Table 4 Target genes and miRNA affection on Th cells at 10 and 15 DPI in GO terms
Infection time | miRNA | miRNA expression pattern | Target gene | Target gene affection on Th cells |
|---|---|---|---|---|
10DPI | gga-miR-145-5p | down | CD276 [48] (B7-H3) | Inhibit Th2 Promote Th1/Th17 |
| Â | gga-miR-214 | down | LEF1 [49] | Inhibit Th2 |
| Â | gga-miR-214 | down | STAT3 [50] | Promote Th1/Th17 |
| Â | gga-miR-214 | down | SOCS5 [51] | Promote Th1 |
| Â | gga-miR-2954 | up | RARA [52] | Promote Th1 |
| Â | gga-miR-7460-3p | down | RIPK2 [53] | Promote Th1/Th17 |
| Â | gga-miR-145-5p | down | MALT1 [54] | Promote Th17 |
15DPI | gga-miR-7460-3p | down | RIPK2 [53] | Promote Th1/Th17 |
| Â | gga-miR-145-5p | down | MALT1 [54] | Promote Th17 |
| Â | gga-miR-148b-5p | down | STAT3 [50] | Promote Th1/Th17 |
| Â | gga-miR-12,265-5p | down | RHOA [55] | Promote Th1/Th17 |
| Â | gga-miR-1674 | up | IL-12B [56] | Promote Th1 |
| Â | gga-miR-12,265-5p | down | IRF4 [57] | Inhibit Th2 |
| Â | gga-miR-2954 | down | RARA [58] | Inhibit Th2 |