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Fig. 9 | BMC Veterinary Research

Fig. 9

From: Spontaneous autoimmune subepidermal blistering diseases in animals: a comprehensive review

Fig. 9

Histopathology of canine epidermolysis bullosa acquisita: a Neutrophils and macrophages form a row (arrows) along the basement membrane zone (BMZ) in the absence of a subepidermal cleft. Such alignment is not observed with eosinophils (arrow heads). b Neutrophils and fewer macrophages cluster below the BMZ and are associated with a microscopic subepidermal cleft that appears to form as clusters of small, subepidermal, clear vacuoles (arrow). c A large subepidermal vesicle contains neutrophils, eosinophils, and a small amount of fibrin in the lumen over similar inflammation in the superficial dermis. d A higher magnification image of the vesicle in image “c” showing many eosinophils mixed with neutrophils in the vesicle lumen. Haematoxylin and eosin

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