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Musculoskeletal disorders and orthopaedics

Section edited by Dr. Hayley Henderson and Tillie Cryer

The musculoskeletal disorders and orthopaedics section considers research that addresses the etiology and treatment of musculoskeletal disorders in veterinary patients. This includes, but not limited to, studies on therapeutic strategies, surgery, diagnostic imaging, genetics and genomics, epidemiology, anatomical studies, and comparative orthopedic studies. 

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  1. Articular osteochondrosis is a common cause of leg weakness in pigs and is defined as a focal delay in the endochondral ossification of the epiphysis. The first demonstrated steps in the pathogenesis consist o...

    Authors: Andreas Finnøy, Kristin Olstad and Magnus B. Lilledahl

    Citation: BMC Veterinary Research 2017 13:270

    Content type: Research article

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  2. Complete rupture of the cranial cruciate ligament (CrCL) in dogs causes profound disturbance to stifle joint biomechanics. The objective of this study was to characterize the effects of cranial cruciate ligame...

    Authors: Stanley E. Kim, Geoffrey J. Zann, Selena Tinga, Erica J. Moore, Antonio Pozzi and Scott A. Banks

    Citation: BMC Veterinary Research 2017 13:250

    Content type: Research article

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  3. Currently, the best resources for assessment of bone tissue using imaging techniques are expensive and available in few medical facilities, thus serum or urinary bone turnover biomarkers could be useful as ear...

    Authors: José A. Camassa, Camila C. Diogo, João P. A. Bordelo, Marília de A. Bonelli, Carlos A. Viegas, Jorge T. Azevedo, Nuno Dourado and Isabel R. Dias

    Citation: BMC Veterinary Research 2017 13:239

    Content type: Research article

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  4. We recently reported that a conformation score derived from the tibial plateau angle (TPA) and the femoral anteversion angle (FAA), best discriminates limbs predisposed to, or affected by cranial cruciate liga...

    Authors: Devin P. Cunningham, Ayman A. Mostafa, Wanda J. Gordan-Evans, Randy J. Boudrieau and Dominique J. Griffon

    Citation: BMC Veterinary Research 2017 13:235

    Content type: Research article

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  5. Fracture of the ilium is common orthopedic injury that often requires surgical stabilization in canine patients. Of the various methods of surgical stabilization available, application of a lateral bone plate ...

    Authors: Allison R Kenzig, James R Butler, Lauren B Priddy, Kristen R Lacy and Steven H Elder

    Citation: BMC Veterinary Research 2017 13:222

    Content type: Research article

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  6. Septic arthritis is a common and potentially devastating disease characterized by severe intra-articular (IA) inflammation and fibrin deposition. Research into equine joint pathologies has focused on inflammat...

    Authors: Stine Mandrup Andreassen, Anne Mette Lindberg Vinther, Søren Saxmose Nielsen, Pia Haubro Andersen, Aziz Tnibar, Annemarie T. Kristensen and Stine Jacobsen

    Citation: BMC Veterinary Research 2017 13:182

    Content type: Research article

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  7. Very little is known about neonatal skeletal development in small-sized purebred dogs. In order to improve this knowledge, 27 spontaneously dead puppies belonging to small-sized breeds were enrolled in this st...

    Authors: S. C. Modina, M.C. Veronesi, M. Moioli, T. Meloni, G. Lodi, V. Bronzo and M. Di Giancamillo

    Citation: BMC Veterinary Research 2017 13:175

    Content type: Research article

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  8. Local circulatory disturbances have been implicated in the development of foot disorders in cattle. The goals of this study were to evaluate the suitability of the interdigital artery in the pastern region in ...

    Authors: H. Müller, M. Heinrich, N. Mielenz, S. Reese, A. Steiner and A. Starke

    Citation: BMC Veterinary Research 2017 13:162

    Content type: Research article

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  9. Aseptic loosening due to bone remodelling processes after total hip replacement is one common cause for revision surgery. In human medicine, dual-energy X-ray absorptiometry (DEXA) is the gold standard for qua...

    Authors: K. Lucas, I. Nolte, V. Galindo-Zamora, M. Lerch, C. Stukenborg-Colsman, B. A. Behrens, A. Bouguecha, S. Betancur, A. Almohallami and P. Wefstaedt

    Citation: BMC Veterinary Research 2017 13:130

    Content type: Methodology article

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  10. White muscle disease (WMD) is a nutritional myopathy caused by selenium (Se) deficiency. In most soils, Se is present in low concentrations, sometimes even below 0.2 mg/kg, a trend which is seen in many countr...

    Authors: Catherine Delesalle, Marco de Bruijn, Sanne Wilmink, Hilde Vandendriessche, Gerben Mol, Berit Boshuizen, Lukas Plancke and Guy Grinwis

    Citation: BMC Veterinary Research 2017 13:121

    Content type: Case Report

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  11. The synovial membrane lines the luminal side of the joint capsule in synovial joints. It maintains joint homeostasis and plays a crucial role in equine joint pathology. When trauma or inflammation is induced i...

    Authors: Line Nymann Thomsen, Preben Dybdahl Thomsen, Alison Downing, Richard Talbot and Lise Charlotte Berg

    Citation: BMC Veterinary Research 2017 13:106

    Content type: Research article

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  12. Recently, intra-articular botulinum toxin A (IA BoNT A) has been shown to reduce joint pain in osteoarthritic dogs. Similar results have been reported in human patients with arthritis. However, the mechanism o...

    Authors: Helka M. Heikkilä, Anna K. Hielm-Björkman, John F. Innes and Outi M. Laitinen-Vapaavuori

    Citation: BMC Veterinary Research 2017 13:74

    Content type: Research article

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  13. The purpose of this study was to measure the muscular activation in four forelimb muscles while dogs performed agility tasks (i.e., jumping and A-frame) and to provide insight into potential relationships betw...

    Authors: Kimberley L. Cullen, James P. Dickey, Stephen H. M. Brown, Stephanie G. Nykamp, Leah R. Bent, Jeffrey J. Thomason and Noël M. M. Moens

    Citation: BMC Veterinary Research 2017 13:68

    Content type: Research article

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  14. During growth, the skeletal structures adapt to the increased loading conditions and mature to a fully-grown skeleton. Subchondral bone density reflects the effect of long-term joint loading and it is expected...

    Authors: W. Dingemanse, M. Müller-Gerbl, I. Jonkers, J. Vander Sloten, H. van Bree and I. Gielen

    Citation: BMC Veterinary Research 2017 13:57

    Content type: Research article

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  15. Most Friesian horses reach their anaerobic threshold during a standardized exercise test (SET) which requires lower intensity exercise than daily routine training. Aim: to study strengths and weaknesses of an ...

    Authors: Cornelis Marinus de Bruijn, Willem Houterman, Margreet Ploeg, Bart Ducro, Berit Boshuizen, Klaartje Goethals, Elisabeth-Lidwien Verdegaal and Catherine Delesalle

    Citation: BMC Veterinary Research 2017 13:49

    Content type: Research article

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  16. Accelerometer-based activity monitoring is a promising new tool in veterinary medicine used to objectively assess activity levels in dogs. To date, it is unknown how device orientation, attachment method, and ...

    Authors: Kyle W. Martin, Anastasia M. Olsen, Colleen G. Duncan and Felix M. Duerr

    Citation: BMC Veterinary Research 2017 13:48

    Content type: Research article

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  17. Non-steroidal anti-inflammatory drugs (NSAIDs), transdermal fentanyl patches, and transmucosal buprenorphine are probably the most commonly used options for providing post-operative analgesia in the early at-h...

    Authors: Masataka Enomoto, Patricia D. Kigin, David Bledsoe, Robyn Slone, Jonathan Hash, Charles E. Smith and B. Duncan X. Lascelles

    Citation: BMC Veterinary Research 2017 13:32

    Content type: Research article

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  18. Congenital cranial bone defects predispose to herniation of meninges, sometimes with brain tissue involvement, to form a cerebrospinal fluid (CSF)–filled cyst in the head. Such defects mainly results from foca...

    Authors: Mosiany Letura Kisipan, Caleb Oburu Orenge, David Njogu Gacheru and Raphael Muchangi Ngure

    Citation: BMC Veterinary Research 2017 13:20

    Content type: Case Report

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  19. Cranial cruciate ligament insufficiency is a common orthopaedic problem in canine patients. This cadaveric and radiographic study was performed with the aim of determining the effect of proximal translation of...

    Authors: Jack D. Neville-Towle, Mariano Makara, Kenneth A. Johnson and Katja Voss

    Citation: BMC Veterinary Research 2017 13:18

    Content type: Research article

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  20. Among bones building the axial and appendicular skeleton, the mandible is characterized by unique morphological and functional traits. The aim of the study was to evaluate morphological, densitometric and mech...

    Authors: Anna Szabelska, Marcin R. Tatara and Witold Krupski

    Citation: BMC Veterinary Research 2017 13:12

    Content type: Research article

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  21. Coxofemoral osteoarthritis is a chronic, disabling condition affecting people and dogs, with THA providing an excellent return to function in severely affected joints. The principal role of THA is to restore a...

    Authors: Ayman A. Mostafa, Karin Lucas, Ingo Nolte and Patrick Wefstaedt

    Citation: BMC Veterinary Research 2016 12:271

    Content type: Research article

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  22. Patellar abnormalities are a common cause of pain and lameness in dogs; however, in vivo the relative motion between the femur and patella in dogs is not well described. The objective of this study was to defi...

    Authors: Erica J. Moore, Stanley E. Kim, Scott A. Banks, Antonio Pozzi, Jason D. Coggeshall and Stephen C. Jones

    Citation: BMC Veterinary Research 2016 12:262

    Content type: Research article

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  23. Joint impact injuries initiate a progressive articular damage finally leading to post-traumatic osteoarthritis (PTOA). Racehorses represent an ideal, naturally available, animal model of the disease. Standardb...

    Authors: Andrea Bertuglia, Eleonora Pagliara, Elena Grego, Alessandro Ricci and Nika Brkljaca-Bottegaro

    Citation: BMC Veterinary Research 2016 12:246

    Content type: Research article

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  24. Subjective pain assessment scales have been widely used for assessing lameness in response to pain, but the accuracy of these scales has been questioned. To assess scale accuracy, 10 lame, presa Canario dogs w...

    Authors: Jose M. Vilar, Belen Cuervo, Monica Rubio, Joaquín Sopena, Juan M. Domínguez, Angelo Santana and Jose M. Carrillo

    Citation: BMC Veterinary Research 2016 12:223

    Content type: Research article

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  25. Platelet-rich plasma (PRP) preparations are a common treatment in equine osteoarthritis (OA). However, there are controversies regarding the ideal concentration of platelets and leukocytes in these biological ...

    Authors: Jorge U. Carmona, Diana L. Ríos, Catalina López, María E. Álvarez, Jorge E. Pérez and Mabel E. Bohórquez

    Citation: BMC Veterinary Research 2016 12:135

    Content type: Research article

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  26. Fracture healing in bone gap is one of the major challenges encountered in Orthopedic Surgery. At present, the treatment includes bone graft, employing either internal or external fixation which has a signific...

    Authors: Mohd Rafiq Mohd Ibrahim, Simmrat Singh, Azhar Mahmood Merican, Hanumantha Rao Balaji Raghavendran, Malliga Raman Murali, Sangeetha Vasudevaraj Naveen and Tunku Kamarul

    Citation: BMC Veterinary Research 2016 12:112

    Content type: Research article

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  27. Retrievers are dogs particularly bred to retrieve birds or other small game, for the retrieval, the dogs are typically sent to the place where the shot game has fallen or to search the field for the wounded bu...

    Authors: Barbara Bockstahler, Alexander Tichy and Patricia Aigner

    Citation: BMC Veterinary Research 2016 12:92

    Content type: Research article

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  28. Navicular bone partition is a rare condition reported in horses, which is during the evaluation of a lameness or prepurchase examination often misinterpreted for a parasagittal fracture. In this report, the cl...

    Authors: Ellen J. van der Zaag, Erik A. W. S. Weerts, Antoon J. M. van den Belt and Willem Back

    Citation: BMC Veterinary Research 2016 12:74

    Content type: Case report

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  29. Mesenchymal stem cells (MSCs) transplantation has become a promising therapeutic choice for musculoskeletal injuries. Joint-related disorders are highly prevalent in horses. Therefore, these animals are consid...

    Authors: N. Ardanaz, F. J. Vázquez, A. Romero, A. R. Remacha, L. Barrachina, A. Sanz, B. Ranera, A. Vitoria, J. Albareda, M. Prades, P. Zaragoza, I. Martín-Burriel and C. Rodellar

    Citation: BMC Veterinary Research 2016 12:65

    Content type: Research article

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  30. In today’s porcine industry, lameness has a major welfare and economic impact, and is often caused by osteochondrosis (OC). The etiological factors of the disease have been studied in depth, however, to this d...

    Authors: Christian P. Bertholle, Ellen Meijer, Willem Back, Arjan Stegeman, P. René van Weeren and Arie van Nes

    Citation: BMC Veterinary Research 2016 12:62

    Content type: Research article

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  31. Intra-articular inflammation resulting in lameness is a common health problem in horses. Exogenous intra-articular hyaluronic acid has been shown to provide an analgesic effect and reduce pain in equine and hu...

    Authors: Tytti M. Niemelä, Riitta-Mari Tulamo and Anna K. Hielm-Björkman

    Citation: BMC Veterinary Research 2016 12:60

    Content type: Research article

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  32. Defects in the abdominal wall of horses have high relapse rate. This is mainly in lateral eventrations and hernias caused by trauma from kicks of other horses or installation structures. The eventration region...

    Authors: Carla Faria Orlandini, Denis Steiner, André Giarola Boscarato, Gabriel Coelho Gimenes and Luiz Romulo Alberton

    Citation: BMC Veterinary Research 2016 12:58

    Content type: Case report

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  33. Monsegmental pedicle instrumentation (MSPI) has been used to treat thoracolumbar fractures. However, there are few reports about the biomechanical characteristics of MSPI compared with traditional short-segmen...

    Authors: Fuxin Wei, Zhiyu Zhou, Le Wang, Shaoyu Liu, Rui Zhong, Xizhe Liu, Shangbin Cui, Ximin Pan, Manman Gao and Yajing Zhao

    Citation: BMC Veterinary Research 2016 12:57

    Content type: Research article

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  34. Bones continually adapt their morphology to their load bearing function. At the level of the subchondral bone, the density distribution is highly correlated with the loading distribution of the joint. Therefor...

    Authors: W. Dingemanse, M. Müller-Gerbl, I. Jonkers, J. Vander Sloten, H. van Bree and I. Gielen

    Citation: BMC Veterinary Research 2016 12:56

    Content type: Research article

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  35. The amputation of a limb is a surgical procedure that is regularly performed in small animal practice. In spite of several clinical reports indicating high owner satisfaction after limb amputation in dogs, an ...

    Authors: Vladimir Galindo-Zamora, Verena von Babo, Nina Eberle, Daniela Betz, Ingo Nolte and Patrick Wefstaedt

    Citation: BMC Veterinary Research 2016 12:20

    Content type: Research article

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  36. Intervertebral disc (IVD) disease is a common spinal disorder in dogs and degeneration and inflammation are significant components of the pathological cascade. Only limited studies have studied the cytokine an...

    Authors: Nicole Willems, Anna R. Tellegen, Niklas Bergknut, Laura B. Creemers, Jeannette Wolfswinkel, Christian Freudigmann, Karin Benz, Guy C. M. Grinwis, Marianna A. Tryfonidou and Björn P. Meij

    Citation: BMC Veterinary Research 2016 12:10

    Content type: Research article

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  37. Craniofacial morphology of sheep with phenotypically observed mandibular distocclusion was analysed using the multivariate techniques principle component analysis and cluster analysis in order to test whether ...

    Authors: T. Eriksen, M. Ganter, O. Distl and C. Staszyk

    Citation: BMC Veterinary Research 2016 12:8

    Content type: Research article

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  38. The anatomical complexity of the horse’s head limits the abilities of radiography. Computed tomography (CT) in combination with contrast enhanced CT is used more often for diagnosing various head pathology in ...

    Authors: Casper P. Crijns, Yseult Baeumlin, Lieve De Rycke, Bart J.G. Broeckx, Lieven Vlaminck, Erik H. J. Bergman, Henri van Bree and Ingrid Gielen

    Citation: BMC Veterinary Research 2016 12:6

    Content type: Research article

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  39. A prime concern of the gait analysis in a heterogeneous group of dogs is the potential influence of factors such as individual body size, body mass, type of gait, and velocity. Thus, this study aimed to evalua...

    Authors: Washington T. Kano, Sheila C. Rahal, Felipe S. Agostinho, Luciane R. Mesquita, Rogerio R. Santos, Frederico O. B. Monteiro, Maira S. Castilho and Alessandra Melchert

    Citation: BMC Veterinary Research 2016 12:2

    Content type: Research article

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  40. In veterinary medicine congenital abnormalities of the diaphragm and pericardium are rare, idiopathic malformations, being reported mainly in dogs. This report documents an unusual case of developmental defect...

    Authors: Alexandru-Flaviu Tăbăran, Andras Laszlo Nagy, Cornel Cătoi, Iancu Morar, Alexandra Tăbăran, Marian Mihaiu and Pompei Bolfa

    Citation: BMC Veterinary Research 2015 11:309

    Content type: Case report

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  41. Degenerative lumbosacral stenosis is a common problem in large breed dogs. For severe degenerative lumbosacral stenosis, conservative treatment is often not effective and surgical intervention remains as the l...

    Authors: Anna R. Tellegen, Nicole Willems, Marianna A. Tryfonidou and Björn P. Meij

    Citation: BMC Veterinary Research 2015 11:299

    Content type: Research article

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  42. Certain postoperative wounds are recognised to be associated with more complications than others and may be termed high-risk. Wound healing can be particularly challenging following high-energy trauma where wo...

    Authors: Karen L. Perry, Lynda Rutherford, David M. R. Sajik and Mieghan Bruce

    Citation: BMC Veterinary Research 2015 11:279

    Content type: Research article

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  43. New clinical oriented approaches are supported by the integration of advanced imaging techniques, e.g. computed tomography and magnetic resonance, with gross anatomy imaging. The interscapular region of the ca...

    Authors: Maurizio Longo, Silvia Clotilde Modina, Andrea Bellotti and Mauro Di Giancamillo

    Citation: BMC Veterinary Research 2015 11:249

    Content type: Methodology article

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  44. Diagnostic imaging is essential to assess the lame patient; lesions of the elbow joint have traditionally been evaluated radiographically, however computed tomography (CT) has been suggested as a useful techni...

    Authors: A. Villamonte-Chevalier, H. van Bree, BJG Broeckx, W. Dingemanse, M. Soler, B. Van Ryssen and I. Gielen

    Citation: BMC Veterinary Research 2015 11:243

    Content type: Research article

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  45. Accelerometers are valid, practical and reliable tools for the measurement of habitual physical activity (PA). Quantification of PA in horses is desirable for use in research and clinical settings. The objecti...

    Authors: R. Morrison, D. G. M. Sutton, C. Ramsoy, N. Hunter-Blair, J. Carnwath, E. Horsfield and P. S. Yam

    Citation: BMC Veterinary Research 2015 11:233

    Content type: Research article

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  46. The purpose of this study was to describe the normal appearance of the bony and soft tissue structures of the stifle joint of a Bengal tiger (Panthera tigris) by low-field magnetic resonance imaging (MRI), and th...

    Authors: Alberto Arencibia, Mario Encinoso, José R. Jáber, Daniel Morales, Diego Blanco, Alejandro Artiles and José M. Vázquez

    Citation: BMC Veterinary Research 2015 11:192

    Content type: Research article

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  47. Variations associated with sex, age, velocity, breed and body geometry should be considered in the determination of kinematic parameters for a gait considered normal.

    Authors: Luis G Faria, Sheila C Rahal, Felipe S Agostinho, Bruno W Minto, Lídia M Matsubara, Washington T Kano, Maira S Castilho and Luciane R Mesquita

    Citation: BMC Veterinary Research 2014 10:294

    Content type: Research article

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  48. Cranial cruciate ligament (CCL) rupture is a very common cause of pelvic limb lameness in dogs. Few studies, using objective and validated outcome evaluation methods, have been published to evaluate long-term ...

    Authors: Sari H Mölsä, Heli K Hyytiäinen,, Anna K Hielm-Björkman and Outi M Laitinen-Vapaavuori

    Citation: BMC Veterinary Research 2014 10:266

    Content type: Research article

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