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Oncology

Section edited by Prof. Cheryl London

The oncology section considers research that addresses the etiology and treatment of cancer in veterinary patients. Research describing cancer prevention, therapeutic strategies, molecular diagnostics, genetics and genomics, epidemiology and comparative oncology are encouraged. Comparative and translational studies are also considered. 

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  1. The microenvironment within solid malignant tumors, including feline mammary gland carcinomas (FMGCs), is commonly hypoxic, possibly due to the lack of functional blood vessels in rapidly proliferating neoplas...

    Authors: Bo Chen, Susanne Je-Han Lin, Wen-Ta Li, Hui-Wen Chang, Victor Fei Pang, Pei-Yi Chu, Chin-Cheng Lee, Hiroyuki Nakayama, Ching-Ho Wu and Chian-Ren Jeng

    Citation: BMC Veterinary Research 2020 16:125

    Content type: Research article

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  2. Lymphoma is a common cancer in dogs. While most dogs receiving chemotherapy experience remission, very few are cured, and median survival times are generally in the 12-month range. Novel approaches to treatmen...

    Authors: Douglas H. Thamm, Jenette K. Joseph, Barbara J. Rose, Travis K. Meuten and Kristen M. Weishaar

    Citation: BMC Veterinary Research 2020 16:97

    Content type: Research article

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  3. Gain-of-function mutations in KIT are driver events of oncogenesis in mast cell tumours (MCTs) affecting companion animals. Somatic mutations of KIT determine the constitutive activation of the tyrosine kinase...

    Authors: Fabio Gentilini, Maria Elena Turba, Claire Dally, Masamine Takanosu, Sena Kurita and Makoto Bonkobara

    Citation: BMC Veterinary Research 2020 16:64

    Content type: Case Report

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  4. Dogs develop cancer spontaneously with age, with breed-specific risk underlying differences in genetics. Mammary tumors are reported as the most frequent neoplasia in intact female dogs. Their high prevalence ...

    Authors: Pauline Thumser-Henner, Katarzyna J. Nytko and Carla Rohrer Bley

    Citation: BMC Veterinary Research 2020 16:30

    Content type: Review

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  5. The epidermal growth factor receptors participate in the physiological processes such as regulation of morphogenesis, proliferation and cell migration, but when overexpressed or overactivated they may play an ...

    Authors: Emerson Soares Veloso, Ivy Nayra Nascimento Gonçalves, Tatiany Luiza Silveira, Fernando Soares Oliveira, Déborah Soares Vieira, Geovanni Dantas Cassali, Helen Lima Del Puerto and Enio Ferreira

    Citation: BMC Veterinary Research 2020 16:24

    Content type: Research article

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  6. Pheochromocytoma (PCC) has poor prognosis and adrenalectomy is hard to be performed, in case of caudal vena cava invasion. The long-term administration of phenoxybenzamine in PCC has not been reported in dogs.

    Authors: Ga-Won Lee, Cho-Rong Yoo, Dan Lee and Hee-Myung Park

    Citation: BMC Veterinary Research 2020 16:3

    Content type: Case Report

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  7. Listeria monocytogenes is a promising therapeutic vaccine vector for cancer immunotherapy. Although highly attenuated, three cases of systemic listeriosis have been reported in people following treatment with Lis...

    Authors: Margaret L. Musser, Erika P. Berger, Cameron Parsons, Sophia Kathariou and Chad M. Johannes

    Citation: BMC Veterinary Research 2019 15:467

    Content type: Case Report

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  8. Peritoneal mesothelioma is a rare abdominal disease; that occasionally occurs congenitally in younger calves. Cytologic examination of peritoneal effusion (PE) was utilized to diagnose this disease, and was no...

    Authors: Yasuhiro Morita, Sadamu Sugiyama, Takeshi Tsuka, Yoshiharu Okamoto, Takehito Morita, Yuji Sunden and Takashi Takeuchi

    Citation: BMC Veterinary Research 2019 15:461

    Content type: Case Report

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  9. Assessment of the efficacy of a multi-agent chemotherapy protocol in which cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP) are administered in canine lymphoma is generally performed by physica...

    Authors: Amadeo M. Parissenti, Laura B. Pritzker, Baoqing Guo, Rashmi Narendrula, Shirly Xiaohui Wang, Lin Laura Lin, Jingchun Pei, Karolina Skowronski, Dorothee Bienzle, J. Paul Woods, Kenneth P. H. Pritzker and Brenda L. Coomber

    Citation: BMC Veterinary Research 2019 15:453

    Content type: Research article

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  10. Evolution of indolent to aggressive lymphoma has been described in dogs but is difficult to distinguish from the de novo development of a second, clonally distinct lymphoma. Differentiation of these scenarios ...

    Authors: Arata Matsuyama, Dorothee Bienzle, Danielle Richardson, Nariman Deravi, Mei-Hua Hwang, Nikos Darzentas and Stefan M. Keller

    Citation: BMC Veterinary Research 2019 15:413

    Content type: Case Report

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  11. Total skin electron beam radiation therapy (TSEBT) is an effective treatment for primary diffuse cutaneous lymphomas in humans. While several techniques exist, they all require significant commitment of staff ...

    Authors: Michael A. Deveau, Megan Sutton, Courtney Baetge and Alison B. Diesel

    Citation: BMC Veterinary Research 2019 15:407

    Content type: Case Report

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  12. Dyslipidemias induce angiogenesis and accelerate the development and in vitro growth of breast tumors. The aim of this study was to assess the lipid and metabolic profile of female dogs with mammary carcinomas...

    Authors: Keidylania Costa-Santos, Karine Damasceno, Ricardo Dias Portela, Ferlando Lima Santos, Genira Carneiro Araújo, Emanoel Ferreira Martins-Filho, Laís Pereira Silva, Thiago Doria Barral, Stefanie Alvarenga Santos and Alessandra Estrela-Lima

    Citation: BMC Veterinary Research 2019 15:401

    Content type: Research article

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  13. Mammary cancer is a common disease affecting female dogs, where approximately 50% of the cases are malignant. There is a subpopulation of cancer cells with stem cell-like features within the tumour microenviro...

    Authors: Consuelo Serrano, Sofía Guzmán, Jose Ignacio Arias and Cristian Gabriel Torres

    Citation: BMC Veterinary Research 2019 15:390

    Content type: Research article

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  14. Chronic inflammation has been implicated in sarcomagenesis. Among various factors, activation of nuclear factor-kappa B (NF-κB) signaling pathway has been documented being able to target genes associated with ...

    Authors: Cheng-Shun Hsueh, Ching-Ho Wu, Cheng-Hsin Shih, Jason Lih-Seng Yeh, Chian-Ren Jeng, Victor Fei Pang, Hue-Ying Chiou and Hui-Wen Chang

    Citation: BMC Veterinary Research 2019 15:365

    Content type: Research article

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  15. Canine and human osteosarcomas (OS) are notably similar and have a high rate of metastasis. There is a poor understanding of the tumor development process, predisposing causes, and varying levels of aggression...

    Authors: Heather Wilson-Robles, Kelli Franks, Roy Pool and Tasha Miller

    Citation: BMC Veterinary Research 2019 15:357

    Content type: Research article

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  16. Estrogens are essential for the development and proper function of several hormone-dependent organs. There are, however, several lines of evidence associating estrogens with mammary carcinogenesis. A marked in...

    Authors: Ana Canadas-Sousa, Marta Santos, Bárbara Leal, Rui Medeiros and Patrícia Dias-Pereira

    Citation: BMC Veterinary Research 2019 15:325

    Content type: Research article

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  17. Oclacitinib is an orally bioavailable Janus Kinase (JAK) inhibitor approved for the treatment of canine atopic dermatitis. Aberrant JAK/ Signal Transducer and Activator of Transcription (STAT) signaling within...

    Authors: Laura E. Barrett, Heather L. Gardner, Lisa G. Barber, Abbey Sadowski and Cheryl A. London

    Citation: BMC Veterinary Research 2019 15:291

    Content type: Research article

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  18. Mammary gland tumor is the most common spontaneous tumor in intact female dogs, and its poor prognosis remains a clinical challenge. Ivermectin, a well-known anti-parasitic agent, has been implicated as a pote...

    Authors: Hongxiu Diao, Nan Cheng, Ying Zhao, Huihao Xu, Haodi Dong, Douglas H. Thamm, Di Zhang and Degui Lin

    Citation: BMC Veterinary Research 2019 15:276

    Content type: Research article

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  19. Thyroid neoplasia is a common endocrine neoplasm in dogs. The boxer is one of the reported breeds predisposed to malignant thyroid neoplasia. However, the association between thyroid neoplasia, malignancy and ...

    Authors: Marie-Pauline Maurin, Dan Davies, Hanne Jahns, Robert E. Shiel and Carmel T. Mooney

    Citation: BMC Veterinary Research 2019 15:228

    Content type: Case Report

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  20. Myxosarcomas are known to be classified as soft tissue sarcomas. However, there is limited clinical characterization pertaining specifically to canine cutaneous myxosarcomas in the literature. The objective of...

    Authors: Yoshimi Iwaki, Stephanie Lindley, Annette Smith, Kaitlin M. Curran and Jayme Looper

    Citation: BMC Veterinary Research 2019 15:217

    Content type: Research article

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  21. Mast cell tumours are the most common cutaneous neoplasms in dogs. Other primary sites include visceral organs, such as the gastrointestinal tract, liver, or spleen, and the oral cavity. Frequent metastatic sites...

    Authors: Juan Carlos Cartagena-Albertus, Antoaneta Moise, Sergio Moya-García, Nora Cámara-Fernández and Jose Alberto Montoya-Alonso

    Citation: BMC Veterinary Research 2019 15:204

    Content type: Case Report

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  22. Sphingosine kinase 1 (SPHK1) is an enzyme that converts pro-apoptotic ceramide and sphingosine into anti-apoptotic sphingosine-1-phosphate. There is growing evidence that SPHK1 activation promotes oncogenic tr...

    Authors: Yi-Chih Chang, Hsiao-Li Chuang, Ji-Hang Yin, Jiunn-Wang Liao, Ter-Hsin Chen and Yu-Chih Wang

    Citation: BMC Veterinary Research 2019 15:155

    Content type: Research article

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  23. This report describes a case of a bronchiolar adenocarcinoma in a 6-year old alpaca mare. For the first time in an alpaca, neoplasia was classified by histopathology as a lepidic-predominant bronchiolar adenoc...

    Authors: Lara Moser, Kristel Kegler, Christina Precht and Patrik Zanolari

    Citation: BMC Veterinary Research 2019 15:139

    Content type: Case Report

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  24. Dogs with appendicular osteosarcoma (OSA) receiving standard amputation and adjuvant chemotherapy demonstrate variable outcome with treatment; however, additional biomarkers would be helpful for predicting the...

    Authors: Kazuki Heishima, Travis Meuten, Kyoko Yoshida, Takashi Mori and Douglas H. Thamm

    Citation: BMC Veterinary Research 2019 15:39

    Content type: Research article

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  25. Cancer is a significant health threat in cats. Chemoresistance is prevalent in solid tumors. The ionophore salinomycin has anti-cancer properties and may work synergistically with chemotherapeutics. The purpos...

    Authors: Lucia Borlle, Abdo Dergham, Zacharie Wund, Brittany Zumbo, Teresa Southard and Kelly R. Hume

    Citation: BMC Veterinary Research 2019 15:36

    Content type: Research article

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  26. Cats spontaneously develop invasive mammary carcinomas with high clinical aggressiveness, and are considered relevant animal models for human breast cancer. Bcl-2 is an anti-apoptotic pro-survival protein, who...

    Authors: Elie Dagher, Jérôme Abadie, Delphine Loussouarn, Dominique Fanuel, Mario Campone and Frédérique Nguyen

    Citation: BMC Veterinary Research 2019 15:25

    Content type: Research article

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  27. Osteosarcoma (OSA) is the most common bone cancer in canines. Both transforming growth factor beta (TGFβ) and Hippo pathway mediators have important roles in bone development, stemness, and cancer progression....

    Authors: Anita K. Luu, Courtney R. Schott, Robert Jones, Andrew C. Poon, Brandon Golding, Roa’a Hamed, Benjamin Deheshi, Anthony Mutsaers, Geoffrey A. Wood and Alicia M. Viloria-Petit

    Citation: BMC Veterinary Research 2018 14:365

    Content type: Research article

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  28. A doxorubicin (DOX)-based chemotherapy protocol, CHOP, is the most effective treatment for canine high-grade B-cell lymphoma; however, the cost and time requirements associated with this protocol are not feasi...

    Authors: Sami Al-Nadaf, Robert B. Rebhun, Kaitlin M. Curran, Rachel O. Venable, Katherine A. Skorupski, Jennifer L. Willcox and Jenna H. Burton

    Citation: BMC Veterinary Research 2018 14:356

    Content type: Research article

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  29. Objective of this study is a feasibility-test comparing hock- and footpad-injection in rats with inoculated MatLyLu - adenocarcinoma tumor model. This study compares the development of an adenocarcinoma model ...

    Authors: Henning Richter, Agnieszka Karol, Katja Nuss, Aymone Lenisa, Erika Bruellmann, Stella-Saphira Maudens, Heinrich Hoffmann, Brigitte von Rechenberg and Patrick R. Kircher

    Citation: BMC Veterinary Research 2018 14:327

    Content type: Research article

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  30. Melanomas are rare in cats. The eye is the most commonly involved site, whereas few data are available about feline non-ocular melanomas (NOMs). Ki-67 thresholds with prognostic relevance have been established...

    Authors: Silvia Sabattini, Andrea Renzi, Francesco Albanese, Marco Fantinati, Antonella Rigillo, Francesca Abramo, Raimondo Tornago, Giovanni Tortorella, Maria Massaro, Teresa Bruna Pagano, Julia Buchholz and Giuliano Bettini

    Citation: BMC Veterinary Research 2018 14:309

    Content type: Research article

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  31. Low-grade alimentary lymphoma (LGAL) is characterised by the infiltration of neoplastic T-lymphocytes, typically in the small intestine. The incidence of LGAL has increased over the last ten years and it is no...

    Authors: Mathieu V Paulin, Lucile Couronné, Jérémy Beguin, Sophie Le Poder, Maxence Delverdier, Marie-Odile Semin, Julie Bruneau, Nadine Cerf-Bensussan, Georgia Malamut, Christophe Cellier, Ghita Benchekroun, Laurent Tiret, Alexander J German, Olivier Hermine and Valérie Freiche

    Citation: BMC Veterinary Research 2018 14:306

    Content type: Research article

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  32. Hemangiosarcoma (HSA) is a malignant tumor derived from endothelial cells which usually shows poor prognosis due to its high invasiveness, metastatic rate and severe hemorrhage from tumor ruptures. Since the p...

    Authors: Keisuke Aoshima, Yuki Fukui, Kevin Christian Montecillo Gulay, Ochbayar Erdemsurakh, Atsuya Morita, Atsushi Kobayashi and Takashi Kimura

    Citation: BMC Veterinary Research 2018 14:301

    Content type: Research article

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  33. Infectious bronchitis (IB) caused by the IB virus (IBV) can cause acute damage to chickens around the world. Therefore, rapid diagnosis and immune status determination are critical for controlling IBV outbreak...

    Authors: Liping Yan, Jianhua Hu, Jing Lei, Zhiyu Shi, Qian Xiao, Zhenwei Bi, Lu Yao, Yuan Li, Yuqing Chen, An Fang, Hui Li, Suquan Song, Min Liao and Jiyong Zhou

    Citation: BMC Veterinary Research 2018 14:284

    Content type: Methodology article

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  34. Effective treatment options for inoperable, metastatic, or recurrent canine pheochromocytomas are lacking. In humans, specific germline mutations exist that drive the development of pheochromocytomas. Pharmace...

    Authors: Margaret L. Musser, Kathryn L. Taikowski, Chad M. Johannes and Philip J. Bergman

    Citation: BMC Veterinary Research 2018 14:272

    Content type: Research article

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  35. Sarcoids are the mostcommon skin tumors in horses, characterized by rare regression, invasiveness and high recurrence following surgical intervention and Delta Papillomaviruses are widely recognized as the cau...

    Authors: Manuela Martano, Karen Power, Brunella Restucci, Ilaria Pagano, Gennaro Altamura, Giuseppe Borzacchiello and Paola Maiolino

    Citation: BMC Veterinary Research 2018 14:266

    Content type: Research article

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  36. Chemotherapeutic options for the treatment of canine lymphoma have not changed in several decades necessitating the identification of new therapeutics to improve patient outcome. KPT-335 (verdinexor) is a nove...

    Authors: Abbey R. Sadowski, Heather L. Gardner, Antonella Borgatti, Heather Wilson, David M. Vail, Joshua Lachowicz, Christina Manley, Avenelle Turner, Mary K. Klein, Angharad Waite, Alexandra Sahora and Cheryl A. London

    Citation: BMC Veterinary Research 2018 14:250

    Content type: Research article

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  37. Malignant fibrous histiocytoma has been uncommonly described in dogs. Several extranasal neoplasias have been reported to result hypertensive epistaxis. There are, however, no published case reports of extrana...

    Authors: Jung-Hyun Kim, Hee-Jin Kim, Sung-Jun Lee and Hun-Young Yoon

    Citation: BMC Veterinary Research 2018 14:235

    Content type: Case Report

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  38. Cytokeratins with epitopes in common with those of alpha (acidic and basic) mammalian keratins have been immunohistochemically demonstrated in the epidermis of reptiles. However, there are no reports of immuno...

    Authors: Jorge Orós, María López-Yánez, Francisco Rodríguez, Pascual Calabuig and Pedro L. Castro

    Citation: BMC Veterinary Research 2018 14:219

    Content type: Research article

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  39. To date, calvarial defects in dogs have traditionally been addressed with different types of implants including bone allograft, polymethylmethacrylate and titanium mesh secured with conventional metallic fixat...

    Authors: Pierre Langer, Cameron Black, Padraig Egan and Noel Fitzpatrick

    Citation: BMC Veterinary Research 2018 14:199

    Content type: Case Report

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  40. Mammary cancer has a high incidence in canines and is an excellent model of spontaneous carcinogenesis. Molecular iodine (I2) exerts antineoplastic effects on different cancer cells activating re-differentiation ...

    Authors: Xóchitl Zambrano-Estrada, Brianda Landaverde-Quiroz, Andrés A. Dueñas-Bocanegra, Marco A. De Paz-Campos, Gerardo Hernández-Alberto, Benjamín Solorio-Perusquia, Manuel Trejo-Mandujano, Laura Pérez-Guerrero, Evangelina Delgado-González, Brenda Anguiano and Carmen Aceves

    Citation: BMC Veterinary Research 2018 14:87

    Content type: Research article

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  41. Squamous cell carcinoma (SCC) is the most common nonodontogenic oral tumor in cats. In the jaw, it usually presents as an ulceroproliferative lesion associated with enlargement of the affected bone.

    Authors: Darja Pavlin, Tamara Dolenšek, Tanja Švara and Ana Nemec

    Citation: BMC Veterinary Research 2018 14:23

    Content type: Case Report

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  42. The use of nutraceuticals is gaining in popularity in human and canine oncology with a relatively limited understanding of the effects in the vastly different tumor types seen in canine oncology. We have previ...

    Authors: Corri B. Levine, Julie Bayle, Vincent Biourge and Joseph J. Wakshlag

    Citation: BMC Veterinary Research 2017 13:388

    Content type: Research article

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  43. c-KIT expression has been related to bone metastasis in human prostate cancer, but whether c-KIT expression can be similarly classified in canine prostatic tissue is unknown. This study assessed c-KIT and Ki67...

    Authors: Carlos Eduardo Fonseca-Alves, Priscilla Emiko Kobayashi, Chiara Palmieri and Renée Laufer-Amorim

    Citation: BMC Veterinary Research 2017 13:380

    Content type: Research article

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  44. Quantitative PCR (qPCR) is a common method for quantifying mRNA expression. Given the heterogeneity present in tumor tissues, it is crucial to normalize target mRNA expression data using appropriate reference ...

    Authors: Gayathri Thevi Selvarajah, Floor A. S. Bonestroo, Elpetra P. M. Timmermans Sprang, Jolle Kirpensteijn and Jan A. Mol

    Citation: BMC Veterinary Research 2017 13:354

    Content type: Research article

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  45. Early signs of canine transitional cell carcinoma (TCC) are frequently assumed to be caused by other lower urinary tract diseases (LUTD) such as urinary tract infections, resulting in late diagnosis of TCC whi...

    Authors: Michael S. Kent, Allison Zwingenberger, Jodi L. Westropp, Laura E. Barrett, Blythe P. Durbin-Johnson, Paramita Ghosh and Ruth L. Vinall

    Citation: BMC Veterinary Research 2017 13:339

    Content type: Research article

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  46. Hyperthermia is an established anti-cancer treatment but is limited by tolerance of adjacent normal tissues. Parenteral administration of gold nanorods (NRs) as a photosensitizer amplifies the effects of hyper...

    Authors: Elizabeth M. Schuh, Roberta Portela, Heather L. Gardner, Christian Schoen and Cheryl A. London

    Citation: BMC Veterinary Research 2017 13:294

    Content type: Research article

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  47. Canine joint sarcomas, designated synovial sarcomas, are uncommon malignant mesenchymal neoplasms that occur in the large joints of the extremities of middle-aged, large-breed dogs. We report the diagnosis of ...

    Authors: SER Lovell, RK Burchell, PJ Roady, RL Fredrickson and A Gal

    Citation: BMC Veterinary Research 2017 13:247

    Content type: Case Report

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  48. The chick embryo chorioallantoic membrane (CAM) model is well described in human medicine as a cost-effective, easy to perform preclinical oncological model for observing pro- and antiangiogenic response, tumo...

    Authors: Katarzyna Zabielska-Koczywąs, Agata Wojtkowska, Izabella Dolka, Anna Małek, Magdalena Walewska, Anna Wojtalewicz, Artur Żbikowski and Roman Lechowski

    Citation: BMC Veterinary Research 2017 13:201

    Content type: Research article

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