Fig. 2From: Granulation tissue-type hemangioma in a 6-week-old puppy – a case reportA, B HE-stain: Split population of plump endothelial cells with a moderate amount of basophilic cytoplasm and a round to oval nucleus with finely stippled chromatin (arrows) build erythrocyte-filled channels (asterisk) as well as spindle cells with a moderate amount of pale basophilic cytoplasm and oval nuclei with mostly one nucleolus and coarsely clumped chromatin with a fibrous stroma surrounding the vascular structures (arrowheads); C Factor-VIII-related antigen: Positive signal of endothelial cells (arrows); D, E SMA: Mainly positive signal of spindle cells (arrowheads) and negative endothelial cells (arrows)Back to article page