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Table 2 The mean ± standard deviation of HR (beat/ min), RR (breath/ min) and RT (°C) measured at different times 10 minutes prior- and 10, 20, 30, 45, 60, 75, and 90 minutes post- the epidural analgesia in rabbits. Group A: lidocaine epidural, group B: tramadol epidural, and group C: lidocaine-tramadol epidural

From: Antinociceptive effect of lidocaine, tramadol, and their combination for lumbosacral epidural analgesia in rabbits undergoing experimental knee surgery

Variables

Groups

Monitoring time (minutes)

−10

10

20

30

45

60

75

90

HR (beat/min)

A

144.0 ± 0.4 a

142.0 ± 0.5 a

134.6 ± 0.5 b

132.0 ± 0.6 b

124.5 ± 0.8 b

124.0 ± 0.6 *b

127.5 ± 0.8 *b

137.5 ± 0.8 b

B

144.0 ± 0.4 a

143.0 ± 0.6 a

140.8 ± 0.8 a

131.0 ± 0.8 a

127.7 ± 0.5 a

123.0 ± 0.8 *b

127.3 ± 0.8 *b

135.5 ± 0.8 a

C

145.0 ± 1.5 a

128.0 ± 0.9 *b

115.3 ± 0.8 *c

108.0 ± 1.1 *b

107.0 ± 1.4 c

103.7 ± 0.5 *c

122.7 ± 0.8 *b

131.3 ± 0.8 c

RR (breath/min)

A

60.0 ± 0.6 a

55.7 ± 0.8 a

51.5 ± 0.5 a

48.2 ± 0.7 a

47.3 ± 0.8 a

49.7 ± 0.7 *b

53.2 ± 0.8 *b

59.7 ± 1.0 a

B

60.2 ± 0.9 a

57.0 ± 0.6a

54.3 ± 0.8 *b

45.8 ± 0.7 *b

44.3 ± 0.8 a,b

44.3 ± 0.8 *c

48.0 ± 0.6 *c

59.8 ± 1.4 a

C

59.5 ± 0.8 a

52.0 ± 1.9 *b

46.0 ± 0.9 *c

43.3 ± 0.8 *c

41.0 ± 0.9 b

37.0 ± 0.6 *d

34.3 ± 0.8 *d

43.3 ± 0.8 *b

RT °C

A

39.4 ± 0.08 a

39.3 ± 0.05 a

39.2 ± 0.09 a

38.4 ± 0.08 * b

38.4 ± 0.06 b

38.3 ± 0.05 *b

39.0 ± 0.05 a,b

39.2 ± 0.05 a, b

B

39.5 ± 0.07 a

39.4 ± 0.05 b

39.2 ± 0.05 a

38.6 ± 0.08 b

38.4 ± 0.05 b

38.3 ± 0.05 b

39.0 ± 0.05 b

39.3 ± 0.04 b

C

39.5 ± 0.07 a

39.1 ± 0.05 b

38.2 ± 0.06 b

37.5 ± 0.06 *c

37.2 ± 0.06 c

37.2 ± 0.04 *c

37.7 ± 0.08 *c

38.8 ± 0.06 b

  1. Means with different superscript letters are significantly different at P < 0.05 among groups
  2. Means with an asterisk (*) differ significantly (P < 0.05) from baseline
  3. All within interaction, Wilks’ Lambda, P < 0.001; Within time, Wilks’ Lambda, P < 0.0001; Time * groups, Wilks’ Lambda, P < 0.001