A novel strategy for developing vaccine candidate against Jaagsiekte sheep retrovirus from the envelope and gag proteins: an in-silico approach

Table 2 The eight predicted cytotoxic T cells epitopes, their antigenicity, allergenicity, and toxicity from the envelope and gag proteins

Protein	Epitope	Alleles	Start	End	Vaxijen^a Antigenicity
Envelope protein	YKWICVTKK^b	BoLA-T2C	468	476	1.7367
	HISPQQANI^b	BoLA-T2C	120	128	1.5736
	ISFYGLTTQ^b	BoLA-T2a	128	136	1.1064
	RGVAKGEQV^b	BoLA-HD6	330	338	1.0778
	GVTGFLYPR^b	BoLA-T2a	285	293	0.9625
	MKIQCHANY^b	BoLA-D18.4	460	468	0.8693
	SLLGGKSDI^b	BoLA-T2C	111	119	0.7804
	HLNCSNCIL^b	BoLA-T2C	317	325	0.6677
Gag protein	TSYEMLIGE^b	BoLA-T2a	347	355	1.5370
	CFKNLTIAL^b	BoLA-T2C	179	187	1.4302
	RKKGDLSDF^b	BoLA-D18.4	452	460	1.3402
	CLDFDNDEL^b	BoLA-T2C	88	96	1.1209
	GQPGHRAAV^b	BoLA-D18.4	513	521	1.0927
	RQAQRLGEV^b	BoLA-D18.4	240	248	1.0927
	NSGCFVCGQ^b	BoLA-T2a	506	514	1.0792
	AMAAALQGK^b	BoLA-T2a	476	484	1.0711

^aThe threshold for the Vaxijen antigenicity was 0.4
^bRepresents the epitopes entered in the structure of the vaccine construct. All the predicted epitopes were shown to be non-allergen and non-toxic

ISSN: 1746-6148