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Clinical pathology, physiology and immunology

Section edited by Prof. Jose Joaquin Ceron

The clinical pathology, physiology and immunology section considers a broad range of submissions discussing the physiological processes that occur in healthy animals and underlie stress and disease. This includes, but not limited to, studies on biomarkers, biochemistry, cytopathology, endocrinology, pathophysiology, proteomics, hematopathology, immunology, and molecular diagnostics. Comparative medicine studies are also considered. 

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  1. Content type: Research article

    The weaning period is critical for stress-related diseases and infections. Currently, large amounts of therapeutic antimicrobials are used to treat infections in the livestock production, especially in piglets...

    Authors: Tobias Gräber, Holger Kluge, Sebastian Granica, Gert Horn, Corinna Brandsch and Gabriele I Stangl

    Citation: BMC Veterinary Research 2014 10:210

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  2. Content type: Research article

    Nasal secretion (NS) was investigated as a source of information regarding the mucosal and systemic immune status of cattle challenged by respiratory disease. A method for the collection of substantial volumes...

    Authors: M Faizal Ghazali, HH Caline Koh-Tan, Mark McLaughlin, Paul Montague, Nicholas N Jonsson and P David Eckersall

    Citation: BMC Veterinary Research 2014 10:204

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  3. Content type: Research article

    Feeding polyphenol-rich plant products has been shown to increase the gain:feed ratio in growing pigs. The reason for this finding has not yet been elucidated. In order to find the reasons for an increase of t...

    Authors: Anja Fiesel, Denise K Gessner, Erika Most and Klaus Eder

    Citation: BMC Veterinary Research 2014 10:196

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  4. Content type: Research article

    This study investigated effects on cardiovascular parameters during anaesthesia with isoflurane (ISO, 2-3 Vol%), ketamine-xylazine (KX, 100 mg kg-1 + 5 mg kg-1) or a combination of medetomidine-midazolam-fentanyl...

    Authors: Maike Albrecht, Julia Henke, Sabine Tacke, Michael Markert and Brian Guth

    Citation: BMC Veterinary Research 2014 10:198

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  5. Content type: Research article

    Establishment of haematological and biochemical reference intervals is important to assess health of animals on individual and population level. Reference intervals for 13 haematological and 34 biochemical var...

    Authors: Anne Randi Græsli, Åsa Fahlman, Alina L Evans, Mads Frost Bertelsen, Jon Martin Arnemo and Søren Saxmose Nielsen

    Citation: BMC Veterinary Research 2014 10:183

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  6. Content type: Research article

    Epidermal growth factor (EGF) is an important growth factor in regulation of cell proliferation, differentiation, survival and apoptosis. Studies showed that food-grade Lactococcus lactis (L. lactis) and NICE exp...

    Authors: Dingyue Wang, Shengyu Xu, Yan Lin, Zhengfeng Fang, Lianqiang Che, Bai Xue and De Wu

    Citation: BMC Veterinary Research 2014 10:171

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  7. Content type: Research article

    The exact aetiology of canine sino-nasal aspergillosis (SNA) is unknown. In man, dysfunction in innate immunity, particularly in the function of pattern recognition receptors, is implicated in the pathogenesis...

    Authors: Elise Mercier, Iain R Peters, Frédéric Farnir, Rachel Lavoué, Michael Day, Cécile Clercx and Dominique Peeters

    Citation: BMC Veterinary Research 2014 10:187

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  8. Content type: Research article

    Decreasing the rate of protein emptying from the stomach may improve efficiency of utilization of dietary amino acids for protein deposition. Some studies in rats and humans have shown casein to be more slowly...

    Authors: Tanya J Tycholis, John P Cant, Vern R Osborne and Anna K Shoveller

    Citation: BMC Veterinary Research 2014 10:177

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  9. Content type: Research article

    The objective of this study was to investigate the effects of feeding a high-concentrate corn straw diet on the release of endotoxin in the rumen and the changes of pro-inflammatory cytokines in the mammary gl...

    Authors: Jun Zhou, Guozhong Dong, Changjin Ao, Sen Zhang, Min Qiu, Xi Wang, Yongxia Wu, Khas Erdene, Lu Jin, Chunlong Lei and Zhu Zhang

    Citation: BMC Veterinary Research 2014 10:172

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  10. Content type: Research article

    Non-alcoholic fatty liver disease (NAFLD), an emerging public health problem, may be a highly atherogenic condition. But the relationship between fatty liver diseases and carotid atherosclerosis in small-anima...

    Authors: Jing Wu, Hua Zhang, Hao Zheng and Ying Jiang

    Citation: BMC Veterinary Research 2014 10:162

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  11. Content type: Research article

    In any calf rearing system it is desirable to obtain healthy animals, and reduce morbidity, mortality, and economic losses. Bovine syndesmochorial placentation prevents the direct transfer of bovine immunoglob...

    Authors: Teódulo Quezada-Tristán, Viridiana L García-Flor, Raúl Ortiz-Martínez, José L Arredondo-Figueroa, Leticia E Medina-Esparza, Arturo G Valdivia-Flores and Ana L Montoya-Navarrete

    Citation: BMC Veterinary Research 2014 10:159

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  12. Content type: Research article

    Previously, we evaluated a minimally invasive epidermal lipid sampling method called skin scrub, which achieved reproducible and comparable results to skin scraping. The present study aimed at investigating re...

    Authors: Mandy Angelbeck-Schulze, Reinhard Mischke, Karl Rohn, Marion Hewicker-Trautwein, Hassan Y Naim and Wolfgang Bäumer

    Citation: BMC Veterinary Research 2014 10:152

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  13. Content type: Research article

    Probiotics are beneficial bacteria that are able to colonize the host digestive system, increasing the natural flora and preventing colonization of pathogenic organisms and thus, securing optimal utility of th...

    Authors: Teck Chwen Loh, Di Wai Choe, Hooi Ling Foo, Awis Qurni Sazili and Mohd Hair Bejo

    Citation: BMC Veterinary Research 2014 10:149

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  14. Content type: Research article

    Photoperiod is known to cause physiological changes in seasonal mammals, including changes in body weight, physical activity, reproductive status, and adipose tissue gene expression in several species. The obj...

    Authors: Akihiro Mori, Kelly L Kappen, Anna C Dilger and Kelly S Swanson

    Citation: BMC Veterinary Research 2014 10:146

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  15. Content type: Research article

    Conjugated linoleic acid (CLA), a C18 fatty acid with conjugated double bonds, has been shown to serve as a powerful anti-obesity agent by several research groups, although the precise mechanism remains elusiv...

    Authors: Renli Qi, Feiyun Yang, Jinxiu Huang, Han Peng, Yan Liu and Zuohua Liu

    Citation: BMC Veterinary Research 2014 10:141

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  16. Content type: Research article

    Glucokinase (GK) is a metabolic enzyme encoded by the GCK gene and expressed in glucose-sensitive tissues, principally pancreatic islets cell and hepatocytes. The GK protein acts in pancreatic islets as a “glucos...

    Authors: Sara Lindbloom-Hawley, Michelle LeCluyse, Vanessa Vandersande, Gerald Henry Lushington and Thomas Schermerhorn

    Citation: BMC Veterinary Research 2014 10:130

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  17. Content type: Research article

    Passively acquired maternal derived immunity (MDI) is a double-edged sword. Maternal derived antibody-mediated immunity (AMI) and cell-mediated immunity (CMI) are critical immediate defenses for the neonate; h...

    Authors: Meggan Bandrick, Kara Theis and Thomas W Molitor

    Citation: BMC Veterinary Research 2014 10:124

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  18. Content type: Research article

    Serotonin (5-hydroytryptamine or 5HT) is associated with numerous behavioral and psychological factors and is a biochemical marker of mood. 5HT is involved in the hypothalamic regulation of energy consumption....

    Authors: Hyung-Jin Park, Sang-Eun Lee, Jung-Hyun Oh, Kyoung-Won Seo and Kun-Ho Song

    Citation: BMC Veterinary Research 2014 10:113

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  19. Content type: Research article

    Canine babesiosis is a tick-borne disease that is caused by the haemoprotozoan parasites of the genus Babesia. There are limited data on serum proteomics in dogs, and none of the effect of babesiosis on the serum...

    Authors: Josipa Kuleš, Vladimir Mrljak, Renata Barić Rafaj, Jelena Selanec, Richard Burchmore and Peter D Eckersall

    Citation: BMC Veterinary Research 2014 10:111

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  20. Content type: Research article

    Oxidative stress and inflammation can be altered by dietary factors in various species. However, little data are available in true carnivorous species such as domestic cats. As numerous anti-inflammatory and a...

    Authors: Adronie Verbrugghe, Geert PJ Janssens, Hannelore Van de Velde, Eric Cox, Stefaan De Smet, Bruno Vlaeminck and Myriam Hesta

    Citation: BMC Veterinary Research 2014 10:104

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  21. Content type: Research article

    The abomasal helminth Teladorsagia circumcincta is one of the most economically important parasites affecting sheep in temperate regions. Infection is particularly detrimental to lambs, in which it can cause pron...

    Authors: Nicola M Craig, David W Smith, Judith A Pate, Ivan W Morrison and Pamela A Knight

    Citation: BMC Veterinary Research 2014 10:87

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  22. Content type: Research article

    Colostrum intake by newborn lambs plays a fundamental role in the perinatal period, ensuring lamb survival. In this study, blood plasma samples from two groups of newborn lambs (Colostrum group and Delayed Col...

    Authors: Lorenzo Enrique Hernández-Castellano, André Martinho Almeida, Miguel Ventosa, Ana Varela Coelho, Noemí Castro and Anastasio Argüello

    Citation: BMC Veterinary Research 2014 10:85

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  23. Content type: Research article

    Endogamy increases the risk of manifestation of deleterious recessive genes. Mitochondrial DNA allows the separation of American Zebu (Bos indicus and Bos taurus) and evaluate the effect of mitochondrial DNA on p...

    Authors: Auricélio A Macedo, Joely F F Bittar, Paula B Bassi, Juliano B Ronda, Eustáquio R Bittar, João C C Panetto, Márcio S S Araujo, Renato L Santos and Olindo A Martins-Filho

    Citation: BMC Veterinary Research 2014 10:79

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  24. Content type: Review

    Paraoxonase 1 (PON1) is a widely studied enzyme based on its protective role against poisoning by organophosphate (OP) metabolites of specific OP insecticides and in vascular disease, as well as its use as bio...

    Authors: Jose J Ceron, Fernando Tecles and Asta Tvarijonaviciute

    Citation: BMC Veterinary Research 2014 10:74

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  25. Content type: Research article

    The aim of this study is to compare metabolic parameters, malondialdehyde as a lipid oxidation marker, and lipid profiles between dogs with untreated hyperlipidemia and hyperlipidemia with treatment, in order ...

    Authors: Gebin Li, Koh Kawasumi, Yuki Okada, Shingo Ishikawa, Ichiro Yamamoto, Toshiro Arai and Nobuko Mori

    Citation: BMC Veterinary Research 2014 10:67

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  26. Content type: Research article

    The effect of digoxin administration on the serum concentration of the cardiac troponin I (cTnI) has not been reported to date in equidae. This study was therefore designed to evaluate the effect of digoxin on...

    Authors: Mohamed Tharwat and Fahd Al-Sobayil

    Citation: BMC Veterinary Research 2014 10:64

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  27. Content type: Research article

    Fish meal and fish oil are increasingly replaced by ingredients from terrestrial sources in the feeds for farmed salmonids due to expanding production and reduced availability of marine feed raw material. Fish...

    Authors: Torfinn Moldal, Guro Løkka, Jannicke Wiik-Nielsen, Lars Austbø, Bente E Torstensen, Grethe Rosenlund, Ole Bendik Dale, Magne Kaldhusdal and Erling Olaf Koppang

    Citation: BMC Veterinary Research 2014 10:60

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  28. Content type: Research article

    In dogs, occurrence of lipid metabolism disorders such as obesity and diabetes mellitus has increased markedly in recent years. Hyperlipidemia has been regarded as a common characteristic for obese animals and...

    Authors: Koh Kawasumi, Nanae Kashiwado, Yuki Okada, Masaki Sawamura, Yasuhiro Sasaki, Eiji Iwazaki, Nobuko Mori, Ichiro Yamamoto and Toshiro Arai

    Citation: BMC Veterinary Research 2014 10:57

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  29. Content type: Research article

    In dairy cows, the periparturient phase is a stressful period, which is commonly associated with strong metabolic adaptations and the development of pathophysiologic conditions and disorders. Some of the sympt...

    Authors: Denise K Gessner, Gloria Schlegel, Robert Ringseis, Frieder J Schwarz and Klaus Eder

    Citation: BMC Veterinary Research 2014 10:46

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  30. Content type: Methodology article

    Mycoplasma bovis (M. bovis) is a major, but often overlooked, pathogen documented to cause respiratory disease, mastitis, and arthritis in cattle throughout China since 2008. Here, we report the development of a ...

    Authors: Ping Fu, Zhenhong Sun, Yuewei Zhang, Ziqiang Yu, Haiyan Zhang, Dan Su, Fei Jiang and Wenxue Wu

    Citation: BMC Veterinary Research 2014 10:42

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  31. Content type: Research article

    Dysregulation of apoptosis has been implicated in a range of diseases including tumors, neurodegenerative and autoimmine diseases, as well as allergic asthma and chronic obstructive pulmonary disease (COPD) in...

    Authors: Artur Niedzwiedz, Zbigniew Jaworski, Bartlomiej Tykalowski and Marcin Smialek

    Citation: BMC Veterinary Research 2014 10:29

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  32. Content type: Research article

    Despite the precise pathogenesis of atopic dermatitis (AD) is unknown, an immune dysregulation that causes Th2-predominant inflammation and an intrinsic defect in skin barrier function are currently the two ma...

    Authors: Francesca Abramo, Luca Campora, Francesco Albanese, Maria Federica della Valle, Luigia Cristino, Stefania Petrosino, Vincenzo Di Marzo and Vincenzo Miragliotta

    Citation: BMC Veterinary Research 2014 10:21

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  33. Content type: Methodology article

    Presently, few data exist on the level and duration of anti-protective antigen (PA) IgG in vaccinated livestock. Various adaptation of enzyme-linked immunosorbent assays (ELISAs) have been developed in studies...

    Authors: Okechukwu C Ndumnego, Jannie Crafford, Wolfgang Beyer and Henriette van Heerden

    Citation: BMC Veterinary Research 2013 9:265

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  34. Content type: Research article

    The fat mass and obesity associated gene (FTO) is widely investigated in humans regarding its important roles in obesity and type 2 diabetes. Studies in mammals demonstrate that FTO is also associated with inf...

    Authors: Yanhong Zhang, Feng Guo, Yingdong Ni and Ruqian Zhao

    Citation: BMC Veterinary Research 2013 9:257

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  35. Content type: Research article

    Sheep caseous lymphadenitis (CLA), caused by Corynebacterium pseudotuberculosis (Cp), is associated with direct economic losses and presents significant zoonotic potential. Despite the importance of the disease, ...

    Authors: Bruno L Bastos, Dan Loureiro, José T Raynal, Maria T Guedes, Vera Lúcia Costa Vale, Lilia F Moura-Costa, José E Guimarães, Vasco Azevedo, Ricardo W Portela and Roberto Meyer

    Citation: BMC Veterinary Research 2013 9:254

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  36. Content type: Research article

    Biomarkers are useful tools in research and clinical practice where they are often used to detect and monitor differences in the physiological state of an animal. The proteins IGF-1, IGFBP-3, GHR, CRP, SAA, Hp...

    Authors: Mackenzie J Slifierz, Robert Friendship, Cornelius FM de Lange, Marko Rudar and Abdolvahab Farzan

    Citation: BMC Veterinary Research 2013 9:247

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  37. Content type: Research article

    Sled dogs commonly suffer from diarrhea. Although multiple etiologies exist there are limited field studies using synbiotics as a supplement to prevent or treat diarrhea. The objective of this study was to exa...

    Authors: Jason W Gagné, Joseph J Wakshlag, Kenneth W Simpson, Scot E Dowd, Shalini Latchman, Dawn A Brown, Kit Brown, Kelly S Swanson and George C Fahey Jr

    Citation: BMC Veterinary Research 2013 9:246

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  38. Content type: Research article

    As the world warms up, heat stress is becoming a major cause of economic loss in the livestock industry. Long-time exposure of animals to hyperthermia causes extensive cell apoptosis, which is harmful to them....

    Authors: Zhimin Gao, Fenghua Liu, Peng Yin, Changrong Wan, Shasha He, Xiaoxi Liu, Hong Zhao, Tao Liu, Jianqin Xu and Shining Guo

    Citation: BMC Veterinary Research 2013 9:241

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  39. Content type: Research article

    In humans, adipose tissue (AT) originating from different depots shows varying gene expression profiles. In horses, the risk of certain metabolic disorders may also be influenced by the impact of specific AT d...

    Authors: Lien Bruynsteen, Tim Erkens, Luc J Peelman, Richard Ducatelle, Geert PJ Janssens, Patricia A Harris and Myriam Hesta

    Citation: BMC Veterinary Research 2013 9:240

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  40. Content type: Research article

    The objective of this study was to provide for the first time data on plasma catecholamines, cortisol, glutathione and malondialdehyde after long term dehydration (20 days) in the presence and absence of angio...

    Authors: Mahmoud Alhaj Ali, Elsadig Kazzam, Naheed Amir, Fred Nyberg and Abdu Adem

    Citation: BMC Veterinary Research 2013 9:232

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  41. Content type: Research article

    Atrophic rhinitis is a widely prevalent infectious disease of swine caused by Bordetella bronchiseptica and Pasteurella multocida. The course of the disease is considered to be different depending on the principa...

    Authors: Tibor Magyar, Tamás Donkó, Imre Repa and Melinda Kovács

    Citation: BMC Veterinary Research 2013 9:222

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  42. Content type: Research article

    Aglepristone (RU534) is an antiprogestin used for pregnancy termination, parturition induction and conservative pyometra treatment in bitches. Its molecular structure is similar to mifepristone, an antiprogest...

    Authors: Piotr Jurka, Lidia Szulc-Dąbrowska, Joanna Borkowska and Anna Winnicka

    Citation: BMC Veterinary Research 2013 9:220

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  43. Content type: Research article

    The purpose of this study was to test the hypothesis that dog plasma concentrations of selected nutrients decrease after undergoing caloric restriction for weight loss. Thirty-one overweight dogs that had succ...

    Authors: Deborah E Linder, Lisa M Freeman, Shelley L Holden, Vincent Biourge and Alexander J German

    Citation: BMC Veterinary Research 2013 9:219

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  44. Content type: Research article

    Digital Dermatitis (DD) is a common disease of dairy cows, the pathogenesis of which is still not clear. This study examined some host responses associated with the typical lesions, in an attempt to further el...

    Authors: Walid Refaai, Richard Ducatelle, Peter Geldhof, Belgacem Mihi, Mahasen El-shair and Geert Opsomer

    Citation: BMC Veterinary Research 2013 9:193

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  45. Content type: Research article

    Mammalian sirtuins are homologs to the yeast silent information regulator 2 (Sir2), which is an NAD-dependent deacetylase. Sirtuins are comprised of 7 proteins, and each has different target proteins. Sirtuin ...

    Authors: Shingo Ishikawa, Gebin Li, Hiroshi Takemitsu, Megumi Fujiwara, Nobuko Mori, Ichiro Yamamoto and Toshiro Arai

    Citation: BMC Veterinary Research 2013 9:187

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  46. Content type: Research article

    A recent study showed that niacin supplementation counteracts the obesity-induced muscle fiber switching from oxidative type I to glycolytic type II and increases the number of type I fibers in skeletal muscle...

    Authors: Muckta Khan, Robert Ringseis, Frank-Christoph Mooren, Karsten Krüger, Erika Most and Klaus Eder

    Citation: BMC Veterinary Research 2013 9:177

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