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Table 1 Base substitutions and corresponding amino acid substitutions in the genome of the SARS-CoV-2 virus found in the infected dog of this study

From: Detection of SARS-CoV-2 in a dog with hemorrhagic diarrhea

Genome Positiona

Gene

Base changeb

Protein

Non-Synonymous substitution

241

5' UTR

C > T

-

-

445

ORF1ab

T > C

NSP1

-

3037

C > T

NSP3

-

6286

C > T

-

14408

C > T

NSP12

Pro323Leu

15313

G > A

Ala625Thr

15418

G > T

Ala660Ser

21255

G > C

NSP16

-

21776

S

G > C

S

Gly72Arg

22227

C > T

Ala222Val

22766

A > G

Ile402Val

23068

T > C

-

23403

A > G

Asp614Gly

24034

C > T

-

26530

M

A > G

M

Asp3Gly

27944

ORF8

C > T

8

-

28083

G > T

Glu64STOP

28378

N

G > T

N

-

28703

G > C

Asp144His

28932

C > T

Ala220Val

29645

ORF10

G > T

10

Val30Leu

  1. aPosition in the consensus genome (GenBank NC_045512.2)
  2. bSubstitution relative to the base in the consensus genome. As the sequencing was based on the genome retrotranscribed to DNA, thymine should correspond to uracil in the viral RNA genome