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Clinical pathology, physiology and immunology

Section edited by Prof. Jose Joaquin Ceron

The clinical pathology, physiology and immunology section considers a broad range of submissions discussing the physiological processes that occur in healthy animals and underlie stress and disease. This includes, but not limited to, studies on biomarkers, biochemistry, cytopathology, endocrinology, pathophysiology, proteomics, hematopathology, immunology, and molecular diagnostics. Comparative medicine studies are also considered. 

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  1. Designing a potent recombinant vaccine, using the appropriate subunits with the greatest effect on stimulating the immune system, especially in the case of intracellular pathogens such as gram negative Brucella M...

    Authors: Narges Nazifi, Mojtaba Tahmoorespur, Mohammad Hadi Sekhavati, Alireza Haghparast and Ali Mohammad Behroozikhah

    Citation: BMC Veterinary Research 2019 15:402

    Content type: Research article

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  2. In horses a number of small intestinal diseases is potentially life threatening. Among them are Equine Grass Sickness (EGS), which is characterised by enteric neurodegeneration of unknown aetiology, as well as...

    Authors: Maria S. Unterköfler, Bruce C. McGorum, Elspeth M. Milne and Theresia F. Licka

    Citation: BMC Veterinary Research 2019 15:400

    Content type: Research article

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  3. Cytotoxic T-lymphocyte antigen 4 (CTLA-4) is known as an immune inhibitory receptor that is expressed on activated effector T cells and regulatory T cells. When CTLA-4 binds to CD80 or CD86, immunoinhibitory s...

    Authors: Kei Watari, Satoru Konnai, Naoya Maekawa, Tomohiro Okagawa, Yasuhiko Suzuki, Shiro Murata and Kazuhiko Ohashi

    Citation: BMC Veterinary Research 2019 15:380

    Content type: Research article

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  4. The aim of this study was to investigate the association between plasma β-hydroxybutyric acid (BHBA) and conjugated linoleic acid in postpartum Polish Holstein-Friesian (PHF) cows. The experiment was carried o...

    Authors: Kamila Puppel, Marcin Gołębiewski, Paweł Solarczyk, Grzegorz Grodkowski, Jan Slósarz, Małgorzata Kunowska-Slósarz, Marek Balcerak, Tomasz Przysucha, Aleksandra Kalińska and Beata Kuczyńska

    Citation: BMC Veterinary Research 2019 15:367

    Content type: Research article

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  5. Glucocorticoids, among the most widely utilized drugs in veterinary medicine, are employed to treat a wide variety of diseases; however, their use often induces adverse events in dogs. The efficacy of glucocor...

    Authors: Kosei Yamanaka, Masaru Okuda and Takuya Mizuno

    Citation: BMC Veterinary Research 2019 15:363

    Content type: Research article

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  6. Bovine tuberculosis (bTB) is prevalent in dairy cattle in Ethiopia. Currently used diagnostic tools such as the single intradermal comparative tuberculin test (SICTT) are time consuming and labor intensive. A ...

    Authors: Aboma Zewude, Temesgen Mohammed, Lemma Terfassa, W. Garrett Hunt, Xueliang Pan, Joan Miquel Balada-Llasat, Wondwossen Gebreyes, Jordi B. Torrelles, Shu-Hua Wang and Gobena Ameni

    Citation: BMC Veterinary Research 2019 15:359

    Content type: Research article

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  7. The oral glucose test (OGT) is a useful tool for diagnosing insulin dysregulation (ID) and is somewhat repeatable in ponies under consistent management. This study aimed to determine whether the insulin and in...

    Authors: Danielle M. Fitzgerald, Christopher C. Pollitt, Donald M. Walsh, Martin N. Sillence and Melody A. de Laat

    Citation: BMC Veterinary Research 2019 15:345

    Content type: Research article

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  8. The objective of this study was to assess the efficacy of a trivalent vaccine mixture and compare it to the respective monovalent vaccines against Mycoplasma hyopneumoniae, porcine circovirus type 2 (PCV2), and p...

    Authors: Taehwan Oh, Kee Hwan Park, Siyeon Yang, Jiwoon Jeong, Ikjae Kang, Changhoon Park and Chanhee Chae

    Citation: BMC Veterinary Research 2019 15:342

    Content type: Research article

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  9. Poor hygiene of housing induces a systemic inflammatory response. Because inflammation and oxidative stress are processes that can sustain each other, the ways pigs are able to activate their antioxidant defen...

    Authors: K. Sierżant, M-H. Perruchot, E. Merlot, N. Le Floc’h and F. Gondret

    Citation: BMC Veterinary Research 2019 15:341

    Content type: Research article

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  10. The antibody-dependent cellular cytotoxicity (ADCC) is a cell-mediated immune defense mechanism in which effector immune cells actively lyse antibody-coated target cells. The ADCC of tumor cells is employed in...

    Authors: Yoseop Kim, Soo-Hyeon Lee, Cheol-Jung Kim, Je-Jung Lee, Dohyeon Yu, Soomin Ahn, Dong-Jun Shin and Sang-Ki Kim

    Citation: BMC Veterinary Research 2019 15:339

    Content type: Research article

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  11. Current guidelines recommend parvovirus revaccination of adult dogs no more frequently than every 3 years. The aim of this study was to determine the prevalence of dogs showing protective serum antibody titres...

    Authors: Ada Rota, Andrea Dogliero, Elvira Muratore, Paola Pregel, Angela Del Carro and Loretta Masoero

    Citation: BMC Veterinary Research 2019 15:335

    Content type: Research article

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  12. Both diabetes mellitus (DM) and obesity are common in cats. The adipokines leptin, adiponectin, resistin and omentin are thought to have important roles in human obesity and glucose homeostasis; however, their...

    Authors: Maggie C. Williams, Chantal J. McMillan, Elisabeth R. Snead, Kanae Takada and Prasanth K. Chelikani

    Citation: BMC Veterinary Research 2019 15:332

    Content type: Research article

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  13. Dogs that have clinical leishmaniosis (ClinL), caused by the parasite Leishmania infantum, are commonly co-infected with other pathogens, especially vector-borne pathogens (VBP). A recent PCR-based study found th...

    Authors: Charalampos Attipa, Laia Solano-Gallego, Christian M. Leutenegger, Kostas Papasouliotis, Francesca Soutter, Jörg Balzer, Scott Carver, Jesse S. Buch and Séverine Tasker

    Citation: BMC Veterinary Research 2019 15:331

    Content type: Research article

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  14. Non-specific immunotherapeutics have been evaluated previously in dogs, primarily for cancer treatment. However, there remains a need for a more broadly targeted, general purpose immunotherapeutic capable of a...

    Authors: William Wheat, Lyndah Chow, Alana Kuzmik, Sirikul Soontararak, Jade Kurihara, Michael Lappin and Steven Dow

    Citation: BMC Veterinary Research 2019 15:330

    Content type: Research article

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  15. Dietary structure in ruminants is closely connected with the composition of gastrointestinal microbiota. Merging study has shown that dietary induced SARA causes the alteration of microbial community in the ce...

    Authors: Guangjun Chang, Huanmin Zhang, Yan Wang, Nana Ma, Roy Animesh Chandra, Gengping Ye, Su Zhuang, Weiyun Zhu and Xiangzhen Shen

    Citation: BMC Veterinary Research 2019 15:298

    Content type: Research article

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  16. Platelet-rich plasma (PRP) is a therapeutic biologic that is used for treatment of musculoskeletal pathologies in equine athletes. Due to the expense of PRP kits, and the volumes obtained, freezing aliquots fo...

    Authors: Andrew K. McClain and Taralyn M. McCarrel

    Citation: BMC Veterinary Research 2019 15:292

    Content type: Research article

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  17. Capillary electrophoresis of plasma proteins has shown great potential as a complementary diagnostic tool for avian species. However, reference intervals for plasma proteins are sparse or lacking for several f...

    Authors: Jørgen Flo, Mari Engvig Løseth, Christian Sonne, Veerle L. B. Jaspers and Hege Brun-Hansen

    Citation: BMC Veterinary Research 2019 15:290

    Content type: Research article

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  18. Bovine mastitis caused by Staphylococcus aureus (S. aureus) is extremely difficult to control and new methods for its prevention and management are required. Nasal vaccines may prevent initial bovine mastitis inf...

    Authors: Yuya Nagasawa, Yoshio Kiku, Kazue Sugawara, Aya Hirose, Chiaki Kai, Nana Kitano, Toshihiko Takahashi, Tomonori Nochi, Hisashi Aso, Shin-ichi Sawada, Kazunari Akiyoshi and Tomohito Hayashi

    Citation: BMC Veterinary Research 2019 15:286

    Content type: Research article

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  19. Functional Toll-like receptor 4 (TLR4) has been characterized in human and murine platelets indicating that platelets play a role in inflammation and hemostasis during sepsis. It is unclear whether canine plat...

    Authors: Ronald H. L. Li, Nghi Nguyen and Fern Tablin

    Citation: BMC Veterinary Research 2019 15:245

    Content type: Research article

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  20. Vascular access port (VAP) systems are widely used in human medicine to provide long-term venous access. However, in veterinary medicine the use of VAP systems is not common practice and publications on their ...

    Authors: Kiona S. de Nies, Hedwig S. Kruitwagen, Giora van Straten, Leonie W. L. van Bruggen, Joris H. Robben, Baukje A. Schotanus, Ies Akkerdaas and Anne Kummeling

    Citation: BMC Veterinary Research 2019 15:240

    Content type: Methodology article

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  21. Recently, serotype 4 fowl adenovirus (FAdV-4) has spread widely and caused huge economic loss to poultry industry. However, little is known about the molecular pathogenesis of FAdV-4. Fiber protein is thought ...

    Authors: Hongxia Shao, Yanan Lu, Weikang Wang, Tuofan Li, Jianjun Zhang, Zhimin Wan, Guangchen Liang, Wei Gao, Aijian Qin and Jianqiang Ye

    Citation: BMC Veterinary Research 2019 15:232

    Content type: Research article

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  22. Acute ruminal acidosis (ARA) is a metabolic disease of cattle characterized by an aseptic synovitis. ARA is the result of an increased intake of highly fermentable carbohydrates that frequently occurs in dairy...

    Authors: Alejandra I. Hidalgo, María D. Carretta, Pablo Alarcón, Carolina Manosalva, Ananda Müller, Max Navarro, María A. Hidalgo, Thilo Kaehne, Anja Taubert, Carlos R. Hermosilla and Rafael A. Burgos

    Citation: BMC Veterinary Research 2019 15:225

    Content type: Research article

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  23. The role played by the humoral immune response in animals vaccinated against a mycobacterial disease such as paratuberculosis, is not well understood. Sheep vaccinated against Mycobacterium avium subsp. paratuber...

    Authors: Hannah B. Pooley, Douglas J. Begg, Karren M. Plain, Richard J. Whittington, Auriol C. Purdie and Kumudika de Silva

    Citation: BMC Veterinary Research 2019 15:223

    Content type: Research article

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  24. Periodontal disease is the most common oral disease of dogs and has been associated with systemic disease. The purpose of the present study was to determine the extent of periodontal disease in a population of...

    Authors: Corrin Wallis, Ilaria Pesci, Alison Colyer, Lisa Milella, Peter Southerden, Lucy J. Holcombe and Neil Desforges

    Citation: BMC Veterinary Research 2019 15:207

    Content type: Research article

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  25. Nodular lymphoid hyperplasia (NLH) is one of the most common non-neoplastic splenic lesions in dogs, especially in old ones, showing a splenic enlargement. More recent studies have been focused on Contrast Enh...

    Authors: Cyndi Mangano, Francesco Macrì, Simona Di Pietro, Michela Pugliese, Silvia Santoro, Nicola M. Iannelli, Giuseppe Mazzullo, Rosalia Crupi and Massimo De Majo

    Citation: BMC Veterinary Research 2019 15:196

    Content type: Research article

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  26. Perinatal mortality may vary between herds, but the cost of deaths are always higher than value of the calf. When diagnosing the cause of a calf’s death it is important to determine when it occurred, before or...

    Authors: Paulina Jawor, Adam Ząbek, Wojciech Wojtowicz, Dawid Król, Tadeusz Stefaniak and Piotr Młynarz

    Citation: BMC Veterinary Research 2019 15:189

    Content type: Research article

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  27. Melanosis of lymph nodes in black pigs has generally been related to regression of congenital melanoma and, occasionally, to ingestion of acorns. The aim of this manuscript is to confirm the hypothesis of a po...

    Authors: Giovanni Lanteri, Jessica Maria Abbate, Carmelo Iaria, Daniele Macrì, Vincenzo Ferrantelli and Fabio Marino

    Citation: BMC Veterinary Research 2019 15:186

    Content type: Research article

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  28. Intracranial abscess formation is an extremely rare and sporadically documented disease in South American Camelids (SACs). Herein we report the first case of otogenic brain abscess formation in this species.

    Authors: Sonja Franz, Sandra Högler, Michaela Gumpenberger and Agnes Dadak

    Citation: BMC Veterinary Research 2019 15:183

    Content type: Case Report

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  29. Breast cancer resistance protein (BCRP) and multidrug resistance protein 4 (MRP4) are involved in uric acid excretion in humans and mice. Despite evidence suggesting that renal proximal tubular epithelial cell...

    Authors: Xuedong Ding, Manman Li, Chenglu Peng, Zhi Wang, Shoufa Qian, Yuying Ma, Tianyi Fang, Shibin Feng, Yu Li, Xichun Wang, Jinchun Li and Jinjie Wu

    Citation: BMC Veterinary Research 2019 15:180

    Content type: Research article

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  30. Dogs with various medical diseases are usually treated at hospitals; however, the prognostic markers in dogs remain unknown. The aim of this study was to investigate the ability of serum cortisol concentration...

    Authors: Masashi Yuki, Reina Aoyama, Takashi Hirano, Reina Tawada, Mizuho Ogawa, Eiji Naitoh, Daiki Kainuma and Noriyuki Nagata

    Citation: BMC Veterinary Research 2019 15:170

    Content type: Research article

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  31. In broilers chickens, the molecular bases for promoting muscle development and growth requires further investigation. Therefore, the current study aimed to investigate the effects of daily thermal manipulation...

    Authors: Mohamed Borhan Al-Zghoul and Sabry Mohamed El-Bahr

    Citation: BMC Veterinary Research 2019 15:166

    Content type: Research article

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  32. Biomarkers of oxidative stress in pigs have been measured in serum/plasma samples. However, blood collection in pigs can be highly stressful to the animals. Saliva is a biological fluid with several advantages...

    Authors: Camila Peres Rubio, Eva Mainau, José Joaquín Cerón, Maria Dolores Contreras-Aguilar, Silvia Martínez-Subiela, Elena Navarro, Fernando Tecles, Xavier Manteca and Damian Escribano

    Citation: BMC Veterinary Research 2019 15:144

    Content type: Research article

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  33. Feline hyperthyroidism, the most common endocrinopathy in older cats, provides a spontaneous model for human thyrotoxicosis. Human thyrotoxicosis is associated with redox unbalance, which may result in organ d...

    Authors: Alessia Candellone, Paola Gianella, Lara Ceccarelli, Graziella Raviri, Paola Badino, Silvia Roncone, Hans S. Kooistra and Giorgia Meineri

    Citation: BMC Veterinary Research 2019 15:136

    Content type: Research article

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  34. Laminitis is considered as one of the most important causes of hoof lameness in dairy cows, which can lead to enormous economic losses. However, the etiology and pathogenesis of laminitis have not been clarifi...

    Authors: Meng-Yue Tian, Jing-Hui Fan, Zhi-Wei Zhuang, Fei Dai, Cheng-Yu Wang, Hai-Ting Hou and Yu-Zhong Ma

    Citation: BMC Veterinary Research 2019 15:127

    Content type: Research article

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  35. In order to characterize the complete range of lesions, especially minimal, affecting mammary gland and viral antigen distribution and target cells using immunohistochemistry in naturally Visna/maedi (VM) 84 i...

    Authors: E. Gayo, L. Polledo, A. Magalde, A. Balseiro, M. J. García Iglesias, C. Pérez Martínez, S. Preziuso, G. Rossi and J. F. García Marín

    Citation: BMC Veterinary Research 2019 15:109

    Content type: Research article

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  36. A previous study showed that prebiotics and synbiotics administered in ovo into the egg air cell on the 12th day of incubation enhance the growth and development of chickens. However, the influence of this proced...

    Authors: Tadeusz Stefaniak, Jan P. Madej, Stanisław Graczyk, Maria Siwek, Ewa Łukaszewicz, Artur Kowalczyk, Marcin Sieńczyk and Marek Bednarczyk

    Citation: BMC Veterinary Research 2019 15:105

    Content type: Research article

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  37. To conduct a hematological analysis of avian blood samples, standard automated cell counting is unreliable because all avian blood cells are nucleated. Therefore, quantitative white blood cell counting in bird...

    Authors: Lea Carisch, Martina Stirn, Jean Michel Hatt, Karin Federer, Regina Hofmann-Lehmann and Barbara Riond

    Citation: BMC Veterinary Research 2019 15:93

    Content type: Research article

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  38. Limited data are available about the kinetics of mRNA expressions of Heat shock proteins (HSPs) and heat shock factors (HSFs) in the thermally manipulated (TM) broiler chicks during acute heat stress. Therefor...

    Authors: Mohamed Borhan Al-Zghoul and Sabry Mohamed El-Bahr

    Citation: BMC Veterinary Research 2019 15:83

    Content type: Research article

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  39. The sustainability of farming and animal welfare requires the reconsideration of current selection schemes. In particular, implementation of new selection criteria related to animal health and welfare should h...

    Authors: Julie Hervé, Elena Terenina, Karine Haurogné, Elodie Bacou, Elizaveta Kulikova, Marie Allard, Yvon Billon, Jean-Marie Bach, Pierre Mormède and Blandine Lieubeau

    Citation: BMC Veterinary Research 2019 15:71

    Content type: Research article

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  40. Refractory diseases, including bacterial infections, are causing huge economic losses in dairy farming. Despite efforts to prevent and treat those diseases in cattle, including the use of antimicrobials, it is...

    Authors: Sotaro Fujisawa, Satoru Konnai, Tomohiro Okagawa, Naoya Maekawa, Akina Tanaka, Yasuhiko Suzuki, Shiro Murata and Kazuhiko Ohashi

    Citation: BMC Veterinary Research 2019 15:68

    Content type: Research article

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  41. Premilking udder preparation is essential for harvesting high-quality milk as gently, completely, and quickly as possible. The associations between characteristics such as teat-end shape and premilking stimula...

    Authors: Matthias Wieland, Jaclyn M. Melvin, Daryl V. Nydam and Paul D. Virkler

    Citation: BMC Veterinary Research 2019 15:58

    Content type: Research article

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  42. Bacterial lipopolysaccharide and interferon-γ stimulation of rodent macrophages in vitro induces up-regulation of inducible nitric oxide synthase, whereas interleukin-4 stimulation results in increased activit...

    Authors: Heather Imrie and Diana J. L. Williams

    Citation: BMC Veterinary Research 2019 15:45

    Content type: Research article

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  43. Caspases are a family of conserved intracellular cysteine-dependent aspartate-specific cysteine proteases that play important roles in regulating cell death and inflammation. Our previous study revealed the im...

    Authors: Shuo Li, Jiafang Li, Weijiao Peng, Gaixiang Hao and Jinsheng Sun

    Citation: BMC Veterinary Research 2019 15:20

    Content type: Research article

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  44. Staphylococcus aureus, a leading cause of mastitis in dairy cattle, causes severe mastitis and/or chronic persistent infections with detrimental effects on the cows’ wellbeing, lifespan and milk production. Despi...

    Authors: Lindert Benedictus, Lars Ravesloot, Kim Poppe, Ineke Daemen, Eveline Boerhout, Jos van Strijp, Femke Broere, Victor Rutten, Ad Koets and Susanne Eisenberg

    Citation: BMC Veterinary Research 2019 15:15

    Content type: Research article

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  45. Although teleost fish developed acquired immunity firstly in evolution, innate immunity is still very important for them. Innate immunity depends on pattern recognition receptors (PRRs) to distinguish “self” a...

    Authors: Fumiao Zhang, Shijuan Shan, Xiaoyang Xu, Yao Wang, Yonghuan Zhang, Miao Yin and Guiwen Yang

    Citation: BMC Veterinary Research 2019 15:10

    Content type: Research article

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  46. The ideal method for monitoring trilostane therapy in dogs with hypercortisolism is still open to debate. Recently, determination of the pre-trilostane (prepill) cortisol concentration has been proposed to be ...

    Authors: Felicitas Boretti, Caterina Musella, Wanda Burkhardt, Claudia Kuemmerle-Fraune, Barbara Riond, Claudia Reusch and Nadja Sieber-Ruckstuhl

    Citation: BMC Veterinary Research 2018 14:417

    Content type: Research article

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  47. The immune response against tuberculosis in lions is still poorly defined and our understanding is hampered by the lack of lion specific reagents. The process for producing antibodies against a specific antige...

    Authors: Tashnica Taime Sylvester, Sven David Charles Parsons, Paul David van Helden, Michele Ann Miller and Andre Gareth Loxton

    Citation: BMC Veterinary Research 2018 14:410

    Content type: Research article

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