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Musculoskeletal disorders and orthopaedics

Section edited by Dr. Hayley Henderson and Tillie Cryer

The musculoskeletal disorders and orthopaedics section considers research that addresses the etiology and treatment of musculoskeletal disorders in veterinary patients. This includes, but not limited to, studies on therapeutic strategies, surgery, diagnostic imaging, genetics and genomics, epidemiology, anatomical studies, and comparative orthopedic studies. 

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  1. Content type: Research article

    Equine water treadmills (WTs) are growing in popularity because they are believed to allow for high resistance, low impact exercise. However, little is known about the effect of water height on limb loading. T...

    Authors: Persephone Greco-Otto, Michael Baggaley, W. B. Edwards and Renaud Léguillette

    Citation: BMC Veterinary Research 2019 15:329

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  2. Content type: Research article

    Peak reverse torque (PRT) is a valid method to evaluate implants’ secondary stability in the healing bone. The secondary stability is achieved by the implant over time and it has been positively correlated wit...

    Authors: Remigiusz M. Grzeskowiak, Carrie Wheeler, Elizabeth Taylor, James Lillich, James Roush, Alexandru S. Biris and David E. Anderson

    Citation: BMC Veterinary Research 2019 15:321

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  3. Content type: Research article

    Non-steroidal anti-inflammatory drugs (NSAIDs) are an important tool in the management of canine osteoarthritis, with the most recent introduction into the category being grapiprant, a piprant that selectively...

    Authors: Andrea García de Salazar Alcalá, Lucile Gioda, Alia Dehman and Frederic Beugnet

    Citation: BMC Veterinary Research 2019 15:309

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  4. Content type: Research article

    Acetabular fractures comprise 12–30% of canine pelvic fractures and require accurate anatomic reduction and rigid stability to ensure proper healing and minimize future osteoarthritis. Many techniques have bee...

    Authors: Jonathan A. Blakely, James R. Butler, Lauren B. Priddy, Emily M. McCabe, Javier N. Avendaño, Steve H. Elder and Robert Wills

    Citation: BMC Veterinary Research 2019 15:287

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  5. Content type: Research article

    This study aimed to evaluate the safety and efficacy of reduced-dosage ketoprofen with or without tramadol in dogs. Five healthy dogs receiving standard-dosage ketoprofen (2 mg/kg SC, then 1 mg/kg PO daily) co...

    Authors: Beatriz P. Monteiro, Cedric Lambert, Elena Bianchi, Jean Pierre Genevois, Giulio Soldani and Eric Troncy

    Citation: BMC Veterinary Research 2019 15:213

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  6. Content type: Debate

    Bisphosphonates (BPs) are a family of molecules characterized by two key properties: their ability to bind strongly to bone mineral and their inhibitory effects on mature osteoclasts and thus bone resorption. ...

    Authors: Alexis Mitchell, Ashlee E. Watts, Frank H. Ebetino and Larry J. Suva

    Citation: BMC Veterinary Research 2019 15:211

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  7. Content type: Research article

    Joint injury is extremely common in equine athletes and post-traumatic osteoarthritis (PTOA), a progressive and debilitating disease, is estimated to affect 60% of horses in the USA. The limited potential for ...

    Authors: Alexis L. Gale, Renata M. Mammone, Michael E. Dodson, Renata L. Linardi and Kyla F. Ortved

    Citation: BMC Veterinary Research 2019 15:201

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  8. Content type: Research article

    Pedobarographic analyses detect pressure redistribution among limbs and within limbs in humans, equids and dogs. The main objective of this study was to assess the usefulness of a set of pedobarographic parame...

    Authors: Sergio López, José M. Vilar, Mónica Rubio, Joaquín J. Sopena, Angelo Santana, Oliver Rodríguez, José A. Rodríguez-Altonaga and José M. Carrillo

    Citation: BMC Veterinary Research 2019 15:193

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  9. Content type: Case Report

    Clinical outcome after cutaneous reconstruction using genicular artery flaps has not been reported. Major cutaneous defects of the pelvic limb between the stifle and hock are frequent in dogs and closure is di...

    Authors: Ciprian Ober, Joshua Milgram, William McCartney, Marian Taulescu, Cosmin Pestean, Iulia Melega and Liviu Oana

    Citation: BMC Veterinary Research 2019 15:158

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  10. Content type: Research article

    Bilateral non-traumatic cranial cruciate disease is frequently seen in originally unilateral cruciate pathology. Untreated cranial cruciate ligament disease and concurrent meniscal lesions cause progressive os...

    Authors: Elke Van der Vekens, Evelien de Bakker, Evelien Bogaerts, Bart J. G. Broeckx, Richard Ducatelle, Kaatje Kromhout and Jimmy H. Saunders

    Citation: BMC Veterinary Research 2019 15:146

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  11. Content type: Research article

    The limb center of pressure (COP) path measures and quantifies the load distribution within a limb in a still or moving subject. Under this premise, the aim of this study was to test whether data derived from ...

    Authors: Sergio López, José M. Vilar, Mónica Rubio, Joaquin J. Sopena, Elena Damiá, Déborah Chicharro, Angelo Santana and José M. Carrillo

    Citation: BMC Veterinary Research 2019 15:138

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  12. Content type: Research article

    In this research, using computed tomography (CT) and magnetic resonance imaging (MRI), we provide a thorough description of the standard appearance of a right tarsal joint in a Bengal tiger (Panthera tigris). CT ...

    Authors: Alberto Arencibia, Jorge Matos, Mario Encinoso, Francisco Gil, Alejandro Artiles, Francisco Martínez-Gomariz and José Maria Vázquez

    Citation: BMC Veterinary Research 2019 15:126

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  13. Content type: Research article

    The southern tamandua, Tamandua tetradactyla (Linnaeus, 1758), is the most common species of anteater. Even though much is known about its ecology, behavior, and parasites, there is very limited information about...

    Authors: Leonardo Cotts, Roberta V. Amaral, Maíra Laeta, Carlos A. Cunha-Filho and Ricardo Moratelli

    Citation: BMC Veterinary Research 2019 15:120

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  14. Content type: Research article

    Our understanding of the biology of osteoblasts is important as they underpin bone remodelling, fracture healing and processes such as osseointegration. Osteoblasts isolated from human humeral samples display ...

    Authors: Richard L. Meeson, Inês P. Perpétuo, Kevin Parsons, Isabel R. Orriss, Mittal Shah, Andrew A. Pitsillides and Michael Doube

    Citation: BMC Veterinary Research 2019 15:114

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  15. Content type: Research article

    High prevalence of musculoskeletal disorders in racehorses and its impact on horse welfare and racing economics call for improved measures of injury diagnosis and prevention. Serum biomarkers of bone and carti...

    Authors: Agnieszka J. Turlo, Anna Cywinska and David D. Frisbie

    Citation: BMC Veterinary Research 2019 15:66

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  16. Content type: Research article

    Due to the routine use of dexamethasone (DEX) in veterinary and human medicine and its negative impact on the rate of wound healing and skeletal muscle condition, we decided to investigate the effect of DEX on...

    Authors: Iwona Otrocka-Domagała, Katarzyna Paździor-Czapula and Michał Gesek

    Citation: BMC Veterinary Research 2019 15:56

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  17. Content type: Research article

    Young Standardbred horses frequently develop fragments in joints. Some fragments represent osteochondrosis; others are considered developmental, but it is uncertain whether they result from preceding osteochon...

    Authors: Eli H. S. Hendrickson, Sigrid Lykkjen, Nils I. Dolvik and Kristin Olstad

    Citation: BMC Veterinary Research 2018 14:390

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  18. Content type: Research article

    Three-dimensional joint kinematics during canine locomotion are commonly measured using skin marker-based stereophotogrammetry technologies. However, marker-related errors caused by the displacement of the ski...

    Authors: Cheng-Chung Lin, Chia-Lin Chang, Ming Lu, Tung-Wu Lu and Ching-Ho Wu

    Citation: BMC Veterinary Research 2018 14:389

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  19. Content type: Research article

    Internal plate fixation and, more recently, locking plate fixation are commonly used in the repair of fractures in small animal surgery. This retrospective study reviewed the use of the String of Pearls lockin...

    Authors: Matthew R. Field, Ryan Butler, Robert W. Wills and Wilburn M. Maxwell

    Citation: BMC Veterinary Research 2018 14:386

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  20. Content type: Research article

    The need for bone graft substitutes including those being developed to be applied together with new strategies of bone regeneration such as tissue engineering and cell-based approaches is growing. No large ani...

    Authors: James C. Ferguson, Stefan Tangl, Dirk Barnewitz, Antje Genzel, Patrick Heimel, Veronika Hruschka, Heinz Redl and Thomas Nau

    Citation: BMC Veterinary Research 2018 14:330

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  21. Content type: Methodology article

    The presence of cranial tibial subluxation can aid in the detection of joint instability as a result of CrCL injury. Detection of cranial tibial subluxation has been described using the tibial compression test...

    Authors: Katrina A. Castaneda, Caleb C. Hudson and Brian S. Beale

    Citation: BMC Veterinary Research 2018 14:270

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  22. Content type: Research article

    Mechanical interactions between hard floorings and the sole of bovine claws can be reasonable to cause traumatic claw lesions. In this ex vivo study, the direct kinetic impact of concrete and three types of ru...

    Authors: Benjamin Oehme, S. M. Geiger, S. Grund, K. Hainke, J. Munzel and C. K. W. Mülling

    Citation: BMC Veterinary Research 2018 14:259

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  23. Content type: Research article

    Cranial cruciate ligament rupture is the most frequent orthopedic disorder in human and animals. An array of surgical techniques have been described to stabilize the stifle joint in dogs, including intraarticu...

    Authors: Yauheni Zhalniarovich, Marta Mieszkowska, Paulina Przyborowska-Zhalniarovich, Joanna Głodek, Andrzej Sobolewski, Grzegorz Waluś and Zbigniew Adamiak

    Citation: BMC Veterinary Research 2018 14:231

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  24. Content type: Methodology article

    Stifle arthroscopy has been described to have high sensitivity and specificity in the evaluation of menisci in dogs, particularly for the medial meniscus. However, the visualization of menisci can be difficult...

    Authors: Gian Luca Rovesti, Veronica Devesa, Laura Bertorelli and Jesus Rodriguez-Quiros

    Citation: BMC Veterinary Research 2018 14:212

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  25. Content type: Research article

    Inflammatory and degenerative activity inside the joint can be studied in vivo via analysis of synovial fluid (SF) biomarkers, which are molecular markers of inflammatory processes and tissue turnover. The aim...

    Authors: Tytti M. Niemelä, Riitta-Mari Tulamo, Kaisa Aaltonen, Satu M. Sankari and Anna K. Hielm-Björkman

    Citation: BMC Veterinary Research 2018 14:186

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  26. Content type: Research article

    Mammaglobin, a member of secretoglobin family has been recognized as a breast cancer associated protein. Though the exact function of the protein is not fully known, its expression has been reported to be upre...

    Authors: Mamta Pandey, B. V. Sunil Kumar, Kuldip Gupta, Ram Saran Sethi, Ashwani Kumar and Ramneek Verma

    Citation: BMC Veterinary Research 2018 14:184

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  27. Content type: Research article

    Bone healing and assessment of the state of bone bridging is an important part of clinical orthopedics, whether for fracture healing or for follow up of osteotomy procedures. Tibial tuberosity advancement (TTA...

    Authors: Marije Risselada, Matthew D. Winter, Daniel D. Lewis, Emily Griffith and Antonio Pozzi

    Citation: BMC Veterinary Research 2018 14:164

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  28. Content type: Research article

    Despite the importance of inflammation during the pathogenesis of cranial cruciate ligament disease (CCLD) in dogs and despite the latest knowledge suggesting a significant role of adipose tissue in osteoarthr...

    Authors: Manuel R. Schmidli, Bettina Fuhrer, Nadine Kurt, David Senn, Michaela Drögemüller, Ulrich Rytz, David E. Spreng and Simone Forterre

    Citation: BMC Veterinary Research 2018 14:161

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  29. Content type: Research article

    Static posturography and pedobarography are based on the detection of postural imbalance and, consequently, the pressure redistribution between limbs in lame subjects. These techniques have proven to be useful...

    Authors: Lidia Pitti, Maarten Oosterlinck, Maria L. Díaz-Bertrana, José M. Carrillo, Mónica Rubio, Joaquin Sopena, Angelo Santana and José M. Vilar

    Citation: BMC Veterinary Research 2018 14:151

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  30. Content type: Research article

    Pathological changes and resulting functional impairment of the temporomandibular joint (TMJ) can substantially affect physical condition, morbidity, and mortality of wildlife species. Analysis of TMJ disorder...

    Authors: Catharina Ludolphy, Patricia Kahle, Horst Kierdorf and Uwe Kierdorf

    Citation: BMC Veterinary Research 2018 14:150

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  31. Content type: Research article

    The equine m. gluteus medius (GM) is the largest muscle of the horse, its main movement function is the extension of the hip joint. The objective of the present study was to measure equine GM activity in three...

    Authors: Rebeka R. Zsoldos, Anna Voegele, Bjoern Krueger, Ulrike Schroeder, Andreas Weber and Theresia F. Licka

    Citation: BMC Veterinary Research 2018 14:126

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  32. Content type: Research article

    The usefulness of studying posture and its modifications due to locomotor deficiencies of multiple origins has been widely proven in humans. To assess its suitability in the canine species, static posturograph...

    Authors: José M. Carrillo, Maria E. Manera, Mónica Rubio, Joaquin Sopena, Angelo Santana and José M. Vilar

    Citation: BMC Veterinary Research 2018 14:108

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  33. Content type: Research article

    Tiludronate and clodronate are FDA-approved bisphosphonate drug therapies for navicular disease in horses. Although clinical studies have determined their ability to reduce lameness associated with skeletal di...

    Authors: Heather A. Richbourg, Colin F. Mitchell, Ashley N. Gillett and Margaret A. McNulty

    Citation: BMC Veterinary Research 2018 14:105

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  34. Content type: Research article

    Intra-articular administration of stanozolol has shown promising results by improving the clinical management of lameness associated with naturally-occurring osteoarthritis (OA) in horses, and by decreasing os...

    Authors: Mariana Castro Martins, Mandy J. Peffers, Katie Lee and Luis M. Rubio-Martinez

    Citation: BMC Veterinary Research 2018 14:103

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  35. Content type: Research article

    Finite element analysis was used to compare fixation methods for double pelvic osteotomy (DPO). Using 3D scanning a stereolithography (stl) image was produced of a canine pelvis and this was subsequently refin...

    Authors: William McCartney, Bryan MacDonald, Ciprian Andrei Ober, Rubén Lostado-Lorza and Fátima Somovilla Gómez

    Citation: BMC Veterinary Research 2018 14:100

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  36. Content type: Research article

    Cranial cruciate ligament (CrCL) insufficiency is a degenerative condition that is a common cause of pelvic limb lameness and osteoarthritis in dogs. Surgical therapies developed to treat dogs with naturally o...

    Authors: Selena Tinga, Stanley E. Kim, Scott A. Banks, Stephen C. Jones, Brian H. Park, Antonio Pozzi and Daniel D. Lewis

    Citation: BMC Veterinary Research 2018 14:85

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  37. Content type: Research article

    We have previously demonstrated that a mixture of Curcuminoids extract, hydrolyzed COllagen and green Tea extract (CCOT) inhibited inflammatory and catabolic mediator’s synthesis by bovine and human chondrocyt...

    Authors: Fanny Comblain, Nicolas Barthélémy, Michael Lefèbvre, Cédric Schwartz, Isabelle Lesponne, Samuel Serisier, Alexandre Feugier, Marc Balligand and Yves Henrotin

    Citation: BMC Veterinary Research 2017 13:395

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  38. Content type: Research article

    Despite the use of water treadmills (WT) in conditioning horses, the intensity of WT exercise has not been well documented. The workload on a WT is a function of water height and treadmill speed. Therefore, th...

    Authors: Persephone Greco-Otto, Stephanie Bond, Raymond Sides, Grace P. S. Kwong, Warwick Bayly and Renaud Léguillette

    Citation: BMC Veterinary Research 2017 13:360

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  39. Content type: Research article

    Osteochondrosis (OC) is a common, clinically important joint disorder in which endochondral ossification is focally disturbed. Reduced blood supply to growing cartilage is considered an important cause of the ...

    Authors: E. M. van Grevenhof, A. R. D. Gezelle Meerburg, M. C. van Dierendonck, A. J. M. van den Belt, B. van Schaik, P. Meeus and W. Back

    Citation: BMC Veterinary Research 2017 13:324

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  40. Content type: Research article

    Intravenous regional anaesthesia (IVRA) and hindfoot four-point nerve block anaesthesia (NBA) are recommended for local anaesthesia (LA) in the distal limb of dairy cows. Two studies were conducted to compare ...

    Authors: S. Yavari, N. Khraim, G. Szura, A. Starke, E. Engelke, C. Pfarrer, K. Hopster, M. Schmicke, W. Kehler, M. Heppelmann, S. B. R. Kästner and J. Rehage

    Citation: BMC Veterinary Research 2017 13:320

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  41. Content type: Research article

    Chondrotoxic effects of local anaesthetics are well reported in humans and some animal species but knowledge on their toxic effects on synoviocytes or equine chondrocytes or the effects on cellular production ...

    Authors: L. M. Rubio-Martínez, E. Rioja, M. Castro Martins, S. Wipawee, P. Clegg and M. J. Peffers

    Citation: BMC Veterinary Research 2017 13:318

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  42. Content type: Research article

    The physis is the weakest component of immature long bones, and physeal fractures constitute about 30% of fractures in growing dogs. Fractures of the proximal humeral physis typically have a Salter Harris type...

    Authors: Jiawen Ma, Tian Wang, Vedran Lovric, Kenneth A. Johnson and William R. Walsh

    Citation: BMC Veterinary Research 2017 13:306

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  43. Content type: Research article

    Articular osteochondrosis is a common cause of leg weakness in pigs and is defined as a focal delay in the endochondral ossification of the epiphysis. The first demonstrated steps in the pathogenesis consist o...

    Authors: Andreas Finnøy, Kristin Olstad and Magnus B. Lilledahl

    Citation: BMC Veterinary Research 2017 13:270

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  44. Content type: Research article

    Complete rupture of the cranial cruciate ligament (CrCL) in dogs causes profound disturbance to stifle joint biomechanics. The objective of this study was to characterize the effects of cranial cruciate ligame...

    Authors: Stanley E. Kim, Geoffrey J. Zann, Selena Tinga, Erica J. Moore, Antonio Pozzi and Scott A. Banks

    Citation: BMC Veterinary Research 2017 13:250

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  45. Content type: Research article

    Currently, the best resources for assessment of bone tissue using imaging techniques are expensive and available in few medical facilities, thus serum or urinary bone turnover biomarkers could be useful as ear...

    Authors: José A. Camassa, Camila C. Diogo, João P. A. Bordelo, Marília de A. Bonelli, Carlos A. Viegas, Jorge T. Azevedo, Nuno Dourado and Isabel R. Dias

    Citation: BMC Veterinary Research 2017 13:239

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  46. Content type: Research article

    We recently reported that a conformation score derived from the tibial plateau angle (TPA) and the femoral anteversion angle (FAA), best discriminates limbs predisposed to, or affected by cranial cruciate liga...

    Authors: Devin P. Cunningham, Ayman A. Mostafa, Wanda J. Gordan-Evans, Randy J. Boudrieau and Dominique J. Griffon

    Citation: BMC Veterinary Research 2017 13:235

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