Table 2 Mean (± SD) plasma and synovial fluid isoflupredone concentrations following a single intra-articular administration of 8 mg of isoflupredone acetate (Predef® 2X) in the right antebrachiocarpal joint 12 h post intra-articular LPS administration to exercised Thoroughbred horses (n = 8)

Baseline

ND

ND

ND

ND

ND

0.25 h

0.37 ± 0.15

–-

–-

–-

–-

0.5 h

0.66 ± 0.29

–-

–-

–-

–-

0.75 h

0.79 ± 0.32

–-

–-

–-

–-

1.0 h

0.81 ± 0.40

–-

–-

–-

–-

1.5 h

0.87 ± 0.34

–-

–-

–-

–-

2.0 h

1.16 ± 0.44

–-

–-

–-

–-

2.5 h

1.25 ± 0.48

–-

–-

–-

–-

3.0 h

1.46 ± 0.52

–-

–-

–-

–-

4.0 h

1.59 ± 0.47

–-

–-

–-

–-

6.0 h

1.59 ± 0.35

–-

–-

–-

–-

8.0 h

1.29 ± 0.36

–-

–-

–-

–-

12.0 h

1.07 ± 0.26

–-

–-

–-

–-

18.0 h

0.49 ± 0.13

–-

–-

–-

–-

24 h

0.19 ± 0.04

828.9 ± 608.4

0.97 ± 0.77

–-

–-

36 h

0.09 ± 0.03

–-

–-

–-

–-

48 h

 < LOQ

14.2 ± 10.8

ND

–-

–-

72 h

 < LOQ

0.68 ± 0.20

ND

–-

–-

96 h

–-

ND

ND

ND

ND

120 h

–-

ND

ND

–-

–-

Day 7

–-

ND

ND

–-

–-

Day 9

–-

ND

ND

ND

ND

Day 10

–-

ND

ND

–-

–-

Day 14

–-

ND

ND

–-

–-

Day 21

–-

ND

ND

–-

–-

Day 28

–-

ND

ND

ND

ND