Biomarker | T0 | T1 | T2 | T3 | T4 | P-value, Friedman test between time-points | P-value ANOVAa | |
---|---|---|---|---|---|---|---|---|
CTXII (pg/mL) | 0.568 | |||||||
GC | Mean ± SD | 255.2 ± 38.9 | 210.6 ± 95.4 | 386,5 ± 188 | 593.8 ± 51.5 | 593.2 ± 66.1 | 0.003 | |
Median (IQR) | 260.5 (223.7–285.5) | 172.3 (154.4–231.8) | 370.3 (226.1–538.6) | 619.3 (547.9–629.3) | 586.1 (541.9–649.9) | |||
GT | Mean ± SD | 268.3 ± 42 | 238 ± 61.1 | 429.2 ± 201.9 | 566.3 ± 104.6 | 618.1 ± 110.1 | < 0.001 | |
Median (IQR) | 268.1 (231.3–297.3) | 231.3 (211–264.8) | 433 (236.5–622.2) | 547.9 (489.3–607.2) | 617.9 (543.6–640.7) | |||
PGE2 (pg/mL) | 0.078 | |||||||
GC | Mean ± SD | 25.5 ± 10.7 | 82.6 ± 40.4 | 75 ± 38.4 | 47.4 ± 27.5 | 50.9 ± 29.4 | 0.004 | |
Median (IQR) | 21.3 (17.2–33.3) | 81.8 (48.6–122.4) | 65.4 (42–116.5) | 34.1 (31.4–59.8) | 46 (26–81.3) | |||
GT | Mean ± SD | 47.2 ± 40.7 | 60.7 ± 32.2 | 55.8 ± 47.4 | 45.9 ± 46.2 | 60.1 ± 38 | 0.171 | |
Median (IQR) | 26.8 (19–77.5) | 53.7 (38.1–73.7) | 41.9 (31.9–57.3) | 24.4 (17.9–67.7) | 51.2 (34.6–81.4) | |||
Chondroitin sulfate (μg/mL) | 0.318 | |||||||
GC | Mean ± SD | 23.5 ± 9.5 | 26.4 ± 10.6 | 25.4 ± 16 | 31.6 ± 12.7 | 28.8 ± 8.4 | 0.711 | |
Median (IQR) | 21.2 (15.7–29.8) | 25.5 (18.6–29.3) | 18 (13.6–35.4) | 28.4 (25.7–31.7) | 29 (22.2–36.6) | |||
GT | Mean ± SD | 29.4 ± 8.1 | 20.7 ± 5 | 24.2 ± 10.7 | 23.9 ± 18.4 | 34.7 ± 15.7 | 0.103 | |
Median (IQR) | 27.9 (24.9–33.3) | 19.5 (16.9–24.3) | 20.9 (17–30.7) | 15.1 (13.3–29.8) | 33 (22.2–44.2) | |||
Hyaluronic acid (μg/mL) | 0.517 | |||||||
GC | Mean ± SD | 556.5 ± 110.6 | 301.6 ± 113.6 | 365.2 ± 122.8 | 310 ± 120.6 | 381.5 ± 127.7 | 0.034 | |
Median (IQR) | 574.9 (473.5–600.6) | 297.7 (216–383.7) | 372.5 (243.5–484.1) | 328.5 (207–419.9) | 409.4 (297.5–466.4) | |||
GT | Mean ± SD | 579.9 ± 75.3 | 304.8 ± 91.6 | 388.7 ± 168.2 | 392.1 ± 146.6 | 471.5 ± 107 | 0.001 | |
Median (IQR) | 591.2 (504–641.8) | 321.4 (222–370.5) | 337.3 (248.6–534.8) | 405.1 (319.6–508.2) | 518 (392.9–550.6) | |||
p-value Mann-Whitney U test between groups at each time-point | ||||||||
CTXII (pg/mL) | 0,798 | 0,234 | 0,505 | 0,414 | 0,779 | |||
PGE2 (pg/mL) | 0,279 | 0,336 | 0,281 | 0,181 | 0,731 | |||
Chondroitin sulfate (μg/mL) | 0,161 | 0,234 | 0,613 | 0,121 | 0,645 | |||
Hyaluronic acid (μg/mL) | 0,574 | 0,878 | 0,867 | 0,281 | 0,130 |