veterinary Research 2016 12:24

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  3. Content type: Research article

    Cancer is the leading cause of death in older dogs and its prevalence is increasing. There is clearly a need to develop more effective anti-cancer drugs in dogs. SG2000 (SJG-136) is a sequence selective DNA mi...

    Authors: Maria Mellinas-Gomez, Victoria J. Spanswick, Solange R. Paredes-Moscosso, Matthew Robson, R. Barbara Pedley, David E. Thurston, Stephen J. Baines, Anneliese Stell and John A. Hartley

    Citation: BMC Veterinary Research 2015 11:215

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  4. Content type: Research article

    Signal transducer and activator of transcription 3 (STAT3) plays a critical role in tumor development by regulating signaling pathways involved in cell proliferation, survival, metastasis and angiogenesis. STA...

    Authors: Megan E. Brown, Misty D. Bear, Thomas J. Rosol, Chris Premanandan, William C. Kisseberth and Cheryl A. London

    Citation: BMC Veterinary Research 2015 11:206

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  5. Content type: Research article

    Progesterone receptors play a key role in the development of canine mammary tumours, and recent research has focussed on their possible value as therapeutic targets using antiprogestins. Cloning and sequencing...

    Authors: Silvia Guil-Luna, Jan Stenvang, Nils Brünner, Francisco Javier De Andrés, Eva Rollón, Víctor Domingo, Raquel Sánchez-Céspedes, Yolanda Millán and Juana Martín de las Mulas

    Citation: BMC Veterinary Research 2014 10:296

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  6. Content type: Research article

    The antimetabolite 6-thioguanine (6-TG) has been used to treat both human and canine lymphoid malignancies. 6-TG has been shown to be epigenetically active as a demethylating agent in a human lymphoma cell lin...

    Authors: Brian K Flesner, Senthil R Kumar and Jeffrey N Bryan

    Citation: BMC Veterinary Research 2014 10:290

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  7. Content type: Research article

    Cadherins are calcium-dependent cell-to-cell adhesion glycoproteins playing a critical role in the formation and maintenance of normal tissue architecture. In normal mammary gland, E-cadherin is expressed by l...

    Authors: Ana Catarina Figueira, Catarina Gomes, Joana Tavares de Oliveira, Hugo Vilhena, Júlio Carvalheira, Augusto JF de Matos, Patrícia Dias Pereira and Fátima Gärtner

    Citation: BMC Veterinary Research 2014 10:270

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  8. Content type: Research article

    Thymidine kinase 1 (TK1) is a deoxyribonucleic acid (DNA) precursor enzyme and a proliferation biomarker used for prognosis and treatment monitoring of breast cancer in humans. The aim was to determine if seru...

    Authors: Kiran Kumar Jagarlamudi, Sara Westberg, Henrik Rönnberg and Staffan Eriksson

    Citation: BMC Veterinary Research 2014 10:228

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  9. Content type: Research article

    Canine mammary tumors (CMTs) are the most common type of cancer found in female dogs. Establishment and evaluation of tumor cell lines can facilitate investigations of the biological mechanisms of cancer. Diff...

    Authors: Yen-Ling Hsiao, Tai-Zu Hsieh, Chian-Jiun Liou, Yeong-Hsiang Cheng, Chung-Tien Lin, Chi-Yao Chang and Yu-Shen Lai

    Citation: BMC Veterinary Research 2014 10:229

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  10. Content type: Research article

    Human breast cancer is a heterogeneous disease classified by molecular subtyping into luminal A, luminal B, HER2-overexpressing, basal-like, claudin-low and normal-breast like. The routinely applied and standa...

    Authors: Diego Caliari, Valentina Zappulli, Roberta Rasotto, Barbara Cardazzo, Federica Frassineti, Michael H Goldschmidt and Massimo Castagnaro

    Citation: BMC Veterinary Research 2014 10:185

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  11. Content type: Research article

    The NSAID mavacoxib (Trocoxil™) is a recently described selective COX-2 inhibitor used for the management of inflammatory disease in dogs. It has a long plasma half-life, requiring less frequent dosing and sup...

    Authors: Lisa Y Pang, Sally A Argyle, Ayako Kamida, Katherine O’Neill Morrison and David J Argyle

    Citation: BMC Veterinary Research 2014 10:184

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  12. Content type: Research article

    Exportin 1 (XPO1, also known as CRM1), is a chaperone protein responsible for the export of over 200 target proteins out of the nucleus. The expression and activity of XPO1 is upregulated in several human canc...

    Authors: Megan N Breit, William C Kisseberth, Misty D Bear, Yosef Landesman, Trinayan Kashyap, Dilara McCauley, Michael G Kauffman, Sharon Shacham and Cheryl A London

    Citation: BMC Veterinary Research 2014 10:160

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  13. Content type: Research article

    Mast cell tumors (MCTs) are the most common skin tumors in dogs and exhibit variable biologic behavior. Mutations in the c-kit proto-oncogene are associated with the tumorigenesis of MCTs, resulting in growth fac...

    Authors: Charles HC Halsey, Daniel L Gustafson, Barbara J Rose, Amber Wolf-Ringwall, Robert C Burnett, Dawn L Duval, Anne C Avery and Douglas H Thamm

    Citation: BMC Veterinary Research 2014 10:105

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  14. Content type: Research article

    Glutathione (GSH) is one of the most important agents of the antioxidant defense system of the cell because, in conjunction with the enzymes glutathione peroxidase (GSH-Px) and glutathione S transferase pi (GS...

    Authors: Camila Leonel, Gabriela B Gelaleti, Bruna V Jardim, Marina G Moschetta, Vitor R Regiani, Juliana G Oliveira and Debora APC Zuccari

    Citation: BMC Veterinary Research 2014 10:49

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  15. Content type: Research article

    A genetic predisposition for certain tumour types has been proven for some dog breeds. Some studies have suggested that this may also be true for the Golden retriever breed. The present study aimed to examine ...

    Authors: Kim M Boerkamp, Erik Teske, Lonneke R Boon, Guy CM Grinwis, Lindsay van den Bossche and Gerard R Rutteman

    Citation: BMC Veterinary Research 2014 10:34

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  16. Content type: Research article

    Multiple myeloma (MM) is an important human and canine cancer for which novel therapies remain necessary. VDC-1101 (formerly GS-9219), a novel double prodrug of the anti-proliferative nucleotide analog 9-(2-ph...

    Authors: Douglas H Thamm, David M Vail, Ilene D Kurzman, Darius Babusis, Adrian S Ray, Noel Sousa-Powers and Daniel B Tumas

    Citation: BMC Veterinary Research 2014 10:30

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  17. Content type: Research article

    Enzymatic activity of Telomerase Reverse Transcriptase (TERT) is important in maintaining the telomere length and has been implicated in cancer and aging related pathology. Since cancer susceptibility as well as ...

    Authors: Camille A McAloney, Kevin A T Silverstein, Jaime F Modiano and Anindya Bagchi

    Citation: BMC Veterinary Research 2014 10:20

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  18. Content type: Research article

    This study evaluated tyrosine kinase receptor (TKR) expression and activation in canine pulmonary adenocarcinoma (cpAC) biospecimens. As histological similarities exist between human and cpAC, we hypothesized ...

    Authors: Evan T Mariotti, Christopher Premanandan and Gwendolen Lorch

    Citation: BMC Veterinary Research 2014 10:19

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  19. Content type: Methodology article

    Molecular techniques that detect canine lymphoma cells by their clonal antigen receptor gene rearrangement play an increasing role for diagnosis as well as for monitoring minimal residual disease during and af...

    Authors: Kathrin FA Langner, Alexa E Joetzke, Verena Nerschbach, Nina Eberle, Hans-Joachim Schuberth, Mirja Koy, Ingo Nolte and Daniela Betz

    Citation: BMC Veterinary Research 2014 10:1

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  20. Content type: Research article

    The significance of the serotonergic system in bone physiology and, more specifically, the importance of the five hydroxytryptamine receptor 2A (5HTR2A) in normal osteoblast proliferation have been previously ...

    Authors: Shay Bracha, Austin Viall, Cheri Goodall, Bernadette Stang, Craig Ruaux, Bernard Seguin and Patrick E Chappell

    Citation: BMC Veterinary Research 2013 9:251

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  21. Content type: Research article

    The receptor kinase inhibitor toceranib phosphate (Palladia) was approved for use in dogs in 2009 using a dose of 3.25 mg/kg administered every other day. Preliminary data suggests that lower doses of toeceran...

    Authors: Luis Feo Bernabe, Roberta Portela, Sandra Nguyen, William C Kisseberth, Michael Pennell, Mark F Yancey and Cheryl A London

    Citation: BMC Veterinary Research 2013 9:190

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  22. Content type: Research article

    The objective of this study was to evaluate the effect on outcomes of intraoperative recombinant human interleukin-2 injection after surgical resection of peripheral nerve sheath tumours. In this double-blind ...

    Authors: Annika N Haagsman, Astrid CS Witkamp, Bart E Sjollema, Marja JL Kik and Jolle Kirpensteijn

    Citation: BMC Veterinary Research 2013 9:155

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  23. Content type: Research article

    Spontaneous canine mammary tumors constitute a serious clinical problem. There are significant differences in survival between cases with different tumor grades. Unfortunately, the distinction between various ...

    Authors: Karol M Pawłowski, Henryk Maciejewski, Kinga Majchrzak, Izabella Dolka, Jan A Mol, Tomasz Motyl and Magdalena Król

    Citation: BMC Veterinary Research 2013 9:138

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  24. Content type: Research article

    Hairy and enhancer of split 1 (HES1), a basic helix-loop-helix transcriptional repressor, is a downstream target of Notch signaling. Notch signaling and HES1 expression have been linked to growth and survival ...

    Authors: Deanna D Dailey, Kristin P Anfinsen, Liza E Pfaff, EJ Ehrhart, J Brad Charles, Tina B Bønsdorff, Douglas H Thamm, Barbara E Powers, Thora J Jonasdottir and Dawn L Duval

    Citation: BMC Veterinary Research 2013 9:130

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  25. Content type: Research article

    In both women and female dogs, the most prevalent type of malignant neoplasm is the spontaneous mammary tumor. In dogs, half of these are malignant. The treatment of choice for the canine patients is surgical ...

    Authors: Karol M Pawłowski, Joanna Mucha, Kinga Majchrzak, Tomasz Motyl and Magdalena Król

    Citation: BMC Veterinary Research 2013 9:119

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  26. Content type: Research article

    Osteosarcoma (OSA) is the most common primary bone tumor of dogs and carries a poor prognosis despite aggressive treatment. An improved understanding of the biology of OSA is critically needed to allow for dev...

    Authors: Milan Milovancev, Ian Hilgart-Martiszus, Michael J McNamara, Cheri P Goodall, Bernard Seguin, Shay Bracha and Samanthi I Wickramasekara

    Citation: BMC Veterinary Research 2013 9:116

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  27. Content type: Research article

    Oxidative stress, an excess of reactive oxygen species (ROS), causes lipid peroxidation resulting in cell and tissue damages. It may be associated with the development and progression of cancers in dogs. Malon...

    Authors: Arayaporn Macotpet, Fanan Suksawat, Peerapol Sukon, Komgrit Pimpakdee, Ekkachai Pattarapanwichien, Roongpet Tangrassameeprasert and Patcharee Boonsiri

    Citation: BMC Veterinary Research 2013 9:101

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  28. Content type: Research article

    Canine lymphoma represents the most frequent haematopoietic cancer and it shares some similarities with human non-Hodgkin lymphoma. Matrix metalloproteinases (MMPs) and vascular endothelial growth factor (VEGF...

    Authors: Arianna Aricò, Mery Giantin, Maria Elena Gelain, Fulvio Riondato, Stefano Comazzi, Barbara C Rütgen, Sabine E Essler, Mauro Dacasto, Massimo Castagnaro and Luca Aresu

    Citation: BMC Veterinary Research 2013 9:94

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  29. Content type: Research article

    The antibody Ki-67 is a reliable and easy tool to accurately assess the growth fraction of neoplasms in humans and animals, and it has been used to predict the clinical outcome. Therefore, the aim of the prese...

    Authors: Rodrigo Storti Pereira, Augusto Schweigert, Guilherme Dias de Melo, Fernando Vissani Fernandes, Felipe Augusto Ruiz Sueiro and Gisele Fabrino Machado

    Citation: BMC Veterinary Research 2013 9:83

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  30. Content type: Research article

    Triple negative breast cancer (TNBC) in humans is defined by the absence of oestrogen receptor (ER), progesterone receptor (PR) and HER2 overexpression. Mammalian target of rapamycin (mTOR) is overexpressed in...

    Authors: Lorella Maniscalco, Yolanda Millán, Selina Iussich, Mauro Denina, Raquel Sánchez-Céspedes, Francesca Gattino, Bartolomeo Biolatti, Nobuo Sasaki, Takayuki Nakagawa, Maria Flavia Di Renzo, Juana Martín de las Mulas and Raffaella De Maria

    Citation: BMC Veterinary Research 2013 9:80

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  31. Content type: Research article

    The frequency of mammary malignancies in canine patients is even three times over than in human. In various types of cancer different intracellular signalling pathways are perturbed, thus the patients with pat...

    Authors: Karol M Pawłowski, Henryk Maciejewski, Izabella Dolka, Jan A Mol, Tomasz Motyl and Magdalena Król

    Citation: BMC Veterinary Research 2013 9:78

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  32. Content type: Research article

    Autophagy is a self-catabolic mechanism that degrades unnecessary cellular components through lysosomal enzymes. Beclin-1, an autophagy-related protein, establishes the first connection between autophagy and t...

    Authors: Jing-Lan Liu, Kai-Chian Chang, Chun-Chih Lo, Pei-Yi Chu and Chen-Hsuan Liu

    Citation: BMC Veterinary Research 2013 9:75

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  33. Content type: Research article

    The limited within-breed genetic heterogeneity and an enrichment of disease-predisposing alleles have made the dog a very suitable model for the identification of genes associated with risk for specific diseas...

    Authors: Kaja Sverdrup Borge, Malin Melin, Patricio Rivera, Stein Istre Thoresen, Matthew Thomas Webster, Henrik von Euler, Kerstin Lindblad-Toh and Frode Lingaas

    Citation: BMC Veterinary Research 2013 9:69

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  34. Content type: Research article

    Tumor-associated macrophages (TAMs) have high impact on the cancer development because they can facilitate matrix invasion, angiogenesis, and tumor cell motility. It gives cancer cells the capacity to invade n...

    Authors: Magdalena Król, Kinga Majchrzak, Joanna Mucha, Agata Homa, Małgorzata Bulkowska, Arleta Jakubowska, Malwina Karwicka, Karol M Pawłowski and Tomasz Motyl

    Citation: BMC Veterinary Research 2013 9:65

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  35. Content type: Research article

    Osteosarcoma (OS) affects over 8000 dogs/year in the United States. The disease usually arises in the appendicular skeleton and metastasizes to the lung. Dogs with localized appendicular disease benefit from l...

    Authors: Kevin Marley, Stuart C Helfand, Wade A Edris, John E Mata, Alix I Gitelman, Jan Medlock and Bernard Séguin

    Citation: BMC Veterinary Research 2013 9:15

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  36. Content type: Research article

    STAT3 [1] has been shown to be dysregulated in nearly every major cancer, including osteosarcoma (OS). Constitutive activation of STAT3, via aberrant phosphorylation, leads to proliferation, cell survival and ...

    Authors: Jason I Couto, Misty D Bear, Jiayuh Lin, Michael Pennel, Samuel K Kulp, William C Kisseberth and Cheryl A London

    Citation: BMC Veterinary Research 2012 8:244

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  37. Content type: Case report

    Stratified keratinizing squamous epithelium in the ovary has been associated with the diagnosis of ovarian teratoma in cows. Recently, the diagnosis of “epidermoid cyst” has been proposed. A case of squamous m...

    Authors: Renato Lima Santos, Dimitre Giancarlo de Medeiros Peixoto, Andréia Pereira Turchetti, Álan Maia Borges, Ernane Fagundes do Nascimento and Tatiane Alves Paixão

    Citation: BMC Veterinary Research 2012 8:235

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  38. Content type: Research article

    This study aimed to evaluate the relationship between the molecular phenotype of the primary mammary tumor and its related lymph node metastasis in the dog to develop prognostic-predictive models and targeted ...

    Authors: Germana Beha, Barbara Brunetti, Pietro Asproni, Luisa Vera Muscatello, Francesca Millanta, Alessandro Poli, Giuseppe Sarli and Cinzia Benazzi

    Citation: BMC Veterinary Research 2012 8:219

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  39. Content type: Research article

    Bovine papillomaviruses (BPVs) types 1 and 2 are the only known papillomaviruses able to jump the species. In fact, BPVs 1/2 induce neoplasia in their natural bovine host but infection is also associated to ne...

    Authors: Gennaro Altamura, Maria Strazzullo, Annunziata Corteggio, Romina Francioso, Franco Roperto, Maurizio D'Esposito and Giuseppe Borzacchiello

    Citation: BMC Veterinary Research 2012 8:218

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  40. Content type: Research article

    Chemokines play multiple roles in the development and progression in a variety of tumors. Chemokine (C-X-C motif) ligand 7 (CXCL7) has been found associated with pro-inflammatory responses, but its role in can...

    Authors: Hsin-Chien Chiang, Yu-Shan Wang, Chung-Hsi Chou, Albert Taiching Liao, Rea-Min Chu and Chen-Si Lin

    Citation: BMC Veterinary Research 2012 8:216

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  41. Content type: Research article

    Myeloid derived suppressor cells (MDSCs) are a recently described population of immune cells that significantly contribute to the immunosuppression seen in cancer patients. MDSCs are one of the most important ...

    Authors: Matthew Sherger, William Kisseberth, Cheryl London, Susan Olivo-Marston and Tracey L Papenfuss

    Citation: BMC Veterinary Research 2012 8:209

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  42. Content type: Research article

    Components of the extracellular matrix have been studied in an attempt to elucidate the mechanisms involved in the biological behaviour of tumours. The presence of the proteoglycan versican has been strongly a...

    Authors: Karine A Damasceno, Angélica C Bertagnolli, Alessandra Estrela-Lima, Lorena GR Ribeiro, Bruna S Rabelo, Cecília B Campos, André LB Barros and Geovanni D Cassali

    Citation: BMC Veterinary Research 2012 8:195

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  43. Content type: Research article

    Ghrelin is a natural ligand of the growth hormone secretagogue receptor (GHS-R). They are often co-expressed in multiple human tumors and related cancer cell lines what can indicate that the ghrelin/GHS-R axis...

    Authors: Kinga Majchrzak, Karol M Pawłowski, Emilia J Orzechowska, Izabella Dolka, Joanna Mucha, Tomasz Motyl and Magdalena Król

    Citation: BMC Veterinary Research 2012 8:170

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  44. Content type: Research article

    Canine hemangiosarcoma (HSA) is a malignant tumor with poor long-term prognosis due to development of metastasis despite aggressive treatment. The phosphatidyl-inositol-3 kinase/Akt/mammalian target of rapamyc...

    Authors: Atsuko Murai, Samah Abou Asa, Atsushi Kodama, Akihiro Hirata, Tokuma Yanai and Hiroki Sakai

    Citation: BMC Veterinary Research 2012 8:128

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  45. Content type: Research article

    Canine mast cell tumour proliferation depends to a large extent on the activity of KIT, a tyrosine kinase receptor. Inhibitors of the KIT tyrosine kinase have recently been introduced and successfully applied ...

    Authors: Robert Klopfleisch, Anja Meyer, Patricia Schlieben, Angelika Bondzio, Chris Weise, Dido Lenze, Michael Hummel, Ralf Einspanier and Achim D Gruber

    Citation: BMC Veterinary Research 2012 8:96

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  46. Content type: Research article

    Melanocytic proliferations are common in horses but the diagnosis of malignancy is not always straightforward. To improve diagnosis and prognosis, markers of malignancy are needed. Receptor for activated C kin...

    Authors: Cécile Campagne, Sophia Julé, Florence Bernex, Mercedes Estrada, Geneviève Aubin-Houzelstein, Jean-Jacques Panthier and Giorgia Egidy

    Citation: BMC Veterinary Research 2012 8:95

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  47. Content type: Research article

    The bone morphogenetic proteins (BMPs) belong to a unique group of proteins that includes the growth factor TGF-β. BMPs play important roles in cell differentiation, cell proliferation, and inhibition of cell ...

    Authors: Rose Eli Grassi Rici, Dayane Alcântara, Paula Fratini, Cristiane Valverde Wenceslau, Carlos Eduardo Ambrósio, Maria Angelica Miglino and Durvanei Augusto Maria

    Citation: BMC Veterinary Research 2012 8:17

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