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Table 6 Selected cut-offs for NT-proBNP concentrations based on the Youden index

From: Evaluation of new and old biomarkers in dogs with degenerative mitral valve disease

Investigation

Cut-off (pmol/L)

Sensitivity% (95% CI)

Specificity% (95% CI)

AUC (95% CI)

p-value

Stage C compared with controls

  Baseline

 > 1005

85.71 (60.06–97.46)

89.47 (68.61–98.13)

0.87 (0.7–1)

0.0003

  Follow-up

 > 821

100 (60.97–100)

80 (54.81–92.95)

0.94 (0.85–1)

0.0018

Stage C compared with stage B1

  Baseline

 > 1005

85.71 (60.06–97.46)

80.49 (65.99–89.77)

0.85 (0.69–1)

0.0001

  Follow-up

 > 883

100 (60.97–100)

75.76 (58.98–87.17)

0.93 (0.85–2)

0.0008

Stage C compared with stage B2

  Baseline

 > 978.5

85.71 (60.06–97.46)

66.67 (35.42–87.94)

0.8 (0.62–0.98)

0.0167

  Follow-up

 > 1103

83.33 (43.65–99.25)

58.33 (31.95–80.67)

0.76 (0.53–0.99)

NS

  1. This table shows selected cut-offs for NT-proBNP concentrations based on the best values for sensitivity and specificity to differentiate stage C from the other groups at baseline and follow-up examination, CI Confidence interval, AUC Area under the curve, NS Non-significant