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Table 2 Mean concentrations of biomarkers in synovial fluid, measured from T0 to T4 in the GC and GT

From: Effects of oral treatment with chondroitin sulfate and glucosamine in an experimental model of metacarpophalangeal osteoarthritis in horses

Biomarker

 

T0

T1

T2

T3

T4

P-value, Friedman test between time-points

P-value ANOVAa

CTXII (pg/mL)

       

0.568

 GC

Mean ± SD

255.2 ± 38.9

210.6 ± 95.4

386,5 ± 188

593.8 ± 51.5

593.2 ± 66.1

0.003

 

Median (IQR)

260.5 (223.7–285.5)

172.3 (154.4–231.8)

370.3 (226.1–538.6)

619.3 (547.9–629.3)

586.1 (541.9–649.9)

 

 GT

Mean ± SD

268.3 ± 42

238 ± 61.1

429.2 ± 201.9

566.3 ± 104.6

618.1 ± 110.1

< 0.001

 

Median (IQR)

268.1 (231.3–297.3)

231.3 (211–264.8)

433 (236.5–622.2)

547.9 (489.3–607.2)

617.9 (543.6–640.7)

 

PGE2 (pg/mL)

       

0.078

 GC

Mean ± SD

25.5 ± 10.7

82.6 ± 40.4

75 ± 38.4

47.4 ± 27.5

50.9 ± 29.4

0.004

 

Median (IQR)

21.3 (17.2–33.3)

81.8 (48.6–122.4)

65.4 (42–116.5)

34.1 (31.4–59.8)

46 (26–81.3)

 

 GT

Mean ± SD

47.2 ± 40.7

60.7 ± 32.2

55.8 ± 47.4

45.9 ± 46.2

60.1 ± 38

0.171

 

Median (IQR)

26.8 (19–77.5)

53.7 (38.1–73.7)

41.9 (31.9–57.3)

24.4 (17.9–67.7)

51.2 (34.6–81.4)

 

Chondroitin sulfate (μg/mL)

       

0.318

 GC

Mean ± SD

23.5 ± 9.5

26.4 ± 10.6

25.4 ± 16

31.6 ± 12.7

28.8 ± 8.4

0.711

 

Median (IQR)

21.2 (15.7–29.8)

25.5 (18.6–29.3)

18 (13.6–35.4)

28.4 (25.7–31.7)

29 (22.2–36.6)

 

 GT

Mean ± SD

29.4 ± 8.1

20.7 ± 5

24.2 ± 10.7

23.9 ± 18.4

34.7 ± 15.7

0.103

 

Median (IQR)

27.9 (24.9–33.3)

19.5 (16.9–24.3)

20.9 (17–30.7)

15.1 (13.3–29.8)

33 (22.2–44.2)

 

Hyaluronic acid (μg/mL)

       

0.517

 GC

Mean ± SD

556.5 ± 110.6

301.6 ± 113.6

365.2 ± 122.8

310 ± 120.6

381.5 ± 127.7

0.034

 

Median (IQR)

574.9 (473.5–600.6)

297.7 (216–383.7)

372.5 (243.5–484.1)

328.5 (207–419.9)

409.4 (297.5–466.4)

 

 GT

Mean ± SD

579.9 ± 75.3

304.8 ± 91.6

388.7 ± 168.2

392.1 ± 146.6

471.5 ± 107

0.001

 

Median (IQR)

591.2 (504–641.8)

321.4 (222–370.5)

337.3 (248.6–534.8)

405.1 (319.6–508.2)

518 (392.9–550.6)

 

p-value Mann-Whitney U test between groups at each time-point

 

CTXII (pg/mL)

0,798

0,234

0,505

0,414

0,779

 

PGE2 (pg/mL)

0,279

0,336

0,281

0,181

0,731

 

Chondroitin sulfate (μg/mL)

0,161

0,234

0,613

0,121

0,645

 

Hyaluronic acid (μg/mL)

0,574

0,878

0,867

0,281

0,130

 
  1. ANOVA analysis of variance, GC control group, CTX II C-telopeptide of type II Collagen, PGE2 prostaglandin E2, SD standard deviation, GT treated group
  2. aP-value of time-point/group interaction by nonparametric two-way ANOVA