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Table 2 Cardiovascular and echocardiographic variables pre- and post- weight reduction for the dogs that achieved target weight reduction

From: The effect of obesity and subsequent weight reduction on cardiac structure and function in dogs

Variable Before weight reduction After weight reduction P value r value
Median (IQR) Median (IQR)
ECG heart rate 115 (95- 140) 110 (88.75–137.5) 0.722 0.117
Heart rate variability (VVTI) 8.337 (6.7- 10.1) 8.856 (7.69–10.13) 0.367 0.272
SBP (mmHg) 178 (140–184) 148 (136.3–188.8) 0.554 0.164
Hs-cTnI (ng/mL) 0.013 (0.007–0.52) 0.012 (0.009–0.018) 0.657 0.147
NT-proBNP (pmol/L) 371.5 (257.8–530.0) 482.0 (345.0–558.0) 0.262 0.353
LA/Ao 1.305 (1.14–1.44) 1.295 (1.13–1.37) 0.894 0.013
LA major (cm) 3.4 (2.78–3.97) 3.335 (2.87–3.94) 0.722 0.125
LAmax/Ao 2.3 (2.06–2.42) 2.1 (1.75–2.29) 0.176 0.436
IVSd (mm) 10.25 (8.93–12.25) 9.65 (7.88–10.7) 0.158 0.419
LVIDd (mm) 35.2 (27.43–42.25) 34.45 (27.27–42.18) 0.556 0.363
LVFWd (mm) 9.3 (8.28- 10.88) 8.8 (7.9–9.48) 0.099 0.340
IVSs (mm) 13.4 (11.85–15.9) 11.75 (9.65–14.1) 0.029 0.643
LVIDs (mm) 23.75 (17.23–31.27) 25.45 (18.97–27.93) 0.272 0.323
LVFWs (mm) 13.3 (12.1–15.5) 10.55 (10.15–14.3) 0.017 0.702
IVSdN Actual weight 0.41 (0.38–0.47) 0.41 (0.38–0.48) 0.610 0.158
  Target weight 0.46 (0.41–0.55) 0.41 (0.38–0.49) 0.126 0.453
LVIDdN Actual weight 1.31 (1.18–1.41) 1.41 (1.23–1.53) 0.092 0.498
  Target weight 1.44 (1.32–1.60) 1.42 (1.26–1.54) 0.290 0.317
LVFWdN Actual weight 0.44 (0.39–0.51) 0.42 (0.37–0.50) 0.610 0.158
  Target weight 0.49 (0.43–0.55) 0.42 (0.37–0.51) 0.196 0.385
IVSsN Actual weight 0.58 (0.49–0.68) 0.55 (0.48–0.59) 0.224 0.362
  Target weight 0.63 (0.55–0.74) 0.56 (0.50–0.60) 0.011 0.744
LVIDsN Actual weight 0.82 (0.72–0.93) 0.94 (0.81–1.04) 0.011 0.747
  Target weight 0.91 (0.81–1.04) 0.95 (0.83–1.05) 0.196 0.385
LVFWsN Actual weight 0.66 (0.54–0.71) 0.59 (0.54–0.64) 0.196 0.385
  Target weight 0.72 (0.58–0.79) 0.60 (0.54–0.65) 0.009 0.770
EDV (mL)   32 (18–65) 33 (18–64) 0.507 0.200
EDVI (mL/kg) Actual weight 1.67 (1.21–2.09) 2.02 (1.88–2.72) 0.008 0.770
  Target weight 2.31 (1.80–2.59) 2.01 (1.88–2.72) 0.657 0.128
ESV (mL)   13 (6–38) 13 (7–35) 0.180 0.404
ESVI (mL/kg) Actual weight 0.64 (0.42–1.13) 0.92 (0.67–1.41) 0.015 0.702
  Target weight 0.90 (0.65–1.43) 0.92 (0.67–1.41) 0.158 0.407
E velocity (m/s) 0.67 (0.56–0.76) 0.71 (0.53–0.79) 0.965 0.026
MV E/A 1.175 (0.9–1.40) 1.03 (0.88–1.24) 0.824 0.119
E deceleration (ms) 90 (77.75–108) 86.5 (81.75–106.5) 0.76 0.103
IVRT (ms) 73.5 (62.5–87.75) 75 (69–94.25) 0.724 0.113
TAPSE (cm) 1.14 (0.9–1.5) 1.11 (0.8–1.36) 0.789 0.309
Septal E’/A’ 0.695 (0.57–0.83) 0.7 (0.59–0.84) 0.45 0.242
Lateral E’/A’ 0.715 (0.59–0.80) 0.7 (0.6–0.8) 0.824 0.081
Right E’/A’ 0.65 (0.6–0.86) 0.67 (0.56–0.72) 0.262 0.371
Fractional shortening (%) 32 (27–39) 30 (26–34) 0.168 0.411
Ejection Fraction (%) 61 (53–65) 56 (41–69) 0.266 0.349
  1. EDV End diastolic volume, EDVI End diastolic volume index, ESV End systolic volume, ESVI End systolic volume index, hs-cTnI Cardiac troponin I, suffix: -N: indexed to bodyweight, IQR Interquartile range, IVRT Isovolumetric relaxation time, IVSd Interventricular septum in diastole, IVSs Interventricular septum in systole, LA/Ao Left atrium: aorta ratio, LAmax/Ao Left atrium major to aorta ratio, LVFWd Left ventricular free wall in diastole, LVFWs Left ventricular free wall in systole, LVIDd Left ventricular internal diameter in diastole, LVIDs Left ventricular internal diameter in systole, MV Mitral valve, NT-proBNP N-type N-terminal pro-brain natriuretic peptide, SBP Blood pressure, TAPSE Tricuspid annular plane systolic excursion, VVTI Vasovagal tonal index