Table 5 Cytokines and miRNA affection on Th cells at 10 and 15 DPI
Infection time | miRNA | miRNA expression pattern | Cytokine | Cytokine affection on Th cells |
|---|---|---|---|---|
10DPI | gga-miR-2954 | up | IL11RA [59] | Inhibit Th2 |
| Â | gga-miR-16-5p | up | IL5RA [60] | Inhibit Th2 |
| Â | gga-miR-129-5p | up | CD5 [61] | Inhibit Th2 |
| Â | gga-miR-145-5p | down | CD276 [48] (B7-H3) | Inhibit Th2 Promote Th1/Th17 |
| Â | gga-miR-7460-5p | down | TIRAP [62] | promote Th1 |
| Â | gga-miR-132c-5p | up | IFNGR2 [63] | promote Th1 |
| Â | gga-miR-214 | down | SOCS5 [51] | promote Th1 |
| Â | gga-miR-214 | down | promote Th1 Inhibit Th17/TFH | |
| Â | gga-miR-214 | down | CXCR5 [67] | Inhibit TFH |
| Â | gga-miR-2954 | up | CD2AP [68] | Inhibit TFH |
15DPI | gga-miR-2954, gga-miR-12,225-3p | down | IL11RA [59] | promote Th2 |
| Â | gga-miR-222b-5p | up | TRAF1 [69] | promote Th2 |
| Â | gga-miR-12,265-5p, gga-miR-193b-3p | down | Inhibit Th2 Promote Th1/Th17 | |
| Â | gga-miR-16-5p, gga-miR-15b-5p, gga-miR-15c-5p, gga-miR-16c-5p | up | IL5RA [72] | Inhibit Th2 |
| Â | gga-miR-212-5p, gga-miR-15b-5p | up | CD5 [61] | Inhibit Th2 |
| Â | gga-miR-146a-3p | up | SOCS3 [73] | Inhibit Th2 |
| Â | gga-miR-132a-3p, gga-miR-22-3p | up | IL6R [74] | promote Th2 Inhibit Th1 |
| Â | gga-miR-27b-3p | down | CD8A [75] | promote Th1 |
| Â | gga-miR-132c-5p | up | IFNGR2 [63] | promote Th1 |
| Â | gga-miR-1674 | up | IL12B [56] | promote Th1 |
| Â | gga-miR-193b-3p | down | promote Th17 | |
| Â | gga-miR-7460-5p | down | IL1B [78] | Promote Th1/Th17 |
| Â | gga-miR-12,265-5p | down | IL10RA [79] | Inhibit Th1/Th17 |
| Â | gga-miR-222b-5p | up | CCL19 [80] | Inhibit Th1 |
| Â | gga-miR-146a-3p | up | TIRAP [62] | Inhibit Th1 |
| Â | gga-miR-2954, gga-miR-12,225-3p | down | CXCR5 [60] | Promote TFH |