Fig. 1

Severe liver damage caused by ischemia–reperfusion. A Chemical structure of ellagic acid. B C57/B6 mice were subjected to hepatic IRI model (a. before hepatic ischemia, b. start hepatic ischemia, c. ischemia for 90 min, d. reperfusion). C, D and E The hepatocellular function in serum samples was evaluated by detecting ALT, AST, and LDH levels (n = 3). F The relative expression levels of CXCL-1, CXCL-2 and CXCL-10 were determined using qRT-PCR in mice liver specimens (n = 6). G Representative images of hematoxylin and eosin (HE) staining (scale bar, 100 μm). All data are shown as the mean ± SEM.****P < 0.0001, **P < 0.01