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Section edited by Prof. Cheryl London

The oncology section considers research that addresses the etiology and treatment of cancer in veterinary patients. Research describing cancer prevention, therapeutic strategies, molecular diagnostics, genetics and genomics, epidemiology and comparative oncology are encouraged. Comparative and translational studies are also considered. 

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  1. Content type: Research article

    Estrogens are essential for the development and proper function of several hormone-dependent organs. There are, however, several lines of evidence associating estrogens with mammary carcinogenesis. A marked in...

    Authors: Ana Canadas-Sousa, Marta Santos, Bárbara Leal, Rui Medeiros and Patrícia Dias-Pereira

    Citation: BMC Veterinary Research 2019 15:325

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  2. Content type: Research article

    Oclacitinib is an orally bioavailable Janus Kinase (JAK) inhibitor approved for the treatment of canine atopic dermatitis. Aberrant JAK/ Signal Transducer and Activator of Transcription (STAT) signaling within...

    Authors: Laura E. Barrett, Heather L. Gardner, Lisa G. Barber, Abbey Sadowski and Cheryl A. London

    Citation: BMC Veterinary Research 2019 15:291

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  3. Content type: Research article

    Mammary gland tumor is the most common spontaneous tumor in intact female dogs, and its poor prognosis remains a clinical challenge. Ivermectin, a well-known anti-parasitic agent, has been implicated as a pote...

    Authors: Hongxiu Diao, Nan Cheng, Ying Zhao, Huihao Xu, Haodi Dong, Douglas H. Thamm, Di Zhang and Degui Lin

    Citation: BMC Veterinary Research 2019 15:276

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  4. Content type: Case Report

    Thyroid neoplasia is a common endocrine neoplasm in dogs. The boxer is one of the reported breeds predisposed to malignant thyroid neoplasia. However, the association between thyroid neoplasia, malignancy and ...

    Authors: Marie-Pauline Maurin, Dan Davies, Hanne Jahns, Robert E. Shiel and Carmel T. Mooney

    Citation: BMC Veterinary Research 2019 15:228

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  5. Content type: Research article

    Myxosarcomas are known to be classified as soft tissue sarcomas. However, there is limited clinical characterization pertaining specifically to canine cutaneous myxosarcomas in the literature. The objective of...

    Authors: Yoshimi Iwaki, Stephanie Lindley, Annette Smith, Kaitlin M. Curran and Jayme Looper

    Citation: BMC Veterinary Research 2019 15:217

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  6. Content type: Case Report

    Mast cell tumours are the most common cutaneous neoplasms in dogs. Other primary sites include visceral organs, such as the gastrointestinal tract, liver, or spleen, and the oral cavity. Frequent metastatic sites...

    Authors: Juan Carlos Cartagena-Albertus, Antoaneta Moise, Sergio Moya-García, Nora Cámara-Fernández and Jose Alberto Montoya-Alonso

    Citation: BMC Veterinary Research 2019 15:204

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  7. Content type: Research article

    Sphingosine kinase 1 (SPHK1) is an enzyme that converts pro-apoptotic ceramide and sphingosine into anti-apoptotic sphingosine-1-phosphate. There is growing evidence that SPHK1 activation promotes oncogenic tr...

    Authors: Yi-Chih Chang, Hsiao-Li Chuang, Ji-Hang Yin, Jiunn-Wang Liao, Ter-Hsin Chen and Yu-Chih Wang

    Citation: BMC Veterinary Research 2019 15:155

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  8. Content type: Case Report

    This report describes a case of a bronchiolar adenocarcinoma in a 6-year old alpaca mare. For the first time in an alpaca, neoplasia was classified by histopathology as a lepidic-predominant bronchiolar adenoc...

    Authors: Lara Moser, Kristel Kegler, Christina Precht and Patrik Zanolari

    Citation: BMC Veterinary Research 2019 15:139

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  9. Content type: Research article

    Dogs with appendicular osteosarcoma (OSA) receiving standard amputation and adjuvant chemotherapy demonstrate variable outcome with treatment; however, additional biomarkers would be helpful for predicting the...

    Authors: Kazuki Heishima, Travis Meuten, Kyoko Yoshida, Takashi Mori and Douglas H. Thamm

    Citation: BMC Veterinary Research 2019 15:39

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  10. Content type: Research article

    Cancer is a significant health threat in cats. Chemoresistance is prevalent in solid tumors. The ionophore salinomycin has anti-cancer properties and may work synergistically with chemotherapeutics. The purpos...

    Authors: Lucia Borlle, Abdo Dergham, Zacharie Wund, Brittany Zumbo, Teresa Southard and Kelly R. Hume

    Citation: BMC Veterinary Research 2019 15:36

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  11. Content type: Research article

    Cats spontaneously develop invasive mammary carcinomas with high clinical aggressiveness, and are considered relevant animal models for human breast cancer. Bcl-2 is an anti-apoptotic pro-survival protein, who...

    Authors: Elie Dagher, Jérôme Abadie, Delphine Loussouarn, Dominique Fanuel, Mario Campone and Frédérique Nguyen

    Citation: BMC Veterinary Research 2019 15:25

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  12. Content type: Research article

    Osteosarcoma (OSA) is the most common bone cancer in canines. Both transforming growth factor beta (TGFβ) and Hippo pathway mediators have important roles in bone development, stemness, and cancer progression....

    Authors: Anita K. Luu, Courtney R. Schott, Robert Jones, Andrew C. Poon, Brandon Golding, Roa’a Hamed, Benjamin Deheshi, Anthony Mutsaers, Geoffrey A. Wood and Alicia M. Viloria-Petit

    Citation: BMC Veterinary Research 2018 14:365

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  13. Content type: Research article

    A doxorubicin (DOX)-based chemotherapy protocol, CHOP, is the most effective treatment for canine high-grade B-cell lymphoma; however, the cost and time requirements associated with this protocol are not feasi...

    Authors: Sami Al-Nadaf, Robert B. Rebhun, Kaitlin M. Curran, Rachel O. Venable, Katherine A. Skorupski, Jennifer L. Willcox and Jenna H. Burton

    Citation: BMC Veterinary Research 2018 14:356

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  14. Content type: Research article

    Objective of this study is a feasibility-test comparing hock- and footpad-injection in rats with inoculated MatLyLu - adenocarcinoma tumor model. This study compares the development of an adenocarcinoma model ...

    Authors: Henning Richter, Agnieszka Karol, Katja Nuss, Aymone Lenisa, Erika Bruellmann, Stella-Saphira Maudens, Heinrich Hoffmann, Brigitte von Rechenberg and Patrick R. Kircher

    Citation: BMC Veterinary Research 2018 14:327

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  15. Content type: Research article

    Melanomas are rare in cats. The eye is the most commonly involved site, whereas few data are available about feline non-ocular melanomas (NOMs). Ki-67 thresholds with prognostic relevance have been established...

    Authors: Silvia Sabattini, Andrea Renzi, Francesco Albanese, Marco Fantinati, Antonella Rigillo, Francesca Abramo, Raimondo Tornago, Giovanni Tortorella, Maria Massaro, Teresa Bruna Pagano, Julia Buchholz and Giuliano Bettini

    Citation: BMC Veterinary Research 2018 14:309

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  16. Content type: Research article

    Low-grade alimentary lymphoma (LGAL) is characterised by the infiltration of neoplastic T-lymphocytes, typically in the small intestine. The incidence of LGAL has increased over the last ten years and it is no...

    Authors: Mathieu V Paulin, Lucile Couronné, Jérémy Beguin, Sophie Le Poder, Maxence Delverdier, Marie-Odile Semin, Julie Bruneau, Nadine Cerf-Bensussan, Georgia Malamut, Christophe Cellier, Ghita Benchekroun, Laurent Tiret, Alexander J German, Olivier Hermine and Valérie Freiche

    Citation: BMC Veterinary Research 2018 14:306

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  17. Content type: Research article

    Hemangiosarcoma (HSA) is a malignant tumor derived from endothelial cells which usually shows poor prognosis due to its high invasiveness, metastatic rate and severe hemorrhage from tumor ruptures. Since the p...

    Authors: Keisuke Aoshima, Yuki Fukui, Kevin Christian Montecillo Gulay, Ochbayar Erdemsurakh, Atsuya Morita, Atsushi Kobayashi and Takashi Kimura

    Citation: BMC Veterinary Research 2018 14:301

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  18. Content type: Methodology article

    Infectious bronchitis (IB) caused by the IB virus (IBV) can cause acute damage to chickens around the world. Therefore, rapid diagnosis and immune status determination are critical for controlling IBV outbreak...

    Authors: Liping Yan, Jianhua Hu, Jing Lei, Zhiyu Shi, Qian Xiao, Zhenwei Bi, Lu Yao, Yuan Li, Yuqing Chen, An Fang, Hui Li, Suquan Song, Min Liao and Jiyong Zhou

    Citation: BMC Veterinary Research 2018 14:284

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  19. Content type: Research article

    Effective treatment options for inoperable, metastatic, or recurrent canine pheochromocytomas are lacking. In humans, specific germline mutations exist that drive the development of pheochromocytomas. Pharmace...

    Authors: Margaret L. Musser, Kathryn L. Taikowski, Chad M. Johannes and Philip J. Bergman

    Citation: BMC Veterinary Research 2018 14:272

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  20. Content type: Research article

    Sarcoids are the mostcommon skin tumors in horses, characterized by rare regression, invasiveness and high recurrence following surgical intervention and Delta Papillomaviruses are widely recognized as the cau...

    Authors: Manuela Martano, Karen Power, Brunella Restucci, Ilaria Pagano, Gennaro Altamura, Giuseppe Borzacchiello and Paola Maiolino

    Citation: BMC Veterinary Research 2018 14:266

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  21. Content type: Research article

    Chemotherapeutic options for the treatment of canine lymphoma have not changed in several decades necessitating the identification of new therapeutics to improve patient outcome. KPT-335 (verdinexor) is a nove...

    Authors: Abbey R. Sadowski, Heather L. Gardner, Antonella Borgatti, Heather Wilson, David M. Vail, Joshua Lachowicz, Christina Manley, Avenelle Turner, Mary K. Klein, Angharad Waite, Alexandra Sahora and Cheryl A. London

    Citation: BMC Veterinary Research 2018 14:250

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  22. Content type: Case Report

    Malignant fibrous histiocytoma has been uncommonly described in dogs. Several extranasal neoplasias have been reported to result hypertensive epistaxis. There are, however, no published case reports of extrana...

    Authors: Jung-Hyun Kim, Hee-Jin Kim, Sung-Jun Lee and Hun-Young Yoon

    Citation: BMC Veterinary Research 2018 14:235

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  23. Content type: Research article

    Cytokeratins with epitopes in common with those of alpha (acidic and basic) mammalian keratins have been immunohistochemically demonstrated in the epidermis of reptiles. However, there are no reports of immuno...

    Authors: Jorge Orós, María López-Yánez, Francisco Rodríguez, Pascual Calabuig and Pedro L. Castro

    Citation: BMC Veterinary Research 2018 14:219

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  24. Content type: Case Report

    To date, calvarial defects in dogs have traditionally been addressed with different types of implants including bone allograft, polymethylmethacrylate and titanium mesh secured with conventional metallic fixat...

    Authors: Pierre Langer, Cameron Black, Padraig Egan and Noel Fitzpatrick

    Citation: BMC Veterinary Research 2018 14:199

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  25. Content type: Research article

    Mammary cancer has a high incidence in canines and is an excellent model of spontaneous carcinogenesis. Molecular iodine (I2) exerts antineoplastic effects on different cancer cells activating re-differentiation ...

    Authors: Xóchitl Zambrano-Estrada, Brianda Landaverde-Quiroz, Andrés A. Dueñas-Bocanegra, Marco A. De Paz-Campos, Gerardo Hernández-Alberto, Benjamín Solorio-Perusquia, Manuel Trejo-Mandujano, Laura Pérez-Guerrero, Evangelina Delgado-González, Brenda Anguiano and Carmen Aceves

    Citation: BMC Veterinary Research 2018 14:87

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  26. Content type: Case Report

    Squamous cell carcinoma (SCC) is the most common nonodontogenic oral tumor in cats. In the jaw, it usually presents as an ulceroproliferative lesion associated with enlargement of the affected bone.

    Authors: Darja Pavlin, Tamara Dolenšek, Tanja Švara and Ana Nemec

    Citation: BMC Veterinary Research 2018 14:23

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  27. Content type: Research article

    The use of nutraceuticals is gaining in popularity in human and canine oncology with a relatively limited understanding of the effects in the vastly different tumor types seen in canine oncology. We have previ...

    Authors: Corri B. Levine, Julie Bayle, Vincent Biourge and Joseph J. Wakshlag

    Citation: BMC Veterinary Research 2017 13:388

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  28. Content type: Research article

    c-KIT expression has been related to bone metastasis in human prostate cancer, but whether c-KIT expression can be similarly classified in canine prostatic tissue is unknown. This study assessed c-KIT and Ki67...

    Authors: Carlos Eduardo Fonseca-Alves, Priscilla Emiko Kobayashi, Chiara Palmieri and Renée Laufer-Amorim

    Citation: BMC Veterinary Research 2017 13:380

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  29. Content type: Research article

    Quantitative PCR (qPCR) is a common method for quantifying mRNA expression. Given the heterogeneity present in tumor tissues, it is crucial to normalize target mRNA expression data using appropriate reference ...

    Authors: Gayathri Thevi Selvarajah, Floor A. S. Bonestroo, Elpetra P. M. Timmermans Sprang, Jolle Kirpensteijn and Jan A. Mol

    Citation: BMC Veterinary Research 2017 13:354

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  30. Content type: Research article

    Early signs of canine transitional cell carcinoma (TCC) are frequently assumed to be caused by other lower urinary tract diseases (LUTD) such as urinary tract infections, resulting in late diagnosis of TCC whi...

    Authors: Michael S. Kent, Allison Zwingenberger, Jodi L. Westropp, Laura E. Barrett, Blythe P. Durbin-Johnson, Paramita Ghosh and Ruth L. Vinall

    Citation: BMC Veterinary Research 2017 13:339

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  31. Content type: Research article

    Hyperthermia is an established anti-cancer treatment but is limited by tolerance of adjacent normal tissues. Parenteral administration of gold nanorods (NRs) as a photosensitizer amplifies the effects of hyper...

    Authors: Elizabeth M. Schuh, Roberta Portela, Heather L. Gardner, Christian Schoen and Cheryl A. London

    Citation: BMC Veterinary Research 2017 13:294

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  32. Content type: Case Report

    Canine joint sarcomas, designated synovial sarcomas, are uncommon malignant mesenchymal neoplasms that occur in the large joints of the extremities of middle-aged, large-breed dogs. We report the diagnosis of ...

    Authors: SER Lovell, RK Burchell, PJ Roady, RL Fredrickson and A Gal

    Citation: BMC Veterinary Research 2017 13:247

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  33. Content type: Research article

    The chick embryo chorioallantoic membrane (CAM) model is well described in human medicine as a cost-effective, easy to perform preclinical oncological model for observing pro- and antiangiogenic response, tumo...

    Authors: Katarzyna Zabielska-Koczywąs, Agata Wojtkowska, Izabella Dolka, Anna Małek, Magdalena Walewska, Anna Wojtalewicz, Artur Żbikowski and Roman Lechowski

    Citation: BMC Veterinary Research 2017 13:201

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  34. Content type: Research article

    Osteosarcoma (OSA) is a common malignant bone tumor of large breed dogs that occurs at predictable anatomic sites. At the time of initial diagnosis, most affected dogs have occult pulmonary metastases. Even wi...

    Authors: B. G. Murphy, M. Y. Mok, D. York, R. Rebhun, K. D. Woolard, C. Hillman, P. Dickinson and K. Skorupski

    Citation: BMC Veterinary Research 2017 13:189

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  35. Content type: Research article

    The pathological condition of canine prostate cancer resembles that of human androgen-independent prostate cancer. Both canine and human androgen receptor (AR) signalling are inhibited by overexpression of the...

    Authors: Yuiko Kato, Kazuhiko Ochiai, Shota Kawakami, Nobuhiro Nakao, Daigo Azakami, Makoto Bonkobara, Masaki Michishita, Masami Morimatsu, Masami Watanabe and Toshinori Omi

    Citation: BMC Veterinary Research 2017 13:170

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  36. Content type: Research article

    Ki67 index, tumor associated macrophages (TAMs) and mast cells (MCs) are associated with malignancies in animal and human neoplasms including colorectal carcinomas (CRC). This has not been assessed in canine C...

    Authors: M. Woldemeskel, I. Hawkins and L. Whittington

    Citation: BMC Veterinary Research 2017 13:111

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  37. Content type: Research article

    Cutaneous squamous cell carcinoma of the nasal planum in cats is a common indication for antitumor treatment such as external beam radiation therapy. Curative-intent radiation therapy has been described as a v...

    Authors: Evgeniya Gasymova, Valeria Meier, Franco Guscetti, Simona Cancedda, Malgorzata Roos and Carla Rohrer Bley

    Citation: BMC Veterinary Research 2017 13:86

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  38. Content type: Research article

    Canine mammary tumors represent the most common neoplasm in female dogs, and the discovery of cancer biomarkers and their translation to clinical relevant assays is a key requirement in the war on cancer. Sinc...

    Authors: Giovanni Pietro Burrai, Alessandro Tanca, Tiziana Cubeddu, Marcello Abbondio, Marta Polinas, Maria Filippa Addis and Elisabetta Antuofermo

    Citation: BMC Veterinary Research 2017 13:38

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  39. Content type: Research article

    Canine B-cell lymphoma is deemed an ideal model of human non-Hodgkin’s lymphoma where the lymphomas of both species share similar clinical features and biological behaviors. However there are some differences ...

    Authors: Mohamad Zamani-Ahmadmahmudi, Sina Aghasharif and Keyhan Ilbeigi

    Citation: BMC Veterinary Research 2017 13:17

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  40. Content type: Research article

    The aim of this study was to describe the prevalence and tissue distribution of neoplasms in Italian ferrets, compared to the epidemiological data previously reported in USA and Japan.

    Authors: Giancarlo Avallone, Annalisa Forlani, Marco Tecilla, Elena Riccardi, Sara Belluco, Sara Francesca Santagostino, Guido Grilli, Kiumars Khadivi and Paola Roccabianca

    Citation: BMC Veterinary Research 2016 12:275

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  41. Content type: Research article

    Splenic masses are common in older dogs; yet diagnosis preceding splenectomy and histopathology remains elusive. MicroRNAs (miRNAs) are short, non-coding RNAs that play a role in post-transcriptional regulatio...

    Authors: Janet A. Grimes, Nripesh Prasad, Shawn Levy, Russell Cattley, Stephanie Lindley, Harry W. Boothe, Ralph A. Henderson and Bruce F. Smith

    Citation: BMC Veterinary Research 2016 12:272

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  42. Content type: Research article

    Ultrasonography to visualize adrenal gland lesions and evaluate incidentally discovered adrenal masses in dogs has become more reliable with advances in imaging techniques. However, correlations between sonogr...

    Authors: Elena Pagani, Massimiliano Tursi, Chiara Lorenzi, Alberto Tarducci, Barbara Bruno, Enrico Corrado Borgogno Mondino and Renato Zanatta

    Citation: BMC Veterinary Research 2016 12:267

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  43. Content type: Research article

    Effective therapies for transitional cell carcinoma (TCC) are limited, with objective response rates to most chemotherapeutic regimens below 20%. The purpose of this study was to investigate the biologic activ...

    Authors: Sarah B. Rippy, Heather L. Gardner, Sandra M. Nguyen, Emma E. Warry, Roberta F. Portela, William Tod Drost, Eric T. Hostnik, Eric M. Green, Dennis J. Chew, Juan Peng and Cheryl A. London

    Citation: BMC Veterinary Research 2016 12:257

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    The Erratum to this article has been published in BMC Veterinary Research 2016 12:291

  44. Content type: Case Report

    Lung cancer is the most commonly diagnosed neoplasm in humans, however this does not apply to other animal species. Living in an aquatic environment the respiratory system of cetaceans had to undergo unique ad...

    Authors: Cristian M. Suárez-Santana, Carolina Fernández-Maldonado, Josué Díaz-Delgado, Manuel Arbelo, Alejandro Suárez-Bonnet, Antonio Espinosa de los Monteros, Nakita Câmara, Eva Sierra and Antonio Fernández

    Citation: BMC Veterinary Research 2016 12:229

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  45. Content type: Research article

    Leukemia/lymphoma cell lines have been critical in the investigation of the pathogenesis and therapy of hematological malignancies. While human LL cell lines have generally been found to recapitulate the prima...

    Authors: Sarah C. Roode, Daniel Rotroff, Kristy L. Richards, Peter Moore, Alison Motsinger-Reif, Yasuhiko Okamura, Takuya Mizuno, Hajime Tsujimoto, Steven E. Suter and Matthew Breen

    Citation: BMC Veterinary Research 2016 12:207

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  46. Content type: Research article

    Current studies report that aberrations in epigenetic regulators or chromatin modifications are related to tumor development and maintenance. EZH2 (Enhancer of zeste homolog 2) is one of the catalytic subunits...

    Authors: Hyun-Ji Choi, Sungwoong Jang, Jae-Eun Ryu, Hyo-Ju Lee, Han-Byul Lee, Woo-Sung Ahn, Hye-Jin Kim, Hyo-Jin Lee, Hee Jin Lee, Gyung-Yub Gong and Woo-Chan Son

    Citation: BMC Veterinary Research 2016 12:164

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  47. Content type: Research article

    Adjunctive use of nutraceuticals in human cancer has shown promise, but little work has been done in canine neoplasia. Previous human research has shown that polyphenols and carotenoids can target multiple pat...

    Authors: Corri B. Levine, Julie Bayle, Vincent Biourge and Joseph J. Wakshlag

    Citation: BMC Veterinary Research 2016 12:159

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  48. Content type: Case Report

    Ovarian tumors in reptiles are uncommonly reported in the literature and for green iguanas previously reported cases include teratomas, one adenocarcinoma and one papillary cystadenocarcinoma. The present repo...

    Authors: Lucia Bel, Marco Tecilla, Gabriel Borza, Cosmin Pestean, Robert Purdoiu, Ciprian Ober, Liviu Oana and Marian Taulescu

    Citation: BMC Veterinary Research 2016 12:144

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  49. Content type: Research article

    KIT is a tyrosine kinase growth factor receptor. High expression of KIT has been found in several tumors including canine hemangiosarcoma (HSA). This study investigated the correlation of KIT expression and c-kit

    Authors: Yi-Chen Chen, Jiunn-Wang Liao, Wei-Li Hsu and Shih-Chieh Chang

    Citation: BMC Veterinary Research 2016 12:142

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