Fig. 5
From: Curcumol inhibits EMCV replication by activating CH25H and inhibiting the formation of ROs
Schematic model of the mechanism of curcumol inhibiting EMCV replication. EMCV 3C protease can hydrolyze TANK and interfere with the formation of TANK-TBK1-IKKε-IRF3 complex, and inhibit the production of IFN-β. Curcumol can relieve the hydrolysis of TANK protein by EMCV 3C protease and promote the expression of IFN-β. IFN-β activated CH25H through the JAK/STAT signaling pathway. Curcumol inhibits EMCV replication is to reduce host cell cholesterol by activating CH25H and inhibiting the formation of ROs