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Oncology

Section edited by Cheryl London

The oncology section publishes research findings which focus on studies that address the etiology and treatment of cancer in veterinary patients. We consider studies on cancer prevention, therapeutic strategies, molecular diagnostics, genetics and genomics, epidemiology and comparative oncology

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  1. Content type: Research article

    Objective of this study is a feasibility-test comparing hock- and footpad-injection in rats with inoculated MatLyLu - adenocarcinoma tumor model. This study compares the development of an adenocarcinoma model ...

    Authors: Henning Richter, Agnieszka Karol, Katja Nuss, Aymone Lenisa, Erika Bruellmann, Stella-Saphira Maudens, Heinrich Hoffmann, Brigitte von Rechenberg and Patrick R. Kircher

    Citation: BMC Veterinary Research 2018 14:327

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  2. Content type: Research article

    Melanomas are rare in cats. The eye is the most commonly involved site, whereas few data are available about feline non-ocular melanomas (NOMs). Ki-67 thresholds with prognostic relevance have been established...

    Authors: Silvia Sabattini, Andrea Renzi, Francesco Albanese, Marco Fantinati, Antonella Rigillo, Francesca Abramo, Raimondo Tornago, Giovanni Tortorella, Maria Massaro, Teresa Bruna Pagano, Julia Buchholz and Giuliano Bettini

    Citation: BMC Veterinary Research 2018 14:309

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  3. Content type: Research article

    Low-grade alimentary lymphoma (LGAL) is characterised by the infiltration of neoplastic T-lymphocytes, typically in the small intestine. The incidence of LGAL has increased over the last ten years and it is no...

    Authors: Mathieu V Paulin, Lucile Couronné, Jérémy Beguin, Sophie Le Poder, Maxence Delverdier, Marie-Odile Semin, Julie Bruneau, Nadine Cerf-Bensussan, Georgia Malamut, Christophe Cellier, Ghita Benchekroun, Laurent Tiret, Alexander J German, Olivier Hermine and Valérie Freiche

    Citation: BMC Veterinary Research 2018 14:306

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  4. Content type: Research article

    Hemangiosarcoma (HSA) is a malignant tumor derived from endothelial cells which usually shows poor prognosis due to its high invasiveness, metastatic rate and severe hemorrhage from tumor ruptures. Since the p...

    Authors: Keisuke Aoshima, Yuki Fukui, Kevin Christian Montecillo Gulay, Ochbayar Erdemsurakh, Atsuya Morita, Atsushi Kobayashi and Takashi Kimura

    Citation: BMC Veterinary Research 2018 14:301

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  5. Content type: Methodology article

    Infectious bronchitis (IB) caused by the IB virus (IBV) can cause acute damage to chickens around the world. Therefore, rapid diagnosis and immune status determination are critical for controlling IBV outbreak...

    Authors: Liping Yan, Jianhua Hu, Jing Lei, Zhiyu Shi, Qian Xiao, Zhenwei Bi, Lu Yao, Yuan Li, Yuqing Chen, An Fang, Hui Li, Suquan Song, Min Liao and Jiyong Zhou

    Citation: BMC Veterinary Research 2018 14:284

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  6. Content type: Research article

    Effective treatment options for inoperable, metastatic, or recurrent canine pheochromocytomas are lacking. In humans, specific germline mutations exist that drive the development of pheochromocytomas. Pharmace...

    Authors: Margaret L. Musser, Kathryn L. Taikowski, Chad M. Johannes and Philip J. Bergman

    Citation: BMC Veterinary Research 2018 14:272

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  7. Content type: Research article

    Sarcoids are the mostcommon skin tumors in horses, characterized by rare regression, invasiveness and high recurrence following surgical intervention and Delta Papillomaviruses are widely recognized as the cau...

    Authors: Manuela Martano, Karen Power, Brunella Restucci, Ilaria Pagano, Gennaro Altamura, Giuseppe Borzacchiello and Paola Maiolino

    Citation: BMC Veterinary Research 2018 14:266

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  8. Content type: Research article

    Chemotherapeutic options for the treatment of canine lymphoma have not changed in several decades necessitating the identification of new therapeutics to improve patient outcome. KPT-335 (verdinexor) is a nove...

    Authors: Abbey R. Sadowski, Heather L. Gardner, Antonella Borgatti, Heather Wilson, David M. Vail, Joshua Lachowicz, Christina Manley, Avenelle Turner, Mary K. Klein, Angharad Waite, Alexandra Sahora and Cheryl A. London

    Citation: BMC Veterinary Research 2018 14:250

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  9. Content type: Case Report

    Malignant fibrous histiocytoma has been uncommonly described in dogs. Several extranasal neoplasias have been reported to result hypertensive epistaxis. There are, however, no published case reports of extrana...

    Authors: Jung-Hyun Kim, Hee-Jin Kim, Sung-Jun Lee and Hun-Young Yoon

    Citation: BMC Veterinary Research 2018 14:235

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  10. Content type: Research article

    Cytokeratins with epitopes in common with those of alpha (acidic and basic) mammalian keratins have been immunohistochemically demonstrated in the epidermis of reptiles. However, there are no reports of immuno...

    Authors: Jorge Orós, María López-Yánez, Francisco Rodríguez, Pascual Calabuig and Pedro L. Castro

    Citation: BMC Veterinary Research 2018 14:219

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  11. Content type: Case Report

    To date, calvarial defects in dogs have traditionally been addressed with different types of implants including bone allograft, polymethylmethacrylate and titanium mesh secured with conventional metallic fixat...

    Authors: Pierre Langer, Cameron Black, Padraig Egan and Noel Fitzpatrick

    Citation: BMC Veterinary Research 2018 14:199

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  12. Content type: Research article

    Mammary cancer has a high incidence in canines and is an excellent model of spontaneous carcinogenesis. Molecular iodine (I2) exerts antineoplastic effects on different cancer cells activating re-differentiation ...

    Authors: Xóchitl Zambrano-Estrada, Brianda Landaverde-Quiroz, Andrés A. Dueñas-Bocanegra, Marco A. De Paz-Campos, Gerardo Hernández-Alberto, Benjamín Solorio-Perusquia, Manuel Trejo-Mandujano, Laura Pérez-Guerrero, Evangelina Delgado-González, Brenda Anguiano and Carmen Aceves

    Citation: BMC Veterinary Research 2018 14:87

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  13. Content type: Case Report

    Squamous cell carcinoma (SCC) is the most common nonodontogenic oral tumor in cats. In the jaw, it usually presents as an ulceroproliferative lesion associated with enlargement of the affected bone.

    Authors: Darja Pavlin, Tamara Dolenšek, Tanja Švara and Ana Nemec

    Citation: BMC Veterinary Research 2018 14:23

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  14. Content type: Research article

    The use of nutraceuticals is gaining in popularity in human and canine oncology with a relatively limited understanding of the effects in the vastly different tumor types seen in canine oncology. We have previ...

    Authors: Corri B. Levine, Julie Bayle, Vincent Biourge and Joseph J. Wakshlag

    Citation: BMC Veterinary Research 2017 13:388

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  15. Content type: Research article

    c-KIT expression has been related to bone metastasis in human prostate cancer, but whether c-KIT expression can be similarly classified in canine prostatic tissue is unknown. This study assessed c-KIT and Ki67...

    Authors: Carlos Eduardo Fonseca-Alves, Priscilla Emiko Kobayashi, Chiara Palmieri and Renée Laufer-Amorim

    Citation: BMC Veterinary Research 2017 13:380

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  16. Content type: Research article

    Quantitative PCR (qPCR) is a common method for quantifying mRNA expression. Given the heterogeneity present in tumor tissues, it is crucial to normalize target mRNA expression data using appropriate reference ...

    Authors: Gayathri Thevi Selvarajah, Floor A. S. Bonestroo, Elpetra P. M. Timmermans Sprang, Jolle Kirpensteijn and Jan A. Mol

    Citation: BMC Veterinary Research 2017 13:354

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  17. Content type: Research article

    Early signs of canine transitional cell carcinoma (TCC) are frequently assumed to be caused by other lower urinary tract diseases (LUTD) such as urinary tract infections, resulting in late diagnosis of TCC whi...

    Authors: Michael S. Kent, Allison Zwingenberger, Jodi L. Westropp, Laura E. Barrett, Blythe P. Durbin-Johnson, Paramita Ghosh and Ruth L. Vinall

    Citation: BMC Veterinary Research 2017 13:339

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  18. Content type: Research article

    Hyperthermia is an established anti-cancer treatment but is limited by tolerance of adjacent normal tissues. Parenteral administration of gold nanorods (NRs) as a photosensitizer amplifies the effects of hyper...

    Authors: Elizabeth M. Schuh, Roberta Portela, Heather L. Gardner, Christian Schoen and Cheryl A. London

    Citation: BMC Veterinary Research 2017 13:294

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  19. Content type: Case Report

    Canine joint sarcomas, designated synovial sarcomas, are uncommon malignant mesenchymal neoplasms that occur in the large joints of the extremities of middle-aged, large-breed dogs. We report the diagnosis of ...

    Authors: SER Lovell, RK Burchell, PJ Roady, RL Fredrickson and A Gal

    Citation: BMC Veterinary Research 2017 13:247

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  20. Content type: Research article

    The chick embryo chorioallantoic membrane (CAM) model is well described in human medicine as a cost-effective, easy to perform preclinical oncological model for observing pro- and antiangiogenic response, tumo...

    Authors: Katarzyna Zabielska-Koczywąs, Agata Wojtkowska, Izabella Dolka, Anna Małek, Magdalena Walewska, Anna Wojtalewicz, Artur Żbikowski and Roman Lechowski

    Citation: BMC Veterinary Research 2017 13:201

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  21. Content type: Research article

    Osteosarcoma (OSA) is a common malignant bone tumor of large breed dogs that occurs at predictable anatomic sites. At the time of initial diagnosis, most affected dogs have occult pulmonary metastases. Even wi...

    Authors: B. G. Murphy, M. Y. Mok, D. York, R. Rebhun, K. D. Woolard, C. Hillman, P. Dickinson and K. Skorupski

    Citation: BMC Veterinary Research 2017 13:189

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  22. Content type: Research article

    The pathological condition of canine prostate cancer resembles that of human androgen-independent prostate cancer. Both canine and human androgen receptor (AR) signalling are inhibited by overexpression of the...

    Authors: Yuiko Kato, Kazuhiko Ochiai, Shota Kawakami, Nobuhiro Nakao, Daigo Azakami, Makoto Bonkobara, Masaki Michishita, Masami Morimatsu, Masami Watanabe and Toshinori Omi

    Citation: BMC Veterinary Research 2017 13:170

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  23. Content type: Research article

    Ki67 index, tumor associated macrophages (TAMs) and mast cells (MCs) are associated with malignancies in animal and human neoplasms including colorectal carcinomas (CRC). This has not been assessed in canine C...

    Authors: M. Woldemeskel, I. Hawkins and L. Whittington

    Citation: BMC Veterinary Research 2017 13:111

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  24. Content type: Research article

    Cutaneous squamous cell carcinoma of the nasal planum in cats is a common indication for antitumor treatment such as external beam radiation therapy. Curative-intent radiation therapy has been described as a v...

    Authors: Evgeniya Gasymova, Valeria Meier, Franco Guscetti, Simona Cancedda, Malgorzata Roos and Carla Rohrer Bley

    Citation: BMC Veterinary Research 2017 13:86

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  25. Content type: Research article

    Canine mammary tumors represent the most common neoplasm in female dogs, and the discovery of cancer biomarkers and their translation to clinical relevant assays is a key requirement in the war on cancer. Sinc...

    Authors: Giovanni Pietro Burrai, Alessandro Tanca, Tiziana Cubeddu, Marcello Abbondio, Marta Polinas, Maria Filippa Addis and Elisabetta Antuofermo

    Citation: BMC Veterinary Research 2017 13:38

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  26. Content type: Research article

    Canine B-cell lymphoma is deemed an ideal model of human non-Hodgkin’s lymphoma where the lymphomas of both species share similar clinical features and biological behaviors. However there are some differences ...

    Authors: Mohamad Zamani-Ahmadmahmudi, Sina Aghasharif and Keyhan Ilbeigi

    Citation: BMC Veterinary Research 2017 13:17

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  27. Content type: Research article

    The aim of this study was to describe the prevalence and tissue distribution of neoplasms in Italian ferrets, compared to the epidemiological data previously reported in USA and Japan.

    Authors: Giancarlo Avallone, Annalisa Forlani, Marco Tecilla, Elena Riccardi, Sara Belluco, Sara Francesca Santagostino, Guido Grilli, Kiumars Khadivi and Paola Roccabianca

    Citation: BMC Veterinary Research 2016 12:275

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  28. Content type: Research article

    Splenic masses are common in older dogs; yet diagnosis preceding splenectomy and histopathology remains elusive. MicroRNAs (miRNAs) are short, non-coding RNAs that play a role in post-transcriptional regulatio...

    Authors: Janet A. Grimes, Nripesh Prasad, Shawn Levy, Russell Cattley, Stephanie Lindley, Harry W. Boothe, Ralph A. Henderson and Bruce F. Smith

    Citation: BMC Veterinary Research 2016 12:272

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  29. Content type: Research article

    Ultrasonography to visualize adrenal gland lesions and evaluate incidentally discovered adrenal masses in dogs has become more reliable with advances in imaging techniques. However, correlations between sonogr...

    Authors: Elena Pagani, Massimiliano Tursi, Chiara Lorenzi, Alberto Tarducci, Barbara Bruno, Enrico Corrado Borgogno Mondino and Renato Zanatta

    Citation: BMC Veterinary Research 2016 12:267

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  30. Content type: Research article

    Effective therapies for transitional cell carcinoma (TCC) are limited, with objective response rates to most chemotherapeutic regimens below 20%. The purpose of this study was to investigate the biologic activ...

    Authors: Sarah B. Rippy, Heather L. Gardner, Sandra M. Nguyen, Emma E. Warry, Roberta F. Portela, William Tod Drost, Eric T. Hostnik, Eric M. Green, Dennis J. Chew, Juan Peng and Cheryl A. London

    Citation: BMC Veterinary Research 2016 12:257

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    The Erratum to this article has been published in BMC Veterinary Research 2016 12:291

  31. Content type: Case Report

    Lung cancer is the most commonly diagnosed neoplasm in humans, however this does not apply to other animal species. Living in an aquatic environment the respiratory system of cetaceans had to undergo unique ad...

    Authors: Cristian M. Suárez-Santana, Carolina Fernández-Maldonado, Josué Díaz-Delgado, Manuel Arbelo, Alejandro Suárez-Bonnet, Antonio Espinosa de los Monteros, Nakita Câmara, Eva Sierra and Antonio Fernández

    Citation: BMC Veterinary Research 2016 12:229

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  32. Content type: Research article

    Leukemia/lymphoma cell lines have been critical in the investigation of the pathogenesis and therapy of hematological malignancies. While human LL cell lines have generally been found to recapitulate the prima...

    Authors: Sarah C. Roode, Daniel Rotroff, Kristy L. Richards, Peter Moore, Alison Motsinger-Reif, Yasuhiko Okamura, Takuya Mizuno, Hajime Tsujimoto, Steven E. Suter and Matthew Breen

    Citation: BMC Veterinary Research 2016 12:207

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  33. Content type: Research article

    Current studies report that aberrations in epigenetic regulators or chromatin modifications are related to tumor development and maintenance. EZH2 (Enhancer of zeste homolog 2) is one of the catalytic subunits...

    Authors: Hyun-Ji Choi, Sungwoong Jang, Jae-Eun Ryu, Hyo-Ju Lee, Han-Byul Lee, Woo-Sung Ahn, Hye-Jin Kim, Hyo-Jin Lee, Hee Jin Lee, Gyung-Yub Gong and Woo-Chan Son

    Citation: BMC Veterinary Research 2016 12:164

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  34. Content type: Research article

    Adjunctive use of nutraceuticals in human cancer has shown promise, but little work has been done in canine neoplasia. Previous human research has shown that polyphenols and carotenoids can target multiple pat...

    Authors: Corri B. Levine, Julie Bayle, Vincent Biourge and Joseph J. Wakshlag

    Citation: BMC Veterinary Research 2016 12:159

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  35. Content type: Case Report

    Ovarian tumors in reptiles are uncommonly reported in the literature and for green iguanas previously reported cases include teratomas, one adenocarcinoma and one papillary cystadenocarcinoma. The present repo...

    Authors: Lucia Bel, Marco Tecilla, Gabriel Borza, Cosmin Pestean, Robert Purdoiu, Ciprian Ober, Liviu Oana and Marian Taulescu

    Citation: BMC Veterinary Research 2016 12:144

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  36. Content type: Research article

    KIT is a tyrosine kinase growth factor receptor. High expression of KIT has been found in several tumors including canine hemangiosarcoma (HSA). This study investigated the correlation of KIT expression and c-kit

    Authors: Yi-Chen Chen, Jiunn-Wang Liao, Wei-Li Hsu and Shih-Chieh Chang

    Citation: BMC Veterinary Research 2016 12:142

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  37. Content type: Research article

    Canine oral fibrosarcoma (COF) is one of the most common oral tumors in dogs and carries a guarded prognosis due to a lack of effective systemic therapeutic options. Mastinib and imatinib are two commonly used...

    Authors: Milan Milovancev, Stuart C. Helfand, Kevin Marley, Cheri P. Goodall, Christiane V. Löhr and Shay Bracha

    Citation: BMC Veterinary Research 2016 12:85

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  38. Content type: Research article

    Radiation therapy is a palliative treatment modality for canine osteosarcoma, with transient improvement in analgesia observed in many cases. However there is room for improvement in outcome for these patients...

    Authors: Fernanda B. Mantovani, Jodi A. Morrison and Anthony J. Mutsaers

    Citation: BMC Veterinary Research 2016 12:82

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  39. Content type: Research article

    Equine sarcoids are locally invasive, fibroblastic benign skin tumors. Bovine papillomavirus type-1 (BPV-1) and/or Bovine papillomavirus type-2 (BPV-2) are believed to be the causative agent of sarcoids, altho...

    Authors: Manuela Martano, Annunziata Corteggio, Brunella Restucci, Maria Ester De Biase, Giuseppe Borzacchiello and Paola Maiolino

    Citation: BMC Veterinary Research 2016 12:24

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  40. Content type: Research article

    Cancer is the leading cause of death in older dogs and its prevalence is increasing. There is clearly a need to develop more effective anti-cancer drugs in dogs. SG2000 (SJG-136) is a sequence selective DNA mi...

    Authors: Maria Mellinas-Gomez, Victoria J. Spanswick, Solange R. Paredes-Moscosso, Matthew Robson, R. Barbara Pedley, David E. Thurston, Stephen J. Baines, Anneliese Stell and John A. Hartley

    Citation: BMC Veterinary Research 2015 11:215

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  41. Content type: Research article

    Signal transducer and activator of transcription 3 (STAT3) plays a critical role in tumor development by regulating signaling pathways involved in cell proliferation, survival, metastasis and angiogenesis. STA...

    Authors: Megan E. Brown, Misty D. Bear, Thomas J. Rosol, Chris Premanandan, William C. Kisseberth and Cheryl A. London

    Citation: BMC Veterinary Research 2015 11:206

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  42. Content type: Research article

    Progesterone receptors play a key role in the development of canine mammary tumours, and recent research has focussed on their possible value as therapeutic targets using antiprogestins. Cloning and sequencing...

    Authors: Silvia Guil-Luna, Jan Stenvang, Nils Brünner, Francisco Javier De Andrés, Eva Rollón, Víctor Domingo, Raquel Sánchez-Céspedes, Yolanda Millán and Juana Martín de las Mulas

    Citation: BMC Veterinary Research 2014 10:296

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  43. Content type: Research article

    The antimetabolite 6-thioguanine (6-TG) has been used to treat both human and canine lymphoid malignancies. 6-TG has been shown to be epigenetically active as a demethylating agent in a human lymphoma cell lin...

    Authors: Brian K Flesner, Senthil R Kumar and Jeffrey N Bryan

    Citation: BMC Veterinary Research 2014 10:290

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  44. Content type: Research article

    Cadherins are calcium-dependent cell-to-cell adhesion glycoproteins playing a critical role in the formation and maintenance of normal tissue architecture. In normal mammary gland, E-cadherin is expressed by l...

    Authors: Ana Catarina Figueira, Catarina Gomes, Joana Tavares de Oliveira, Hugo Vilhena, Júlio Carvalheira, Augusto JF de Matos, Patrícia Dias Pereira and Fátima Gärtner

    Citation: BMC Veterinary Research 2014 10:270

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  45. Content type: Research article

    Thymidine kinase 1 (TK1) is a deoxyribonucleic acid (DNA) precursor enzyme and a proliferation biomarker used for prognosis and treatment monitoring of breast cancer in humans. The aim was to determine if seru...

    Authors: Kiran Kumar Jagarlamudi, Sara Westberg, Henrik Rönnberg and Staffan Eriksson

    Citation: BMC Veterinary Research 2014 10:228

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  46. Content type: Research article

    Canine mammary tumors (CMTs) are the most common type of cancer found in female dogs. Establishment and evaluation of tumor cell lines can facilitate investigations of the biological mechanisms of cancer. Diff...

    Authors: Yen-Ling Hsiao, Tai-Zu Hsieh, Chian-Jiun Liou, Yeong-Hsiang Cheng, Chung-Tien Lin, Chi-Yao Chang and Yu-Shen Lai

    Citation: BMC Veterinary Research 2014 10:229

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  47. Content type: Research article

    Human breast cancer is a heterogeneous disease classified by molecular subtyping into luminal A, luminal B, HER2-overexpressing, basal-like, claudin-low and normal-breast like. The routinely applied and standa...

    Authors: Diego Caliari, Valentina Zappulli, Roberta Rasotto, Barbara Cardazzo, Federica Frassineti, Michael H Goldschmidt and Massimo Castagnaro

    Citation: BMC Veterinary Research 2014 10:185

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  48. Content type: Research article

    The NSAID mavacoxib (Trocoxil™) is a recently described selective COX-2 inhibitor used for the management of inflammatory disease in dogs. It has a long plasma half-life, requiring less frequent dosing and sup...

    Authors: Lisa Y Pang, Sally A Argyle, Ayako Kamida, Katherine O’Neill Morrison and David J Argyle

    Citation: BMC Veterinary Research 2014 10:184

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  49. Content type: Research article

    Exportin 1 (XPO1, also known as CRM1), is a chaperone protein responsible for the export of over 200 target proteins out of the nucleus. The expression and activity of XPO1 is upregulated in several human canc...

    Authors: Megan N Breit, William C Kisseberth, Misty D Bear, Yosef Landesman, Trinayan Kashyap, Dilara McCauley, Michael G Kauffman, Sharon Shacham and Cheryl A London

    Citation: BMC Veterinary Research 2014 10:160

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