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Clinical pathology, physiology and immunology

The Clinical Pathology, Physiology and Immunology considers all sound science research study types in which laboratory analysis and the use of biomarkers have a major role in enhancing our understanding of animal health. This section is open to any animal species and comparative studies are also considered. Studies must be scientifically valid; for research articles this includes a scientifically sound research question, the use of suitable methods and analysis, and following community-agreed standards relevant to the research field.

 The main topics covered in this section include:

  •   Laboratory assays and methods validation
  •   Laboratory methods applied to study pathophysological changes in disease
  •   Hematology
  •   Clinical Biochemistry
  •   Endocrinology Tests
  •   Immunological Assays
  •   Cytology
  •   Development and validation of new biomarkers including proteomic studies

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  1. Both genetic background and finishing system can alter fat deposition, thus indicating their influence on adipogenic and lipogenic factors. However, the molecular mechanisms underlying fat deposition and fatty...

    Authors: Ana Sofia Henriques da Costa, Virgínia Maria Rico Pires, Carlos Mendes Godinho Andrade Fontes and José António Mestre Prates

    Citation: BMC Veterinary Research 2013 9:118

    Content type: Research article

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  2. In the present study, the influence of bacterial infection, lipopolysacharides (LPS) and hydroxyethyl starch (HES) on platelet function in a parallel plate flow chamber were measured. Experiments were performe...

    Authors: Annika Ferkau, Hans-Jörg Gillmann, Reinhard Mischke, Simone Calmer, Silke Ecklebe, Monia Abid, Jan-Wighard Minde, Frank Echtermeyer and Gregor Theilmeier

    Citation: BMC Veterinary Research 2013 9:112

    Content type: Research article

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  3. Vibriosis caused by V. anguillarum is a commonly encountered disease in Atlantic cod farms and several studies indicate that the initiation of infection occurs after the attachment of the pathogen to the mucosal ...

    Authors: Binoy Rajan, Jep Lokesh, Viswanath Kiron and Monica F Brinchmann

    Citation: BMC Veterinary Research 2013 9:103

    Content type: Research article

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  4. Ruminal acidosis is responsible for the onset of different pathologies in dairy and feedlot cattle, but there are major difficulties in the diagnosis. This study modelled the data obtained from various blood v...

    Authors: Giorgio Marchesini, Roberta De Nardi, Matteo Gianesella, Anna-Lisa Stefani, Massimo Morgante, Antonio Barberio, Igino Andrighetto and Severino Segato

    Citation: BMC Veterinary Research 2013 9:98

    Content type: Research article

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  5. Serum amyloid A (SAA) is the major acute phase protein in horses. Its concentration increases in various pathologies but also in response to prolonged, strenuous effort. The purpose of this study was to establ...

    Authors: Anna Cywinska, Lucjan Witkowski, Ewa Szarska, Antoni Schollenberger and Anna Winnicka

    Citation: BMC Veterinary Research 2013 9:91

    Content type: Research article

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  6. Fatty liver is a major metabolic disorder in dairy cows and is believed to result in major economic losses in dairy farming due to decreased health status, reproductive performance and fertility. Currently, th...

    Authors: Ayman Samir Farid, Kazuyuki Honkawa, Eman Mohamed Fath, Nariaki Nonaka and Yoichiro Horii

    Citation: BMC Veterinary Research 2013 9:73

    Content type: Research article

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  7. This study was conducted to evaluate the effects of L-arginine (Arg) on photomicrographs and HSP70 expression in the liver of weanling piglets. Twelve healthy Landrace × Yorkshire piglets that had been weaned ...

    Authors: Xin Wu, Chunyan Xie, Yulong Yin, Fengna Li, Tiejun Li, Ruilin Huang, Zheng Ruan and Zeyuan Deng

    Citation: BMC Veterinary Research 2013 9:63

    Content type: Research article

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  8. The object of this study was to describe and contrast the kinetics of the humoral response in serum and oral fluid specimens during acute porcine reproductive and respiratory syndrome virus (PRRSV) infection. ...

    Authors: Apisit Kittawornrat, Mark Engle, Yaowalak Panyasing, Chris Olsen, Kent Schwartz, Anna Rice, Sergio Lizano, Chong Wang and Jeffrey Zimmerman

    Citation: BMC Veterinary Research 2013 9:61

    Content type: Research article

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  9. Despite the importance of abnormalities in lipoprotein metabolism in clinical canine medicine, the fact that most previously used methods for lipoprotein profiling are rather laborious and time-consuming has b...

    Authors: Panagiotis G Xenoulis, Paul J Cammarata, Rosemary L Walzem, Ronald D Macfarlane, Jan S Suchodolski and Jörg M Steiner

    Citation: BMC Veterinary Research 2013 9:47

    Content type: Research article

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  10. Robenacoxib is a novel and highly selective inhibitor of COX-2 in dogs and cats and because of its acidic nature is regarded as being tissue-selective. Thirty four dogs with stifle osteoarthritis secondary to ...

    Authors: David Bennett, Peter David Eckersall, Mary Waterston, Veronica Marchetti, Alessandra Rota, Eilidh McCulloch and Silvia Sbrana

    Citation: BMC Veterinary Research 2013 9:42

    Content type: Research article

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  11. There is no information on the effects of the breed, gender and age on the cellular content and growth factor (GF) release from equine pure-platelet rich plasma (P-PRP) and pure-platelet rich gel (P-PRG). The ...

    Authors: Carlos E Giraldo, Catalina López, María E Álvarez, Ismael J Samudio, Marta Prades and Jorge U Carmona

    Citation: BMC Veterinary Research 2013 9:29

    Content type: Research article

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  12. Dogs are commonly affected by hyperglycemic conditions. Hyperglycemia compromises the immune response and favors bacterial infections; however, reports on the effects of glucose on neutrophil oxidative metabol...

    Authors: Anelise M Bosco, Breno FM de Almeida, Priscila P Pereira, Luis G Narciso, Valéria MF Lima and Paulo C Ciarlini

    Citation: BMC Veterinary Research 2013 9:24

    Content type: Research article

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  13. Bovine neonatal pancytopenia (BNP) is a disease syndrome in newborn calves of up to four weeks of age, first observed in southern Germany in 2006. By now, cases have been reported in several countries around t...

    Authors: Kerstin N Euler, Stefanie M Hauck, Marius Ueffing and Cornelia A Deeg

    Citation: BMC Veterinary Research 2013 9:18

    Content type: Research article

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  14. Enzyme-linked immunosorbent assay (ELISA) is often used to test wildlife samples for Mycobacterium avium subsp. paratuberculosis (MAP) infection. However, commercially available kits are only validated for use wi...

    Authors: Mathieu Pruvot, Taya L Forde, Jillian Steele, Susan J Kutz, Jeroen De Buck, Frank van der Meer and Karin Orsel

    Citation: BMC Veterinary Research 2013 9:5

    Content type: Research article

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  15. The objective was to determine the effects of agility exercise on dogs of different skill levels with respect to urinary eicosanoids, urinary 15F2t-isoprostane (lipid peroxidation marker) and hematological/bioche...

    Authors: Wendy I Baltzer, Anna M Firshman, Bernadette Stang, Jennifer J Warnock, Elena Gorman and Erica C McKenzie

    Citation: BMC Veterinary Research 2012 8:249

    Content type: Research article

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  16. Biomarkers for the early prediction of canine acute kidney injury (AKI) are clinically important. Recently, neutrophil gelatinase-associated lipocalin (NGAL) was found to be a sensitive biomarker for the predi...

    Authors: Ya-Jane Lee, Yu-Yen Hu, Yi-Shan Lin, Chun-Ting Chang, Fong-Yuan Lin, Min-Liang Wong, Hsu Kuo-Hsuan and Wei-Li Hsu

    Citation: BMC Veterinary Research 2012 8:248

    Content type: Research article

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    The Erratum to this article has been published in BMC Veterinary Research 2013 9:228

  17. Inadequate nutrition in utero may retard foetal growth and alter physiological development of offspring. This study investigated the effects of low and high protein diets fed to primiparous German Landrace sows t...

    Authors: Margret Tuchscherer, Winfried Otten, Ellen Kanitz, Maria Gräbner, Armin Tuchscherer, Olaf Bellmann, Charlotte Rehfeldt and Cornelia C Metges

    Citation: BMC Veterinary Research 2012 8:232

    Content type: Research article

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  18. There are not reported regarding the protocols for obtaining platelet concentrates (PC) in cats for medical purposes. The objectives of this study were: 1) to describe a manual method for producing two kinds o...

    Authors: Raul F Silva, María E Álvarez, Diana L Ríos, Catalina López, Jorge U Carmona and Cleuza MF Rezende

    Citation: BMC Veterinary Research 2012 8:212

    Content type: Research article

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  19. Hematologic and biochemical data are needed to characterize the health status of animal populations over time to determine the habitat quality and captivity conditions. Blood components and the chemical entiti...

    Authors: Julia Marchal, Olène Dorieux, Laurine Haro, Fabienne Aujard and Martine Perret

    Citation: BMC Veterinary Research 2012 8:211

    Content type: Research article

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  20. Toll-like receptor 2 (TLR2) is important to host recognition of invading gram-positive microbes. In goats, these microbes can cause serious mastitis, anthrax, tetanus, and other problems. Transgenic goats cons...

    Authors: Shoulong Deng, Kun Yu, Baolu Zhang, Yuchang Yao, Yufeng Liu, Haijuan He, Hongtao Zhang, Maosheng Cui, Juncai Fu, Zhengxing Lian and Ning Li

    Citation: BMC Veterinary Research 2012 8:196

    Content type: Research article

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  21. Laser surgery is an attractive alternative to other means of section device in terms of tissue inflammation and interaction, which has been extensively used in human and veterinary medicine. Although accidenta...

    Authors: Tommaso Collarile, Nicola Di Girolamo, Giordano Nardini, Ivano Antonio Ciraci and Paolo Selleri

    Citation: BMC Veterinary Research 2012 8:177

    Content type: Case report

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  22. Mucosal epithelia, including those of the oviduct, secrete antimicrobial innate immune molecules (AIIMS). These have bactericidal/bacteriostatic functions against a variety of pathogens. Among the AIIMs, sheep...

    Authors: Shiyong Wen, Guifang Cao, Tuya Bao, LanLing Cheng, Haijun Li, Chenguang Du, Yong Tu, Qi Li, Ruizhen Jian and Pengwei Zhao

    Citation: BMC Veterinary Research 2012 8:143

    Content type: Research article

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  23. The rabbit is a common animal model for ophthalmic research, especially corneal research. Ocular structures grow rapidly during the early stages of life. It is unclear when the rabbit cornea becomes mature and...

    Authors: Andri K Riau, Neil YS Tan, Romesh I Angunawela, Hla M Htoon, Shyam S Chaurasia and Jodhbir S Mehta

    Citation: BMC Veterinary Research 2012 8:138

    Content type: Research article

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  24. Corticosteroids are illegally used in several countries as growth promoters in veal calves and beef cattle, either alone or in association with sex steroids and β-agonists, especially at low dosages and primar...

    Authors: Marta Vascellari, Katia Capello, Annalisa Stefani, Giancarlo Biancotto, Letizia Moro, Roberto Stella, Giandomenico Pozza and Franco Mutinelli

    Citation: BMC Veterinary Research 2012 8:129

    Content type: Research article

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  25. The clinical use of autologous platelet concentrates (also known as platelet-rich plasma) on the field of regenerative therapy, in the last decade has been the subject of several studies especially in equine m...

    Authors: Raul F Silva, Jorge U Carmona and Cleuza MF Rezende

    Citation: BMC Veterinary Research 2012 8:121

    Content type: Research article

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  26. In mammals, the ovarian follicular reserve is highly variable between individuals and impacts strongly on ovarian function and fertility. Nowadays, the best endocrine marker of this reserve in human, mouse and...

    Authors: Belén Lahoz, José L Alabart, Danielle Monniaux, Pascal Mermillod and José Folch

    Citation: BMC Veterinary Research 2012 8:118

    Content type: Research article

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  27. Alterations in lipid metabolism occur when animals are exposed to different feeding systems. In the last few decades, the characterisation of genes involved in fat metabolism and technological advances have en...

    Authors: Elda Dervishi, Margalida Joy, Albina Sanz, Javier Alvarez-Rodriguez, Francisco Molino and Jorge H Calvo

    Citation: BMC Veterinary Research 2012 8:106

    Content type: Research article

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  28. Control of currently circulating re-assorted low-pathogenicity avian influenza (LPAI) H9N2 is a major concern for both animal and human health. Thus, an improved LPAI H9N2 vaccination strategy is needed to ind...

    Authors: Md Masudur Rahman, Erdenebileg Uyangaa, Young Woo Han, Seong Bum Kim, Jin Hyoung Kim, Jin Young Choi and Seong Kug Eo

    Citation: BMC Veterinary Research 2012 8:105

    Content type: Research article

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