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Clinical pathology, physiology and immunology

Section edited by Prof. Jose Joaquin Ceron

The Clinical Pathology, Physiology and Immunology considers all sound science research study types in which laboratory analysis and the use of biomarkers have a major role in enhancing our understanding of animal health. This section is open to any animal species and comparative studies are also considered. Studies must be scientifically valid; for research articles this includes a scientifically sound research question, the use of suitable methods and analysis, and following community-agreed standards relevant to the research field.

 The main topics covered in this section include:

  •   Laboratory assays and methods validation
  •   Laboratory methods applied to study pathophysological changes in disease
  •   Hematology
  •   Clinical Biochemistry
  •   Endocrinology Tests
  •   Immunological Assays
  •   Cytology
  •   Development and validation of new biomarkers including proteomic studies

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  1. Ovarian cancer is diagnosed clinically by detecting ovarian cancer-related factors and markers. Here, we report a case of giant panda ovarian tumor metastasis with a combination of clinical and histopathologic...

    Authors: Qi Gao, Chengdong Wang, Desheng Li, Hemin Zhang, Linhua Deng, Caiwu Li and Zhengli Chen

    Citation: BMC Veterinary Research 2018 14:311

    Content type: Case Report

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  2. In the host immune system, perforin is a cytotoxic effector molecule that eliminate virus-infected and malignant cells. Moreover, some recent studies also imply the involvement of perforin in antibacterial imm...

    Authors: Ting Li, Lei Wang, Yonghuan Zhang, Xinyi Guo, Xinze Chen, Fumiao Zhang, Guiwen Yang, Wujun Wen and Hua Li

    Citation: BMC Veterinary Research 2018 14:299

    Content type: Research article

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  3. In the postpartum cow, early diagnosis of uterine disease is currently problematic due to the lack of reliable, non-invasive diagnostic methods. Cervico-vaginal mucus (CVM) is an easy to collect potentially in...

    Authors: Mounir Adnane, Paul Kelly, Aspinas Chapwanya, Kieran G. Meade and Cliona O’Farrelly

    Citation: BMC Veterinary Research 2018 14:297

    Content type: Methodology article

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  4. Currently, little is known about the effect of sodium butyrate (NaB) on oxidative stress following grain-induced sub-acute ruminal acidosis in dairy goats. In the present study, 18 lactating dairy goats implan...

    Authors: Nana Ma, Juma Ahamed Abaker, Muhammad Shahid Bilal, Hongyu Dai and Xiangzhen Shen

    Citation: BMC Veterinary Research 2018 14:275

    Content type: Research article

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  5. The generation of recombinant proteins for commercialisation must be cost-effective. Despite the cost-effective production of recombinant feline interferon (rFeIFN) by a baculovirus expression system, this rFe...

    Authors: Sachi Minagawa, Yuzuru Nakaso, Masahiro Tomita, Takenori Igarashi, Yoshio Miura, Hideyo Yasuda and Satoshi Sekiguchi

    Citation: BMC Veterinary Research 2018 14:260

    Content type: Research article

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  6. During peripartum period, dairy cows are highly susceptible to energy metabolism disorders such as fatty liver and ketosis. Angiopoietin-like protein 4 (ANGPTL4) and fibroblast growth factor 21 (FGF21), known ...

    Authors: Jianguo Wang, Xiaoyan Zhu, Guanghui She, Yezi Kong, Yazhou Guo, Zhe Wang, Guowen Liu and Baoyu Zhao

    Citation: BMC Veterinary Research 2018 14:236

    Content type: Research article

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  7. Urea and creatinine in saliva have been reported to be possible markers of chronic kidney disease (CKD) in humans. The aim of this study was to assess if urea and creatinine could be measured in canine saliva,...

    Authors: Asta Tvarijonaviciute, Luis Pardo-Marin, Fernando Tecles, Juana Dolores Carrillo, Juan Diego Garcia-Martinez, Luis Bernal, Josep Pastor, José J. Cerón and Silvia Martinez-Subiela

    Citation: BMC Veterinary Research 2018 14:223

    Content type: Research article

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  8. Oxidative stress (OS) associated with an intense exercise may have a negative influence on equine health. The aim of this study was to determine the effects of endurance races on oxidative and antioxidative st...

    Authors: Nika Brkljača Bottegaro, Jelena Gotić, Jelena Šuran, Diana Brozić, Karla Klobučar, Krunoslav Bojanić and Zoran Vrbanac

    Citation: BMC Veterinary Research 2018 14:216

    Content type: Research article

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  9. Staphylococcus aureus (S. aureus) internalization into bovine mammary epithelial cells (bMECs) is considered an important pathogenic mechanism for the establishment of mastitis. Given the interesting link between...

    Authors: Heng Wang, Chongliang Bi, Yinjie Wang, Jun Sun, Xia Meng and Jianji Li

    Citation: BMC Veterinary Research 2018 14:197

    Content type: Research article

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  10. Dogs with canine leishmaniosis (CanL) due to Leishmania infantum can show a wide spectrum of clinical and clinicopathological findings at the time of diagnosis. The aim of this paper is to describe the possible a...

    Authors: J. J. Ceron, L. Pardo-Marin, M. Caldin, T. Furlanello, L. Solano-Gallego, F. Tecles, L. Bernal, G. Baneth and S. Martinez-Subiela

    Citation: BMC Veterinary Research 2018 14:196

    Content type: Review

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  11. Salmonella enterica serovar Typhimurium (Salmonella Typhimurium) is a zoonotic pathogen responsible for severe intestinal pathology in young chickens. Natural resistance-associated macrophage protein (NRAMP) fami...

    Authors: Mashooq Ahmad Dar, Raashid Ahmed, Uneeb Urwat, Syed Mudasir Ahmad, Pervaiz Ahmad Dar, Zahid Amin Kushoo, Tanveer Ali Dar, Peerzada Tajamul Mumtaz, Shakil Ahmad Bhat, Umar Amin, Nadeem Shabir, Hina Fayaz Bhat, Riaz Ahmad Shah, Nazir Ahmad Ganai and Mohammad Heidari

    Citation: BMC Veterinary Research 2018 14:180

    Content type: Research article

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  12. Marine and aquaculture industries are important sectors of the food production and global trade. Unfortunately, the fish food industry is challenged with a plethora of infectious pathogens. The freshwater and ...

    Authors: Michael Gotesman, Simon Menanteau-Ledouble, Mona Saleh, Sven M. Bergmann and Mansour El-Matbouli

    Citation: BMC Veterinary Research 2018 14:178

    Content type: Review

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  13. Mounting evidences observed that subacute ruminal acidosis (SARA) induced by high concentration (HC) diet increases the translocation of histamine from digestive tract into circulation causing a diverse of dis...

    Authors: Guangjun Chang, Lailai Wang, Nana Ma, Wenwen Zhang, Huanmin Zhang, Hongyu Dai and Xiangzhen Shen

    Citation: BMC Veterinary Research 2018 14:168

    Content type: Research article

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  14. The aim of this study was to evaluate salivary alpha-amylase (sAA), considered a non-invasive biomarker for sympathetic nervous system (SNS) activity, and salivary cortisol as possible pain-induced stress biom...

    Authors: María Dolores Contreras-Aguilar, Damián Escribano, María Martín-Cuervo, Fernando Tecles and Jose Joaquín Cerón

    Citation: BMC Veterinary Research 2018 14:156

    Content type: Research article

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  15. Sheep have been traditionally considered as less susceptible to Mycobacterium bovis (Mbovis) infection than other domestic ruminants such as cattle and goats. However, there is increasing evidence for the role of...

    Authors: Raquel Vallejo, Juan Francisco García Marín, Ramón Antonio Juste, Marta Muñoz-Mendoza, Francisco Javier Salguero and Ana Balseiro

    Citation: BMC Veterinary Research 2018 14:154

    Content type: Research article

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  16. In the host innate immune system, various pattern recognition receptors (PRRs) recognize conserved pathogen-associated molecular patterns (PAMPs) and represent an efficient first line of defense against invadi...

    Authors: Hua Li, Ting Li, Yujie Guo, Yujun Li, Yan Zhang, Na Teng, Fumiao Zhang and Guiwen Yang

    Citation: BMC Veterinary Research 2018 14:153

    Content type: Research article

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  17. The aim of the study was to evaluate the impact of herbal extracts on selected immunity mechanisms in clinically healthy pigeons and pigeons inoculated with the pigeon paramyxovirus type 1 (PPMV-1). For the fi...

    Authors: Daria Dziewulska, Tomasz Stenzel, Marcin Śmiałek, Bartłomiej Tykałowski and Andrzej Koncicki

    Citation: BMC Veterinary Research 2018 14:148

    Content type: Research article

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  18. Insulin dysregulation in horses is a metabolic condition defined by high insulin concentrations in the blood and peripheral insulin resistance. This hyperinsulinemia is often associated with severe damage in t...

    Authors: Ákos Kenéz, Tobias Warnken, Karsten Feige and Korinna Huber

    Citation: BMC Veterinary Research 2018 14:146

    Content type: Research article

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  19. Friesian horses are known for their high inbreeding rate resulting in several genetic diseases such as hydrocephaly and dwarfism. This last decade, several studies focused on two other presumed hereditary trai...

    Authors: Veronique Saey, Jonathan Tang, Richard Ducatelle, Siska Croubels, Siegrid De Baere, Stijn Schauvliege, Gunther van Loon and Koen Chiers

    Citation: BMC Veterinary Research 2018 14:139

    Content type: Research article

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  20. Subacute ruminal acidosis (SARA) is a metabolic disease in high-producing dairy cattle, and is accompanied by rumenitis. However, the mechanism of rumenitis remains unclear. Therefore, the aim of this study wa...

    Authors: Chenxu Zhao, Guowen Liu, Xiaobing Li, Yuan Guan, Yazhou Wang, Xue Yuan, Guoquan Sun, Zhe Wang and Xinwei Li

    Citation: BMC Veterinary Research 2018 14:135

    Content type: Research article

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  21. The ovine rumen is involved in host defense responses and acts as the immune interface with the environment. The ruminal mucosal epithelium plays an important role in innate immunity and secretes antimicrobial...

    Authors: Xin Jin, Man Zhang, Xue-min Zhu, Yan-ru Fan, Chen-guang Du, Hua-er Bao, Siri-guleng Xu, Qiao-zhen Tian, Yun-he Wang and Yin-feng Yang

    Citation: BMC Veterinary Research 2018 14:134

    Content type: Research article

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  22. Clostridium novyi-NT (CNV-NT), has shown promise as a bacterolytic therapy for solid tumors in mouse models and in dogs with naturally developing neoplasia. Factors that impact the immunologic response to ther...

    Authors: Amy E. DeClue, Sandra M. Axiak-Bechtel, Yan Zhang, Saurabh Saha, Linping Zhang, David D. Tung and Jeffrey N. Bryan

    Citation: BMC Veterinary Research 2018 14:119

    Content type: Research article

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  23. Species-specific point-of-care tests (POCT) permit a rapid analysis of canine C-reactive protein (CRP), enabling veterinarians to include CRP in clinical decisions. Aim of the study was to evaluate a novel POC...

    Authors: Sarah Hindenberg, Melanie Keßler, Sabine Zielinsky, Judith Langenstein, Andreas Moritz and Natali Bauer

    Citation: BMC Veterinary Research 2018 14:99

    Content type: Research article

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  24. The pathogenesis of postpartum dysgalactia syndrome (PDS) in sows is not fully elucidated and affected sows often present vague clinical signs. Accurate and timely diagnosis is difficult, and PDS is often reco...

    Authors: Marianne Kaiser, Magdalena Jacobson, Pia Haubro Andersen, Poul Bækbo, José Joaquin Cerón, Jan Dahl, Damián Escribano and Stine Jacobsen

    Citation: BMC Veterinary Research 2018 14:83

    Content type: Research article

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    The Correction to this article has been published in BMC Veterinary Research 2018 14:175

  25. The aim of the present study was to assess the effects of subclinical inflammation on specific humoral immunity in dogs vaccinated with Nobivac® DHP based on serum levels of CRP and Hp. Dogs from the group I w...

    Authors: Przemysław Romiszewski, Krzysztof Kostro and Urszula Lisiecka

    Citation: BMC Veterinary Research 2018 14:70

    Content type: Research article

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  26. Carbon monoxide (CO), a common cause of poisoning in human beings has also been implicated in the death of animals. Though there are multiple studies on CO poisoning and relevant lethal blood COHb concentratio...

    Authors: Arya Sobhakumari, Robert H. Poppenga, J. Brad Pesavento and Francisco A. Uzal

    Citation: BMC Veterinary Research 2018 14:67

    Content type: Case Report

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  27. The present study was conducted to investigate the effects of oridonin (ORI) on growth performance, relative organ weight, lymphocyte proliferation, phagocytic function of neutrophils, and cytokine concentrati...

    Authors: Qiu Jue Wu, Xiao Chuan Zheng, Tian Wang and Tie Ying Zhang

    Citation: BMC Veterinary Research 2018 14:34

    Content type: Research article

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  28. The primary aim was to evaluate by means of thromboelastometry (ROTEM) the effects of hydroxyethyl starch (HES) 130/0.4 administered as a constant rate infusion (CRI) on hemostasis in hypoalbuminemic dogs. The...

    Authors: Angelica Botto, Barbara Bruno, Cristiana Maurella, Fulvio Riondato, Alberto Tarducci, Giulio Mengozzi and Antonio Borrelli

    Citation: BMC Veterinary Research 2018 14:33

    Content type: Research article

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  29. The uteruses of most dairy cattle are easily infected by bacteria, especially gram-negative bacteria, following parturition. Macrophages are important cells of the immune system and play a critical role in the...

    Authors: Junsheng Dong, Jianji Li, Luying Cui, Yefan Wang, Jiaqi Lin, Yang Qu and Heng Wang

    Citation: BMC Veterinary Research 2018 14:30

    Content type: Research article

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  30. Phytochemical flavonoids are widely distributed in the environment and are derived from many anthropogenic activities. The isoflavone genistein is a naturally occurring compound found in soya products that are...

    Authors: Carmen Sarasquete, María Úbeda-Manzanaro and Juan B. Ortiz-Delgado

    Citation: BMC Veterinary Research 2018 14:16

    Content type: Research article

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  31. The present study aimed to throw light on the clinical characteristics of abomasal impaction in buffalo calves and its associated biochemical alterations. For this reason, a total of 20 male buffalo calves (Bubal...

    Authors: Maged R. El-Ashker, Mohamed F. Salama, Mohamed E. El-Boshy and Eman A. Abo El-Fadle

    Citation: BMC Veterinary Research 2018 14:2

    Content type: Research article

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  32. The active form of the vitamin D3, 1,25-Dihydroxyvitamin D3 (1,25-(OH)2D3) has been shown to have major effects not only on physiological processes but also on the regulation of the immune system of vertebrates. ...

    Authors: Yolanda Corripio-Miyar, Richard J. Mellanby, Katy Morrison and Tom N. McNeilly

    Citation: BMC Veterinary Research 2017 13:390

    Content type: Research article

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  33. Respiratory co-infections are important factor affecting the profitability of pigs production. Swine influenza virus (SIV) may predispose to secondary infection. Haemophilus parasuis (Hps) can be a primary pathog...

    Authors: Małgorzata Pomorska-Mól, Arkadiusz Dors, Krzysztof Kwit, Ewelina Czyżewska-Dors and Zygmunt Pejsak

    Citation: BMC Veterinary Research 2017 13:376

    Content type: Research article

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  34. The influence of two different sample treatments comprising the enrichment of glycoproteins by boronic acid and dynamic range compression by hexapeptide libraries, on the detection of stress markers in saliva ...

    Authors: Ana Gutiérrez, José Joaquín Cerón, Ebrahim Razzazi-Fazeli, Sarah Schlosser and Fernando Tecles

    Citation: BMC Veterinary Research 2017 13:375

    Content type: Research article

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  35. Thrombelastography is a useful tool in assessment of hemostasis. Beside the traditional variables, the velocity curve and the variable delta have lately earned attention. The velocity curve provides knowledge ...

    Authors: Carolin Engelen, Andreas Moritz, Franziska Barthel and Natali Bauer

    Citation: BMC Veterinary Research 2017 13:366

    Content type: Research article

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  36. The prevalence of dog erythrocyte antigen (DEA 1) in canine population is approximately 40–60%. Often data are limited to a small number of breeds and/or dogs. The aims of this study were to evaluate frequency...

    Authors: E. Carli, A. Carminato, S. Ravagnan, K. Capello, M. T. Antognoni, A. Miglio, T. Furlanello, D. Proverbio, E. Spada, A. Stefani, F. Mutinelli and M. Vascellari

    Citation: BMC Veterinary Research 2017 13:364

    Content type: Research article

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  37. Aim of this prospective experimental study was to assess effects of systemic hypoxemia and hypovolemia on global and gastrointestinal oxygenation and perfusion in anesthetized horses. Therefore, we anesthetize...

    Authors: Klaus Hopster, Liza Wittenberg-Voges, Florian Geburek, Charlotte Hopster-Iversen and Sabine B. R. Kästner

    Citation: BMC Veterinary Research 2017 13:361

    Content type: Research article

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  38. MicroRNAs have important roles in many biological processes. However, the role of miR-139 in healthy mammary gland remains unclear. The objective of this study was to investigate the effects of miR-139 on lact...

    Authors: Yingjun Cui, Xia Sun, Lianfeng Jin, Guangpu Yu, Qingzhang Li, Xuejun Gao, Jinxia Ao and Chunmei Wang

    Citation: BMC Veterinary Research 2017 13:350

    Content type: Research article

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  39. Monophasic Salmonella Typhimurium (mSTM) strains account for up to 8.6% of all human Salmonellosis cases. They have an increasing prevalence during recent years and several human cases with hospitalisation were r...

    Authors: Tobias Theuß, Elke Ueberham, Jörg Lehmann, Thomas Lindner and Sven Springer

    Citation: BMC Veterinary Research 2017 13:343

    Content type: Research article

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  40. Red deer (Cervus elaphus) is regarded as an epidemiologically relevant host for Mycobacterium bovis (M. bovis) and closely related members of the Mycobacterium tuberculosis complex that cause animal tuberculosis ...

    Authors: María Ángeles Risalde, Jobin Thomas, Iker Sevilla, Miriam Serrano, Jose Antonio Ortíz, Joseba Garrido, Mercedes Domínguez, Lucas Domínguez, Christian Gortázar and Jose Francisco Ruíz-Fons

    Citation: BMC Veterinary Research 2017 13:341

    Content type: Research article

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  41. After the accident at the Fukushima Daiichi Nuclear Power Plant, radioactive contaminants were released over a widespread area. Monitoring the biological effects of radiation exposure in animals in the ex-evac...

    Authors: Motoko Morimoto, Ayaka Kato, Jin Kobayashi, Kei Okuda, Yoshikazu Kuwahara, Yasushi Kino, Yasuyuki Abe, Tsutomu Sekine, Tomokazu Fukuda, Emiko Isogai and Manabu Fukumoto

    Citation: BMC Veterinary Research 2017 13:337

    Content type: Research article

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  42. Platelet transfusion therapy poses many challenges in veterinary clinical practice. Lack of readily available blood donors, short shelf-life, and inability to administer a sufficient number of platelets to mee...

    Authors: N. Hlavac, C. S. Lasta, M. L. Dalmolin, L. A. Lacerda, D. de Korte, N. A. Marcondes, S. R. Terra, F. B. Fernandes and F. H. D. González

    Citation: BMC Veterinary Research 2017 13:334

    Content type: Research article

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  43. Melanoma differentiation associated gene 5 (MDA5) and retinoic acid-inducible gene-I (RIG-I) selectively sense cytoplasmic viral RNA to induce an antiviral immune response. Infectious bronchitis virus (IBV) is...

    Authors: Liping Yu, Xiaorong Zhang, Tianqi Wu, Jin Su, Yuyang Wang, Yuexin Wang, Baoyang Ruan, Xiaosai Niu and Yantao Wu

    Citation: BMC Veterinary Research 2017 13:332

    Content type: Research article

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  44. Saliva in dogs, as in humans, is a complex fluid secreted by different salivary glands in the oral cavity to protect the oral mucosa and teeth. The use of saliva as a substitute for blood in diagnosing and pro...

    Authors: Ilaria Iacopetti, Anna Perazzi, Tamara Badon, Silvia Bedin, Barbara Contiero and Rebecca Ricci

    Citation: BMC Veterinary Research 2017 13:330

    Content type: Research article

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  45. The Heavy Horse Pull is a competition where teams of two horses pull an increasingly heavy sled for a short distance. Similar to human wrestlers, some horses may undergo rapid weight change in order to enter a...

    Authors: Persephone Greco-Otto, Shannon Massie, Erin Shields, Marie-France Roy, Edmond Pajor and Renaud Léguillette

    Citation: BMC Veterinary Research 2017 13:317

    Content type: Research article

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  46. Cannabis-based drugs have been shown to be effective in inflammatory diseases. A number of endocannabinoids including N- arachidonoylethanolamide (anandamide, AEA) and 2-arachidonyl glycerol (2-AG) with activi...

    Authors: Carmela Valastro, Debora Campanile, Mariarosaria Marinaro, Delia Franchini, Fabiana Piscitelli, Roberta Verde, Vincenzo Di Marzo and Antonio Di Bello

    Citation: BMC Veterinary Research 2017 13:309

    Content type: Research article

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  47. Modern imaging techniques such as computed tomography (CT) and magnetic resonance imaging (MRI) have the advantage of producing images without superimposition. Whilst CT is a well-established technique for den...

    Authors: Christin Schoppe, Maren Hellige, Karl Rohn, Bernhard Ohnesorge and Astrid Bienert-Zeit

    Citation: BMC Veterinary Research 2017 13:280

    Content type: Research article

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COVID-19 Announcement

As a result of the significant disruption that is being caused by the COVID-19 pandemic we are very aware that many researchers will have difficulty in meeting the timelines associated with our peer review process during normal times.  Please do let us know if you need additional time. Our systems will continue to remind you of the original timelines but we intend to be highly flexible at this time. Thank you.

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