Fig. 4

The alignment and entropy plot (amino acid diversity) of GP5 and M of PRRSV-2 samples with VR2332 strain. Multiple alignments of GP5 (A) and M (B) protein of PRRSV-2 are numbered from start of the GP5 domain (aa 1–200) and M protein domain (aa 1–100), respectively. The sequence of VR2332 is shown at the top of (A) and (B). The meaning of the size and color of the sequence logos is explained in the legend to Fig. 3. A red square box indicates a B-cell epitope region, and a red round box indicates a T-cell epitope region. DE: decoy epitope, NE: neutralizing epitope, HVR: hypervariable region, B epitope: B-cell epitope, T epitope: T-cell epitope