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Cell biology and stem cell research

This section deals with exploratory and basic science research in both cellular and regenerative medicine research that has a focus on improving the understanding of animal health/disease. Examples of topics that are of interest to this section include cellular and molecular biology, stem cells, platelet-rich plasma, development of novel regenerative therapies and methodologies for their clinical application. The translation of research from the bench to the patient, and from the veterinary field to the human field is all of keen interest to this specialty section.

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  1. Exosomes, internal proteins, lipids, and nucleic acids coated by phospholipid bilayer membranes, are one type of small extracellular vesicles, which can mediate cell-cell communication. In recent years, exosom...

    Authors: Dongsheng Li, Huina Luo, Huimin Ruan, Zhisheng Chen, Shengfeng Chen, Bingyun Wang and Yong Xie

    Citation: BMC Veterinary Research 2021 17:272

    Content type: Research article

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  2. The source of multipotent stromal cells (MSC) can have a significant influence on the health and expansion capacity of the cells. As the applications for allogeneic MSCs in the treatment of feline diseases inc...

    Authors: Amy Wysong, Priscilla Ortiz, Douglas Bittel, Lindsey Ott, Francis Karanu, Michael Filla and Lisa Stehno-Bittel

    Citation: BMC Veterinary Research 2021 17:244

    Content type: Research article

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  3. Intrasynovial deep digital flexor tendon (DDFT) injuries occur frequently and are often implicated in cases of navicular disease with poor outcomes and reinjuries. Cell-based approaches to tendon healing are g...

    Authors: Vivian G. Quam, Nadine N. Altmann, Matthew T. Brokken and Sushmitha S. Durgam

    Citation: BMC Veterinary Research 2021 17:138

    Content type: Research article

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  4. Cryopreservation is an efficient way to store spermatozoa and is closely associated with the quality of sperm after the freeze-thaw process. During freeze-thaw cycling, excessive reactive oxygen species (ROS) ...

    Authors: Bin Zhang, Yan Wang, Caihong Wu, Shulei Qiu, Xiaolan Chen, Bingyan Cai and Huimei Xie

    Citation: BMC Veterinary Research 2021 17:127

    Content type: Research article

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  5. Mesenchymal stem cells (MSCs) have generated a great amount of interest in recent years as a novel therapeutic application for improving the quality of pet life and helping them free from painful conditions an...

    Authors: Huina Luo, Dongsheng Li, Zhisheng Chen, Bingyun Wang and Shengfeng Chen

    Citation: BMC Veterinary Research 2021 17:96

    Content type: Research article

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  6. Induced pluripotent stem cells (iPSCs) are undifferentiated stem cells characterized by the ability to differentiate into any cell type in the body. iPSCs are a relatively new and rapidly developing technology...

    Authors: Rachel A. Scarfone, Samantha M. Pena, Keith A. Russell, Dean H. Betts and Thomas G. Koch

    Citation: BMC Veterinary Research 2020 16:477

    Content type: Review

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  7. Canine colostrum milk (CCM) is a specific secretion of the mammary gland that is fundamental for the survival of the newborn. CCM has many described components (immunoglobulins, proteins or fat), but its small...

    Authors: Antonio J. Villatoro, María del Carmen Martín-Astorga, Cristina Alcoholado and José Becerra

    Citation: BMC Veterinary Research 2020 16:417

    Content type: Research article

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  8. Tumours in mammary glands represent the most common neoplasia in bitches, as in humans. This high incidence results in part from the stimulation of sex hormones on these glands. Among mammary tumours, inflamma...

    Authors: Jéssica Borghesi, Sara Caceres, Lara Carolina Mario, Angela Alonso-Diez, Ana Carolina Silveira Rabelo, Maria J. Illera, Gema Silvan, Maria Angélica Miglino, Phelipe O. Favaron, Ana Claudia O. Carreira and Juan Carlos Illera

    Citation: BMC Veterinary Research 2020 16:353

    Content type: Research article

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  9. The ability of adipose tissue-derived multipotent mesenchymal stromal cells/mesenchymal stem cells (ASCs) to differentiate in neural lineages promises progress in the field of regenerative medicine, especially...

    Authors: Sonja Prpar Mihevc, Vesna Kokondoska Grgich, Andreja Nataša Kopitar, Luka Mohorič and Gregor Majdič

    Citation: BMC Veterinary Research 2020 16:282

    Content type: Research article

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  10. Three-dimensional models of cell culture such as organoids and mini organs accord better advantage over regular cell culture because of their ability to simulate organ functions hence, used for disease modelin...

    Authors: Mohan Acharya, Komala Arsi, Annie M. Donoghue, Rohana Liyanage and Narayan C. Rath

    Citation: BMC Veterinary Research 2020 16:179

    Content type: Research article

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  11. Endothelial colony forming cells (ECFCs) may be useful therapeutically in conditions with poor blood supply, such as distal limb wounds in the horse. Encapsulation of ECFCs into injectable hydrogel microsphere...

    Authors: Randolph L. Winter, Yuan Tian, Fred J. Caldwell, Wen J. Seeto, Jey W. Koehler, David A. Pascoe, Shirley Fan, Phillippe Gaillard, Elizabeth A. Lipke and Anne A. Wooldridge

    Citation: BMC Veterinary Research 2020 16:43

    Content type: Research article

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  12. Platelet-rich plasma (PRP) as well as other platelet-derived products have been used as a potential disease-modifying treatment for musculoskeletal diseases, such as osteoarthritis (OA). The restorative proper...

    Authors: Livia Camargo Garbin, C. Wayne McIlwraith and David D. Frisbie

    Citation: BMC Veterinary Research 2019 15:386

    Content type: Research article

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  13. Mesenchymal stem cells are multipotent cells, with capacity for self-renewal and differentiation into tissues of mesodermal origin. These cells are possible therapeutic agents for autoimmune disorders, since t...

    Authors: Inês Esteves Dias, Pedro Olivério Pinto, Luís Carlos Barros, Carlos Antunes Viegas, Isabel Ribeiro Dias and Pedro Pires Carvalho

    Citation: BMC Veterinary Research 2019 15:358

    Content type: Review

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  14. Little is known about the differences among adult and foetal equine mesenchymal stem cells (MSCs), and no data exist about their comparative ultrastructural morphology. The aim of this study was to describe an...

    Authors: B. Merlo, G. Teti, A. Lanci, J. Burk, E. Mazzotti, M. Falconi and E. Iacono

    Citation: BMC Veterinary Research 2019 15:277

    Content type: Research article

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  15. Reported efficacy of platelet-rich plasma (PRP) in regenerative medicine is contradictory. We validated the effects of PRP on proliferation of canine bone marrow-derived multipotent mesenchymal stromal cells (...

    Authors: Sony Pandey, Dawn U. Hickey, Marti Drum, Darryl L. Millis and Maria Cekanova

    Citation: BMC Veterinary Research 2019 15:269

    Content type: Research article

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  16. MSCs secretome is under investigation as an alternative to whole-cell-based therapies, since it is enriched of bioactive molecules: growth factors, cytokines and chemokines. Taking into account the translation...

    Authors: Chiara Bernardini, Martina Bertocchi, Augusta Zannoni, Roberta Salaroli, Irvin Tubon, Giovanni Dothel, Mercedes Fernandez, Maria Laura Bacci, Laura Calzà and Monica Forni

    Citation: BMC Veterinary Research 2019 15:123

    Content type: Research article

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  17. Dairy cows with metabolic disorder in peripartal period display high inflammatory levels. Adipose tissue is a major endocrine organ, which is closely related to systemic inflammation. Retinoic acid (RA), an ac...

    Authors: Qiushi Xu, Hongdou Jia, Li Ma, Guowen Liu, Chuang Xu, Ying Li, Xinwei Li and Xiaobing Li

    Citation: BMC Veterinary Research 2019 15:48

    Content type: Research article

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  18. Mesenchymal stem cells are used for different therapeutic approaches, e.g. for osteoarthritis, lesions of the tendon as well as for bone defects. Current research on the mechanism of stem cells on the repair o...

    Authors: Michele Christian Klymiuk, Natalie Balz, Mohamed I. Elashry, Manuela Heimann, Sabine Wenisch and Stefan Arnhold

    Citation: BMC Veterinary Research 2019 15:42

    Content type: Research article

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  19. Laminitis is often associated with endocrinopathies that cause hyperinsulinemia and is also induced experimentally by hyperinsulinemia, suggesting that insulin initiates laminitis pathogenesis. Hyperinsulinemi...

    Authors: Lynne Cassimeris, Julie B. Engiles and Hannah Galantino-Homer

    Citation: BMC Veterinary Research 2019 15:24

    Content type: Research article

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  20. Inflammatory bowel disease (IBD) is an intractable autoimmune disease, relatively common in cats, with chronic vomiting and diarrhea. Previous studies have reported that mesenchymal stem cells (MSCs) alleviate...

    Authors: Ju-Hyun AN, Woo-Jin SONG, Qiang LI, Sang-Min KIM, Ji-In YANG, Min-Ok RYU, A Ryung NAM, Dong Ha BHANG, Yun-Chan JUNG and Hwa-Young YOUN

    Citation: BMC Veterinary Research 2018 14:354

    Content type: Research article

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  21. In the field of diabetes research, many studies on cell therapy have been conducted using mesenchymal stem cells. This research was intended to shed light on the influence of canine adipose-tissue-derived mese...

    Authors: Hyeon-Jin Kim, Qiang Li, Woo-Jin Song, Hye-Mi Yang, Su-Yeon Kim, Sang-Chul Park, Jin-Ok Ahn and Hwa-Young Youn

    Citation: BMC Veterinary Research 2018 14:351

    Content type: Research article

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  22. The porcine brain is gyrencephalic with similar gray and white matter composition and size more comparable to the human rather than the rodent brain; however, there is lack of information about neural progenit...

    Authors: Eunhye Kim, Seon-Ung Hwang, Junchul David Yoon, Hyunggee Kim, Gabsang Lee and Sang-Hwan Hyun

    Citation: BMC Veterinary Research 2018 14:331

    Content type: Research article

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  23. Endothelial progenitor cells (EPCs) contribute to neovascularization and vascular repair in vivo and are attractive for clinical use in ischemic disease. Tracking of stem and progenitor cells is essential to d...

    Authors: Randolph L. Winter, Wen J. Seeto, Yuan Tian, Fred J. Caldwell, Elizabeth A. Lipke and Anne A. Wooldridge

    Citation: BMC Veterinary Research 2018 14:247

    Content type: Research article

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  24. This study aimed at assessing the effectiveness and safety of repeated administrations of allogeneic bone marrow-derived mesenchymal stem cells (BM-MSCs) primed with tumor necrosis factor (TNF)-α and interfero...

    Authors: Laura Barrachina, Ana Rosa Remacha, Antonio Romero, Arantza Vitoria, Jorge Albareda, Marta Prades, Mercedes Roca, Pilar Zaragoza, Francisco José Vázquez and Clementina Rodellar

    Citation: BMC Veterinary Research 2018 14:241

    Content type: Research article

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  25. Articular cartilage lacks a regenerative response. Embryonic stem cells (ESCs) are a source of pluripotent cells for cartilage regeneration. Their use, however, is associated with a risk of teratoma developmen...

    Authors: Susanna Pilichi, Stefano Rocca, Maria Dattena, Roy Ransom Pool, Laura Mara, Daniela Sanna, Gerolamo Masala, Maria Lucia Manunta, Simone Dore, Andrea Manunta and Eraldo Sanna Passino

    Citation: BMC Veterinary Research 2018 14:213

    Content type: Research article

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  26. Canine neutrophils release neutrophil extracellular traps (NETs) in response to lipopolysaccharide but NETs from clinical septic dogs had not been identified. The primary aim is to describe the methodology of ...

    Authors: Ronald H. L. Li, Lynelle R. Johnson, Casey Kohen and Fern Tablin

    Citation: BMC Veterinary Research 2018 14:210

    Content type: Methodology article

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  27. Skin wound healing includes a system of biological processes, collectively restoring the integrity of the skin after injury. Healing by second intention refers to repair of large and deep wounds where the tiss...

    Authors: T. Martinello, C. Gomiero, A. Perazzi, I. Iacopetti, F. Gemignani, G. M. DeBenedictis, S. Ferro, M. Zuin, E. Martines, P. Brun, L. Maccatrozzo, K. Chiers, J. H. Spaas and M. Patruno

    Citation: BMC Veterinary Research 2018 14:202

    Content type: Research article

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  28. Exosomes are defined as extracellular membrane vesicles, 30–150 nm in diameter, derived from all types of cells. They originate via endocytosis and then they are released through exocytosis to the extracellula...

    Authors: Matias Aguilera-Rojas, Brit Badewien-Rentzsch, Johanna Plendl, Barbara Kohn and Ralf Einspanier

    Citation: BMC Veterinary Research 2018 14:179

    Content type: Research article

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  29. Sodium pentosan polysulfate (NaPPS) was testified as a chondroprotective drug in with a detailed rationale of the disease-modifying activity. This study was undertaken to determine whether anti-osteoarthritis ...

    Authors: H. M. Suranji Wijekoon, Eugene C. Bwalya, Jing Fang, Sangho Kim, Kenji Hosoya and Masahiro Okumura

    Citation: BMC Veterinary Research 2018 14:152

    Content type: Research article

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  30. During the storage of packed red blood cells (pRBC), packed cell volume (PCV), bacterial contamination and percentage of haemolysis [percentage of free haemoglobin (HGB) in relation to the total HGB] are impor...

    Authors: C. Blasi Brugué, Rui R. F. Ferreira, I. Mesa Sanchez, Rita M. C. Graça, Inês M. Cardoso, Augusto J. F. de Matos and Rafael Ruiz de Gopegui

    Citation: BMC Veterinary Research 2018 14:141

    Content type: Research article

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  31. Feline eosinophilic keratitis (FEK) is a chronic keratopathy caused by a suspected immune mediated response to an unknown antigenic stimulus. The purpose of this study was to investigate the safety and therape...

    Authors: Antonio J. Villatoro, Silvia Claros, Viviana Fernández, Cristina Alcoholado, Fernando Fariñas, Antonio Moreno, José Becerra and José A. Andrades

    Citation: BMC Veterinary Research 2018 14:116

    Content type: Research article

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  32. Mesenchymal stem cells derived from the synovial membrane (MSCSM) have a greater potential for joint regeneration, besides the capacity for chondrogenic differentiation, since they are a source closer to the c...

    Authors: Vitor Hugo Santos, João Pedro Hübbe Pfeifer, Jaqueline Brandão de Souza, Betsabéia Heloisa Gentilha Milani, Rogério Antonio de Oliveira, Marjorie Golim Assis, Elenice Deffune, Andrei Moroz and Ana Liz Garcia Alves

    Citation: BMC Veterinary Research 2018 14:114

    Content type: Research article

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    The Correction to this article has been published in Stem Cell Research & Therapy 2018 9:259

  34. Stem cell-based therapies are an attractive option to promote regeneration and repair defective tissues and organs. Thanks to their multipotency, high proliferation rate and the lack of major ethical limitatio...

    Authors: Antoine D. Veron, Cécile Bienboire-Frosini, François Feron, Elisa Codecasa, Arnaud Deveze, Dany Royer, Paul Watelet, Pietro Asproni, Kevin Sadelli, Camille Chabaud, Jean-claude Stamegna, Joël Fagot, Michel Khrestchatisky, Alessandro Cozzi, François S. Roman, Patrick Pageat…

    Citation: BMC Veterinary Research 2018 14:17

    Content type: Methodology article

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  35. Canine diabetes is a strikingly prevalent and growing disease, and yet the standard treatment of a twice-daily insulin injection is both cumbersome to pet owners and only moderately effective. Islet transplant...

    Authors: Stephen Harrington, S. Janette Williams, Vern Otte, Sally Barchman, Cheryl Jones, Karthik Ramachandran and Lisa Stehno-Bittel

    Citation: BMC Veterinary Research 2017 13:264

    Content type: Research article

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  37. Mesenchymal Stem Cells (MSCs) are a promising therapeutic tool in veterinary medicine. Currently the subcutaneous adipose tissue is the leading source of MSCs in dogs. MSCs derived from distinct fat depots hav...

    Authors: Francisca Bahamondes, Estefania Flores, Gino Cattaneo, Flavia Bruna and Paulette Conget

    Citation: BMC Veterinary Research 2017 13:166

    Content type: Research article

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  38. The increasing interest in platelet-rich plasma (PRP) based therapies is as yet accompanied by inconsistent information regarding nearly all aspects of handling and application. Among these storage stability o...

    Authors: Gregor Hauschild, Florian Geburek, Georg Gosheger, Maria Eveslage, Daniela Serrano, Arne Streitbürger, Sara Johannlükens, Dirk Menzel and Reinhard Mischke

    Citation: BMC Veterinary Research 2017 13:7

    Content type: Research article

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  39. Dendritic cells are professional antigen-presenting cells that play an essential role in the initiation and modulation of T cell responses. They have been studied widely for their potential clinical applicatio...

    Authors: Anja Ziegler, Helen Everett, Eman Hamza, Mattia Garbani, Vinzenz Gerber, Eliane Marti and Falko Steinbach

    Citation: BMC Veterinary Research 2016 12:254

    Content type: Research article

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  40. Large bone defects in canines usually require assistance to achieve healing. Implantation of osteoinductive factors can promote bone healing, while transplantation of osteoprogenitor cells can enhance bone reg...

    Authors: Takamasa Itoi, Yasuji Harada, Hiroyuki Irie, Michiko Sakamoto, Katsutoshi Tamura, Takuya Yogo, Satoshi Soeta, Hajime Amasaki, Yasushi Hara and Masahiro Tagawa

    Citation: BMC Veterinary Research 2016 12:201

    Content type: Research article

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  41. In addition to their value as livestock, pigs are susceptible to classical swine fever virus (CSFV) and can serve as reservoirs for CSFV, allowing it to develop into an epizootic. CSFV, a pestivirus of the Fla...

    Authors: Yicheng Zhao, Tiedong Wang, Li Yao, Bo Liu, Chunbo Teng and Hongsheng Ouyang

    Citation: BMC Veterinary Research 2016 12:169

    Content type: Methodology article

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  42. Lactose, as the primary osmotic component in milk, is the major determinant of milk volume. Glucose is the primary precursor of lactose. However, the effect of glucose on lactose synthesis in dairy cow mammary...

    Authors: Ye Lin, Xiaoxu Sun, Xiaoming Hou, Bo Qu, Xuejun Gao and Qingzhang Li

    Citation: BMC Veterinary Research 2016 12:81

    Content type: Research article

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  43. Recently, equine multipotent mesenchymal stromal cells (MSC) have received significant attention as therapy for various conditions due to their proposed regenerative and immune-modulating capacity. MSC are com...

    Authors: Lynn B. Williams, Keith A. Russell, Judith B. Koenig and Thomas G. Koch

    Citation: BMC Veterinary Research 2016 12:45

    Content type: Research article

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  44. Intra-articular injection of corticosteroids is used to treat the inflammatory pain of arthritis and osteoarthritis (OA), but our previous study found a deleterious effect of these steroids on chondrocyte cell...

    Authors: Puntita Siengdee, Tiwaporn Radeerom, Similan Kuanoon, Thippaporn Euppayo, Waranee Pradit, Siriwadee Chomdej, Siriwan Ongchai and Korakot Nganvongpanit

    Citation: BMC Veterinary Research 2015 11:298

    Content type: Research article

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  45. Isolation of mesenchymal stem cells (MSCs) in equines, has been reported for different tissues including bone marrow, adipose, umbilical cord, peripheral blood, and yolk sac. In regard to the MSCs derived from...

    Authors: Aline Ambrogi Franco Prado, Phelipe Oliveira Favaron, Luis Claudio Lopes Correia da Silva, Raquel Yvonne Arantes Baccarin, Maria Angelica Miglino and Durvanei Augusto Maria

    Citation: BMC Veterinary Research 2015 11:281

    Content type: Research article

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  46. The objective of the present study was to evaluate the effect of the ionic product (IP) of BG60S on osteoblastic activity. The following media groups were created: DMEM, which is formed by osteoblasts in basal me...

    Authors: Endrigo G L Alves, Rogéria Serakides, Isabel R. Rosado, Marivalda M. Pereira, Natália M. Ocarino, Humberto P. Oliveira, Alfredo M. Góes and Cleuza M F Rezende

    Citation: BMC Veterinary Research 2015 11:247

    Content type: Research article

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  47. To explore the morphological evidence of immunoglobulin G (IgG) participating in intestinal mucosal immunity, 8 healthy adult Bactrian camels used. First, IgG was successfully isolated from their serum and rab...

    Authors: Wang-Dong Zhang, Wen-Hui Wang and Shuai Jia

    Citation: BMC Veterinary Research 2015 11:222

    Content type: Research article

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  48. Endometrial adenocarcinomas are a rare type of tumour in cats. Though different morphologies have been reported, the most frequent histological type of feline endometrial adenocarcinoma (FEA) is the papillary ...

    Authors: Ana Laura Saraiva, Rita Payan-Carreira, Fátima Gärtner, Marta R. Fortuna da Cunha, Alexandra Rêma, Fátima Faria, Lígia M. Lourenço and Maria dos Anjos Pires

    Citation: BMC Veterinary Research 2015 11:204

    Content type: Research article

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  49. The liver has a large regenerative capacity. Hepatocytes can replicate and regenerate a diseased liver. However, as is the case in severe liver diseases, this replication may become insufficient or exhausted a...

    Authors: Baukje A Schotanus, Hedwig S Kruitwagen, Ted SGAM van den Ingh, Monique E van Wolferen, Jan Rothuizen, Louis C Penning and Bart Spee

    Citation: BMC Veterinary Research 2014 10:309

    Content type: Research article

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  50. Articular cartilage has poor intrinsic capacity for regeneration because of its avascularity and very slow cellular turnover. Defects deriving from trauma or joint disease tend to be repaired with fibrocartila...

    Authors: Susanna Pilichi, Stefano Rocca, Roy R Pool, Maria Dattena, Gerolamo Masala, Laura Mara, Daniela Sanna, Sara Casu, Maria L Manunta, Andrea Manunta and Eraldo Sanna Passino

    Citation: BMC Veterinary Research 2014 10:301

    Content type: Research article

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