Skip to main content


Clinical pathology, physiology and immunology

Section edited by Prof. Jose Joaquin Ceron

The clinical pathology, physiology and immunology section considers a broad range of submissions discussing the physiological processes that occur in healthy animals and underlie stress and disease. This includes, but not limited to, studies on biomarkers, biochemistry, cytopathology, endocrinology, pathophysiology, proteomics, hematopathology, immunology, and molecular diagnostics. Comparative medicine studies are also considered. 

Page 4 of 6

  1. Content type: Research article

    Host defence peptides are a diverse group of small, cationic peptides and are important elements of the first line of defense against pathogens in animals. Expression and functional analysis of host defense pe...

    Authors: Mi Ok Lee, Hyun-Jun Jang, Deivendran Rengaraj, Seo-Yeong Yang, Jae Yong Han, Susan J. Lamont and James E. Womack

    Citation: BMC Veterinary Research 2016 12:231

    Published on:

  2. Content type: Research article

    We previously identified two phenotypes of CD4+ cells with and without reactions to anti-pig CD4 monoclonal antibodies by flow cytometry in a herd of Microminipigs. In this study, we analyzed the coding sequen...

    Authors: Tatsuya Matsubara, Naohito Nishii, Satoshi Takashima, Masaki Takasu, Noriaki Imaeda, Kayo Aiki-Oshimo, Kazuaki Yamazoe, Michinori Kakisaka, Shin-nosuke Takeshima, Yoko Aida, Yoshie Kametani, Jerzy K. Kulski, Asako Ando and Hitoshi Kitagawa

    Citation: BMC Veterinary Research 2016 12:222

    Published on:

  3. Content type: Research article

    Approximately 20 % of obese dogs have metabolic disturbances similar to those observed in human metabolic syndrome, a condition known as obesity-related metabolic dysfunction. This condition is associated with...

    Authors: Asta Tvarijonaviciute, Jose J. Ceron, Carlos de Torre, Blanka B. Ljubić, Shelley L. Holden, Yann Queau, Penelope J. Morris, Josep Pastor and Alexander J. German

    Citation: BMC Veterinary Research 2016 12:211

    Published on:

  4. Content type: Research article

    This study aimed to investigate the possible serum protein changes after endotoxin administration in healthy and choline-treated calves using proteomics. These results are expected to contribute to the underst...

    Authors: Z. Yilmaz, O. Eralp Inan, M. Kocaturk, A. T. Baykal, O. Hacariz, I. Hatipoglu, A. Tvarijonaviciute, M. Cansev, J. Ceron and I. H. Ulus

    Citation: BMC Veterinary Research 2016 12:210

    Published on:

  5. Content type: Research article

    Ancylostoma spp. is one of the most prevalent canine intestinal nematode infections which usually causes subclinical disease in adult dogs and has zoonotic implications. Therefore, the...

    Authors: Elizabeth M. S. Schmidt, Asta Tvarijonaviciute, Silvia Martinez-Subiela, José J. Cerón and Peter D. Eckersall

    Citation: BMC Veterinary Research 2016 12:203

    Published on:

  6. Content type: Research article

    Corynebacterium pseudotuberculosis is the etiologic agent of caseous lymphadenitis (CL), a chronic disease that affects goats and sheep. CL is characterized by the formation of granulo...

    Authors: Vera Lúcia Costa Vale, Marcos da Costa Silva, Andréia Pacheco de Souza, Soraya Castro Trindade, Lília Ferreira de Moura-Costa, Ellen Karla Nobre dos Santos-Lima, Ivana Lucia de Oliveira Nascimento, Hugo Saba Pereira Cardoso, Edson de Jesus Marques, Bruno Jean Adrien Paule and Roberto José Meyer Nascimento

    Citation: BMC Veterinary Research 2016 12:195

    Published on:

  7. Content type: Research article

    Canine atopic dermatitis (cAD) is a common chronic and pruritic skin disease in dogs. The development of cAD involves complex interactions between environmental antigens, genetic predisposition and a number of...

    Authors: Alicja Majewska, Małgorzata Gajewska, Kourou Dembele, Henryk Maciejewski, Adam Prostek and Michał Jank

    Citation: BMC Veterinary Research 2016 12:174

    Published on:

  8. Content type: Research article

    Hereditary bisalbuminemia is a relatively rare anomaly characterized by the occurrence of two albumin fractions on serum protein separation by electrophoresis. In human medicine, it is usually revealed by chan...

    Authors: Claudia Gili, Federico Bonsembiante, Renzo Bonanni, Alessia Giordano, Sabina Ledda, Giorgia Beffagna, Saverio Paltrinieri, Matteo Sommer and Maria Elena Gelain

    Citation: BMC Veterinary Research 2016 12:172

    Published on:

  9. Content type: Review

    The aim of this review is to study the main spectrophotometric methods used to evaluate total antioxidant capacity (TAC) in serum samples of dogs. Total antioxidant capacity (TAC) is an analyte frequently used...

    Authors: Camila Peres Rubio, Josefa Hernández-Ruiz, Silvia Martinez-Subiela, Asta Tvarijonaviciute and José Joaquin Ceron

    Citation: BMC Veterinary Research 2016 12:166

    Published on:

  10. Content type: Research article

    The anatomy of the adrenal glands has been widely studied in many species of domestic and wild mammals. However, there are no available literature reports describing the morphology and morphometry of the adren...

    Authors: Karolina Barszcz, Helena Przespolewska, Katarzyna Olbrych, Michał Czopowicz, Joanna Klećkowska-Nawrot, Karolina Goździewska-Harłajczuk and Marta Kupczyńska

    Citation: BMC Veterinary Research 2016 12:161

    Published on:

  11. Content type: Research article

    The artificial colloid, hydroxyethyl starch (HES), is recommended for intravascular volume expansion and colloid-osmotic pressure enhancement in dogs and cats. A well-known side effect of HES solutions in huma...

    Authors: Nathalie A. Albrecht, Judith Howard, Alan Kovacevic and Katja N. Adamik

    Citation: BMC Veterinary Research 2016 12:155

    Published on:

  12. Content type: Research article

    Samples for diagnostic procedures often require some form of pre-analytical preparation for preservation or safe handling during transportation prior to analysis in the laboratory. This is particularly importa...

    Authors: Funmilola C. Thomas, Andre M. Santana, Mary Waterston, Hayley Haining and Peter David Eckersall

    Citation: BMC Veterinary Research 2016 12:151

    Published on:

  13. Content type: Methodology article

    Canine reticulated platelets (r-PLTs) i.e., juvenile PLTs reflecting thrombopoiesis can be measured automatically with the hematology analyzer Sysmex XT-2000iV using manual gating options. However, the impact ...

    Authors: Dana E. Oellers, Natali Bauer, Melanie Ginder, Sigrid Johannes, Iris Pernecker and Andreas Moritz

    Citation: BMC Veterinary Research 2016 12:148

    Published on:

  14. Content type: Methodology article

    The objective of the present study was to optimize and validate an automated method to assess the total antioxidant capacity (TAC) in serum of dogs using the cupric reducing antioxidant capacity (CUPRAC) metho...

    Authors: Camila Peres Rubio, Asta Tvarijonaviciute, Silvia Martinez-Subiela, Josefa Hernández-Ruiz and José Joaquin Cerón

    Citation: BMC Veterinary Research 2016 12:137

    Published on:

  15. Content type: Research article

    Long-term high-concentrate diet (HCD) feeding can cause subacute ruminal acidosis in cows and subsequently trigger systemic inflammatory and immune responses. Therefore, we conducted the present study in which...

    Authors: Di Jin, Guangjun Chang, Kai Zhang, Junfei Guo, Tianle Xu and Xiangzhen Shen

    Citation: BMC Veterinary Research 2016 12:128

    Published on:

  16. Content type: Research article

    Common carp (Cyprinus carpio L.), one of the most economically valuable commercial farming fish species in China, is often infected by a variety of viruses. As the first line of defence against microbial pathogen...

    Authors: Yaoyao Zhu, Chenchen Qi, Shijuan Shan, Fumiao Zhang, Hua Li, Liguo An and Guiwen Yang

    Citation: BMC Veterinary Research 2016 12:127

    Published on:

  17. Content type: Research article

    Horses are much predisposed and susceptible to excessive and acute inflammatory responses that cause the recruitment and stimulation of polymorphnuclear granulocytes (PMN) together with peripheral blood mononu...

    Authors: Simon Rütten, Gerald F. Schusser, Getu Abraham and Wieland Schrödl

    Citation: BMC Veterinary Research 2016 12:117

    Published on:

  18. Content type: Research article

    In humans, the presence of antiphospholipid antibodies (aPL) is frequently found in immune thrombocytopenia. The present study investigated whether aPL and any aPL subtypes are associated with canine thrombocy...

    Authors: Yu-Chen Chen, Lang-Ming Chi, Kuan-Chih Chow, Shiow-Her Chiou, Yi-Hsin Fan, Shu-Peng Ho, Yu-Chen Hsu, Yu-Chyi Hwang, Meng-Xing Wu, Wei-Ming Lee, Shiun-Long Lin, Chau-Loong Tsang and Frank Chiahung Mao

    Citation: BMC Veterinary Research 2016 12:106

    Published on:

  19. Content type: Research article

    This study assessed the effects of sedation using a combination of fentanyl, midazolam and medetomidine in comparison to ketamine. Rhesus Macaques (Macaca mulatta), (n = 16, 5 males and 3 females randomly allocat...

    Authors: Henri G. M. J. Bertrand, Yvette C. Ellen, Stevie O’Keefe and Paul A. Flecknell

    Citation: BMC Veterinary Research 2016 12:93

    Published on:

  20. Content type: Research article

    Local inflammation may progress into systemic inflammation. To increase our understanding of the basic immunological processes during transition of equine local inflammation into a systemic state, investigatio...

    Authors: Anne Mette L. Vinther, Peter M. H. Heegaard, Kerstin Skovgaard, Rikke Buhl, Stine M. Andreassen and Pia H. Andersen

    Citation: BMC Veterinary Research 2016 12:83

    Published on:

  21. Content type: Research article

    This study was aimed at evaluating the clinical protection, the level of Porcine circovirus type 2 (PCV2) viremia and the immune response (antibodies and IFN-γ secreting cells (SC)) in piglets derived from PCV2 v...

    Authors: Paolo Martelli, Roberta Saleri, Giulia Ferrarini, Elena De Angelis, Valeria Cavalli, Michele Benetti, Luca Ferrari, Elena Canelli, Paolo Bonilauri, Elena Arioli, Antonio Caleffi, Heiko Nathues and Paolo Borghetti

    Citation: BMC Veterinary Research 2016 12:77

    Published on:

  22. Content type: Research article

    Ketogenesis is a secondary metabolic pathway to provide energy to dairy cows during early lactation; however when the production of ketone bodies (acetoacetate, acetone, ß- hydroxybutyrate) is above certain le...

    Authors: Pedro Melendez, Pablo Pinedo, José Bastias, Maria Paz Marin, Carolina Rios, Consuelo Bustamante, Natalia Adaro and Mario Duchens

    Citation: BMC Veterinary Research 2016 12:50

    Published on:

  23. Content type: Research article

    Goat caseous lymphadenitis (CLA) is a chronic disease caused by Corynebacterium pseudotuberculosis. However, there is paucity of data about goat’s acute phase response during the course of CLA. This study was con...

    Authors: Z. K. H. Jeber, Z. MohdJin, F. F. Jesse, A. A. Saharee, J. Sabri, R. Yusoff and H. Wahid

    Citation: BMC Veterinary Research 2016 12:48

    Published on:

  24. Content type: Research article

    Nonesterified fatty acids (NEFAs) are involved in proinflammatory processes in cattle, including in the increased expression of adhesion molecules in endothelial cells. However, the mechanisms underlying these...

    Authors: Anitsi Loaiza, María D. Carretta, Anja Taubert, Carlos Hermosilla, María A. Hidalgo and Rafael A. Burgos

    Citation: BMC Veterinary Research 2016 12:38

    Published on:

  25. Content type: Methodology article

    Dairy cows have a massive demand for glucose at the onset of lactation. A poor adaption to this period leads to an excessive negative energy balance with an increased risk for ketosis and impaired animal healt...

    Authors: B. Mair, M. Drillich, D. Klein-Jöbstl, P. Kanz, S. Borchardt, L. Meyer, I. Schwendenwein and M. Iwersen

    Citation: BMC Veterinary Research 2016 12:34

    Published on:

  26. Content type: Case report

    Diabetes insipidus (DI) is a rare disease in humans and animals, which is caused by the lack of production, malfunction or dysfunction of the distal nephron to the antidiuretic effect of the antidiuretic hormo...

    Authors: Alexander Grahofer, Natalie Wiedemar, Corinne Gurtner, Cord Drögemüller and Heiko Nathues

    Citation: BMC Veterinary Research 2016 12:22

    Published on:

  27. Content type: Methodology article

    Although a metabolic profile represents a valid tool utilized in dairy herds to determine abnormalities in blood chemistry related to an increased risk of production diseases, there are no studies on applicati...

    Authors: Luigi Calamari, Annarita Ferrari, Andrea Minuti and Erminio Trevisi

    Citation: BMC Veterinary Research 2016 12:4

    Published on:

  28. Content type: Research article

    Free-ranging brown bears exhibit highly contrasting physiological states throughout the year. They hibernate 6 months of the year, experiencing a decrease in body temperature, heart rate, respiratory rate and ...

    Authors: Anne Randi Græsli, Alina L. Evans, Åsa Fahlman, Mads F. Bertelsen, Stéphane Blanc and Jon M. Arnemo

    Citation: BMC Veterinary Research 2015 11:301

    Published on:

  29. Content type: Research article

    Clinical appearance and evolution of Canine Leishmaniosis (CL) are the consequence of complex interactions between the parasite and the genetic and immunological backgrounds. We investigated the effect of an i...

    Authors: Laura Cortese, Mariangela Annunziatella, Anna Teresa Palatucci, Sarah Lanzilli, Valentina Rubino, Alessandro Di Cerbo, Sara Centenaro, Gianandrea Guidetti, Sergio Canello and Giuseppe Terrazzano

    Citation: BMC Veterinary Research 2015 11:295

    Published on:

  30. Content type: Research article

    The aim of the current study was to evaluate the effect of different thermal manipulation (TM) protocols during embryogenesis on thermotolerance acquisition parameters during subsequent thermal challenge (TC) ...

    Authors: Mohammad-Borhan Al-Zghoul, Sabry M. El-Bahr, Raida K. Al-Rukibat, Abd Elhafeed S. Dalab, Thnaian A. Althnaian and Saeed Y. Al-ramadan

    Citation: BMC Veterinary Research 2015 11:292

    Published on:

  31. Content type: Research article

    Feline hepatic lipidosis (FHL) is a common cholestatic disease affecting cats of any breed, age and sex. Both choline deficiency and low hepatic phosphatidylethanolamine N-methyltransferase (PEMT) activity are...

    Authors: Chiara Valtolina, Arie B. Vaandrager, Robert P. Favier, Joris H. Robben, Maidina Tuohetahuntila, Anne Kummeling, Isabelle Jeusette and Jan Rothuizen

    Citation: BMC Veterinary Research 2015 11:280

    Published on:

  32. Content type: Research article

    Feline platelets are prone to clumping after blood collection, rendering the determination of accurate platelet counts difficult for clinical laboratories and resulting in a high incidence of pseudothrombocyto...

    Authors: Barbara Riond, Andrea Katharina Waßmuth, Sonja Hartnack, Regina Hofmann-Lehmann and Hans Lutz

    Citation: BMC Veterinary Research 2015 11:276

    Published on:

  33. Content type: Research article

    Previous work showed that weaning stress causes gut barrier dysfunction partly by triggering the release of corticotropin releasing factor (CRF) and thereby inducing the degranulation of intestinal mast cell (...

    Authors: Alessandro Mereu, Gemma Tedó, Adam J. Moeser, Gerald Rimbach and Ignacio R. Ipharraguerre

    Citation: BMC Veterinary Research 2015 11:274

    Published on:

  34. Content type: Research article

    Negative energy balance (NEB) is a common pathological foundation of ketosis and fatty liver. Liver and fat tissue are the major organs of lipid metabolism and take part in modulating lipid oxidative capacity ...

    Authors: Chuang Xu, Qiushi Xu, Yuanyuan Chen, Wei Yang, Cheng Xia, Hongjiang Yu, Kuilin Zhu, Taiyu Shen and Ziyang Zhang

    Citation: BMC Veterinary Research 2015 11:271

    Published on:

  35. Content type: Research article

    Prenatally stressed offspring exhibit increased susceptibility to inflammatory disorders due to in utero programming. Research into the effects of n-3 PUFAs shows promising results for the treatment and preventio...

    Authors: Rebecca E. Fisher-Heffernan, Mamun M. Or’Rashid, Ousama AlZahal, Margaret Quinton, Herman J. Boermans, Brian W. McBride, Timothy R. H. Regnault and Niel A. Karrow

    Citation: BMC Veterinary Research 2015 11:266

    Published on:

  36. Content type: Research article

    The transition period of dairy cows, around parturition and the onset of lactation, involves endocrine and metabolic changes to compensate for an increased energy requirement aggravated by reduced feed intake....

    Authors: S. Imhasly, C. Bieli, H. Naegeli, L. Nyström, M. Ruetten and C. Gerspach

    Citation: BMC Veterinary Research 2015 11:252

    Published on:

  37. Content type: Research article

    Following the recent development of a new approach to quantitative analysis of IgG concentrations in bovine serum using transmission infrared spectroscopy, the potential to measure IgG levels using technology ...

    Authors: Ibrahim Elsohaby, Siyuan Hou, J. Trenton McClure, Christopher B. Riley, R. Anthony Shaw and Gregory P. Keefe

    Citation: BMC Veterinary Research 2015 11:218

    Published on:

  38. Content type: Research article

    Milk acute phase proteins (APP) have been identified and show promise as biomarkers of mastitis. However analysis of their profile in dairy cows from a production herd is necessary in order to confirm their be...

    Authors: Funmilola Clara Thomas, Mary Waterston, Peter Hastie, Timothy Parkin, Hayley Haining and Peter David Eckersall

    Citation: BMC Veterinary Research 2015 11:207

    Published on:

  39. Content type: Research article

    In vitro platelet aggregation in feline blood samples is a well-known phenomenon in veterinary clinical laboratories resulting in high numbers of pseudothrombocytopenia. Several attempts have been made to prev...

    Authors: Barbara Riond, Andrea Katharina Waßmuth, Sonja Hartnack, Regina Hofmann-Lehmann and Hans Lutz

    Citation: BMC Veterinary Research 2015 11:183

    Published on:

  40. Content type: Research article

    Serum haptoglobin (Hp) and haptoglobin matrix metalloproteinase 9 complexes (Hp-MMP 9) have been identified as biomarkers with diagnostic potential in cattle with conditions resulting in an acute inflammatory ...

    Authors: Christy J Hanthorn, Grant A Dewell, Renee D Dewell, Vickie L Cooper, Chong Wang, Paul J Plummer and Jeffrey Lakritz

    Citation: BMC Veterinary Research 2014 10:285

    Published on:

  41. Content type: Research article

    The aim of this study was to determine the ability of two feed additives, a fumarate-malate (FM) and a polyphenol-essential oil mixture (PM), in attenuating the drop of ruminal pH and the metabolic and immune ...

    Authors: Roberta De Nardi, Giorgio Marchesini, Jan C Plaizier, Shucong Li, Ehsan Khafipour, Rebecca Ricci, Igino Andrighetto and Severino Segato

    Citation: BMC Veterinary Research 2014 10:277

    Published on:

  42. Content type: Research article

    Stoned olive pomace (SOP), which represents approximately 50% of the conversion process of olive in oil, is largely not-utilized and creates costs for its disposal and problems related to environmental impact. In...

    Authors: Grazia Pallara, Arianna Buccioni, Roberta Pastorelli, Sara Minieri, Marcello Mele, Stefano Rapaccini, Anna Messini, Mariano Pauselli, Maurizio Servili, Luciana Giovannetti and Carlo Viti

    Citation: BMC Veterinary Research 2014 10:271

    Published on:

  43. Content type: Research article

    Bovine respiratory disease (BRD) is a costly feature of modern cattle production. Early and accurate detection of BRD may prove useful in the successful management of this disease. The primary objective of the...

    Authors: Charles A Hinds, Andrew J Niehaus, Christopher Premanandan, Paivi J Rajala-Schultz, Donald M Rings and Jeffrey Lakritz

    Citation: BMC Veterinary Research 2014 10:261

    Published on:

  44. Content type: Research article

    In order to characterize the functional properties of canine protein C (CnPC), the zymogen needs to be purified from plasma. The goals of this study were (1) to purify protein C from fresh frozen canine plasma...

    Authors: Valerie M Wong, Dorothee Bienzle, M Anthony Hayes, Paul Taylor and R Darren Wood

    Citation: BMC Veterinary Research 2014 10:251

    Published on:

  45. Content type: Research article

    Following infection and initial multiplication in the gut lumen, Salmonella Typhimurium crosses the intestinal epithelial barrier and comes into contact with cells of the host immune system. Mononuclear phagocyte...

    Authors: Kamila Kyrova, Hana Stepanova, Ivan Rychlik, Ondrej Polansky, Lenka Leva, Zuzana Sekelova, Martin Faldyna and Jiri Volf

    Citation: BMC Veterinary Research 2014 10:244

    Published on:

  46. Content type: Research article

    In ruminants, lower ruminal pH causes massive disruption of ruminal epithelial structure during periods of feeding high-concentrate diets. However, the influence of excessive organic fatty acids in the lumen o...

    Authors: Shiyu Tao, Yongqian Duanmu, Haibo Dong, Jing Tian, Yingdong Ni and Ruqian Zhao

    Citation: BMC Veterinary Research 2014 10:235

    Published on:

  47. Content type: Research article

    The supplementation of fat to lactating dairy cows has long been used as a management tool to increase dietary energy density for improving cow production, reproduction and to alleviate negative energy balance...

    Authors: John R Otto, Bunmi S Malau-Aduli, Razaq O Balogun, Peter Nish and Aduli E O Malau-Aduli

    Citation: BMC Veterinary Research 2014 10:224

    Published on:

  48. Content type: Research article

    Endocardiosis is the most common heart disease in Dachshunds and is therefore an important cause of cardiac morbidity and death. In recent years we have observed an increasing interest in the development of ne...

    Authors: Magdalena Hulanicka, Magdalena Garncarz, Marta Parzeniecka-Jaworska and Michał Jank

    Citation: BMC Veterinary Research 2014 10:205

    Published on:

  49. Content type: Research article

    The snatch-farrowed porcine-colostrum-deprived (SF-pCD) pig model, in which neonates are raised on commercially available bovine colostrum, is an alternative model for porcine infectious disease research. It i...

    Authors: Yanyun Huang, Andrea Ladinig, Carolyn Ashley, Deborah M Haines and John CS Harding

    Citation: BMC Veterinary Research 2014 10:219

    Published on: