Pharmacokinetics and pharmacodynamics of intra-articular isoflupredone following administration to horses with lipopolysaccharide-induced synovitis

Table 3 Model typical values (tv) for isoflupredone following a single intra-articular administration of 8 mg of isoflupredone acetate (Predef® 2X) in the right antebrachiocarpal joint 12 h post intra-articular LPS administration, to exercised Thoroughbred horses (n = 8)

tvV_plasma denotes the value of the plasma volume of isoflupredone; tvCl the clearance of drug from plasma; tvVSyn the clearance of drug from synovial fluid; tvKap the rate of absorption of isoflupredone from the joint into the plasma in the absence of LPS; tvCLCSyn the clearance of drug from synovial fluid; dKapdLPS1 the effect of LPS on Kap; stdev0 the estimated residual standard deviation for plasma data; stdev1 the corresponding value for the synovial fluid data; HL_plasma, the elimination half-life of drug from plasma; KapHL the half-life of absorption of the drug into plasma from synovial fluid in the absence of LPS; Syn_HL the elimination half-life of drug from synovial fluid; Kap_LPS the rate the rate of absorption of isoflupredone from the joint into the plasma during LPS; Kap_LPS_HL the half-life of absorption of the drug into plasma from synovial fluid during LPS administration

ISSN: 1746-6148