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Table 1 Patient characteristics of all dogs included in the study (n = 55)

From: Tissue S100/calgranulin expression and blood neutrophil-to-lymphocyte ratio (NLR) in dogs with lower urinary tract urothelial carcinoma

Parameter

Urothelial carcinoma

Non-neoplastic urinary tract disease

Healthy control dogs

P value†

Total number of dogs

22

26

7

–

 analyzed by IHC

9

5

6

 in NLR analysis

21

26

1

Age†,*, in years

11.2A

6.6B

6.5a,B

0.0001

 median [range]

[6.8–14.3]

[0.3–14.5]

[2.0–10.0]

Weight, in kg

26.0

14.5

21.8

0.5074

 median [range]

[6.2–49.0]

[3.0–54.0]

[5.2–41.5]

Sex

 male (n) / female (sp)

4 (2) / 18 (6)

20 (5) / 6 (4)

7 (2) /0 (0)

< 0.0001

Breed

 pure-bred

12 (55%)

21 (81%)

5 (71%)

0.1450

 mixed breed

10 (45%)

5 (19%)

2 (29%)

Biopsy typeb

 endoscopic

9 (90%)

3 (43%)

1 (14%)

–

 surgical

0

4 (57%)

0

 post-mortem

1 (10%)

0

6 (86%)

Primary disease locationb

 urethra

4 (40%)

1 (20%)

–

–

 urinary bladder

6 (60%)

4 (80%)

Tissues evaluatedb

 urethra

5 (50%)

1 (17%)

5 (71%)

–

 urinary bladder

6 (60%)

6 (83%)

7 (100%)

Treatment

 treatment-naïve

8 (36%)

19 (79%)c

–

–

 NSAID treatment

14 (64%)

5 (21%)c

Urine culture

 positive

3 (25%)d

8 (44%)e

–

–

 negative

9 (75%)d

10 (56%)e

  1. IHC Immunohistochemistry, n Neutered, NLR Neutrophil-to-lymphocyte ratio, NSAID Non-steroidal anti-inflammatory drug, sp Spayed
  2. †bold font indicates significance at P < 0.05
  3. * values with a different capital superscript letter (A, B) differ significantly at P < 0.05
  4. a only available from 6 control dogs
  5. b only shown for dogs included in IHC analyses
  6. c only available from 24 dogs
  7. d only available from 12 dogs
  8. e only available from 18 dogs