Table 3 Effects of DWP16001 on blood, serum and urinary biochemistry of obese dogs in 8 weeks

WBC (× 10³μL)

7.93 ± 2.83

11.12 ± 3.69

7.75 ± 2.04

10.01 ± 3.35

RBC × 10⁶μL)

6.90 ± 0.99

6.92 ± 0.79

72.22 ± 0.32

6.55 ± 1.08

Hb (g/dL)

16.36 ± 1.98

16.34 ± 2.68

16.40 ± 0.70

16.16 ± 2.15

Hct (%)

47.94 ± 7.61

49.86 ± 7.08

50.26 ± 1.94

46.76 ± 6.13

Platelet (× 10³/μL)

422.60 ± 12.98

392.20 ± 11.16

307.40 ± 6.02

299.10 ± 7.65*

Glu (mg/dL)

113.80 ± 10.85

107.20 ± 10.85

97.77 ± 10.19

94.00 ± 13.47

Insulin (ng/mL)

133.27 ± 16.43

126.60 ± 15.45

99.82 ± 18.48*

110.75 ± 21.96

TC (mg/dL)

236.40 ± 69.21

183.84 ± 36.01

298.00 ± 71.14

309.00 ± 129.40

TG (mg/dL)

361.60 ± 622.34

142.00 ± 95.55

133.86 ± 70.19

282.60 ± 419.03

TP (mg/dL)

6.48 ± 0.66

6.78 ± 0.66

6.43 ± 0.32

6.14 ± 0.54

ALB (g/dL)

3.04 ± 0.30

3.48 ± 0.42

2.95 ± 0.19

2.92 ± 0.29

GGT (IU/L)

13.20 ± 14.55

7.80 ± 1.64

9.46 ± 5.37

21.60 ± 29.36

ALT(IU/L)

50.60 ± 29.33

18.84 ± 4.00*

36.80 ± 14.43*

38.60 ± 19.72

AST(IU/L)

44.80 ± 16.21

31.00 ± 1.83

31.84 ± 12.92

110.00 ± 167.92

ALP(IU/L)

211.60 ± 199.74

84.60 ± 63.96*

146.20 ± 121.67

186.20 ± 184.59

CPK(IU/L)

129.40 ± 35.82

111.12 ± 30.97*

136.50 ± 42.99

260.40 ± 126.79

BUN (mg/dL)

15.12 ± 6.30

18.70 ± 10.29

22.25 ± 8.64

23.44 ± 13.17

CRE (mg/dL)

1.20 ± 0.31

0.78 ± 0.21*

0.82 ± 0.15

0.92 ± 0.36

Urinary GLU (grade)

0

2 ± 0.12

4

4