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Musculoskeletal disorders and orthopaedics

The musculoskeletal disorders and orthopaedics section considers research that addresses the etiology and treatment of musculoskeletal disorders in veterinary patients. This includes, but not limited to, studies on therapeutic strategies, surgery, diagnostic imaging, genetics and genomics, epidemiology, anatomical studies, and comparative orthopedic studies. 

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  1. Stifle arthroscopy has been described to have high sensitivity and specificity in the evaluation of menisci in dogs, particularly for the medial meniscus. However, the visualization of menisci can be difficult...

    Authors: Gian Luca Rovesti, Veronica Devesa, Laura Bertorelli and Jesus Rodriguez-Quiros

    Citation: BMC Veterinary Research 2018 14:212

    Content type: Methodology article

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  2. Inflammatory and degenerative activity inside the joint can be studied in vivo via analysis of synovial fluid (SF) biomarkers, which are molecular markers of inflammatory processes and tissue turnover. The aim...

    Authors: Tytti M. Niemelä, Riitta-Mari Tulamo, Kaisa Aaltonen, Satu M. Sankari and Anna K. Hielm-Björkman

    Citation: BMC Veterinary Research 2018 14:186

    Content type: Research article

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  3. Mammaglobin, a member of secretoglobin family has been recognized as a breast cancer associated protein. Though the exact function of the protein is not fully known, its expression has been reported to be upre...

    Authors: Mamta Pandey, B. V. Sunil Kumar, Kuldip Gupta, Ram Saran Sethi, Ashwani Kumar and Ramneek Verma

    Citation: BMC Veterinary Research 2018 14:184

    Content type: Research article

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  5. Bone healing and assessment of the state of bone bridging is an important part of clinical orthopedics, whether for fracture healing or for follow up of osteotomy procedures. Tibial tuberosity advancement (TTA...

    Authors: Marije Risselada, Matthew D. Winter, Daniel D. Lewis, Emily Griffith and Antonio Pozzi

    Citation: BMC Veterinary Research 2018 14:164

    Content type: Research article

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  6. Despite the importance of inflammation during the pathogenesis of cranial cruciate ligament disease (CCLD) in dogs and despite the latest knowledge suggesting a significant role of adipose tissue in osteoarthr...

    Authors: Manuel R. Schmidli, Bettina Fuhrer, Nadine Kurt, David Senn, Michaela Drögemüller, Ulrich Rytz, David E. Spreng and Simone Forterre

    Citation: BMC Veterinary Research 2018 14:161

    Content type: Research article

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  7. Static posturography and pedobarography are based on the detection of postural imbalance and, consequently, the pressure redistribution between limbs in lame subjects. These techniques have proven to be useful...

    Authors: Lidia Pitti, Maarten Oosterlinck, Maria L. Díaz-Bertrana, José M. Carrillo, Mónica Rubio, Joaquin Sopena, Angelo Santana and José M. Vilar

    Citation: BMC Veterinary Research 2018 14:151

    Content type: Research article

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  8. Pathological changes and resulting functional impairment of the temporomandibular joint (TMJ) can substantially affect physical condition, morbidity, and mortality of wildlife species. Analysis of TMJ disorder...

    Authors: Catharina Ludolphy, Patricia Kahle, Horst Kierdorf and Uwe Kierdorf

    Citation: BMC Veterinary Research 2018 14:150

    Content type: Research article

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  9. The equine m. gluteus medius (GM) is the largest muscle of the horse, its main movement function is the extension of the hip joint. The objective of the present study was to measure equine GM activity in three...

    Authors: Rebeka R. Zsoldos, Anna Voegele, Bjoern Krueger, Ulrike Schroeder, Andreas Weber and Theresia F. Licka

    Citation: BMC Veterinary Research 2018 14:126

    Content type: Research article

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  10. The usefulness of studying posture and its modifications due to locomotor deficiencies of multiple origins has been widely proven in humans. To assess its suitability in the canine species, static posturograph...

    Authors: José M. Carrillo, Maria E. Manera, Mónica Rubio, Joaquin Sopena, Angelo Santana and José M. Vilar

    Citation: BMC Veterinary Research 2018 14:108

    Content type: Research article

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  12. Tiludronate and clodronate are FDA-approved bisphosphonate drug therapies for navicular disease in horses. Although clinical studies have determined their ability to reduce lameness associated with skeletal di...

    Authors: Heather A. Richbourg, Colin F. Mitchell, Ashley N. Gillett and Margaret A. McNulty

    Citation: BMC Veterinary Research 2018 14:105

    Content type: Research article

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  14. Intra-articular administration of stanozolol has shown promising results by improving the clinical management of lameness associated with naturally-occurring osteoarthritis (OA) in horses, and by decreasing os...

    Authors: Mariana Castro Martins, Mandy J. Peffers, Katie Lee and Luis M. Rubio-Martinez

    Citation: BMC Veterinary Research 2018 14:103

    Content type: Research article

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  15. Finite element analysis was used to compare fixation methods for double pelvic osteotomy (DPO). Using 3D scanning a stereolithography (stl) image was produced of a canine pelvis and this was subsequently refin...

    Authors: William McCartney, Bryan MacDonald, Ciprian Andrei Ober, Rubén Lostado-Lorza and Fátima Somovilla Gómez

    Citation: BMC Veterinary Research 2018 14:100

    Content type: Research article

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  16. Cranial cruciate ligament (CrCL) insufficiency is a degenerative condition that is a common cause of pelvic limb lameness and osteoarthritis in dogs. Surgical therapies developed to treat dogs with naturally o...

    Authors: Selena Tinga, Stanley E. Kim, Scott A. Banks, Stephen C. Jones, Brian H. Park, Antonio Pozzi and Daniel D. Lewis

    Citation: BMC Veterinary Research 2018 14:85

    Content type: Research article

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  17. We have previously demonstrated that a mixture of Curcuminoids extract, hydrolyzed COllagen and green Tea extract (CCOT) inhibited inflammatory and catabolic mediator’s synthesis by bovine and human chondrocyt...

    Authors: Fanny Comblain, Nicolas Barthélémy, Michael Lefèbvre, Cédric Schwartz, Isabelle Lesponne, Samuel Serisier, Alexandre Feugier, Marc Balligand and Yves Henrotin

    Citation: BMC Veterinary Research 2017 13:395

    Content type: Research article

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  18. Despite the use of water treadmills (WT) in conditioning horses, the intensity of WT exercise has not been well documented. The workload on a WT is a function of water height and treadmill speed. Therefore, th...

    Authors: Persephone Greco-Otto, Stephanie Bond, Raymond Sides, Grace P. S. Kwong, Warwick Bayly and Renaud Léguillette

    Citation: BMC Veterinary Research 2017 13:360

    Content type: Research article

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  19. Osteochondrosis (OC) is a common, clinically important joint disorder in which endochondral ossification is focally disturbed. Reduced blood supply to growing cartilage is considered an important cause of the ...

    Authors: E. M. van Grevenhof, A. R. D. Gezelle Meerburg, M. C. van Dierendonck, A. J. M. van den Belt, B. van Schaik, P. Meeus and W. Back

    Citation: BMC Veterinary Research 2017 13:324

    Content type: Research article

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  20. Intravenous regional anaesthesia (IVRA) and hindfoot four-point nerve block anaesthesia (NBA) are recommended for local anaesthesia (LA) in the distal limb of dairy cows. Two studies were conducted to compare ...

    Authors: S. Yavari, N. Khraim, G. Szura, A. Starke, E. Engelke, C. Pfarrer, K. Hopster, M. Schmicke, W. Kehler, M. Heppelmann, S. B. R. Kästner and J. Rehage

    Citation: BMC Veterinary Research 2017 13:320

    Content type: Research article

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  21. Chondrotoxic effects of local anaesthetics are well reported in humans and some animal species but knowledge on their toxic effects on synoviocytes or equine chondrocytes or the effects on cellular production ...

    Authors: L. M. Rubio-Martínez, E. Rioja, M. Castro Martins, S. Wipawee, P. Clegg and M. J. Peffers

    Citation: BMC Veterinary Research 2017 13:318

    Content type: Research article

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  22. The physis is the weakest component of immature long bones, and physeal fractures constitute about 30% of fractures in growing dogs. Fractures of the proximal humeral physis typically have a Salter Harris type...

    Authors: Jiawen Ma, Tian Wang, Vedran Lovric, Kenneth A. Johnson and William R. Walsh

    Citation: BMC Veterinary Research 2017 13:306

    Content type: Research article

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  23. Articular osteochondrosis is a common cause of leg weakness in pigs and is defined as a focal delay in the endochondral ossification of the epiphysis. The first demonstrated steps in the pathogenesis consist o...

    Authors: Andreas Finnøy, Kristin Olstad and Magnus B. Lilledahl

    Citation: BMC Veterinary Research 2017 13:270

    Content type: Research article

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  24. Complete rupture of the cranial cruciate ligament (CrCL) in dogs causes profound disturbance to stifle joint biomechanics. The objective of this study was to characterize the effects of cranial cruciate ligame...

    Authors: Stanley E. Kim, Geoffrey J. Zann, Selena Tinga, Erica J. Moore, Antonio Pozzi and Scott A. Banks

    Citation: BMC Veterinary Research 2017 13:250

    Content type: Research article

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  25. Currently, the best resources for assessment of bone tissue using imaging techniques are expensive and available in few medical facilities, thus serum or urinary bone turnover biomarkers could be useful as ear...

    Authors: José A. Camassa, Camila C. Diogo, João P. A. Bordelo, Marília de A. Bonelli, Carlos A. Viegas, Jorge T. Azevedo, Nuno Dourado and Isabel R. Dias

    Citation: BMC Veterinary Research 2017 13:239

    Content type: Research article

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  26. We recently reported that a conformation score derived from the tibial plateau angle (TPA) and the femoral anteversion angle (FAA), best discriminates limbs predisposed to, or affected by cranial cruciate liga...

    Authors: Devin P. Cunningham, Ayman A. Mostafa, Wanda J. Gordan-Evans, Randy J. Boudrieau and Dominique J. Griffon

    Citation: BMC Veterinary Research 2017 13:235

    Content type: Research article

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  27. Fracture of the ilium is common orthopedic injury that often requires surgical stabilization in canine patients. Of the various methods of surgical stabilization available, application of a lateral bone plate ...

    Authors: Allison R Kenzig, James R Butler, Lauren B Priddy, Kristen R Lacy and Steven H Elder

    Citation: BMC Veterinary Research 2017 13:222

    Content type: Research article

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  28. Septic arthritis is a common and potentially devastating disease characterized by severe intra-articular (IA) inflammation and fibrin deposition. Research into equine joint pathologies has focused on inflammat...

    Authors: Stine Mandrup Andreassen, Anne Mette Lindberg Vinther, Søren Saxmose Nielsen, Pia Haubro Andersen, Aziz Tnibar, Annemarie T. Kristensen and Stine Jacobsen

    Citation: BMC Veterinary Research 2017 13:182

    Content type: Research article

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  29. Very little is known about neonatal skeletal development in small-sized purebred dogs. In order to improve this knowledge, 27 spontaneously dead puppies belonging to small-sized breeds were enrolled in this st...

    Authors: S. C. Modina, M.C. Veronesi, M. Moioli, T. Meloni, G. Lodi, V. Bronzo and M. Di Giancamillo

    Citation: BMC Veterinary Research 2017 13:175

    Content type: Research article

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  30. Local circulatory disturbances have been implicated in the development of foot disorders in cattle. The goals of this study were to evaluate the suitability of the interdigital artery in the pastern region in ...

    Authors: H. Müller, M. Heinrich, N. Mielenz, S. Reese, A. Steiner and A. Starke

    Citation: BMC Veterinary Research 2017 13:162

    Content type: Research article

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  31. Aseptic loosening due to bone remodelling processes after total hip replacement is one common cause for revision surgery. In human medicine, dual-energy X-ray absorptiometry (DEXA) is the gold standard for qua...

    Authors: K. Lucas, I. Nolte, V. Galindo-Zamora, M. Lerch, C. Stukenborg-Colsman, B. A. Behrens, A. Bouguecha, S. Betancur, A. Almohallami and P. Wefstaedt

    Citation: BMC Veterinary Research 2017 13:130

    Content type: Methodology article

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  32. White muscle disease (WMD) is a nutritional myopathy caused by selenium (Se) deficiency. In most soils, Se is present in low concentrations, sometimes even below 0.2 mg/kg, a trend which is seen in many countr...

    Authors: Catherine Delesalle, Marco de Bruijn, Sanne Wilmink, Hilde Vandendriessche, Gerben Mol, Berit Boshuizen, Lukas Plancke and Guy Grinwis

    Citation: BMC Veterinary Research 2017 13:121

    Content type: Case Report

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  33. The synovial membrane lines the luminal side of the joint capsule in synovial joints. It maintains joint homeostasis and plays a crucial role in equine joint pathology. When trauma or inflammation is induced i...

    Authors: Line Nymann Thomsen, Preben Dybdahl Thomsen, Alison Downing, Richard Talbot and Lise Charlotte Berg

    Citation: BMC Veterinary Research 2017 13:106

    Content type: Research article

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  35. Recently, intra-articular botulinum toxin A (IA BoNT A) has been shown to reduce joint pain in osteoarthritic dogs. Similar results have been reported in human patients with arthritis. However, the mechanism o...

    Authors: Helka M. Heikkilä, Anna K. Hielm-Björkman, John F. Innes and Outi M. Laitinen-Vapaavuori

    Citation: BMC Veterinary Research 2017 13:74

    Content type: Research article

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  36. The purpose of this study was to measure the muscular activation in four forelimb muscles while dogs performed agility tasks (i.e., jumping and A-frame) and to provide insight into potential relationships betw...

    Authors: Kimberley L. Cullen, James P. Dickey, Stephen H. M. Brown, Stephanie G. Nykamp, Leah R. Bent, Jeffrey J. Thomason and Noël M. M. Moens

    Citation: BMC Veterinary Research 2017 13:68

    Content type: Research article

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  37. During growth, the skeletal structures adapt to the increased loading conditions and mature to a fully-grown skeleton. Subchondral bone density reflects the effect of long-term joint loading and it is expected...

    Authors: W. Dingemanse, M. Müller-Gerbl, I. Jonkers, J. Vander Sloten, H. van Bree and I. Gielen

    Citation: BMC Veterinary Research 2017 13:57

    Content type: Research article

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  38. Most Friesian horses reach their anaerobic threshold during a standardized exercise test (SET) which requires lower intensity exercise than daily routine training. Aim: to study strengths and weaknesses of an ...

    Authors: Cornelis Marinus de Bruijn, Willem Houterman, Margreet Ploeg, Bart Ducro, Berit Boshuizen, Klaartje Goethals, Elisabeth-Lidwien Verdegaal and Catherine Delesalle

    Citation: BMC Veterinary Research 2017 13:49

    Content type: Research article

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  39. Accelerometer-based activity monitoring is a promising new tool in veterinary medicine used to objectively assess activity levels in dogs. To date, it is unknown how device orientation, attachment method, and ...

    Authors: Kyle W. Martin, Anastasia M. Olsen, Colleen G. Duncan and Felix M. Duerr

    Citation: BMC Veterinary Research 2017 13:48

    Content type: Research article

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  40. Non-steroidal anti-inflammatory drugs (NSAIDs), transdermal fentanyl patches, and transmucosal buprenorphine are probably the most commonly used options for providing post-operative analgesia in the early at-h...

    Authors: Masataka Enomoto, Patricia D. Kigin, David Bledsoe, Robyn Slone, Jonathan Hash, Charles E. Smith and B. Duncan X. Lascelles

    Citation: BMC Veterinary Research 2017 13:32

    Content type: Research article

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  41. Congenital cranial bone defects predispose to herniation of meninges, sometimes with brain tissue involvement, to form a cerebrospinal fluid (CSF)–filled cyst in the head. Such defects mainly results from foca...

    Authors: Mosiany Letura Kisipan, Caleb Oburu Orenge, David Njogu Gacheru and Raphael Muchangi Ngure

    Citation: BMC Veterinary Research 2017 13:20

    Content type: Case Report

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  42. Cranial cruciate ligament insufficiency is a common orthopaedic problem in canine patients. This cadaveric and radiographic study was performed with the aim of determining the effect of proximal translation of...

    Authors: Jack D. Neville-Towle, Mariano Makara, Kenneth A. Johnson and Katja Voss

    Citation: BMC Veterinary Research 2017 13:18

    Content type: Research article

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  43. Among bones building the axial and appendicular skeleton, the mandible is characterized by unique morphological and functional traits. The aim of the study was to evaluate morphological, densitometric and mech...

    Authors: Anna Szabelska, Marcin R. Tatara and Witold Krupski

    Citation: BMC Veterinary Research 2017 13:12

    Content type: Research article

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  44. Coxofemoral osteoarthritis is a chronic, disabling condition affecting people and dogs, with THA providing an excellent return to function in severely affected joints. The principal role of THA is to restore a...

    Authors: Ayman A. Mostafa, Karin Lucas, Ingo Nolte and Patrick Wefstaedt

    Citation: BMC Veterinary Research 2016 12:271

    Content type: Research article

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  45. Patellar abnormalities are a common cause of pain and lameness in dogs; however, in vivo the relative motion between the femur and patella in dogs is not well described. The objective of this study was to defi...

    Authors: Erica J. Moore, Stanley E. Kim, Scott A. Banks, Antonio Pozzi, Jason D. Coggeshall and Stephen C. Jones

    Citation: BMC Veterinary Research 2016 12:262

    Content type: Research article

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  46. Joint impact injuries initiate a progressive articular damage finally leading to post-traumatic osteoarthritis (PTOA). Racehorses represent an ideal, naturally available, animal model of the disease. Standardb...

    Authors: Andrea Bertuglia, Eleonora Pagliara, Elena Grego, Alessandro Ricci and Nika Brkljaca-Bottegaro

    Citation: BMC Veterinary Research 2016 12:246

    Content type: Research article

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  47. Subjective pain assessment scales have been widely used for assessing lameness in response to pain, but the accuracy of these scales has been questioned. To assess scale accuracy, 10 lame, presa Canario dogs w...

    Authors: Jose M. Vilar, Belen Cuervo, Monica Rubio, Joaquín Sopena, Juan M. Domínguez, Angelo Santana and Jose M. Carrillo

    Citation: BMC Veterinary Research 2016 12:223

    Content type: Research article

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  48. Platelet-rich plasma (PRP) preparations are a common treatment in equine osteoarthritis (OA). However, there are controversies regarding the ideal concentration of platelets and leukocytes in these biological ...

    Authors: Jorge U. Carmona, Diana L. Ríos, Catalina López, María E. Álvarez, Jorge E. Pérez and Mabel E. Bohórquez

    Citation: BMC Veterinary Research 2016 12:135

    Content type: Research article

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  49. Fracture healing in bone gap is one of the major challenges encountered in Orthopedic Surgery. At present, the treatment includes bone graft, employing either internal or external fixation which has a signific...

    Authors: Mohd Rafiq Mohd Ibrahim, Simmrat Singh, Azhar Mahmood Merican, Hanumantha Rao Balaji Raghavendran, Malliga Raman Murali, Sangeetha Vasudevaraj Naveen and Tunku Kamarul

    Citation: BMC Veterinary Research 2016 12:112

    Content type: Research article

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  50. Retrievers are dogs particularly bred to retrieve birds or other small game, for the retrieval, the dogs are typically sent to the place where the shot game has fallen or to search the field for the wounded bu...

    Authors: Barbara Bockstahler, Alexander Tichy and Patricia Aigner

    Citation: BMC Veterinary Research 2016 12:92

    Content type: Research article

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