Parameter | Estimate | CV% |
---|
tvVplasma (mL) | 423,442.6 | 19.7 |
tvCl (ng*h/mL) | 337,682.9 | 11.2 |
tvVsyn (mL) | 557.5 | 24.3 |
tvKap (1/h) | 0.077 | 10.7 |
tvCLsyn (ng*h/mL) | 22.5 | 33.2 |
dKapdLPS1 | 0.333 | 38.5 |
stdev0 | 0.249 | 4.67 |
stdev1 | 0.584 | 22.0 |
HLplasma (h) | 0.869 | 18.1 |
Kap_HL (h) | 9.03 | 10.7 |
Syn_HL (h) | 17.1 | 19.8 |
Kap_LPS(1/h) | 0.107 | 11.6 |
Kap_LPS_HL(h) | 6.47 | 11.6 |
- tvVplasma denotes the value of the plasma volume of isoflupredone; tvCl the clearance of drug from plasma; tvVSyn the clearance of drug from synovial fluid; tvKap the rate of absorption of isoflupredone from the joint into the plasma in the absence of LPS; tvCLCSyn the clearance of drug from synovial fluid; dKapdLPS1 the effect of LPS on Kap; stdev0 the estimated residual standard deviation for plasma data; stdev1 the corresponding value for the synovial fluid data; HLplasma, the elimination half-life of drug from plasma; KapHL the half-life of absorption of the drug into plasma from synovial fluid in the absence of LPS; Syn_HL the elimination half-life of drug from synovial fluid; Kap_LPS the rate the rate of absorption of isoflupredone from the joint into the plasma during LPS; Kap_LPS_HL the half-life of absorption of the drug into plasma from synovial fluid during LPS administration