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Neurology and neuroscience

Section edited by Prof. Holger Volk

The neurology and neuroscience section combines all aspects of this specialty into a single section, and also includes those aspects of neurology and neurosurgery that overlap with other disciplines, such as internal medicine, surgery, imaging, and pathology. This section encourages high-quality submissions of basic and clinical research on the anatomy, development, and physiology of the nervous system as well as all aspects of clinical neurology, including the development, prevention, diagnosis and treatment of diseases of the central and peripheral nervous system, including muscular diseases. Comparative and translational studies relevant to the central or peripheral nervous system of all domestic and non-domestic species are considered. 
 

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  1. Progressive myelomalacia (PMM) is a usually fatal complication of acute intervertebral disc extrusion (IVDE) in dogs but its risk factors are poorly understood. The objective of this retrospective case-control...

    Authors: Aude Castel, Natasha J. Olby, Hongyu Ru, Christopher L. Mariani, Karen R. Muñana and Peter J. Early

    Citation: BMC Veterinary Research 2019 15:433

    Content type: Research article

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  2. Infectious canine hepatitis is a rarely encountered disease, that is caused by Canine Adenovirus-1. Clinical signs can vary dramatically, and neurological signs are rarely seen. Neurological manifestation of t...

    Authors: Samuel J. Hornsey, Hélène Philibert, Dale L. Godson and Elisabeth C. R. Snead

    Citation: BMC Veterinary Research 2019 15:418

    Content type: Case Report

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  3. Currently, [18F] altanserin is the most frequently used PET-radioligand for serotonin2A (5-HT2A) receptor imaging in the human brain but has never been validated in dogs. In vivo imaging of this receptor in the c...

    Authors: Glenn Pauwelyn, Lise Vlerick, Robrecht Dockx, Jeroen Verhoeven, Andre Dobbeleir, Tim Bosmans, Kathelijne Peremans, Christian Vanhove, Ingeborgh Polis and Filip De Vos

    Citation: BMC Veterinary Research 2019 15:415

    Content type: Research article

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  4. Transport stress not only causes physiological changes but also induces behavioral responses, including anxiety-like and depression-like behavioral responses in animals. The neuronal nitric oxide synthase (nNO...

    Authors: Jia Wang, Jiao Li, Mingyuan Yu, Yuying Wang and Yunfei Ma

    Citation: BMC Veterinary Research 2019 15:323

    Content type: Research article

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  5. The split spinal cord malformation (SSCM) is an uncommon congenital malformation of the vertebral canal in which parts of the spinal cord are longitudinally duplicated. In SSCM Type I, each spinal cord has its...

    Authors: Lara Górriz-Martín, Jasmin Neßler, Iris Voelker, Sina Reinartz, Andrea Tipold, Ottmar Distl, Andreas Beineke, Juergen Rehage and Maike Heppelmann

    Citation: BMC Veterinary Research 2019 15:307

    Content type: Case Report

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  6. Cervical vertebral stenotic myelopathy (CVSM) remains one of the most important abnormalities of the cervical spine resulting in neurological deficits in horses. The aim of the following study was to compare t...

    Authors: Magdalena Szklarz, Anna Lipinska, Malwina Slowikowska, Artur Niedzwiedz, Krzysztof Marycz and Maciej Janeczek

    Citation: BMC Veterinary Research 2019 15:296

    Content type: Case Report

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  7. During skull ontogenesis, growth centers in the skull base and calvarial bones allow gradual expansion of the cranial vault. Premature growth termination of cranial base synchondroses and/or calvarial sutures ...

    Authors: Daniela Farke, Carsten Staszyk, Klaus Failing, Robert M. Kirberger and Martin J. Schmidt

    Citation: BMC Veterinary Research 2019 15:221

    Content type: Research article

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  8. Degenerative myelopathy (DM) is a progressive neurodegenerative disease frequently found in Pembroke Welsh Corgis (PWCs). Most DM-affected PWCs are homozygous for the mutant superoxide dismutase 1 (SOD1) allele; ...

    Authors: Kohei Nakata, Kazuki Heishima, Hiroki Sakai, Osamu Yamato, Yu Furusawa, Hidetaka Nishida, Sadatoshi Maeda and Hiroaki Kamishina

    Citation: BMC Veterinary Research 2019 15:192

    Content type: Research article

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  9. A retrospective case series study was undertaken to describe the magnetic resonance imaging (MRI) findings in Pug dogs with thoracolumbar myelopathy and concurrent caudal articular process (CAP) dysplasia. Ele...

    Authors: Colin J. Driver, Jeremy Rose, Anna Tauro, Ricardo Fernandes and Clare Rusbridge

    Citation: BMC Veterinary Research 2019 15:182

    Content type: Research article

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  10. Mutations in the N-myc downstream-regulated gene 1 (NDRG1) can cause degenerative polyneuropathy in humans, dogs, and rodents. In humans, this motor and sensory neuropathy is known as Charcot-Marie-Tooth disease ...

    Authors: Fredrik S. Skedsmo, Michael A. Tranulis, Arild Espenes, Kristian Prydz, Kaspar Matiasek, Gjermund Gunnes, Lene C. Hermansen and Karin H. Jäderlund

    Citation: BMC Veterinary Research 2019 15:121

    Content type: Research article

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  11. Polymelia is a congenital defect characterized by one or more supernumerary legs. The genetics and aetiology of this condition in cattle have not yet been thoroughly investigated even though several case repor...

    Authors: Ute Morath-Huss, Cord Drögemüller, Michael Stoffel, Christina Precht, Patrik Zanolari and Claudia Spadavecchia

    Citation: BMC Veterinary Research 2019 15:102

    Content type: Case Report

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  12. Osseous- associated cervical spondylomyelopathy (OA-CSM) has a high prevalence in Great Danes. In order to understand the progression of osseous changes, we aimed to perform a long-term computed tomographic (C...

    Authors: Daniella Vansteenkiste, Paula Martin-Vaquero, Marília Bonelli, Luciana B. da Costa and Ronaldo C. da Costa

    Citation: BMC Veterinary Research 2019 15:90

    Content type: Research article

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  13. β-amyloid (Aβ) can accumulate in the brain of aged dogs, and within vessels walls, the disease is called cerebral amyloid angiopathy (CAA). In humans, Alzheimer’s disease and CAA are strongly correlated with c...

    Authors: Laís Limeira Rodrigues, Leonardo Pereira Mesquita, Rafael Carneiro Costa, Raquel Gonçalves Gomes, Daniel Arrais Biihrer and Paulo César Maiorka

    Citation: BMC Veterinary Research 2018 14:370

    Content type: Case Report

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  14. Paralytic form of rabies is frequent in cattle in Latin America, but it is uncommon in goats. There are few clinical reports on furious rabies affecting goats, and the sporadic cases of rabid goats from survei...

    Authors: Igor Louzada Moreira, Davi Emanuel Ribeiro de Sousa, Jair Alves Ferreira-Junior, Márcio Botelho de Castro, Tayná Cardim Morais Fino, José Renato Junqueira Borges, Benito Soto-Blanco and Antonio Carlos Lopes Câmara

    Citation: BMC Veterinary Research 2018 14:338

    Content type: Case report

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  15. Distinguishing between meningeal-based and intra-axial lesions by means of magnetic resonance (MR) imaging findings may occasionally be challenging. Meningiomas and gliomas account for most of the total primar...

    Authors: Tommaso Banzato, Marco Bernardini, Giunio B. Cherubini and Alessandro Zotti

    Citation: BMC Veterinary Research 2018 14:317

    Content type: Methodology article

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  16. When surgical treatment of cervical vertebral malformation is considered, precise localization of compression sites is essential, but remains challenging. Magnetic motor evoked potentials (mMEP) from paraverte...

    Authors: Joke Rijckaert, Bart Pardon, Luc Van Ham, Philip Joosten, Gunther van Loon and Piet Deprez

    Citation: BMC Veterinary Research 2018 14:290

    Content type: Methodology article

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  17. Incubation period, disease progression, pathology and clinical presentation of classical scrapie in sheep are highly dependent on PRNP genotype, time and route of inoculation and prion strain. Our experimental mo...

    Authors: Siv Meling, Kerstin Skovgaard, Kjetil Bårdsen, Peter Mikael Helweg Heegaard and Martha J. Ulvund

    Citation: BMC Veterinary Research 2018 14:281

    Content type: Research article

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  18. Levetiracetam can be used for seizure control alone or in combination with other antiepileptic medications. A previous study achieved the minimum targeted serum drug concentration after rectal administration o...

    Authors: Giulia Cagnotti, Rosangela Odore, Giulia Gardini, Stefano Amedeo, Iride Bertone, Giulia Guerriero, Laura Lentini, Elena Dappiano and Antonio D’Angelo

    Citation: BMC Veterinary Research 2018 14:189

    Content type: Research article

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  19. The enteric nervous system (ENS), located in the intestinal wall and characterized by considerable independence from the central nervous system, consists of millions of cells. Enteric neurons control the major...

    Authors: Slawomir Gonkowski, Krystyna Makowska and Jaroslaw Calka

    Citation: BMC Veterinary Research 2018 14:169

    Content type: Research article

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  20. Hydrocephalus is a multifactorial condition, whose aetiology is not fully understood. Congenital hydrocephalus frequently occurs in small and brachycephalic dog breeds. Although it is widely accepted that the ...

    Authors: Wojciech Sokołowski, Norbert Czubaj, Michał Skibniewski, Karolina Barszcz, Marta Kupczyńska, Wojciech Kinda and Zdzisław Kiełbowicz

    Citation: BMC Veterinary Research 2018 14:162

    Content type: Research article

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  21. There are indications that transcranial electrical stimulation (TES) assesses the motor function of the spinal cord in horses in a more sensitive and reproducible fashion than transcranial magnetic stimulation...

    Authors: Sanne Lotte Journée, Henricus Louis Journée, Cornelis Marinus de Bruijn and Cathérine John Ghislaine Delesalle

    Citation: BMC Veterinary Research 2018 14:121

    Content type: Research article

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  22. Syringomyelia is a pathological condition in which fluid-filled cavities (syringes) form and expand in the spinal cord. Syringomyelia is often linked with obstruction of the craniocervical junction and a Chiar...

    Authors: Srdjan Cirovic, Robert Lloyd, Jelena Jovanovik, Holger A. Volk and Clare Rusbridge

    Citation: BMC Veterinary Research 2018 14:82

    Content type: Research article

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  23. The Rocky Mountain elk (Cervus elaphus nelsoni) prion protein gene (PRNP) is polymorphic at codon 132, with leucine (L132) and methionine (M132) allelic variants present in the population. In elk experimentally i...

    Authors: S. Jo Moore, Catherine E. Vrentas, Soyoun Hwang, M. Heather West Greenlee, Eric M. Nicholson and Justin J. Greenlee

    Citation: BMC Veterinary Research 2018 14:80

    Content type: Research article

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  24. Understanding the efficacy and safety profile of antiepileptic drugs (AEDs) in feline epilepsy is a crucial consideration for managing this important brain disease. However, there is a lack of information abou...

    Authors: Marios Charalambous, Akos Pakozdy, Sofie F. M. Bhatti and Holger A. Volk

    Citation: BMC Veterinary Research 2018 14:64

    Content type: Research article

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  25. In birds there are reports of intracranial lesions but not of the clinical, computed tomographic and histopathologic features of acute intraparenchymal cerebral haemorrhage in Iberian golden eagle.

    Authors: Cláudia S. Baptista, Carla Monteiro, Hélder Fernandes, Ana Canadas, Luísa Guardão and Joana C. Santos

    Citation: BMC Veterinary Research 2018 14:60

    Content type: Case Report

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  26. One of the most common chronic neurological disorders in dogs is idiopathic epilepsy (IE) diagnosed as epilepsy without structural changes in the brain. In the current study the hypothesis should be proven tha...

    Authors: Lisa Frank, Matthias Lüpke, Draginja Kostic, Wolfgang Löscher and Andrea Tipold

    Citation: BMC Veterinary Research 2018 14:50

    Content type: Research article

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  27. Although thoracic vertebral malformations with kyphosis and scoliosis are often considered incidental findings on diagnostic imaging studies of screw-tailed brachycephalic breeds, they have been suggested to i...

    Authors: Maria Claudia C. M. Inglez de Souza, Richard Ryan, Gert ter Haar, Rowena M. A. Packer, Holger A. Volk and Steven De Decker

    Citation: BMC Veterinary Research 2018 14:5

    Content type: Research article

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  28. Leucine-rich glioma-inactivated (LGI) proteins play a critical role in synaptic transmission. Dysfunction of these genes and encoded proteins is associated with neurological disorders such as genetic epilepsy ...

    Authors: Yoshihiko Yu, Daisuke Hasegawa, Aki Fujiwara-Igarashi, Yuji Hamamoto, Shunta Mizoguchi, Takayuki Kuwabara and Michio Fujita

    Citation: BMC Veterinary Research 2017 13:389

    Content type: Research article

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  29. A classic sign of canine syringomyelia (SM) is scratching towards one shoulder. Using magnetic resonance imaging (MRI) we investigate the spinal cord lesion relating to this phenomenon which has characteristic...

    Authors: Zoe R. Nalborczyk, Angus K. McFadyen, Jelena Jovanovik, Anna Tauro, Colin J. Driver, Noel Fitzpatrick, Susan P. Knower and Clare Rusbridge

    Citation: BMC Veterinary Research 2017 13:340

    Content type: Research article

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  30. Idiopathic epilepsy is one of the most common neurological disorders in dogs. Unfortunately, up to 30% of dogs with idiopathic epilepsy show no improvement under antiepileptic drug treatment. Diffusion-weighte...

    Authors: Antje Hartmann, Steffen Sager, Klaus Failing, Marion Sparenberg and Martin J. Schmidt

    Citation: BMC Veterinary Research 2017 13:338

    Content type: Research article

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  31. Cerebral coenurosis is a disease of the central nervous system in sheep and goats, and is usually fatal unless surgical relief is provided. Information regarding neuroanaesthesia in veterinary medicine in goat...

    Authors: Verónica Vieitez, Ignacio Álvarez Gómez de Segura, Víctor López Rámis, Massimo Santella and Luis Javier Ezquerra

    Citation: BMC Veterinary Research 2017 13:287

    Content type: Case Report

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  32. French Bulldog (FB) has significantly gained in popularity over the last few years, and seems to be frequently affected by various neurological conditions. The purpose of this retrospective study was to report...

    Authors: Vincent Mayousse, Loïc Desquilbet, Aurélien Jeandel and Stéphane Blot

    Citation: BMC Veterinary Research 2017 13:212

    Content type: Research article

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  33. Discectomies are a common surgical treatment for disc herniations in the canine spine. However, the effect of these procedures on intervertebral disc tissue is not fully understood. The objective of this study...

    Authors: Peter Grunert, Yu Moriguchi, Brian P. Grossbard, Rodolfo J. Ricart Arbona, Lawrence J. Bonassar and Roger Härtl

    Citation: BMC Veterinary Research 2017 13:193

    Content type: Research article

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  34. Epilepsy in the cat is a serious medical condition. To date there are no licensed treatments for feline epilepsy and no well-controlled clinical studies on the efficacy or safety of antiepileptic drugs in cats...

    Authors: Odilo Engel, Thilo von Klopmann, Arianna Maiolini, Jessica Freundt-Revilla and Andrea Tipold

    Citation: BMC Veterinary Research 2017 13:172

    Content type: Research article

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  35. Chiari-like malformation in the Cavalier King Charles Spaniel is a herniation of the cerebellum and brainstem into or through the foramen magnum. This condition predisposes to Syringomyelia; fluid filled syrin...

    Authors: Emil Olsen, Emma Jane Suiter, Thilo Pfau, Imelda M McGonnell, Kaspar Matiasek, Anna Giejda and Holger Andreas Volk

    Citation: BMC Veterinary Research 2017 13:159

    Content type: Research article

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  36. A study to investigate transmission of classical scrapie via goat milk was carried out in sheep: firstly, lambs were challenged orally with goat scrapie brain homogenate to confirm transmission of scrapie from...

    Authors: Timm Konold, Laura J. Phelan, Ben R. Donnachie, Melanie J. Chaplin, Saira Cawthraw and Lorenzo González

    Citation: BMC Veterinary Research 2017 13:122

    Content type: Research article

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  37. Autophagy is a highly regulated process involving the bulk degradation of cytoplasmic macromolecules and organelles in mammalian cells via the lysosomal system. Dysregulation of autophagy is implicated in the ...

    Authors: D. De Biase, A. Costagliola, T.B. Pagano, G. Piegari, S. Wojcik, J. Dziewiątkowski, E. Grieco, G. Mattace Raso, V. Russo, S. Papparella and O. Paciello

    Citation: BMC Veterinary Research 2017 13:102

    Content type: Research article

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  38. Behavioural changes associated with idiopathic epilepsy (IE) have been identified in dogs, with fear and anxiety-related problems seen in both drug-naïve dogs and dogs treated with anti-epileptic drugs (AEDs)....

    Authors: Rowena M. A. Packer, Luisa De Risio and Holger A. Volk

    Citation: BMC Veterinary Research 2017 13:90

    Content type: Research article

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  39. Cervical spondylomyelopathy (CSM), also known as wobbler syndrome, affects mainly large and giant-breed dogs, causing compression of the cervical spinal cord and/or nerve roots. Structural and dynamic componen...

    Authors: Marília de Albuquerque Bonelli, Ronaldo Casimiro da Costa, Paula Martin-Vaquero and Carolina Gonçalves Dias Lima

    Citation: BMC Veterinary Research 2017 13:77

    Content type: Research article

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  40. Epilepsy is the most common neurological disease in veterinary practice. However, contrary to human medicine, epilepsy classification in veterinary medicine had not been clearly defined until recently. A numbe...

    Authors: Yuji Hamamoto, Daisuke Hasegawa, Shunta Mizoguchi, Yoshihiko Yu, Masae Wada, Takayuki Kuwabara, Aki Fujiwara-Igarashi and Michio Fujita

    Citation: BMC Veterinary Research 2016 12:248

    Content type: Research article

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  41. Canine ventral atlantoaxial (AA) stabilization is most commonly performed in very small dogs and is technically challenging due to extremely narrow bone corridors. Multiple implantation sites have been suggest...

    Authors: Guillaume Leblond, Luis Gaitero, Noel M. Moens, Alex zur Linden, Fiona M. K. James, Gabrielle Monteith and John Runciman

    Citation: BMC Veterinary Research 2016 12:188

    Content type: Methodology article

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  42. Hippocampal necrosis in cats has been reported to be associated with epileptic seizures. Magnetic resonance imaging (MRI) features of temporal lobe (TL) abnormalities in epileptic cats have been described but ...

    Authors: Anne Christine Claßen, Sibylle Kneissl, Johann Lang, Alexander Tichy and Akos Pakozdy

    Citation: BMC Veterinary Research 2016 12:165

    Content type: Research article

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  43. Acute Idiopathic Polyradiculoneuritis, an animal model for the axonal form of the Guillain – Barre Syndrome in humans and the acquired myasthenia gravis are different autoimmune disorders affecting the periphe...

    Authors: Gabriela Dumitrita Stanciu and Gheorghe Solcan

    Citation: BMC Veterinary Research 2016 12:111

    Content type: Case report

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  44. Evaluating beneficial effects of potential protective therapies following cardiac arrest in rodent models could be enhanced by exploring behavior and cognitive functions. The Morris Water Maze is a well-known ...

    Authors: Wolfgang Weihs, Alexandra-M Warenits, Florian Ettl, Ingrid A. M. Magnet, Ursula Teubenbacher, Andreas Hilpold, Andreas Schober, Christoph Testori, Akos Tiboldi, Katharina Tillmann Mag, Michael Holzer, Sandra Hoegler, Andreas Janata and Fritz Sterz

    Citation: BMC Veterinary Research 2016 12:103

    Content type: Research article

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  45. The safety profile of anti-epileptic drugs (AEDs) is an important consideration for the regulatory bodies, owners and prescribing clinicians. Information on their adverse effects still remains limited. A syste...

    Authors: Marios Charalambous, Sara K. Shivapour, David C. Brodbelt and Holger A. Volk

    Citation: BMC Veterinary Research 2016 12:79

    Content type: Research article

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  46. Functional magnetic resonance imaging (fMRI) is an advanced and frequently used technique for studying brain functions in humans and increasingly so in animals. A key element of analyzing fMRI data is group an...

    Authors: Jan-Peter Bach, Matthias Lüpke, Peter Dziallas, Patrick Wefstaedt, Stefan Uppenkamp, Hermann Seifert and Ingo Nolte

    Citation: BMC Veterinary Research 2016 12:32

    Content type: Research article

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  47. Classical scrapie is a transmissible spongiform encephalopathy (TSE) that affects sheep and goats. Our previous bioassay studies in lambs revealed that scrapie prions could be detected in association with peri...

    Authors: Rohana P. Dassanayake, Sally A. Madsen-Bouterse, Thomas C. Truscott, Dongyue Zhuang, Michelle R. Mousel, William C. Davis and David A. Schneider

    Citation: BMC Veterinary Research 2016 12:27

    Content type: Research article

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