Clinical pathology, physiology and immunology

Section edited by Jose Joaquin Ceron

The clinical pathology, physiology and immunology section covers a broad range of studies regarding the physiological processes that occur in healthy animals and the animals’ response to stress and different diseases such as infectious diseases. This section considers research articles on biomarkers; biochemistry; cytopathology; endocrinology; pathophysiology; proteomics; hematopathology; immunology amd molecular diagnostics

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  1. Research article

    Preparation and evaluation of goose reovirus inactivated vaccine

    Infection with Goose Reovirus (GRV) can cause serious economic losses in the goose breeding industry. In this study, the GRV allantoic fluid was concentrated and used as an antigen in a formalin-inactivated oi...

    Xiaoyu Niu, Bingqian Zhang, Xianglong Yu, Xin Zhang, Yanguo Dou, Yi Tang and Youxiang Diao

    BMC Veterinary Research 2017 13:214

    Published on: 6 July 2017

  2. Research article

    Immunogenicity and protective efficacy of a Salmonella Enteritidis sptP mutant as a live attenuated vaccine candidate

    Salmonella enterica serovar Enteritidis (S. Enteritidis) is a highly adaptive pathogen in both humans and animals. As a Salmonella Type III secretion system (T3SS) effector, Salmonella

    Zhijie Lin, Peipei Tang, Yang Jiao, Xilong Kang, Qiuchun Li, Xiulong Xu, Jun Sun, Zhiming Pan and Xinan Jiao

    BMC Veterinary Research 2017 13:194

    Published on: 24 June 2017

  3. Case Report

    Fibrinogen deficiency in a dog - a case report

    Among coagulation disorders, primary fibrinogen deficiency is very rare in dogs. It is divided into hypofibrinogenemia, afibrinogenemia and dysfibrinogenemia. Afibrinogenemia has been described in three dogs. ...

    Franck Jolivet, Armelle Diquélou, Catherine Trumel, Simon Privat and Olivier Dossin

    BMC Veterinary Research 2017 13:183

    Published on: 19 June 2017

  4. Research article

    Comparison of the effects of 7.2% hypertonic saline and 20% mannitol on whole blood coagulation and platelet function in dogs with suspected intracranial hypertension - a pilot study

    Hyperosmolar therapy with either mannitol or hypertonic saline (HTS) is commonly used in the treatment of intracranial hypertension (ICH). In vitro data indicate that both mannitol and HTS affect coagulation a...

    Ivayla D. Yozova, Judith Howard, Diana Henke, Daniel Dirkmann and Katja N. Adamik

    BMC Veterinary Research 2017 13:185

    Published on: 19 June 2017

  5. Research article

    Measurement of Creatine kinase and Aspartate aminotransferase in saliva of dogs: a pilot study

    Muscle enzymes in saliva have been reported to be possible markers of heart and muscle damage in humans. The aim of this study was to assess if Creatine kinase (CK) and Aspartate aminotransferase (AST) activit...

    Asta Tvarijonaviciute, Tomas Barranco, Monica Rubio, Jose Maria Carrillo, Silvia Martinez-Subiela, Fernando Tecles, Juana Dolores Carrillo and José J. Cerón

    BMC Veterinary Research 2017 13:168

    Published on: 9 June 2017

  6. Research article

    The effects of different velogenic NDV infections on the chicken bursa of Fabricius

    Virulent Newcastle disease virus (NDV) was reported to cause rapid depletion of chicken bursa of Fabricius. Severe pathological condition of the organ is commonly associated with high levels of virus replicati...

    Y. W. Kristeen-Teo, S. K. Yeap, S. W. Tan, A. R. Omar, A. Ideris, S. G. Tan and N. B. Alitheen

    BMC Veterinary Research 2017 13:151

    Published on: 31 May 2017

  7. Research article

    Evaluation of a species-specific C-reactive protein assay for the dog on the ABX Pentra 400 clinical chemistry analyzer

    A canine-specific immunoturbidimetric CRP assay, Gentian Canine CRP Immunoassay) with species-specific controls and calibrators was introduced and recently evaluated on the clinical chemistry analyzer Abbott A...

    Sarah Hindenberg, Stefanie Klenner-Gastreich, Nicole Kneier, Sabine Zielinsky, Kris Gommeren, Natali Bauer and Andreas Moritz

    BMC Veterinary Research 2017 13:146

    Published on: 30 May 2017

  8. Research article

    Course of serum amyloid A (SAA) plasma concentrations in horses undergoing surgery for injuries penetrating synovial structures, an observational clinical study

    Injuries penetrating synovial structures are common in equine practice and often result in septic synovitis. Significantly increased plasma levels of serum amyloid A (SAA) have been found in various infectious...

    Eva Haltmayer, Ilse Schwendenwein and Theresia F. Licka

    BMC Veterinary Research 2017 13:137

    Published on: 22 May 2017

  9. Research article

    Quantifying capture stress in free ranging European roe deer (Capreolus capreolus)

    To understand and reduce the concomitant effects of trapping and handling procedures in wildlife species, it is essential to measure their physiological impact. Here, we examined individual variation in stress...

    Nikolaus Huber, Sebastian G. Vetter, Alina L. Evans, Petter Kjellander, Susanne Küker, Ulrika A. Bergvall and Jon M. Arnemo

    BMC Veterinary Research 2017 13:127

    Published on: 10 May 2017

  10. Research article

    chTLR4 pathway activation by Astragalus polysaccharide in bursa of Fabricius

    The Toll-like receptor 4 (TLR4) pathway involves in the pathogen recognition and defense against infection in mammals. Considering that avian and mammalian TLR are differentially mediated, the action of a natu...

    Ruili Zhang, Qun Yu, Guangliang Shi, Rui Liu, Weiqian Zhang, Xia Zhao, Guangxing Li and Ming Ge

    BMC Veterinary Research 2017 13:119

    Published on: 2 May 2017

    The Erratum to this article has been published in BMC Veterinary Research 2017 13:129

  11. Research article

    Relation of antioxidant status at admission and disease severity and outcome in dogs naturally infected with Babesia canis canis

    Canine babesiosis is caused by species of the Babesia genus and has become an emerging disease worldwide. To the authors’ knowledge there are no reports in which antioxidants have been analyzed in different prese...

    Martina Crnogaj, José Joaquin Cerón, Iva Šmit, Ivana Kiš, Jelena Gotić, Mirna Brkljačić, Vesna Matijatko, Camila Peres Rubio, Nada Kučer and Vladimir Mrljak

    BMC Veterinary Research 2017 13:114

    Published on: 24 April 2017

  12. Research article

    Diagnostic performance of the urinary canine calgranulins in dogs with lower urinary or urogenital tract carcinoma

    Onset of canine transitional cell carcinoma (TCC) and prostatic carcinoma (PCA) is usually insidious with dogs presenting at an advanced stage of the disease. A biomarker that can facilitate early detection of...

    Romy M. Heilmann, Elizabeth A. McNiel, Niels Grützner, David J. Lanerie, Jan S. Suchodolski and Jörg M. Steiner

    BMC Veterinary Research 2017 13:112

    Published on: 21 April 2017

  13. Research article

    Revelation of mRNAs and proteins in porcine milk exosomes by transcriptomic and proteomic analysis

    Milk is a complex liquid that provides nutrition to newborns. Recent reports demonstrated that milk is enriched in maternal-derived exosomes that are involved in fetal physiological and pathological conditions...

    Ting Chen, Qian-Yun Xi, Jia-Jie Sun, Rui-Song Ye, Xiao Cheng, Rui-Ping Sun, Song-Bo Wang, Gang Shu, Li-Na Wang, Xiao-Tong Zhu, Qing-Yan Jiang and Yong-Liang Zhang

    BMC Veterinary Research 2017 13:101

    Published on: 13 April 2017

  14. Research article

    Variation in fat content between liver lobes and comparison with histopathological scores in dairy cows with fatty liver

    The assessment of a liver biopsy remains the gold standard for diagnosing and staging fatty liver in dairy cows, which is often necessary for diagnostic and research purposes. Accuracy of the diagnosis relays ...

    C. Gerspach, S. Imhasly, R. Klingler, M. Hilbe, S. Hartnack and M. Ruetten

    BMC Veterinary Research 2017 13:98

    Published on: 12 April 2017

  15. Research article

    Expression profiles of immune mediators in feline Coronavirus-infected cells and clinical samples of feline Coronavirus-positive cats

    There are two biotypes of feline coronavirus (FCoV): the self-limiting feline enteric coronavirus (FECV) and the feline infectious peritonitis virus (FIPV), which causes feline infectious peritonitis (FIP), a ...

    Nikoo Safi, Amin Haghani, Shing Wei Ng, Gayathri Thevi Selvarajah, Farina Mustaffa-Kamal and Abdul Rahman Omar

    BMC Veterinary Research 2017 13:92

    Published on: 7 April 2017

  16. Research article

    Evaluation of antigen-induced synovitis in a porcine model: Immunological, arthroscopic and kinetic studies

    Synovitis is an inflammation-related disease linked to rheumatoid arthritis, osteoarthritis, infections and trauma. This inflammation is accompanied by immune cells infiltration which initiates an inflammatory...

    Francisco-Javier Vela, Francisco-Miguel Sánchez-Margallo, Rebeca Blázquez, Verónica Álvarez, Raquel Tarazona, M. Teresa Mangas-Ballester, Alejandro Cristo and Javier G. Casado

    BMC Veterinary Research 2017 13:93

    Published on: 7 April 2017

  17. Research article

    Differential circulating concentrations of adipokines, glucagon and adropin in a clinical population of lean, overweight and diabetic cats

    Dyslipidemia, dysregulated adipokine secretion and alteration in glucagon and adropin concentrations are important obesity-related factors in the pathophysiology of human Type 2 diabetes; however, their roles ...

    Rizaldy C. Zapata, Melissa D. Meachem, Natalia Cavalca Cardoso, Susan O. Mehain, Chantal J. McMillan, Elisabeth R. Snead and Prasanth K. Chelikani

    BMC Veterinary Research 2017 13:85

    Published on: 4 April 2017

  18. Research article

    Blood markers of fibrinolysis and endothelial activation in canine babesiosis

    Canine babesiosis is a tick-borne disease caused by hemoprotozoan parasites of the genus Babesia. The disease can be clinically classified into uncomplicated and complicated forms. The aim of this study was to as...

    Josipa Kuleš, Jelena Gotić, Vladimir Mrljak and Renata Barić Rafaj

    BMC Veterinary Research 2017 13:82

    Published on: 31 March 2017

  19. Research article

    Phenotyping and comparing the immune cell populations of free-ranging Atlantic bottlenose dolphins (Tursiops truncatus) and dolphins under human care

    Studies suggest that free-ranging bottlenose dolphins exhibit a suppressed immune system because of exposure to contaminants or microorganisms. However, due to a lack of commercially available antibodies speci...

    Mahyar Nouri-Shirazi, Brittany F. Bible, Menghua Zeng, Saba Tamjidi and Gregory D. Bossart

    BMC Veterinary Research 2017 13:78

    Published on: 27 March 2017

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