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Clinical pathology, physiology and immunology

Section edited by Jose Joaquin Ceron

The clinical pathology, physiology and immunology section covers a broad range of studies regarding the physiological processes that occur in healthy animals and the animals’ response to stress and different diseases such as infectious diseases. This section considers research articles on biomarkers; biochemistry; cytopathology; endocrinology; pathophysiology; proteomics; hematopathology; immunology amd molecular diagnostics

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  1. Content type: Research article

    Caspases are a family of conserved intracellular cysteine-dependent aspartate-specific cysteine proteases that play important roles in regulating cell death and inflammation. Our previous study revealed the im...

    Authors: Shuo Li, Jiafang Li, Weijiao Peng, Gaixiang Hao and Jinsheng Sun

    Citation: BMC Veterinary Research 2019 15:20

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  2. Content type: Research article

    Although teleost fish developed acquired immunity firstly in evolution, innate immunity is still very important for them. Innate immunity depends on pattern recognition receptors (PRRs) to distinguish “self” a...

    Authors: Fumiao Zhang, Shijuan Shan, Xiaoyang Xu, Yao Wang, Yonghuan Zhang, Miao Yin and Guiwen Yang

    Citation: BMC Veterinary Research 2019 15:10

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  3. Content type: Research article

    Staphylococcus aureus, a leading cause of mastitis in dairy cattle, causes severe mastitis and/or chronic persistent infections with detrimental effects on the cows’ wellbeing, lifespan and milk production. Despi...

    Authors: Lindert Benedictus, Lars Ravesloot, Kim Poppe, Ineke Daemen, Eveline Boerhout, Jos van Strijp, Femke Broere, Victor Rutten, Ad Koets and Susanne Eisenberg

    Citation: BMC Veterinary Research 2019 15:15

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  4. Content type: Research article

    The ideal method for monitoring trilostane therapy in dogs with hypercortisolism is still open to debate. Recently, determination of the pre-trilostane (prepill) cortisol concentration has been proposed to be ...

    Authors: Felicitas Boretti, Caterina Musella, Wanda Burkhardt, Claudia Kuemmerle-Fraune, Barbara Riond, Claudia Reusch and Nadja Sieber-Ruckstuhl

    Citation: BMC Veterinary Research 2018 14:417

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  5. Content type: Research article

    The immune response against tuberculosis in lions is still poorly defined and our understanding is hampered by the lack of lion specific reagents. The process for producing antibodies against a specific antige...

    Authors: Tashnica Taime Sylvester, Sven David Charles Parsons, Paul David van Helden, Michele Ann Miller and Andre Gareth Loxton

    Citation: BMC Veterinary Research 2018 14:410

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  6. Content type: Research article

    Foot-and-mouth disease (FMD) can be controlled by either stamping out or vaccination, a choice which depends on both the economic importance of the livestock sector as well as the disease status. In FMD-free c...

    Authors: Yeong-Lim Kang, Ji-Yun Jeong, Hwi-Yeon Choi, Yanhong Zhang, Yumei Liu, Ho-Jong Lee, Jong-Chul Choi, So-Hyun Lee, Beom-Joo Lee, Sang-Won Lee, Joong-Bok Lee, Ki-hyun Cho and Seung-Yong Park

    Citation: BMC Veterinary Research 2018 14:371

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  7. Content type: Research article

    Pre-weaning milk replacer (MR) feeding program is a key factor affecting the health and welfare of lambs during their weaning. Weaning stress is well known as an inducement that negatively impacts the immune s...

    Authors: Qian Zhang, Chong Li, Xiaolin Niu, Zhian Zhang, Fadi Li and Fei Li

    Citation: BMC Veterinary Research 2018 14:366

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  8. Content type: Case Report

    Listeria (L.) monocytogenes as the causative agent of listeriosis in humans and different animal species, has its reservoir in the environment. It can be found in the gut and faeces of healthy pigs, but under cer...

    Authors: Heiko Stein, Beatrix Stessl, Rene Brunthaler, Igor Loncaric, Herbert Weissenböck, Ursula Ruczizka, Andrea Ladinig and Lukas Schwarz

    Citation: BMC Veterinary Research 2018 14:362

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  9. Content type: Research article

    Chicken erythrocytes are involved in immunity through binding of toll-like receptors (TLRs) with their ligands to activate downstream signaling and lead to cytokine production in erythrocytes. Some avian β-def...

    Authors: Sheng Niu, Ali Raza Jahejo, Fa-jie Jia, Xin Li, Guan-bao Ning, Ding Zhang, Hai-li Ma, Wei-fang Hao, Wen-wei Gao, Yu-jun Zhao, Shi-min Gao, Gui-lan Li, Jian-hui Li, Fang Yan, Rong-kun Gao, Yu-hai Bi…

    Citation: BMC Veterinary Research 2018 14:363

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  10. Content type: Research article

    Bovine tuberculosis (bTB) caused by Mycobacterium bovis has previously been diagnosed in warthogs and infection can be highly prevalent (> 30%) in endemic areas. Thus, warthogs could potentially be an important s...

    Authors: Eduard O. Roos, Francisco Olea-Popelka, Peter Buss, Guy A. Hausler, Robin Warren, Paul D. van Helden, Sven D. C. Parsons, Lin-Mari de Klerk-Lorist and Michele A. Miller

    Citation: BMC Veterinary Research 2018 14:360

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  11. Content type: Research article

    Canine Distemper Virus (CDV) and Canine Parvovirus (CPV) lead to infections with high mortality rates in dogs. These viruses affect unvaccinated dogs or dogs with incomplete vaccination protocols. Vaccination ...

    Authors: Beatriz Vila Nova, Eva Cunha, Nuno Sepúlveda, Manuela Oliveira, Berta São Braz, Luis Tavares, Virgílio Almeida and Solange Gil

    Citation: BMC Veterinary Research 2018 14:348

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  12. Content type: Research article

    Avoidance of antigenic stimuli was found to significantly reverse airway obstruction of horses with severe equine asthma (sEA). To date, no published study investigated the influence of steaming hay on lower a...

    Authors: Marie Orard, Erika Hue, Anne Couroucé, Céline Bizon-Mercier, Marie-Pierre Toquet, Meriel Moore-Colyer, Laurent Couëtil, Stéphane Pronost, Romain Paillot, Magali Demoor and Eric A. Richard

    Citation: BMC Veterinary Research 2018 14:345

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  13. Content type: Research article

    Because antibiotic use in livestock is assumed to contribute to the emerging public health crisis of antibiotic resistance, alternatives are required. Phytogenic additives are extensively studied due to their ...

    Authors: Tobias Gräber, Holger Kluge, Sebastian Granica, Gert Horn, Jutta Kalbitz, Corinna Brandsch, Antje Breitenstein, Christine Brütting and Gabriele I. Stangl

    Citation: BMC Veterinary Research 2018 14:346

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  14. Content type: Research article

    Postpartum dysgalactia syndrome (PDS) in sows is difficult to diagnose and the pathogenesis is obscure. Hormonal changes related to the disease are often difficult to distinguish from those found in the normal...

    Authors: Marianne Kaiser, Stine Jacobsen, Pia Haubro Andersen, Poul Bækbo, José Joaquin Cerón, Jan Dahl, Damián Escribano, Peter Kappel Theil and Magdalena Jacobson

    Citation: BMC Veterinary Research 2018 14:334

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  15. Content type: Research article

    In this work, we report an electrochemical biosensor for the detection of anti-hemagglutinin antibodies against the swine virus H1N1 present in mice sera immunized with mixture of His6-H1 HA in monomeric and olig...

    Authors: Edyta Mikuła, Cristiane Erdmann Silva, Edyta Kopera, Konrad Zdanowski, Jerzy Radecki and Hanna Radecka

    Citation: BMC Veterinary Research 2018 14:328

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  16. Content type: Research article

    Cleft palate is a birth defect characterized by a lack of fusion between structures forming the palate. Causes include a multitude of factors, both genetic and environmental. Computed tomography (CT) is widely...

    Authors: Filip Pankowski, Sławomir Paśko, Andrzej Max, Bartłomiej Szal, Małgorzata Dzierzęcka, Joanna Gruszczyńska, Paweł Szaro, Marek Gołębiowski and Bartłomiej Jan Bartyzel

    Citation: BMC Veterinary Research 2018 14:316

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  17. Content type: Case Report

    Ovarian cancer is diagnosed clinically by detecting ovarian cancer-related factors and markers. Here, we report a case of giant panda ovarian tumor metastasis with a combination of clinical and histopathologic...

    Authors: Qi Gao, Chengdong Wang, Desheng Li, Hemin Zhang, Linhua Deng, Caiwu Li and Zhengli Chen

    Citation: BMC Veterinary Research 2018 14:311

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  18. Content type: Research article

    In the host immune system, perforin is a cytotoxic effector molecule that eliminate virus-infected and malignant cells. Moreover, some recent studies also imply the involvement of perforin in antibacterial imm...

    Authors: Ting Li, Lei Wang, Yonghuan Zhang, Xinyi Guo, Xinze Chen, Fumiao Zhang, Guiwen Yang, Wujun Wen and Hua Li

    Citation: BMC Veterinary Research 2018 14:299

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  19. Content type: Methodology article

    In the postpartum cow, early diagnosis of uterine disease is currently problematic due to the lack of reliable, non-invasive diagnostic methods. Cervico-vaginal mucus (CVM) is an easy to collect potentially in...

    Authors: Mounir Adnane, Paul Kelly, Aspinas Chapwanya, Kieran G. Meade and Cliona O’Farrelly

    Citation: BMC Veterinary Research 2018 14:297

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  20. Content type: Research article

    Currently, little is known about the effect of sodium butyrate (NaB) on oxidative stress following grain-induced sub-acute ruminal acidosis in dairy goats. In the present study, 18 lactating dairy goats implan...

    Authors: Nana Ma, Juma Ahamed Abaker, Muhammad Shahid Bilal, Hongyu Dai and Xiangzhen Shen

    Citation: BMC Veterinary Research 2018 14:275

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  21. Content type: Research article

    The generation of recombinant proteins for commercialisation must be cost-effective. Despite the cost-effective production of recombinant feline interferon (rFeIFN) by a baculovirus expression system, this rFe...

    Authors: Sachi Minagawa, Yuzuru Nakaso, Masahiro Tomita, Takenori Igarashi, Yoshio Miura, Hideyo Yasuda and Satoshi Sekiguchi

    Citation: BMC Veterinary Research 2018 14:260

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  22. Content type: Research article

    During peripartum period, dairy cows are highly susceptible to energy metabolism disorders such as fatty liver and ketosis. Angiopoietin-like protein 4 (ANGPTL4) and fibroblast growth factor 21 (FGF21), known ...

    Authors: Jianguo Wang, Xiaoyan Zhu, Guanghui She, Yezi Kong, Yazhou Guo, Zhe Wang, Guowen Liu and Baoyu Zhao

    Citation: BMC Veterinary Research 2018 14:236

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  23. Content type: Research article

    Urea and creatinine in saliva have been reported to be possible markers of chronic kidney disease (CKD) in humans. The aim of this study was to assess if urea and creatinine could be measured in canine saliva,...

    Authors: Asta Tvarijonaviciute, Luis Pardo-Marin, Fernando Tecles, Juana Dolores Carrillo, Juan Diego Garcia-Martinez, Luis Bernal, Josep Pastor, José J. Cerón and Silvia Martinez-Subiela

    Citation: BMC Veterinary Research 2018 14:223

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  24. Content type: Research article

    Oxidative stress (OS) associated with an intense exercise may have a negative influence on equine health. The aim of this study was to determine the effects of endurance races on oxidative and antioxidative st...

    Authors: Nika Brkljača Bottegaro, Jelena Gotić, Jelena Šuran, Diana Brozić, Karla Klobučar, Krunoslav Bojanić and Zoran Vrbanac

    Citation: BMC Veterinary Research 2018 14:216

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  25. Content type: Review

    Dogs with canine leishmaniosis (CanL) due to Leishmania infantum can show a wide spectrum of clinical and clinicopathological findings at the time of diagnosis. The aim of this paper is to describe the possible a...

    Authors: J. J. Ceron, L. Pardo-Marin, M. Caldin, T. Furlanello, L. Solano-Gallego, F. Tecles, L. Bernal, G. Baneth and S. Martinez-Subiela

    Citation: BMC Veterinary Research 2018 14:196

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  26. Content type: Research article

    Staphylococcus aureus (S. aureus) internalization into bovine mammary epithelial cells (bMECs) is considered an important pathogenic mechanism for the establishment of mastitis. Given the interesting link between...

    Authors: Heng Wang, Chongliang Bi, Yinjie Wang, Jun Sun, Xia Meng and Jianji Li

    Citation: BMC Veterinary Research 2018 14:197

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  27. Content type: Review

    Marine and aquaculture industries are important sectors of the food production and global trade. Unfortunately, the fish food industry is challenged with a plethora of infectious pathogens. The freshwater and ...

    Authors: Michael Gotesman, Simon Menanteau-Ledouble, Mona Saleh, Sven M. Bergmann and Mansour El-Matbouli

    Citation: BMC Veterinary Research 2018 14:178

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  28. Content type: Research article

    Salmonella enterica serovar Typhimurium (Salmonella Typhimurium) is a zoonotic pathogen responsible for severe intestinal pathology in young chickens. Natural resistance-associated macrophage protein (NRAMP) fami...

    Authors: Mashooq Ahmad Dar, Raashid Ahmed, Uneeb Urwat, Syed Mudasir Ahmad, Pervaiz Ahmad Dar, Zahid Amin Kushoo, Tanveer Ali Dar, Peerzada Tajamul Mumtaz, Shakil Ahmad Bhat, Umar Amin, Nadeem Shabir, Hina Fayaz Bhat, Riaz Ahmad Shah, Nazir Ahmad Ganai and Mohammad Heidari

    Citation: BMC Veterinary Research 2018 14:180

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  29. Content type: Research article

    Mounting evidences observed that subacute ruminal acidosis (SARA) induced by high concentration (HC) diet increases the translocation of histamine from digestive tract into circulation causing a diverse of dis...

    Authors: Guangjun Chang, Lailai Wang, Nana Ma, Wenwen Zhang, Huanmin Zhang, Hongyu Dai and Xiangzhen Shen

    Citation: BMC Veterinary Research 2018 14:168

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  30. Content type: Research article

    The aim of this study was to evaluate salivary alpha-amylase (sAA), considered a non-invasive biomarker for sympathetic nervous system (SNS) activity, and salivary cortisol as possible pain-induced stress biom...

    Authors: María Dolores Contreras-Aguilar, Damián Escribano, María Martín-Cuervo, Fernando Tecles and Jose Joaquín Cerón

    Citation: BMC Veterinary Research 2018 14:156

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  31. Content type: Research article

    Sheep have been traditionally considered as less susceptible to Mycobacterium bovis (Mbovis) infection than other domestic ruminants such as cattle and goats. However, there is increasing evidence for the role of...

    Authors: Raquel Vallejo, Juan Francisco García Marín, Ramón Antonio Juste, Marta Muñoz-Mendoza, Francisco Javier Salguero and Ana Balseiro

    Citation: BMC Veterinary Research 2018 14:154

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  32. Content type: Research article

    In the host innate immune system, various pattern recognition receptors (PRRs) recognize conserved pathogen-associated molecular patterns (PAMPs) and represent an efficient first line of defense against invadi...

    Authors: Hua Li, Ting Li, Yujie Guo, Yujun Li, Yan Zhang, Na Teng, Fumiao Zhang and Guiwen Yang

    Citation: BMC Veterinary Research 2018 14:153

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  33. Content type: Research article

    The aim of the study was to evaluate the impact of herbal extracts on selected immunity mechanisms in clinically healthy pigeons and pigeons inoculated with the pigeon paramyxovirus type 1 (PPMV-1). For the fi...

    Authors: Daria Dziewulska, Tomasz Stenzel, Marcin Śmiałek, Bartłomiej Tykałowski and Andrzej Koncicki

    Citation: BMC Veterinary Research 2018 14:148

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  34. Content type: Research article

    Insulin dysregulation in horses is a metabolic condition defined by high insulin concentrations in the blood and peripheral insulin resistance. This hyperinsulinemia is often associated with severe damage in t...

    Authors: Ákos Kenéz, Tobias Warnken, Karsten Feige and Korinna Huber

    Citation: BMC Veterinary Research 2018 14:146

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  35. Content type: Research article

    Friesian horses are known for their high inbreeding rate resulting in several genetic diseases such as hydrocephaly and dwarfism. This last decade, several studies focused on two other presumed hereditary trai...

    Authors: Veronique Saey, Jonathan Tang, Richard Ducatelle, Siska Croubels, Siegrid De Baere, Stijn Schauvliege, Gunther van Loon and Koen Chiers

    Citation: BMC Veterinary Research 2018 14:139

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  36. Content type: Research article

    The ovine rumen is involved in host defense responses and acts as the immune interface with the environment. The ruminal mucosal epithelium plays an important role in innate immunity and secretes antimicrobial...

    Authors: Xin Jin, Man Zhang, Xue-min Zhu, Yan-ru Fan, Chen-guang Du, Hua-er Bao, Siri-guleng Xu, Qiao-zhen Tian, Yun-he Wang and Yin-feng Yang

    Citation: BMC Veterinary Research 2018 14:134

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  37. Content type: Research article

    Subacute ruminal acidosis (SARA) is a metabolic disease in high-producing dairy cattle, and is accompanied by rumenitis. However, the mechanism of rumenitis remains unclear. Therefore, the aim of this study wa...

    Authors: Chenxu Zhao, Guowen Liu, Xiaobing Li, Yuan Guan, Yazhou Wang, Xue Yuan, Guoquan Sun, Zhe Wang and Xinwei Li

    Citation: BMC Veterinary Research 2018 14:135

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  38. Content type: Research article

    Clostridium novyi-NT (CNV-NT), has shown promise as a bacterolytic therapy for solid tumors in mouse models and in dogs with naturally developing neoplasia. Factors that impact the immunologic response to ther...

    Authors: Amy E. DeClue, Sandra M. Axiak-Bechtel, Yan Zhang, Saurabh Saha, Linping Zhang, David D. Tung and Jeffrey N. Bryan

    Citation: BMC Veterinary Research 2018 14:119

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  39. Content type: Research article

    Species-specific point-of-care tests (POCT) permit a rapid analysis of canine C-reactive protein (CRP), enabling veterinarians to include CRP in clinical decisions. Aim of the study was to evaluate a novel POC...

    Authors: Sarah Hindenberg, Melanie Keßler, Sabine Zielinsky, Judith Langenstein, Andreas Moritz and Natali Bauer

    Citation: BMC Veterinary Research 2018 14:99

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  40. Content type: Research article

    The pathogenesis of postpartum dysgalactia syndrome (PDS) in sows is not fully elucidated and affected sows often present vague clinical signs. Accurate and timely diagnosis is difficult, and PDS is often reco...

    Authors: Marianne Kaiser, Magdalena Jacobson, Pia Haubro Andersen, Poul Bækbo, José Joaquin Cerón, Jan Dahl, Damián Escribano and Stine Jacobsen

    Citation: BMC Veterinary Research 2018 14:83

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    The Correction to this article has been published in BMC Veterinary Research 2018 14:175

  41. Content type: Research article

    The aim of the present study was to assess the effects of subclinical inflammation on specific humoral immunity in dogs vaccinated with Nobivac® DHP based on serum levels of CRP and Hp. Dogs from the group I w...

    Authors: Przemysław Romiszewski, Krzysztof Kostro and Urszula Lisiecka

    Citation: BMC Veterinary Research 2018 14:70

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  42. Content type: Case Report

    Carbon monoxide (CO), a common cause of poisoning in human beings has also been implicated in the death of animals. Though there are multiple studies on CO poisoning and relevant lethal blood COHb concentratio...

    Authors: Arya Sobhakumari, Robert H. Poppenga, J. Brad Pesavento and Francisco A. Uzal

    Citation: BMC Veterinary Research 2018 14:67

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  43. Content type: Research article

    The primary aim was to evaluate by means of thromboelastometry (ROTEM) the effects of hydroxyethyl starch (HES) 130/0.4 administered as a constant rate infusion (CRI) on hemostasis in hypoalbuminemic dogs. The...

    Authors: Angelica Botto, Barbara Bruno, Cristiana Maurella, Fulvio Riondato, Alberto Tarducci, Giulio Mengozzi and Antonio Borrelli

    Citation: BMC Veterinary Research 2018 14:33

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  44. Content type: Research article

    The present study was conducted to investigate the effects of oridonin (ORI) on growth performance, relative organ weight, lymphocyte proliferation, phagocytic function of neutrophils, and cytokine concentrati...

    Authors: Qiu Jue Wu, Xiao Chuan Zheng, Tian Wang and Tie Ying Zhang

    Citation: BMC Veterinary Research 2018 14:34

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  45. Content type: Research article

    The uteruses of most dairy cattle are easily infected by bacteria, especially gram-negative bacteria, following parturition. Macrophages are important cells of the immune system and play a critical role in the...

    Authors: Junsheng Dong, Jianji Li, Luying Cui, Yefan Wang, Jiaqi Lin, Yang Qu and Heng Wang

    Citation: BMC Veterinary Research 2018 14:30

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  46. Content type: Research article

    Phytochemical flavonoids are widely distributed in the environment and are derived from many anthropogenic activities. The isoflavone genistein is a naturally occurring compound found in soya products that are...

    Authors: Carmen Sarasquete, María Úbeda-Manzanaro and Juan B. Ortiz-Delgado

    Citation: BMC Veterinary Research 2018 14:16

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  47. Content type: Research article

    The present study aimed to throw light on the clinical characteristics of abomasal impaction in buffalo calves and its associated biochemical alterations. For this reason, a total of 20 male buffalo calves (Bubal...

    Authors: Maged R. El-Ashker, Mohamed F. Salama, Mohamed E. El-Boshy and Eman A. Abo El-Fadle

    Citation: BMC Veterinary Research 2018 14:2

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  48. Content type: Research article

    The active form of the vitamin D3, 1,25-Dihydroxyvitamin D3 (1,25-(OH)2D3) has been shown to have major effects not only on physiological processes but also on the regulation of the immune system of vertebrates. ...

    Authors: Yolanda Corripio-Miyar, Richard J. Mellanby, Katy Morrison and Tom N. McNeilly

    Citation: BMC Veterinary Research 2017 13:390

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