Table 8 Selected cut-off values for cTnI concentrations based on the Youden index
From: Evaluation of new and old biomarkers in dogs with degenerative mitral valve disease
Investigation | Cut-off (ng/mL) | Sensitivity% (95% CI) | Specificity% (95% CI) | AUC (95% CI) | p-value |
|---|---|---|---|---|---|
Stage C compared with controls | |||||
  Baseline |  > 0.085 | 85.71(60.06–97.46) | 85.71(65.36–95.02) | 0.93(0.86–1) |  < 0.0001 |
  Follow Up |  > 0.075 | 71.43(35.89–94.92) | 82.35(58.97–93.81) | 0.82(0.64–0.99) | 0.0158 |
Stage C compared with Stage B1 | |||||
  Baseline |  > 0.085 | 92.86(68.53–99.63) | 75.61 (60.66–86.17) | 0.94(0.88–1) |  < 0.0001 |
  Follow Up |  > 0.075 | 71.43(35.89–94.92) | 69.70 (52.66–82.62) | 0.83 (0.66–0.99) | 0.0072 |
Stage C compared with Stage B2 | |||||
  Baseline |  > 0.085 | 85.71(60.06–97.46) | 77.78(45.26–96.05) | 0.9 (0.78–1) | 0.0015 |
  Follow-up |  > 0.075 | 71.43(35.89–94.92) | 58.33(31.95–80.67) | 0.65 (0.41–0.9) | NS |