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Neurology and neuroscience

The neurology and neuroscience section combines all aspects of this specialty into a single section, and also includes those aspects of neurology and neurosurgery that overlap with other disciplines, such as internal medicine, surgery, imaging, and pathology. This section encourages high-quality submissions of basic and clinical research on the anatomy, development, and physiology of the nervous system as well as all aspects of clinical neurology, including the development, prevention, diagnosis and treatment of diseases of the central and peripheral nervous system, including muscular diseases. Comparative and translational studies relevant to the central or peripheral nervous system of all domestic and non-domestic species are considered. 
 

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  1. Understanding the efficacy and safety profile of antiepileptic drugs (AEDs) in feline epilepsy is a crucial consideration for managing this important brain disease. However, there is a lack of information abou...

    Authors: Marios Charalambous, Akos Pakozdy, Sofie F. M. Bhatti and Holger A. Volk

    Citation: BMC Veterinary Research 2018 14:64

    Content type: Research article

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  2. In birds there are reports of intracranial lesions but not of the clinical, computed tomographic and histopathologic features of acute intraparenchymal cerebral haemorrhage in Iberian golden eagle.

    Authors: Cláudia S. Baptista, Carla Monteiro, Hélder Fernandes, Ana Canadas, Luísa Guardão and Joana C. Santos

    Citation: BMC Veterinary Research 2018 14:60

    Content type: Case Report

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  3. One of the most common chronic neurological disorders in dogs is idiopathic epilepsy (IE) diagnosed as epilepsy without structural changes in the brain. In the current study the hypothesis should be proven tha...

    Authors: Lisa Frank, Matthias Lüpke, Draginja Kostic, Wolfgang Löscher and Andrea Tipold

    Citation: BMC Veterinary Research 2018 14:50

    Content type: Research article

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  4. Although thoracic vertebral malformations with kyphosis and scoliosis are often considered incidental findings on diagnostic imaging studies of screw-tailed brachycephalic breeds, they have been suggested to i...

    Authors: Maria Claudia C. M. Inglez de Souza, Richard Ryan, Gert ter Haar, Rowena M. A. Packer, Holger A. Volk and Steven De Decker

    Citation: BMC Veterinary Research 2018 14:5

    Content type: Research article

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  5. Leucine-rich glioma-inactivated (LGI) proteins play a critical role in synaptic transmission. Dysfunction of these genes and encoded proteins is associated with neurological disorders such as genetic epilepsy ...

    Authors: Yoshihiko Yu, Daisuke Hasegawa, Aki Fujiwara-Igarashi, Yuji Hamamoto, Shunta Mizoguchi, Takayuki Kuwabara and Michio Fujita

    Citation: BMC Veterinary Research 2017 13:389

    Content type: Research article

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  6. A classic sign of canine syringomyelia (SM) is scratching towards one shoulder. Using magnetic resonance imaging (MRI) we investigate the spinal cord lesion relating to this phenomenon which has characteristic...

    Authors: Zoe R. Nalborczyk, Angus K. McFadyen, Jelena Jovanovik, Anna Tauro, Colin J. Driver, Noel Fitzpatrick, Susan P. Knower and Clare Rusbridge

    Citation: BMC Veterinary Research 2017 13:340

    Content type: Research article

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  7. Idiopathic epilepsy is one of the most common neurological disorders in dogs. Unfortunately, up to 30% of dogs with idiopathic epilepsy show no improvement under antiepileptic drug treatment. Diffusion-weighte...

    Authors: Antje Hartmann, Steffen Sager, Klaus Failing, Marion Sparenberg and Martin J. Schmidt

    Citation: BMC Veterinary Research 2017 13:338

    Content type: Research article

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  8. Cerebral coenurosis is a disease of the central nervous system in sheep and goats, and is usually fatal unless surgical relief is provided. Information regarding neuroanaesthesia in veterinary medicine in goat...

    Authors: Verónica Vieitez, Ignacio Álvarez Gómez de Segura, Víctor López Rámis, Massimo Santella and Luis Javier Ezquerra

    Citation: BMC Veterinary Research 2017 13:287

    Content type: Case Report

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  9. French Bulldog (FB) has significantly gained in popularity over the last few years, and seems to be frequently affected by various neurological conditions. The purpose of this retrospective study was to report...

    Authors: Vincent Mayousse, Loïc Desquilbet, Aurélien Jeandel and Stéphane Blot

    Citation: BMC Veterinary Research 2017 13:212

    Content type: Research article

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  10. Discectomies are a common surgical treatment for disc herniations in the canine spine. However, the effect of these procedures on intervertebral disc tissue is not fully understood. The objective of this study...

    Authors: Peter Grunert, Yu Moriguchi, Brian P. Grossbard, Rodolfo J. Ricart Arbona, Lawrence J. Bonassar and Roger Härtl

    Citation: BMC Veterinary Research 2017 13:193

    Content type: Research article

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  11. Epilepsy in the cat is a serious medical condition. To date there are no licensed treatments for feline epilepsy and no well-controlled clinical studies on the efficacy or safety of antiepileptic drugs in cats...

    Authors: Odilo Engel, Thilo von Klopmann, Arianna Maiolini, Jessica Freundt-Revilla and Andrea Tipold

    Citation: BMC Veterinary Research 2017 13:172

    Content type: Research article

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  12. Chiari-like malformation in the Cavalier King Charles Spaniel is a herniation of the cerebellum and brainstem into or through the foramen magnum. This condition predisposes to Syringomyelia; fluid filled syrin...

    Authors: Emil Olsen, Emma Jane Suiter, Thilo Pfau, Imelda M McGonnell, Kaspar Matiasek, Anna Giejda and Holger Andreas Volk

    Citation: BMC Veterinary Research 2017 13:159

    Content type: Research article

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  13. A study to investigate transmission of classical scrapie via goat milk was carried out in sheep: firstly, lambs were challenged orally with goat scrapie brain homogenate to confirm transmission of scrapie from...

    Authors: Timm Konold, Laura J. Phelan, Ben R. Donnachie, Melanie J. Chaplin, Saira Cawthraw and Lorenzo González

    Citation: BMC Veterinary Research 2017 13:122

    Content type: Research article

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  14. Autophagy is a highly regulated process involving the bulk degradation of cytoplasmic macromolecules and organelles in mammalian cells via the lysosomal system. Dysregulation of autophagy is implicated in the ...

    Authors: D. De Biase, A. Costagliola, T.B. Pagano, G. Piegari, S. Wojcik, J. Dziewiątkowski, E. Grieco, G. Mattace Raso, V. Russo, S. Papparella and O. Paciello

    Citation: BMC Veterinary Research 2017 13:102

    Content type: Research article

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  15. Behavioural changes associated with idiopathic epilepsy (IE) have been identified in dogs, with fear and anxiety-related problems seen in both drug-naïve dogs and dogs treated with anti-epileptic drugs (AEDs)....

    Authors: Rowena M. A. Packer, Luisa De Risio and Holger A. Volk

    Citation: BMC Veterinary Research 2017 13:90

    Content type: Research article

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  16. Cervical spondylomyelopathy (CSM), also known as wobbler syndrome, affects mainly large and giant-breed dogs, causing compression of the cervical spinal cord and/or nerve roots. Structural and dynamic componen...

    Authors: Marília de Albuquerque Bonelli, Ronaldo Casimiro da Costa, Paula Martin-Vaquero and Carolina Gonçalves Dias Lima

    Citation: BMC Veterinary Research 2017 13:77

    Content type: Research article

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  18. Epilepsy is the most common neurological disease in veterinary practice. However, contrary to human medicine, epilepsy classification in veterinary medicine had not been clearly defined until recently. A numbe...

    Authors: Yuji Hamamoto, Daisuke Hasegawa, Shunta Mizoguchi, Yoshihiko Yu, Masae Wada, Takayuki Kuwabara, Aki Fujiwara-Igarashi and Michio Fujita

    Citation: BMC Veterinary Research 2016 12:248

    Content type: Research article

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  19. Canine ventral atlantoaxial (AA) stabilization is most commonly performed in very small dogs and is technically challenging due to extremely narrow bone corridors. Multiple implantation sites have been suggest...

    Authors: Guillaume Leblond, Luis Gaitero, Noel M. Moens, Alex zur Linden, Fiona M. K. James, Gabrielle Monteith and John Runciman

    Citation: BMC Veterinary Research 2016 12:188

    Content type: Methodology article

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  20. Hippocampal necrosis in cats has been reported to be associated with epileptic seizures. Magnetic resonance imaging (MRI) features of temporal lobe (TL) abnormalities in epileptic cats have been described but ...

    Authors: Anne Christine Claßen, Sibylle Kneissl, Johann Lang, Alexander Tichy and Akos Pakozdy

    Citation: BMC Veterinary Research 2016 12:165

    Content type: Research article

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  21. Acute Idiopathic Polyradiculoneuritis, an animal model for the axonal form of the Guillain – Barre Syndrome in humans and the acquired myasthenia gravis are different autoimmune disorders affecting the periphe...

    Authors: Gabriela Dumitrita Stanciu and Gheorghe Solcan

    Citation: BMC Veterinary Research 2016 12:111

    Content type: Case report

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  22. Evaluating beneficial effects of potential protective therapies following cardiac arrest in rodent models could be enhanced by exploring behavior and cognitive functions. The Morris Water Maze is a well-known ...

    Authors: Wolfgang Weihs, Alexandra-M Warenits, Florian Ettl, Ingrid A. M. Magnet, Ursula Teubenbacher, Andreas Hilpold, Andreas Schober, Christoph Testori, Akos Tiboldi, Katharina Tillmann Mag, Michael Holzer, Sandra Hoegler, Andreas Janata and Fritz Sterz

    Citation: BMC Veterinary Research 2016 12:103

    Content type: Research article

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  23. The safety profile of anti-epileptic drugs (AEDs) is an important consideration for the regulatory bodies, owners and prescribing clinicians. Information on their adverse effects still remains limited. A syste...

    Authors: Marios Charalambous, Sara K. Shivapour, David C. Brodbelt and Holger A. Volk

    Citation: BMC Veterinary Research 2016 12:79

    Content type: Research article

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  24. Functional magnetic resonance imaging (fMRI) is an advanced and frequently used technique for studying brain functions in humans and increasingly so in animals. A key element of analyzing fMRI data is group an...

    Authors: Jan-Peter Bach, Matthias Lüpke, Peter Dziallas, Patrick Wefstaedt, Stefan Uppenkamp, Hermann Seifert and Ingo Nolte

    Citation: BMC Veterinary Research 2016 12:32

    Content type: Research article

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  25. Classical scrapie is a transmissible spongiform encephalopathy (TSE) that affects sheep and goats. Our previous bioassay studies in lambs revealed that scrapie prions could be detected in association with peri...

    Authors: Rohana P. Dassanayake, Sally A. Madsen-Bouterse, Thomas C. Truscott, Dongyue Zhuang, Michelle R. Mousel, William C. Davis and David A. Schneider

    Citation: BMC Veterinary Research 2016 12:27

    Content type: Research article

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  26. The purpose of this study was to prove the hypothesis that C-reactive protein (CRP) and nerve growth factor (NGF) may be potential biomarkers for lower urinary tract disorders and may be able to distinguish be...

    Authors: Ulrike Kordass, Regina Carlson, Veronika Maria Stein and Andrea Tipold

    Citation: BMC Veterinary Research 2016 12:7

    Content type: Research article

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  27. [11C]-3-amino-4-(2-dimethylaminomethyl-phenylsulfanyl)-benzonitrile ([11C]DASB) is currently the mostly used radiotracer for positron emission tomography (PET) quantitative studies of the serotonin transporter (S...

    Authors: Olivia Taylor, Nick Van Laeken, Filip De Vos, Ingeborgh Polis, Tim Bosmans, Ingeborg Goethals, Rik Achten, Andre Dobbeleir, Eva Vandermeulen, Chris Baeken, Jimmy Saunders and Kathelijne Peremans

    Citation: BMC Veterinary Research 2015 11:308

    Content type: Research article

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  28. The aims of this field trial were to describe the clinical-pathologic findings in calves with otitis media (OM) and media-interna (OMI), to evaluate, through the development of a scoring system, the effectiven...

    Authors: I. Bertone, C. Bellino, G. L. Alborali, A. Cagnasso, G. Cagnotti, E. Dappiano, M. Lizzi, M. Miciletta, A. Ramacciotti, P. Gianella and A. D’Angelo

    Citation: BMC Veterinary Research 2015 11:297

    Content type: Research article

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  29. An ovine model can cast great insight in translational neuroscientific research due to its large brain volume and distinct regional neuroanatomical structures. The present study examined the applicability of b...

    Authors: Wonhye Lee, Stephanie D. Lee, Michael Y. Park, Lori Foley, Erin Purcell-Estabrook, Hyungmin Kim and Seung-Schik Yoo

    Citation: BMC Veterinary Research 2015 11:262

    Content type: Methodology article

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  30. The objective of this study was to develop and assess the reliability of a modified scoring system for evaluating the function of the two pelvic limbs separately, in ambulatory thoracolumbar myelopathy dogs. A...

    Authors: Chung-Sheng Lee, R. Timothy Bentley, Hsin-Yi Weng and Gert J. Breur

    Citation: BMC Veterinary Research 2015 11:241

    Content type: Research article

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  31. Imepitoin is a novel antiepileptic drug for the treatment of canine idiopathic epilepsy. The present study was conducted to demonstrate superior antiepileptic activity of a high dose of 30 mg/kg BID over a low...

    Authors: Chris Rundfeldt, Andrea Tipold and Wolfgang Löscher

    Citation: BMC Veterinary Research 2015 11:228

    Content type: Research article

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  32. This study describes the ultrasonographic appearance of the atlanto-occipital space and ultrasound-guided collection of cerebrospinal fluid (CSF) in cattle. The atlanto-occipital space of 73 euthanized cattle ...

    Authors: Ueli Braun, Jeannette Attiger and Carina Brammertz

    Citation: BMC Veterinary Research 2015 11:227

    Content type: Research article

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  33. We compared the changes in cell morphology, total and differential cell counts between cerebrospinal fluid (CSF) samples analyzed within an hour of collection (fresh sample) and after the addition of autologou...

    Authors: C. Bellino, B. Miniscalco, I. Bertone, A. Cagnasso, E. Occhiena, P. Gianella and A. D’Angelo

    Citation: BMC Veterinary Research 2015 11:201

    Content type: Research article

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  34. Previous studies in humans have reported that the dimensions of the intervertebral foramina change significantly with movement of the spine. Cervical spondylomyelopathy (CSM) in dogs is characterized by dynami...

    Authors: Renato M. Ramos, Ronaldo C. da Costa, Andre LA Oliveira, Manoj K. Kodigudla and Vijay K. Goel

    Citation: BMC Veterinary Research 2015 11:184

    Content type: Research article

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  35. Various antiepileptic drugs (AEDs) are used for the management of canine idiopathic epilepsy (IE). Information on their clinical efficacy remains limited. A systematic review was designed to evaluate existing ...

    Authors: Marios Charalambous, David Brodbelt and Holger A Volk

    Citation: BMC Veterinary Research 2014 10:257

    Content type: Research article

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  36. Atypical bovine spongiform encephalopathies (BSEs), classified as H-type and L-type BSE based on the Western immunoblot profiles, are naturally occurring diseases in cattle, which are phenotypically different ...

    Authors: Timm Konold, Laura J Phelan, Derek Clifford, Melanie J Chaplin, Saira Cawthraw, Michael J Stack and Marion M Simmons

    Citation: BMC Veterinary Research 2014 10:243

    Content type: Research article

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  37. Anatomical differences between humans and domestic mammals preclude the use of reported stereotactic approaches to the brainstem in animals. In animals, brainstem biopsies are required both for histopathologic...

    Authors: Anne Staudacher, Anna Oevermann, Michael H Stoffel and Daniela Gorgas

    Citation: BMC Veterinary Research 2014 10:216

    Content type: Methodology article

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  38. Chemokines such as MIP-3β/CCL19 are important factors in the mechanism of cell migration and pathogenesis of central nervous system (CNS) inflammatory reactions. The hypothesis of this study is that CCL19, als...

    Authors: Janina Bartels, Brett G Darrow, Scott J Schatzberg, Lijing Bu, Regina Carlson and Andrea Tipold

    Citation: BMC Veterinary Research 2014 10:157

    Content type: Research article

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  39. Cryptococcus spp. are saprophytic and opportunistic fungal pathogens that are known to cause severe disease in immunocompromised animals. In goats there are reports of clinical cryptococcal pneumonia and mastitis...

    Authors: George Stilwell and Hugo Pissarra

    Citation: BMC Veterinary Research 2014 10:84

    Content type: Case report

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  40. An inexpensive method of generating continuous data on hind limb function in dogs with spinal cord injury is needed to facilitate multicentre clinical trials. This study aimed to define normal fore limb, hind ...

    Authors: Natasha J Olby, Ji-Hey Lim, Kellett Babb, Kathleen Bach, Cullen Domaracki, Kim Williams, Emily Griffith, Tonya Harris and Audrey Muguet-Chanoit

    Citation: BMC Veterinary Research 2014 10:58

    Content type: Methodology article

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  41. Dermoid sinus is an uncommon epithelial-lined fistula that may be associated with vertebral malformations. In humans, Klippel-Feil syndrome (KFS) is a rare condition characterized by congenital cervical verteb...

    Authors: Natasha Barrios, Marcelo Gómez, Marcelo Mieres, Frank Vera and Genaro Alvial

    Citation: BMC Veterinary Research 2014 10:54

    Content type: Case report

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  42. Thrombosis has been associated to some diseases like hyperadrenocorticism (HAC). Several drugs can alter the balance, such as the corticosteroid prednisone, used mainly for its anti-inflammatory and immunosupp...

    Authors: Felipe Gazza Romão, Elza Fernanda Campos, Claudio Roberto Scabelo Mattoso and Regina Kiomi Takahira

    Citation: BMC Veterinary Research 2013 9:268

    Content type: Research article

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  43. Epilepsy is one of the most common chronic neurological disorders in dogs characterized by recurrent seizures. The endocannabinoid (EC) system plays a central role in suppressing pathologic neuronal excitabili...

    Authors: Felix K Gesell, Alexander A Zoerner, Christina Brauer, Stefan Engeli, Dimitros Tsikas and Andrea Tipold

    Citation: BMC Veterinary Research 2013 9:262

    Content type: Research article

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  44. Functional magnetic resonance imaging (fMRI) is a technique able to localize neural activity in the brain by detecting associated changes in blood flow. It is an essential tool for studying human functional ne...

    Authors: Jan-Peter Bach, Matthias Lüpke, Peter Dziallas, Patrick Wefstaedt, Stefan Uppenkamp, Hermann Seifert and Ingo Nolte

    Citation: BMC Veterinary Research 2013 9:210

    Content type: Research article

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  45. Mammalian juveniles undergo dramatic changes in body conformation during development. As one of the most common companion animals, the time line and trajectory of a dog’s development and its body’s re-proporti...

    Authors: Daniela Helmsmüller, Patrick Wefstaedt, Ingo Nolte and Nadja Schilling

    Citation: BMC Veterinary Research 2013 9:203

    Content type: Research article

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  46. Eventing is generally recognized as a challenging equestrian discipline and wastage figures for this discipline are relatively high. There is a need for information that provides insight into the causes of was...

    Authors: CarolienCBM Munsters, Jan van den Broek, Emile Welling, René van Weeren and MarianneM Sloet van Oldruitenborgh-Oosterbaan

    Citation: BMC Veterinary Research 2013 9:182

    Content type: Research article

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  47. Tumescent anaesthesia (TA) is a widely used technique in oncologic surgeries necessitating large resection margins. This technique produces transoperative and postoperative analgesia, reduces surgical bleeding...

    Authors: Leonardo de Freitas Guimaraes Arcoverde Credie, Stelio Pacca Loureiro Luna, Fabio Futema, Luciano Cacciari Baruffaldi Almeida da Silva, Giancarlo Bressane Gomes, Jaqueline Neratika Negrette Garcia and Lidia Raquel de Carvalho

    Citation: BMC Veterinary Research 2013 9:178

    Content type: Research article

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  48. Bovine tuberculosis (BTB) and bovine brucellosis are two important milk-borne zoonoses that have been shown to be prevalent to various degrees in Ethiopian cattle.

    Authors: Rea Tschopp, Birhanu Abera, Sabi Yao Sourou, Emmanuelle Guerne-Bleich, Abraham Aseffa, Alehegne Wubete, Jakob Zinsstag and Douglas Young

    Citation: BMC Veterinary Research 2013 9:163

    Content type: Research article

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  49. Lissencephaly is a rare developmental brain disorder in veterinary and human medicine associated with defects in neuronal migration leading to a characteristic marked reduction or absence of the convolutional ...

    Authors: Valentín Pérez, Aroa Suárez-Vega, Miguel Fuertes, Julio Benavides, Laetitia Delgado, M Carmen Ferreras and Juan José Arranz

    Citation: BMC Veterinary Research 2013 9:156

    Content type: Research article

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